Inverted point-scanning laser confocal microscope with spectral detection. Ideal for imaging live cells or tissue.

Features Include:

  • CO2 and temperature incubation for live cells and tissue
  • Fully motorised X-Y-Z stage
  • Z-stacks
  • Tiled imaging
  • Mark and Find
  • Automated image capture experiments
  • Online fingerprinting – for imaging with multiple spectrally overlapping fluorophores and removing background fluorescence

Objectives:

  • Air:
    • 10x 0.45 NA / 2000µm WD / 0.439 μm/pixel,
    • 20x 0.8 NA / 550µm WD / 0.22 μm/pixel,
  • Water:
    • 40x 1.1 NA / 620µm WD / 0.11 μm/pixel,
  • Oil:
    • 63x 1.4 NA / 190µm WD / 0.19 μm/pixel

Fluorescent Filter Sets (for checking sample with oculars):

  • DAPI
  • GFP / Alexa 488
  • Cy3 / Alexa 546/555/568
  • Cy5 / Alexa 633/647

Lasers:

  • Blue laser diode (405nm)
    • DAPI
  • Argon laser (458/477/488/514nm)
    • GFP / YFP / FITC / Alexa488
  • Melles Griot DPSS 561nm
    • Cy3 / Alexa 546/555/568 / Alexa 594 / mCherry
  • HeNe 633nm
    • Cy5 / Alexa647

Laser Power:

Measurement at BFP

  • 405nm (1.51 mW),
  • 458nm (0.06 mW),
  • 488nm (0.9 mW),
  • 514nm (0.3 mW),
  • 561nm (1.2 mW),
  • 633nm (1.1 mW)

Instructions

Guide to using the LSM 510 META