Queensland Brain Institute (QBI) neuroscientists are using a multidisciplinary approach to improve the understanding of motor neuron disease.

A small proportion of MND patients carry mutations in the superoxide dismutase (SOD1) gene and earlier research has found transgenic mice carrying the mutant SOD1 gene undergo progressive motor neuron loss. As such, QBI researchers are now investigating ways of preventing cell death associated with MND in SOD1 mice.

Additionally, researchers are assessing the usefulness of MRI for monitoring disease progression, searching for MND biomarkers in patient blood samples and understanding the role of the TDP-43 protein aggregation. TDP-43 is a DNA binding protein involved in gene regulation – its function in the nervous system is currently unknown and its role in the pathogenesis of MND remains unclear.

QBI is co-leading Australia's largest collaborative project in the search for new risk genes and therapies to treat MND using whole genome analysis to collectively identify new risk genes. Comprising 16 researchers from nine MND centres across Australia, as well as international collaborators, the consortium will build an integrated infrastructure to collect and analyse biological samples and clinical data. 

With MND treatment still a long way off, early diagnosis and the subsequent management and care of the patient are critical. QBI is currently working with MND patients to determine whether MND-specific biomarkers exist in the blood and whether these markers can be used to predict the course of the disease.

MND research at the Queensland Brain Institute is possible largely because of our many donors, including Peter Goodenough and Ross Maclean. The Peter Goodenough and Wantoks Research Laboratory and Ross Maclean Senior Research Fellowship are named respectively in their honour.

QBI MND researchers

Scott Sullivan Research Fellow, Dr Shyuan Ngo, is trying to understand how a change in the way the body uses energy can affect the onset of MND and how it might also affect how the disease progresses differently in people. Ultimately, her work aims to deliver personalised treatments for MND patients. Watch more about her here:


 

Professor Naomi Wray and her team, funded through the Ice Bucket Challenge, have discovered three new genes associated with MND. This knowledge will be used to assist clinicians in diagnosing MND, and could lead to the development of therapeutic targets.

Professor Perry Bartlett has established that a gene, EphA4, regulates MND progression through its involvement motor neuron loss in the spinal cord. In his laboratory, Dr Jing Zhao is investigating the impact of different forms of this gene on MND progression, and identified it as a potential therapeutic target.

QBI Director Professor Pankaj Sah’s laboratory are testing interventions for MND that have the potential to be developed into treatments. Dr Margreet Ridder is using genetic techniques in a mouse model of MND to prevent motor neurons in the spinal cord from dying.

Dr Jean Giacomotto is using new multi-gene approaches to model MND in zebrafish to better understand the disease.

 

If you would like more information about MND, or require support, please contact MND Australia on 02 9816 5322 or info@mndaust.asn.au