Cellular regulation of stress and depression

About

Neuronal plasticity, the extraordinary ability of neurons and neural circuits to change with experience, is a fundamental brain principle which provides framework to understand processes such as learning and memory. While these changes occur across multiple domains of neuronal structure and properties, a fascinating and perhaps extreme form of neuronal plasticity is addition of new neurons into existing circuitry i.e. neurogenesis.

Our research program seeks to:

  • Understand mechanisms that drive the production and integration of new neurons in the adult brain;
  • And investigate functions of adult-born neurons in the regulation of emotion and cognitive processes in health and disease.

The Jhaveri group goals are to uncover new mechanisms that are central to neurogenic regulation and learn how new neurons impact neural circuits and behaviour, and translate these principles to better understand and ultimately treat cognitive and mood-related deficits associated with anxiety and depression.

Our studies have revealed that distinct populations of quiescent neural stem/precursor cells that are activated by multiple, discrete neurochemical signals exist in the adult hippocampus. We have also co-led a study in which we demonstrated that the basolateral amygdala (BLA) harbours resident neural precursors which proliferate and generate new, functional neurons that integrate into the local circuitry in the adult brain.

Our current efforts are focused on understanding the molecular and functional potential of these distinct stem/precursor cells, how their activity is modulated by stress, and what role they play in the regulation of mood and cognition. We are also interested in determining whether new neurons confer behavioural resilience and are important during recovery following chronic stress. A key aspect of our research program is to determine whether selective activation of quiescent neural precursor cells could provide a new approach for the treatment of depressive/anxiety disorders and lead to the development of novel, effective and safe antidepressants.

With a joint appointment between Mater Research Institute, UQ and QBI, we are addressing these questions and have developed, as well as utilised, a combination of innovative and multi-modal approaches including sophisticated mouse genetic models, in vivo lineage tracing using viral vectors, flow cytomtery, cell culture, transcriptomics, high-resolution confocal microscopy, cognitive- and mood-related behavioural tests.

Contact

  dhanisha@uq.edu.au


Group Publications

Research Areas

  • Neural plasticity
  • Chronic stress, anxiety and depression
  • Neurogenesis in the adult brain


Apply for a PhD

Group Leader

  • Dr Dhanisha Jhaveri

    Senior Research Fellow
    Mater Research Institute-UQ
    Senior Research Fellow
    Queensland Brain Institute

Research Members


Students

 

EphA4 regulates hippocampal neural precursor proliferation in the adult mouse brain by d-Serine modulation of N-methyl-d-aspartate receptor signaling

Zhao, Jing, Taylor, Chanel J, Newcombe, Estella A, Spanevello, Mark D, O’Keeffe, Imogen, Cooper, Leanne T, Jhaveri, Dhanisha J, Boyd, Andrew W and Bartlett, Perry F (2018) EphA4 regulates hippocampal neural precursor proliferation in the adult mouse brain by d-Serine modulation of N-methyl-d-aspartate receptor signaling. Cerebral Cortex, doi:10.1093/cercor/bhy319

Adult vitamin D deficiency exacerbates impairments caused by social stress in BALB/c and C57BL/6 mice

Groves, Natalie J., Zhou, Mei, Jhaveri, Dhanisha J., McGrath, John J. and Burne, Thomas H. J. (2017) Adult vitamin D deficiency exacerbates impairments caused by social stress in BALB/c and C57BL/6 mice. Psychoneuroendocrinology, 86 53-63. doi:10.1016/j.psyneuen.2017.09.003

Evidence for newly generated interneurons in the basolateral amygdala of adult mice

Jhaveri, D. J., Tedoldi, A., Hunt, S., Sullivan, R., Watts, N. R., Power, J. M., Bartlett, P. F. and Sah, P. (2017) Evidence for newly generated interneurons in the basolateral amygdala of adult mice. Molecular Psychiatry, 23 3: 521-532. doi:10.1038/mp.2017.134

A morphology independent approach for identifying dividing adult neural stem cells in the mouse hippocampus

Harris, Lachlan, Zalucki, Oressia, Oishi, Sabrina, Burne, Thomas H., Jhaveri, Dhanisha J. and Piper, Michael (2017) A morphology independent approach for identifying dividing adult neural stem cells in the mouse hippocampus. Developmental Dynamics, 247 1: 194-200. doi:10.1002/dvdy.24545

Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus

Jhaveri, Dhanisha J., O'Keeffe, Imogen, Robinson, Gregory J., Zhao, Qiong-Yi, Zhang, Zong Hong, Nink, Virginia, Narayanan, Ramesh K., Osborne, Geoffrey W., Wray, Naomi R. and Bartlett, Perry F. (2015) Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus. Journal of Neuroscience, 35 21: 8132-8144. doi:10.1523/JNEUROSCI.0504-15.2015

A comparative study of techniques for differential expression analysis on RNA-seq data

Zhang, Zong Hong, Jhaveri, Dhanisha J., Marshall, Vikki M., Bauer, Denis C., Edson, Janette, Narayanan, Ramesh K., Robinson, Gregory J., Lundberg, Andreas E., Bartlett, Perry F., Wray, Naomi R. and Zhao, Qiong-Yi (2014) A comparative study of techniques for differential expression analysis on RNA-seq data. PLoS One, 9 8: 1-11. doi:10.1371/journal.pone.0103207

Opposing effects of α2- and β-adrenergic receptor stimulation on quiescent neural precursor cell activity and adult hippocampal neurogenesis

Jhaveri, Dhanisha J., Nanavaty, Ishira, Prosper, Boris W., Marathe, Swanand, Husain, Basma F. A., Kernie, Steven G., Bartlett, Perry F. and Vaidya, Vidita A. (2014) Opposing effects of α2- and β-adrenergic receptor stimulation on quiescent neural precursor cell activity and adult hippocampal neurogenesis. PLoS One, 9 6: e98736.1-e98736.11. doi:10.1371/journal.pone.0098736

SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus

Saharan, Sumiti, Jhaveri, Dhanisha J. and Bartlett, Perry F. (2013) SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. Journal of Neuroscience Research, 91 5: 642-659. doi:10.1002/jnr.23199

The therapeutic potential of endogenous hippocampal stem cells for the treatment of neurological disorders

Taylor, Chanel J., Jhaveri, Dhanisha J. and Bartlett, Perry F. (2013) The therapeutic potential of endogenous hippocampal stem cells for the treatment of neurological disorders. Frontiers in Cellular Neuroscience, 7 JANUARY 2013: 5.1-5.7. doi:10.3389/fncel.2013.00005

Activation of different neural precursor populations in the adult hippocampus: Does this lead to new neurons with discrete functions?

Jhaveri, Dhanisha J., Taylor, Chanel J. and Bartlett, Perry F. (2012) Activation of different neural precursor populations in the adult hippocampus: Does this lead to new neurons with discrete functions?. Developmental Neurobiology, 72 7: 1044-1058. doi:10.1002/dneu.22027

Oncostatin M regulates neural precursor activity in the adult brain

Beatus, Paul, Jhaveri, Dhanisha J., Walker, Tara L., Lucas, Peter G., Rietze, Rodney L., Cooper, Helen M., Morikawa, Yoshihiro and Bartlett, Perry F. (2011) Oncostatin M regulates neural precursor activity in the adult brain. Developmental Neurobiology, 71 7: 619-633. doi:10.1002/dneu.20871

Activation of neural precursors in the adult neurogenic niches

Vukovic, Jana, Blackmore, Daniel, Jhaveri, Dhanisha and Bartlett, Perry F. (2011) Activation of neural precursors in the adult neurogenic niches. Neurochemistry International, 59 3: 341-346. doi:10.1016/j.neuint.2011.04.003

Norepinephrine directly activates adult hippocampal precursors via beta(3)-adrenergic receptors

Jhaveri, Dhanisha J., Mackay, Eirinn W., Hamlin, Adam S., Marathe, Swananda V., Nandam, L. Sanjay, Vaidya, Vidita A. and Bartlett, Perry F. (2010) Norepinephrine directly activates adult hippocampal precursors via beta(3)-adrenergic receptors. Journal of Neuroscience, 30 7: 2795-2806. doi:10.1523/JNEUROSCI.3780-09.2010

α2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment

Yanpallewar, Sudhirkumar U., Fernandes, Kimberly, Marathe, Swananda V., Vadodaria, Krishna C., Jhaveri, Dhanisha, Rommelfanger, Karen, Ladiwala, Uma, Jha, Shanker, Muthig, Verena, Hein, Lutz, Bartlett, Perry, Weinshenker, David and Vaidya, Vidita A. (2010) α2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment. Journal of Neuroscience, 30 3: 1096-1109. doi:10.1523/JNEUROSCI.2309-09.2010

5-HT7, neurogenesis and antidepressants: A promising therapeutic axis for treating depression

Nandam, L. Sanjay, Jhaveri, Dhanisha and Bartlett, Perry (2007) 5-HT7, neurogenesis and antidepressants: A promising therapeutic axis for treating depression. Clinical and Experimental Pharmacology and Physiology, 34 5-6: 546-551. doi:10.1111/j.1440-1681.2007.04608.x

   Dr Dhanisha Jhaveri

Honours project

Title:  Investigating the cellular mechanisms of anxiety and depression using a pre-clinical model

Supervisor: Dr Dhanisha Jhaveri.

Please email dhanisha@uq.edu.au for more information.