Dr Dhanisha Jhaveri
Senior Research Fellow
Queensland Brain Institute
Dr Dhanisha Jhaveri: Cellular regulation of stress and depression
The Jhaveri group goals are to uncover new mechanisms that are central to neurogenic regulation and learn how new neurons impact neural circuits and behaviour, and translate these principles to better understand and ultimately treat cognitive and mood-related deficits associated with anxiety and depression.
Researcher biography
Dr Dhanisha Jhaveri has a joint appointment at Mater Research and the Queensland Brain Institute (QBI) and is a Mater Foundation Senior Research Fellow and a Group Leader. Dhanisha's research group is investigating the fundamental mechanisms that drive the renewal of neurons in the adult brain, with the goal of harnessing this form of neural plasticity to relieve the emotional and cognitive burdens associated with chronic stress and depression.
Dhanisha received her PhD from the Tata Institute of Fundamental Research (TIFR), India, under the supervision of Professor Veronica Rodrigues, where she unravelled the molecular mechanisms that wire the olfactory axons in the fly (Drosophila) brain. In recognition of her doctoral work she was awarded the Indian National Science Academy medal for Young Scientist of the Year in 2003. Fascinated by the discovery that the production of new neurons continues in the adult brain, she then joined the laboratory of Professor Perry Bartlett at the Queensland Brain Institute as a Human Frontiers Science Program Postdoctoral Fellow. She has made major discoveries that have transformed our understanding of the regulation and roles of neural stem cells in the adult brain. Her work uncovered that a subclass clinical antidepressants directly activates neural stem cells in the hippocampus, a brain region implicated in regulating mood and cognitive functions. She also pioneered the development of a new cell sorting protocol to purify neural stem cells which revealed presence of distinct stem cell populations in this brain region.
Publications
Book Chapter
Jhaveri, Dhanisha J., Prosper, Boris W. and Bartlett, Perry F. (2013). Culturing and expansion of precursor cells from the adult hippocampus. Neural Progenitor Cells: Methods and Protocols. (pp. 41-51) edited by Brent A. Reynolds and Loic P. Deleyrolle. New York, NY, United States: Humana Press. doi: 10.1007/978-1-62703-574-3_4
Journal Articles
Madrid, Lidia I., Hafey, Katelyn, Bandhavkar, Saurabh, Bodea, Gabriela O., Jimenez-Martin, Javier, Milne, Michael, Walker, Tara L., Faulkner, Geoffrey J., Coulson, Elizabeth J. and Jhaveri, Dhanisha J. (2023). Stimulation of the muscarinic receptor M4 regulates neural precursor cell proliferation and promotes adult hippocampal neurogenesis. Development, 151 (1) dev201835. doi: 10.1242/dev.201835
Jhaveri, Dhanisha J., McGonigal, Aileen, Becker, Christel, Benoliel, Jean-Jacques, Nandam, L. Sanjay, Soncin, Lisa, Kotwas, Iliana, Bernard, Christophe and Bartolomei, Fabrice (2023). Stress and Epilepsy: Towards Understanding of Neurobiological Mechanisms for Better Management. eneuro, 10 (11) ENEURO.0200-23.2023, ENEURO.0200-23.2023. doi: 10.1523/eneuro.0200-23.2023
Guntupalli, Sumasri, Park, Pojeong, Han, Dae Hee, Zhang, Lingrui, Yong, Xuan Ling Hilary, Ringuet, Mitchell, Blackmore, Daniel G., Jhaveri, Dhanisha J., Koentgen, Frank, Widagdo, Jocelyn, Kaang, Bong-Kiun and Anggono, Victor (2023). Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility. The Journal of Neuroscience, 43 (30), 5448-5457. doi: 10.1523/jneurosci.1542-22.2023
Jones, Katherine L., Zhou, Mei and Jhaveri, Dhanisha J. (2022). Dissecting the role of adult hippocampal neurogenesis towards resilience versus susceptibility to stress-related mood disorders. npj Science of Learning, 7 (1) 16, 1-8. doi: 10.1038/s41539-022-00133-y
Blackmore, Daniel G., Steyn, Frederik J., Carlisle, Alison, O’Keeffe, Imogen, Vien, King-Year, Zhou, Xiaoqing, Leiter, Odette, Jhaveri, Dhanisha, Vukovic, Jana, Waters, Michael J. and Bartlett, Perry F. (2021). An exercise ‘sweet spot’ reverses cognitive deficits of ageing by growth hormone-induced neurogenesis. iScience, 24 (11) 103275, 1-25. doi: 10.1016/j.isci.2021.103275
Conroy, Jacinta N., Jhaveri, Dhanisha J. and Coulson, Elizabeth J. (2021). Fast-Trk(B)ing the mechanism of antidepressants. Neuron, 109 (10), 1593-1595. doi: 10.1016/j.neuron.2021.04.027
Madrid, Lidia I., Jimenez-Martin, Javier, Coulson, Elizabeth J. and Jhaveri, Dhanisha J. (2021). Cholinergic regulation of adult hippocampal neurogenesis and hippocampus-dependent functions. The International Journal of Biochemistry & Cell Biology, 134 105969, 1-6. doi: 10.1016/j.biocel.2021.105969
Zhang, Zhe, Jhaveri, Dhanisha, Sharmin, Sazia, Harvey, Tracey J., Dawson, Paul A., Piper, Michael and Simmons, David G. (2020). Cell-extrinsic requirement for sulfate in regulating hippocampal neurogenesis. Biology Open, 9 (7) bio053132, 1-7. doi: 10.1242/bio.053132
Nandam, L. Sanjay, Brazel, Matthew, Zhou, Mei and Jhaveri, Dhanisha J. (2020). Cortisol and major depressive disorder-translating findings from humans to animal models and back. Frontiers in Psychiatry, 10 974, 974. doi: 10.3389/fpsyt.2019.00974
Groves, Natalie, O’Keeffe, Imogen, Lee, Wendy, Toft, Alexandra, Blackmore, Daniel, Bandhavkar, Saurabh, Coulson, Elizabeth J., Bartlett, Perry F. and Jhaveri, Dhanisha J. (2020). Blockade of TrkB but not p75 NTR activates a subpopulation of quiescent neural precursor cells and enhances neurogenesis in the adult mouse hippocampus. Developmental Neurobiology, 79 (9-10) dneu.22729, 868-879. doi: 10.1002/dneu.22729
Zhao, Jing, Taylor, Chanel J, Newcombe, Estella A, Spanevello, Mark D, O’Keeffe, Imogen, Cooper, Leanne T, Jhaveri, Dhanisha J, Boyd, Andrew W and Bartlett, Perry F (2018). EphA4 regulates hippocampal neural precursor proliferation in the adult mouse brain by d-Serine modulation of N-methyl-d-aspartate receptor signaling. Cerebral Cortex, 29 (10), 4381-4397. doi: 10.1093/cercor/bhy319
Groves, Natalie J., Zhou, Mei, Jhaveri, Dhanisha J., McGrath, John J. and Burne, Thomas H. J. (2017). Adult vitamin D deficiency exacerbates impairments caused by social stress in BALB/c and C57BL/6 mice. Psychoneuroendocrinology, 86, 53-63. doi: 10.1016/j.psyneuen.2017.09.003
Jhaveri, D. J., Tedoldi, A., Hunt, S., Sullivan, R., Watts, N. R., Power, J. M., Bartlett, P. F. and Sah, P. (2017). Evidence for newly generated interneurons in the basolateral amygdala of adult mice. Molecular Psychiatry, 23 (3), 521-532. doi: 10.1038/mp.2017.134
Harris, Lachlan, Zalucki, Oressia, Oishi, Sabrina, Burne, Thomas H., Jhaveri, Dhanisha J. and Piper, Michael (2017). A morphology independent approach for identifying dividing adult neural stem cells in the mouse hippocampus. Developmental Dynamics, 247 (1), 194-200. doi: 10.1002/dvdy.24545
Jhaveri, Dhanisha J., O'Keeffe, Imogen, Robinson, Gregory J., Zhao, Qiong-Yi, Zhang, Zong Hong, Nink, Virginia, Narayanan, Ramesh K., Osborne, Geoffrey W., Wray, Naomi R. and Bartlett, Perry F. (2015). Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus. Journal of Neuroscience, 35 (21), 8132-8144. doi: 10.1523/JNEUROSCI.0504-15.2015
Zhang, Zong Hong, Jhaveri, Dhanisha J., Marshall, Vikki M., Bauer, Denis C., Edson, Janette, Narayanan, Ramesh K., Robinson, Gregory J., Lundberg, Andreas E., Bartlett, Perry F., Wray, Naomi R. and Zhao, Qiong-Yi (2014). A comparative study of techniques for differential expression analysis on RNA-seq data. PLoS One, 9 (8) e103207, 1-11. doi: 10.1371/journal.pone.0103207
Jhaveri, Dhanisha J., Nanavaty, Ishira, Prosper, Boris W., Marathe, Swanand, Husain, Basma F. A., Kernie, Steven G., Bartlett, Perry F. and Vaidya, Vidita A. (2014). Opposing effects of α2- and β-adrenergic receptor stimulation on quiescent neural precursor cell activity and adult hippocampal neurogenesis. PLoS One, 9 (6) e98736, e98736.1-e98736.11. doi: 10.1371/journal.pone.0098736
Saharan, Sumiti, Jhaveri, Dhanisha J. and Bartlett, Perry F. (2013). SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. Journal of Neuroscience Research, 91 (5), 642-659. doi: 10.1002/jnr.23199
Taylor, Chanel J., Jhaveri, Dhanisha J. and Bartlett, Perry F. (2013). The therapeutic potential of endogenous hippocampal stem cells for the treatment of neurological disorders. Frontiers in Cellular Neuroscience, 7 (JANUARY 2013) ARTN 5, 5.1-5.7. doi: 10.3389/fncel.2013.00005
Jhaveri, Dhanisha J., Taylor, Chanel J. and Bartlett, Perry F. (2012). Activation of different neural precursor populations in the adult hippocampus: Does this lead to new neurons with discrete functions?. Developmental Neurobiology, 72 (7), 1044-1058. doi: 10.1002/dneu.22027
Beatus, Paul, Jhaveri, Dhanisha J., Walker, Tara L., Lucas, Peter G., Rietze, Rodney L., Cooper, Helen M., Morikawa, Yoshihiro and Bartlett, Perry F. (2011). Oncostatin M regulates neural precursor activity in the adult brain. Developmental Neurobiology, 71 (7), 619-633. doi: 10.1002/dneu.20871
Vukovic, Jana, Blackmore, Daniel, Jhaveri, Dhanisha and Bartlett, Perry F. (2011). Activation of neural precursors in the adult neurogenic niches. Neurochemistry International, 59 (3), 341-346. doi: 10.1016/j.neuint.2011.04.003
Jhaveri, Dhanisha J., Mackay, Eirinn W., Hamlin, Adam S., Marathe, Swananda V., Nandam, L. Sanjay, Vaidya, Vidita A. and Bartlett, Perry F. (2010). Norepinephrine directly activates adult hippocampal precursors via beta(3)-adrenergic receptors. Journal of Neuroscience, 30 (7), 2795-2806. doi: 10.1523/JNEUROSCI.3780-09.2010
Yanpallewar, Sudhirkumar U., Fernandes, Kimberly, Marathe, Swananda V., Vadodaria, Krishna C., Jhaveri, Dhanisha, Rommelfanger, Karen, Ladiwala, Uma, Jha, Shanker, Muthig, Verena, Hein, Lutz, Bartlett, Perry, Weinshenker, David and Vaidya, Vidita A. (2010). α2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment. Journal of Neuroscience, 30 (3), 1096-1109. doi: 10.1523/JNEUROSCI.2309-09.2010
Nandam, L. Sanjay, Jhaveri, Dhanisha and Bartlett, Perry (2007). 5-HT7, neurogenesis and antidepressants: A promising therapeutic axis for treating depression. Clinical and Experimental Pharmacology and Physiology, 34 (5-6), 546-551. doi: 10.1111/j.1440-1681.2007.04608.x
Jhaveri, DJ, Nandam, LS and Bartlett, PF (2007). The slice-sphere assay: A combinatorial approach to evaluate neural precursor activity. Journal of Neurochemistry, 102, 185-185.
Sen, A., Shetty, C., Jhaveri, D. and Rodrigues, V. (2005). Distinct types of glial cells populate the Drosophila antenna. BMC Developmental Biology, 5 (25) 25, 1-11. doi: 10.1186/1471-213X-5-25
Jhaveri, Dhanisha, Saharan, Sumiti, Sen, Anindya and Rodrigues, Veronica (2004). Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling. Development, 131 (9), 1903-1912. doi: 10.1242/dev.01083
Jhaveri, D and Rodrigues, V (2002). Sensory neurons of the Atonal lineage pioneer the formation of glomeruli within the adult Drosophila olfactory lobe. Development, 129 (5), 1251-1260.
Jhaveri, D, Sen, A and Rodrigues, V (2000). Mechanisms underlying olfactory neuronal connectivity in Drosophila - The atonal lineage organizes the periphery while sensory neurons and glia pattern the olfactory lobe. Developmental Biology, 226 (1), 73-87. doi: 10.1006/dbio.2000.9855
Jhaveri, Dhanisha, Sen, Anindya, Reddy, G. Venugopala and Rodrigues, Veronica (2000). Sense organ identity in the Drosophila antenna is specified by the expression of the proneural gene atonal. Mechanisms of Development, 99 (1-2), 101-111. doi: 10.1016/S0925-4773(00)00487-1
Conference Papers
Jhaveri, D., O'Keeffe, I., Robinson, G., Zhao, Q-Y., Zhang, Z. H., Nink, V., Osborne, G., Wray, N. and Bartlett, P. (2015). Presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex United Kingdom: Wiley-Blackwell.
Bartlett, P. F., Jhaveri, D. and Taylor, C. J. (2012). Activation of different neurogenic precursor populations in the hippocampus. 19th Biennial Meeting of the International Society for Developmental Neuroscience (ISDN), Mumbai India, 11-14 January 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.ijdevneu.2012.03.330
Jhaveri, Dhanisha, Newcombe, Estella, Nink, Virginia, Osborne, Geoffrey, Vaidya, Vidita and Bartlett, Perry (2012). Norepinephrine stimulates a distinct precursor population in the adult hippocampus. 19th Biennial Meeting of the International-Society-for-Developmental-Neuroscience (ISDN), Mumbai, India, 11-14 January 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.ijdevneu.2012.03.332
Bartlett, P. F., Young, K., Bull, N. and Jhaveri, D. (2006). Regulation of neural precursor survival, proliferation and differentiation by BDNF. 16th Biennial Meeting of the International-Society-for-Developmental-Neuroscience, Banff, Canada, Aug 24-28, 2006. doi: 10.1016/j.ijdevneu.2006.09.053
Preprint
Bodea, Gabriela O., Ferreiro, Maria E., Sanchez-Luque, Francisco J., Botto, Juan M., Rasmussen, Jay, Rahman, Muhammed A., Fenlon, Laura R., Gubert, Carolina, Gerdes, Patricia, Bodea, Liviu-Gabriel, Ajjikuttira, Prabha, Kozulin, Peter, Billon, Victor, Morell, Santiago, Kempen, Marie-Jeanne H.C., Love, Chloe J., Palmer, Lucy M., Ewing, Adam D., Jhaveri, Dhanisha J., Richardson, Sandra R., Hannan, Anthony J. and Faulkner, Geoffrey J. (2022). LINE-1 retrotransposon activation intrinsic to interneuron development.
Data Collection
Musco, Hannah , Gratten, Jake and Jhaveri, Dhanisha (2021). Hannah Musco-Honours Supplementary tables. The University of Queensland. (Dataset) doi: 10.48610/c59d22a