Neurons are inherently plastic and have the ability to modify their synaptic strength and connectivity, as well as adjusting their intrinsic excitability. Our lab is interested in understanding the underlying mechanisms from the regulation of neuronal trafficking to the control of activity-dependent gene expression.

  • We discovered the role of the protein interacting with C-kinase 1 (PICK1), the only protein with a PDZ protein-protein interaction domain and a BAR lipid-binding/dimerization domain, in regulating the pre-synaptic cargo retrieval (Yong et al., Cell Rep., 2020).
  • We provided the first evidence for a role of a long non-coding RNA, Meg3, in regulating the trafficking of AMPA receptors during synaptic potentiation (Tan and Widagdo et al., Front. Cell. Neurosci., 2017).
  • We discovered that all AMPA receptor subunits undergo activity-dependent ubiquitination to regulate receptor intracellular sorting and degradation (Widagdo et al., Cell Rep., 2015). We subsequently showed that the same ubiquitination pathway underlies amyloid-β-induced loss of the GluA1 subunit and synaptic depression (Guntupalli et al., J. Biol. Chem., 2017).

Research Articles

Review Articles

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  • ARC Project Grant (DP190101390) “Regulation of glutamate receptor dynamics in mammalian central neurons” (2019-2022).
  • NHMRC Project Grant (GNT1138452) “Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6” (2018-2021).
  • ARC Project Grant (DP170102402) “Regulation of synaptic vesicle endocytosis by membrane-sensing proteins” (2017-2019).
  • NHMRC Project Grant (GNT1099114) “Sorting out the synapse: the role of intracellular trafficking in NMDA receptor homeostasis” (2016-2018)
  • Activity-dependent regulation of glutamate receptor trafficking
  • Epitranscriptomic regulation of synaptic plasticity, learning and memory
  • Structure and function analysis of synaptic proteins
  • Neuronal trafficking in pre- and post-synaptic compartments
  • Post-translational regulation of synaptic function
  • Regulation of activity-dependent gene expression by post-transcriptional RNA methylation
  • RNA biology of neuronal plasticity