Cellular regulation of stress and depression

About

We are interested in understanding the fundamental mechanisms that drive the renewal of neurons in the adult brain and harness this form of neural plasticity to relieve the emotional and cognitive burdens associated with chronic stress and depression. The discovery of neural stem cells capable of generating new, functional neurons (i.e. neurogenesis) in the adult mammalian brain has led to a paradigm shift in neuroscience. The hippocampus is one such area where new neurons are generated and integrated into the existing neural circuitry throughout life, making a significant contribution to the regulation of mood and cognition.  However, our understanding of how these newborn neurons regulate such diverse brain functions remains incomplete.

Our studies have revealed that distinct populations of quiescent stem cells that are activated by multiple, discrete neurochemical signals exist in the adult hippocampus. Our current efforts are focused on understanding the molecular and functional potential of these distinct stem cells, how their activity is modulated by stress, and what role they play in the regulation of mood versus cognition in mouse models of depression/anxiety. We are also interested in determining whether new neurons confer behavioural resilience and are important during recovery following chronic stress.  A key aspect of our research program is to determine whether selective activation of quiescent neural stem cells could provide a new approach for the treatment of depressive/anxiety disorders and lead to the development of novel, effective and safe antidepressants.

Contact

  +61 7 334 66381

  dhanisha@uq.edu.au


Group Publications

Research Areas

  • Neural plasticity
  • Chronic stress and depression
  • Neurogenesis in the adult brain
  • Stem cell activation in the hippocampus 
  • Stem cell regulation of mood versus cognition

Group Leader

  • Dr Dhanisha Jhaveri

    Senior Research Fellow
    Mater Research Institute-UQ
    Senior Research Fellow
    Queensland Brain Institute

Research Members

  • Ms Wendy Lee

    Adjunct Research Assistant
    Queensland Brain Institute
    Affiliate Professional Staff
    Mater Research Institute-UQ

Students


Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus

Jhaveri, Dhanisha J., O'Keeffe, Imogen, Robinson, Gregory J., Zhao, Qiong-Yi, Zhang, Zong Hong, Nink, Virginia, Narayanan, Ramesh K., Osborne, Geoffrey W., Wray, Naomi R. and Bartlett, Perry F. (2015) Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus. Journal of Neuroscience35 21: 8132-8144. doi:10.1523/JNEUROSCI.0504-15.2015

A comparative study of techniques for differential expression analysis on RNA-seq data

Zhang, Zong Hong, Jhaveri, Dhanisha J., Marshall, Vikki M., Bauer, Denis C., Edson, Janette, Narayanan, Ramesh K., Robinson, Gregory J., Lundberg, Andreas E., Bartlett, Perry F., Wray, Naomi R. and Zhao, Qiong-Yi (2014) A comparative study of techniques for differential expression analysis on RNA-seq data. PLoS One9 8: 1-11. doi:10.1371/journal.pone.0103207

Opposing effects of α2- and β-adrenergic receptor stimulation on quiescent neural precursor cell activity and adult hippocampal neurogenesis

Jhaveri, Dhanisha J., Nanavaty, Ishira, Prosper, Boris W., Marathe, Swanand, Husain, Basma F. A., Kernie, Steven G., Bartlett, Perry F. and Vaidya, Vidita A. (2014) Opposing effects of α2- and β-adrenergic receptor stimulation on quiescent neural precursor cell activity and adult hippocampal neurogenesis. PLoS One9 6: e98736.1-e98736.11. doi:10.1371/journal.pone.0098736

SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus

Saharan, Sumiti, Jhaveri, Dhanisha J. and Bartlett, Perry F. (2013) SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. Journal of Neuroscience Research91 5: 642-659. doi:10.1002/jnr.23199

The therapeutic potential of endogenous hippocampal stem cells for the treatment of neurological disorders

Taylor, Chanel J., Jhaveri, Dhanisha J. and Bartlett, Perry F. (2013) The therapeutic potential of endogenous hippocampal stem cells for the treatment of neurological disorders. Frontiers in Cellular Neuroscience7 JANUARY 2013: 5.1-5.7. doi:10.3389/fncel.2013.00005

Activation of different neural precursor populations in the adult hippocampus: Does this lead to new neurons with discrete functions?

Jhaveri, Dhanisha J., Taylor, Chanel J. and Bartlett, Perry F. (2012) Activation of different neural precursor populations in the adult hippocampus: Does this lead to new neurons with discrete functions?. Developmental Neurobiology72 7: 1044-1058. doi:10.1002/dneu.22027

Oncostatin M regulates neural precursor activity in the adult brain

Beatus, Paul, Jhaveri, Dhanisha J., Walker, Tara L., Lucas, Peter G., Rietze, Rodney L., Cooper, Helen M., Morikawa, Yoshihiro and Bartlett, Perry F. (2011) Oncostatin M regulates neural precursor activity in the adult brain.Developmental Neurobiology71 7: 619-633. doi:10.1002/dneu.20871

Activation of neural precursors in the adult neurogenic niches

Vukovic, Jana, Blackmore, Daniel, Jhaveri, Dhanisha and Bartlett, Perry F. (2011) Activation of neural precursors in the adult neurogenic niches. Neurochemistry International59 3: 341-346. doi:10.1016/j.neuint.2011.04.003

Norepinephrine directly activates adult hippocampal precursors via beta(3)-adrenergic receptors

Jhaveri, Dhanisha J., Mackay, Eirinn W., Hamlin, Adam S., Marathe, Swananda V., Nandam, L. Sanjay, Vaidya, Vidita A. and Bartlett, Perry F. (2010) Norepinephrine directly activates adult hippocampal precursors via beta(3)-adrenergic receptors. Journal of Neuroscience30 7: 2795-2806. doi:10.1523/JNEUROSCI.3780-09.2010

α2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment

Yanpallewar, Sudhirkumar U., Fernandes, Kimberly, Marathe, Swananda V., Vadodaria, Krishna C., Jhaveri, Dhanisha, Rommelfanger, Karen, Ladiwala, Uma, Jha, Shanker, Muthig, Verena, Hein, Lutz, Bartlett, Perry, Weinshenker, David and Vaidya, Vidita A. (2010) α2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment. Journal of Neuroscience30 3: 1096-1109. doi:10.1523/JNEUROSCI.2309-09.2010

5-HT7, neurogenesis and antidepressants: A promising therapeutic axis for treating depression

Nandam, L. Sanjay, Jhaveri, Dhanisha and Bartlett, Perry (2007) 5-HT7, neurogenesis and antidepressants: A promising therapeutic axis for treating depression. Clinical and Experimental Pharmacology and Physiology34 5-6: 546-551. doi:10.1111/j.1440-1681.2007.04608.x

The slice-sphere assay: A combinatorial approach to evaluate neural precursor activity

Jhaveri, DJ, Nandam, LS and Bartlett, PF (2007) The slice-sphere assay: A combinatorial approach to evaluate neural precursor activity. Journal of Neurochemistry102 185-185.

Distinct types of glial cells populate the Drosophila antenna

Sen, A., Shetty, C., Jhaveri, D. and Rodrigues, V. (2005) Distinct types of glial cells populate the Drosophila antenna.BMC Developmental Biology5 25: 1-11. doi:10.1186/1471-213X-5-25

Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling

Jhaveri, Dhanisha, Saharan, Sumiti, Sen, Anindya and Rodrigues, Veronica (2004) Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling. Development131 9: 1903-1912. doi:10.1242/dev.01083

Sensory neurons of the Atonal lineage pioneer the formation of glomeruli within the adult Drosophila olfactory lobe

Jhaveri, D and Rodrigues, V (2002) Sensory neurons of the Atonal lineage pioneer the formation of glomeruli within the adult Drosophila olfactory lobe. Development129 5: 1251-1260.

Mechanisms underlying olfactory neuronal connectivity in Drosophila - The atonal lineage organizes the periphery while sensory neurons and glia pattern the olfactory lobe

Jhaveri, D, Sen, A and Rodrigues, V (2000) Mechanisms underlying olfactory neuronal connectivity in Drosophila - The atonal lineage organizes the periphery while sensory neurons and glia pattern the olfactory lobe. Developmental Biology226 1: 73-87. doi:10.1006/dbio.2000.9855

Sense organ identity in the Drosophila antenna is specified by the expression of the proneural gene atonal

Jhaveri, D, Sen, A, Reddy, GV and Rodrigues, V (2000) Sense organ identity in the Drosophila antenna is specified by the expression of the proneural gene atonal. Mechanisms of Development99 1-2: 101-111. doi:10.1016/S0925-4773(00)00487-1