Professor Naomi Wray
Affiliate NHMRC Leadership Fellow
Queensland Brain Institute
Professor Naomi Wray: Program in complex trait genomics
The Wray laboratory focusses on understanding the genetic contribution to psychiatric and neurological disorders. The group specialises in applying new analytical methods of genomic data to provide insights into these complex disorders, with an ultimate goal to improve diagnosis, prognosis and treatments. The lab plays a key role in the international Psychiatric Genomics Consortium and Prof Wray co-leads the sporadic ALS Australia systems genomics consortium (SALSA), funded by the IceBucket Challenge.
Researcher biography
Naomi Wray is the Michael Davys Professor in the Department of Psychiatry, University of Oxford. She holds an appointment at the Institute for Molecular Bioscience (IMB) within the University of Queensland. She joined UQ Queensland Brain Institute in 2011 moving to the IMB in 2015. She was Head of the Centre for Population & Disease Genomics within IMB 2018-2023. Her Oxford appointment started in 2023.
Her research focuses on development and application of quantitative genetics and genomics methodologies across complex diseases, disorders and traits, but particularly psychiatric-related traits.
She is a National Health and Medical Research Council (NHMRC) Leadership Fellow, a Fellow of the Australian Academy of Science and a Fellow of the Australian Academy of Health and Medical Science. In 2020 she was awarded the NHMRC Elizabeth Blackburn Award for Leadership in Basic Science and the 2021 International Society of Psychiatric Genetics Ming Tsuang Lifetime Achievement Award. She is a Clarivate Highly Cited researcher.
She was Director of the Program in Complex Trait Genomics (PCTG) funded as an NHMRC Program Grant 2017-2022. She plays a key role in the International Psychiatric Genomics Consortium and established the sporadic ALS Australia systems genomics consortium (SALSA) funded by the MND Research Australia IceBucket Challenge and FightMND. She is a co-investigator on the Australian Genetics of Depression Study (AGDS) and is currently launching the AGDS-Cello project focussed on establishing a cell line resource from participants with a detailed history of anti-depressant use and response measures. She is part of an NHMRC Synergy (2023-2027) "Rhythms and blues: Personalising care for body clock dysfunction in mood disorders".
She is secretary of the International Society of Psychiatric Genetics, and is on the editorial advisory boards of JAMA Psychiatry, Neuron, Royal Society Open and Research Directions: Depression.
Book Chapters
Wray, Naomi R., Byrne, Enda M., Stringer, Sven and Mowry, Bryan J. (2014). Future directions in genetics of psychiatric disorders. Behavior genetics of psychopathology. (pp. 311-337) edited by Soo Hyun Rhee and Angelica Ronald. New York, NY, United States: Springer New York. doi: 10.1007/978-1-4614-9509-3_11
Wray, Naomi R., Coventry, William L., James, Michael R., Montgomery, Grant W., Eaves, Lindon J. and Martin, Nicholas G. (2008). Use of Monozygotic Twins to Investigate the Relationship between 5HTTLPR Genotype, Depression and Stressful Life Events: An Application of Item Response Theory. Genetic Effects on Environmental Vulnerability to Disease. (pp. 48-59) wiley. doi: 10.1002/9780470696781.ch4
Wray, Naomi R., Coventry, William L., James, Michael R., Montgomery, Grant W., Eaves, Lindon J. and Martin, Nicholas G. (2008). Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of item response theory. Genetic effects on environmental vulnerability to disease. (pp. 48-67) Chichester, United Kingdom: John Wiley & Sons. doi: 10.1002/9780470696781.ch4
Wray, Naomi R. and Visscher, Peter M. (2007). Mapping common disease genes. Mapping common disease genes. (pp. 59-79) CAMBRIDGE: CAMBRIDGE UNIV PRESS. doi: 10.1017/CBO9780511543555.005
Journal Articles
Wang, Xiaotong, Walker, Alicia, Revez, Joana A., Ni, Guiyan, Visscher, Peter M., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan R.I., Colodro-Conde, Lucía ... Sullivan, Patrick F. (2023). Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability. The American Journal of Human Genetics, 110 (7), 1207-1215. doi: 10.1016/j.ajhg.2023.06.006
Jameei, Hadis, Rakesh, Divyangana, Zalesky, Andrew, Cairns, Murray J, Reay, William R, Wray, Naomi R and Di Biase, Maria A (2023). Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review. Schizophrenia Bulletin. doi: 10.1093/schbul/sbad087
Wu, Yeda, Goleva, Slavina B., Breidenbach, Lindsay B., Kim, Minsoo, MacGregor, Stuart, Gandal, Michael J., Davis, Lea K. and Wray, Naomi R. (2023). 150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility. Cell Genomics, 3 (7) 100326, 100326. doi: 10.1016/j.xgen.2023.100326
Chundru, V. Kartik, Marioni, Riccardo E., Pendergast, James G. D., Lin, Tian, Beveridge, Allan J., Martin, Nicholas G, Montgomery, Grant W., Hume, David A., Deary, Ian J., Visscher, Peter M., Wray, Naomi R. and McRae, Allan F. (2023). Rare genetic variants underlie outlying levels of DNA methylation and gene-expression. Human Molecular Genetics, 32 (11), 1912-1921. doi: 10.1093/hmg/ddad028
Hsu, Yu-Han H., Pintacuda, Greta, Liu, Ruize, Nacu, Eugeniu, Kim, April, Tsafou, Kalliopi, Petrossian, Natalie, Crotty, William, Suh, Jung Min, Riseman, Jackson, Martin, Jacqueline M., Biagini, Julia C., Mena, Daya, Ching, Joshua K.T., Malolepsza, Edyta, Li, Taibo, Singh, Tarjinder, Ge, Tian, Egri, Shawn B., Tanenbaum, Benjamin, Stanclift, Caroline R., Apffel, Annie M., Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T.R., Farh, Kai-How, Holmans, Peter A., Lee, Phil ... Lage, Kasper (2023). Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia. iScience, 26 (5) 106701, 106701. doi: 10.1016/j.isci.2023.106701
Sullivan, Patrick F., Meadows, Jennifer R. S., Gazal, Steven, Phan, BaDoi N., Li, Xue, Genereux, Diane P., Dong, Michael X., Bianchi, Matteo, Andrews, Gregory, Sakthikumar, Sharadha, Nordin, Jessika, Roy, Ananya, Christmas, Matthew J., Marinescu, Voichita D., Wang, Chao, Wallerman, Ola, Xue, James, Yao, Shuyang, Sun, Quan, Szatkiewicz, Jin, Wen, Jia, Huckins, Laura M., Lawler, Alyssa, Keough, Kathleen C., Zheng, Zhili, Zeng, Jian, Wray, Naomi R., Li, Yun, Johnson, Jessica ... Zoonomia Consortium§ (2023). Leveraging base-pair mammalian constraint to understand genetic variation and human disease. Science, 380 (6643) eabn2937, 367-+. doi: 10.1126/science.abn2937
Yap, Chloe X., Henders, Anjali K., Alvares, Gail A., Giles, Corey, Huynh, Kevin, Nguyen, Anh, Wallace, Leanne, McLaren, Tiana, Yang, Yuanhao, Hernandez, Leanna M., Gandal, Michael J., Hansell, Narelle K., Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren P., Leslie, Jodie, Levis Frenk, Mira, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Miller, Jessica L., Nunn, Lorelle, Strike, Lachlan T. ... The Busselton Health Study Investigators (2023). Interactions between the lipidome and genetic and environmental factors in autism. Nature Medicine, 29 (4), 936-949. doi: 10.1038/s41591-023-02271-1
Trinh, Nhung T. H., Munk-Olsen, Trine, Wray, Naomi R., Bergink, Veerle, Nordeng, Hedvig M. E., Lupattelli, Angela and Liu, Xiaoqin (2023). Timing of Antidepressant Discontinuation During Pregnancy and Postpartum Psychiatric Outcomes in Denmark and Norway. JAMA Psychiatry, 80 (5) yoi230003, 441. doi: 10.1001/jamapsychiatry.2023.0041
Nabais, Marta F., Gadd, Danni A., Hannon, Eilis, Mill, Jonathan, McRae, Allan F. and Wray, Naomi R. (2023). An overview of DNA methylation-derived trait score methods and applications. Genome Biology, 24 (1) 28. doi: 10.1186/s13059-023-02855-7
Albiñana, Clara, Zhu, Zhihong, Borbye-Lorenzen, Nis, Boelt, Sanne Grundvad, Cohen, Arieh S., Skogstrand, Kristin, Wray, Naomi R., Revez, Joana A, Privé, Florian, Petersen, Liselotte V., Bulik, Cynthia M., Plana-Ripoll, Oleguer, Musliner, Katherine L., Agerbo, Esben, Børglum, Anders D., Hougaard, David M., Nordentoft, Merete, Werge, Thomas, Mortensen, Preben Bo, Vilhjálmsson, Bjarni J. and McGrath, John J. (2023). Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots. Nature Communications, 14 (1) 852, 1-16. doi: 10.1038/s41467-023-36392-5
Momin, Md. Moksedul, Lee, Soohyun, Wray, Naomi R. and Lee, S. Hong (2023). Significance tests for R2 of out-of-sample prediction using polygenic scores. The American Journal of Human Genetics, 110 (2), 349-358. doi: 10.1016/j.ajhg.2023.01.004
Qiao, Zhen, Sidorenko, Julia, Revez, Joana A., Xue, Angli, Lu, Xueling, Pärna, Katri, Snieder, Harold, Visscher, Peter M., Wray, Naomi R., Yengo, Loic and Lifelines Cohort Study (2023). Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose. Nature Communications, 14 (1) 451, 1-11. doi: 10.1038/s41467-023-36013-1
Li, Ang, Liu, Shouye, Bakshi, Andrew, Jiang, Longda, Chen, Wenhan, Zheng, Zhili, Sullivan, Patrick F., Visscher, Peter M., Wray, Naomi R., Yang, Jian and Zeng, Jian (2023). mBAT-combo: a more powerful test to detect gene-trait associations from GWAS data. American Journal of Human Genetics, 110 (1), 30-43. doi: 10.1016/j.ajhg.2022.12.006
Willemse, Sean W., Roes, Kit C. B., Van Damme, Philip, Hardiman, Orla, Ingre, Caroline, Povedano, Monica, Wray, Naomi R., Gijzen, Marleen, de Pagter, Mirjam S., Demaegd, Koen C., Janse, Annemarie F. C., Vink, Roel G., Sleutjes, Boudewijn T. H. M., Chiò, Adriano, Corcia, Philippe, Reviers, Evy, Al-Chalabi, Ammar, Kiernan, Matthew C., van den Berg, Leonard H., van Es, Michael A. and van Eijk, Ruben P. A. (2022). Lithium carbonate in amyotrophic lateral sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A: protocol for a confirmatory, randomized, group-sequential, event-driven, double-blind, placebo-controlled trial. Trials, 23 (1) 978. doi: 10.1186/s13063-022-06906-5
Gomez, Lina, Díaz-Torres, Santiago, Colodro-Conde, Lucía, Garcia-Marin, Luis M., Yap, Chloe X., Byrne, Enda M., Yengo, Loic, Lind, Penelope A., Wray, Naomi R., Medland, Sarah E., Hickie, Ian B., Lupton, Michelle K., Rentería, Miguel E., Martin, Nicholas G. and Campos, Adrian I. (2022). Phenotypic and genetic factors associated with donation of DNA and consent to record linkage for prescription history in the Australian Genetics of Depression Study. European Archives of Psychiatry and Clinical Neuroscience, 273 (6), 1359-1368. doi: 10.1007/s00406-022-01527-0
Couvy-Duchesne, Baptiste, Zhang, Futao, Kemper, Kathryn E., Sidorenko, Julia, Wray, Naomi R., Visscher, Peter M., Colliot, Olivier and Yang, Jian (2022). Parsimonious model for mass-univariate vertexwise analysis. Journal of Medical Imaging, 9 (5), 1-19. doi: 10.1117/1.JMI.9.5.052404
Charlesworth, Brian, Goddard, Michael E., Meyer, Karin, Visscher, Peter M., Weir, Bruce S. and Wray, Naomi R. (2022). Author Correction: From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill. Nature Genetics, 54 (9), 1448-1448. doi: 10.1038/s41588-022-01160-6
Campos, Adrian I., Byrne, Enda M., Iorfino, Frank, Fabbri, Chiara, Hickie, Ian B., Lewis, Cathryn M., Wray, Naomi R., Medland, Sarah E., Rentería, Miguel E. and Martin, Nicholas G. (2022). Clinical, demographic, and genetic risk factors of treatment‐attributed suicidality in >10,000 Australian adults taking antidepressants. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 189 (6), 196-206. doi: 10.1002/ajmg.b.32913
Charlesworth, Brian, Goddard, Michael E., Meyer, Karin, Visscher, Peter M., Weir, Bruce S. and Wray, Naomi R. (2022). From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill. Nature Genetics, 54 (7), 934-939. doi: 10.1038/s41588-022-01103-1
Kiewa, Jacqueline, Meltzer-Brody, Samantha, Milgrom, Jeannette, Bennett, Elizabeth, Mackle, Tracey, Guintivano, Jerry, Hickie, Ian B, Colodro-Conde, Lucia, Medland, Sarah E, Martin, Nick, Wray, Naomi and Byrne, Enda (2022). Lifetime prevalence and correlates of perinatal depression in a case-cohort study of depression. BMJ Open, 12 (8) e059300, 1-7. doi: 10.1136/bmjopen-2021-059300
Freydenzon, Anna, Nabais, Marta F., Lin, Tian, Williams, Kelly L., Wallace, Leanne, Henders, Anjali K., Blair, Ian P., Wray, Naomi R., Pamphlett, Roger and McRae, Allan F. (2022). Association between DNA methylation variability and self-reported exposure to heavy metals. Scientific Reports, 12 (1) 10582, 1-9. doi: 10.1038/s41598-022-13892-w
Cadby, Gemma, Giles, Corey, Melton, Phillip E., Huynh, Kevin, Mellett, Natalie A., Duong, Thy, Nguyen, Anh, Cinel, Michelle, Smith, Alex, Olshansky, Gavriel, Wang, Tingting, Brozynska, Marta, Inouye, Mike, McCarthy, Nina S., Ariff, Amir, Hung, Joseph, Hui, Jennie, Beilby, John, Dubé, Marie-Pierre, Watts, Gerald F., Shah, Sonia, Wray, Naomi R., Lim, Wei Ling Florence, Chatterjee, Pratishtha, Martins, Ian, Laws, Simon M., Porter, Tenielle, Vacher, Michael, Bush, Ashley I. ... Moses, Eric K. (2022). Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease. Nature Communications, 13 (1) 3124, 1-17. doi: 10.1038/s41467-022-30875-7
Pain, Oliver, Hodgson, Karen, Trubetskoy, Vassily, Ripke, Stephan, Marshe, Victoria S., Adams, Mark J., Byrne, Enda M., Campos, Adrian I., Carrillo-Roa, Tania, Cattaneo, Annamaria, Als, Thomas D., Souery, Daniel, Dernovsek, Mojca Z., Fabbri, Chiara, Hayward, Caroline, Henigsberg, Neven, Hauser, Joanna, Kennedy, James L., Lenze, Eric J., Lewis, Glyn, Müller, Daniel J., Martin, Nicholas G., Mulsant, Benoit H., Mors, Ole, Perroud, Nader, Porteous, David J., Rentería, Miguel E., Reynolds, Charles F., Rietschel, Marcella ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2022). Identifying the Common Genetic Basis of Antidepressant Response. Biological Psychiatry Global Open Science, 2 (2), 115-126. doi: 10.1016/j.bpsgos.2021.07.008
Trubetskoy, Vassily, Pardiñas, Antonio F, Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B, Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A, Hall, Lynsey S, Lam, Max, Watanabe, Kyoko, Frei, Oleksandr, Ge, Tian, Harwood, Janet C, Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L, Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G ... Schizophrenia Working Group of the Psychiatric Genomics Consortium (2022). Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature, 604 (7906), 502-508. doi: 10.1038/s41586-022-04434-5
Bian, Beilei, Couvy-Duchesne, Baptiste, Wray, Naomi R. and McRae, Allan F. (2022). The role of critical immune genes in brain disorders: insights from neuroimaging immunogenetics. Brain Communications, 4 (2) fcac078, fcac078. doi: 10.1093/braincomms/fcac078
Zhang, Sai, Cooper-Knock, Johnathan, Weimer, Annika K., Shi, Minyi, Moll, Tobias, Marshall, Jack N.G., Harvey, Calum, Nezhad, Helia Ghahremani, Franklin, John, Souza, Cleide dos Santos, Ning, Ke, Wang, Cheng, Li, Jingjing, Dilliott, Allison A., Farhan, Sali, Elhaik, Eran, Pasniceanu, Iris, Livesey, Matthew R., Eitan, Chen, Hornstein, Eran, Kenna, Kevin P., Blair, Ian, Wray, Naomi R., Kiernan, Matthew, Mitne Neto, Miguel, Chio, Adriano, Cauchi, Ruben, Robberecht, Wim, van Damme, Philip ... Snyder, Michael P. (2022). Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis. Neuron, 110 (6), 992-1008. doi: 10.1016/j.neuron.2021.12.019
Kiewa, Jacqueline, Meltzer‐Brody, Samantha, Milgrom, Jeanette, Guintivano, Jerry, Hickie, Ian B., Whiteman, David C., Olsen, Catherine M., Colodro‐Conde, Lucía, Medland, Sarah E., Martin, Nicholas G., Wray, Naomi R. and Byrne, Enda M. (2022). Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non-perinatal depression. Depression and Anxiety, 39 (3), 182-191. doi: 10.1002/da.23232
Hop, Paul J., Zwamborn, Ramona A.J., Hannon, Eilis, Shireby, Gemma L., Nabais, Marta F., Walker, Emma M., van Rheenen, Wouter, van Vugt, Joke J.F.A., Dekker, Annelot M., Westeneng, Henk-Jan, Tazelaar, Gijs H.P., van Eijk, Kristel R., Moisse, Matthieu, Baird, Denis, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Ticozzi, Nicola, Ratti, Antonia, Cooper-Knock, Jonathan, Morrison, Karen E., Shaw, Pamela J., Basak, A. Nazli, Chiò, Adriano, Calvo, Andrea, Moglia, Cristina, Canosa, Antonio, Brunetti, Maura, Grassano, Maurizio, Gotkine, Marc ... Brain MEND Consortium (2022). Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Science Translational Medicine, 14 (633) eabj0264, 1-15. doi: 10.1126/scitranslmed.abj0264
Howard, David M., Pain, Oliver, Arathimos, Ryan, Barbu, Miruna C., Amador, Carmen, Walker, Rosie M., Jermy, Bradley, Adams, Mark J., Deary, Ian J., Porteous, David, Campbell, Archie, Sullivan, Patrick F., Evans, Kathryn L., Arseneault, Louise, Wray, Naomi R., Meaney, Michael, McIntosh, Andrew M. and Lewis, Cathryn M. (2022). Methylome-wide association study of early life stressors and adult mental health. Human Molecular Genetics, 31 (4), 651-664. doi: 10.1093/hmg/ddab274
Mullins, Niamh, Kang, JooEun, Campos, Adrian I., Coleman, Jonathan R I, Edwards, Alexis C., Galfalvy, Hanga, Levey, Daniel F., Lori, Adriana, Shabalin, Andrey, Starnawska, Anna, Su, Mei-Hsin, Watson, Hunna J., Adams, Mark, Awasthi, Swapnil, Gandal, Michael, Hafferty, Jonathan D., Hishimoto, Akitoyo, Kim, Minsoo, Okazaki, Satoshi, Otsuka, Ikuo, Ripke, Stephan, Ware, Erin B., Bergen, Andrew W., Berrettini, Wade H., Bohus, Martin, Brandt, Harry, Chang, Xiao, Chen, Wei J., Chen, Hsi-Chung ... Ruderfer, Douglas M. (2022). Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors. Biological Psychiatry, 91 (3), 313-327. doi: 10.1016/j.biopsych.2021.05.029
van Rheenen, Wouter, van der Spek, Rick A. A., Bakker, Mark K., van Vugt, Joke J. F. A., Hop, Paul J., Zwamborn, Ramona A. J., de Klein, Niek, Westra, Harm-Jan, Bakker, Olivier B., Deelen, Patrick, Shireby, Gemma, Hannon, Eilis, Moisse, Matthieu, Baird, Denis, Restuadi, Restuadi, Dolzhenko, Egor, Dekker, Annelot M., Gawor, Klara, Westeneng, Henk-Jan, Tazelaar, Gijs H. P., van Eijk, Kristel R., Kooyman, Maarten, Byrne, Ross P., Doherty, Mark, Heverin, Mark, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Ticozzi, Nicola ... SLAP Consortium (2022). Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nature Genetics, 54 (3), 361-361. doi: 10.1038/s41588-022-01020-3
Campos, Adrian I., Byrne, Enda M., Mitchell, Brittany L., Wray, Naomi R., Lind, Penelope A., Licinio, Julio, Medland, Sarah E., Martin, Nicholas G., Hickie, Ian B. and Rentería, Miguel E. (2022). Impact of CYP2C19 metaboliser status on SSRI response: a retrospective study of 9500 participants of the Australian Genetics of Depression Study. The Pharmacogenomics Journal, 22 (2), 130-135. doi: 10.1038/s41397-022-00267-7
Restuadi, Restuadi, Steyn, Frederik J., Kabashi, Edor, Ngo, Shyuan T., Cheng, Fei-Fei, Nabais, Marta F., Thompson, Mike J., Qi, Ting, Wu, Yang, Henders, Anjali K., Wallace, Leanne, Bye, Chris R., Turner, Bradley J., Ziser, Laura, Mathers, Susan, McCombe, Pamela A., Needham, Merrilee, Schultz, David, Kiernan, Matthew C., van Rheenen, Wouter, van den Berg, Leonard H., Veldink, Jan H., Ophoff, Roel, Gusev, Alexander, Zaitlen, Noah, McRae, Allan F., Henderson, Robert D., Wray, Naomi R., Giacomotto, Jean and Garton, Fleur C. (2022). Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1. Genome Medicine, 14 (1) 7, 7. doi: 10.1186/s13073-021-01006-6
van Rheenen, Wouter, van der Spek, Rick A. A., Bakker, Mark K., van Vugt, Joke J. F. A., Hop, Paul J., Zwamborn, Ramona A. J., de Klein, Niek, Westra, Harm-Jan, Bakker, Olivier B., Deelen, Patrick, Shireby, Gemma, Hannon, Eilis, Moisse, Matthieu, Baird, Denis, Restuadi, Restuadi, Dolzhenko, Egor, Dekker, Annelot M., Gawor, Klara, Westeneng, Henk-Jan, Tazelaar, Gijs H. P., van Eijk, Kristel R., Kooyman, Maarten, Byrne, Ross P., Doherty, Mark, Heverin, Mark, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Ticozzi, Nicola ... SLAP Consortium (2021). Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nature Genetics, 53 (12), 1636-1648. doi: 10.1038/s41588-021-00973-1
Yap, Chloe X., Henders, Anjali K., Alvares, Gail A., Wood, David L.A., Krause, Lutz, Tyson, Gene W., Restuadi, Restuadi, Wallace, Leanne, McLaren, Tiana, Hansell, Narelle K., Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren P., Leslie, Jodie, Frenk, Mira Levis, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Miller, Jessica L., Nunn, Lorelle, Holtmann, Gerald, Strike, Lachlan T., de Zubicaray, Greig I. ... Gratten, Jacob (2021). Autism-related dietary preferences mediate autism-gut microbiome associations. Cell, 184 (24), 5916-5931.e17. doi: 10.1016/j.cell.2021.10.015
Campos, Adrian I., Mulcahy, Aoibhe, Thorp, Jackson G., Wray, Naomi R., Byrne, Enda M., Lind, Penelope A., Medland, Sarah E., Martin, Nicholas G., Hickie, Ian B. and Rentería, Miguel E. (2021). Understanding genetic risk factors for common side effects of antidepressant medications. Communications Medicine, 1 (1) 45, 1-10. doi: 10.1038/s43856-021-00046-8
Ni, Guiyan, Zeng, Jian, Revez, Joana A., Wang, Ying, Zheng, Zhili, Ge, Tian, Restuadi, Restuadi, Kiewa, Jacqueline, Nyholt, Dale R., Coleman, Jonathan R.I., Smoller, Jordan W., Yang, Jian, Visscher, Peter M. and Wray, Naomi R. (2021). A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts. Biological Psychiatry, 90 (9), 611-620. doi: 10.1016/j.biopsych.2021.04.018
Mitchell, Brittany L., Campos, Adrian I., Whiteman, David C., Olsen, Catherine M., Gordon, Scott D., Walker, Adam J., Dean, Olivia M., Berk, Michael, Hickie, Ian B., Medland, Sarah E., Wray, Naomi R., Martin, Nicholas G. and Byrne, Enda M. (2021). The Australian Genetics of Depression Study: new risk loci and dissecting heterogeneity between subtypes. Biological Psychiatry, 92 (3), 227-235. doi: 10.1016/j.biopsych.2021.10.021
Wang, Xiaotong, Lin, Tian, Yengo, Loic, Sidorenko, Julia, Wray, Naomi R. and Levinson, Douglas F. (2021). Polygenic burden could explain high rates of affective disorders in a community with restricted founder population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 186 (6), 367-375. doi: 10.1002/ajmg.b.32876
McGrath, John J. and Wray, Naomi R. (2021). Seven short reflections on the notion of schizophrenia. Schizophrenia Research, 242, 96-97. doi: 10.1016/j.schres.2021.09.026
Vucic, Steve, Wray, Naomi, Henders, Anjali, Henderson, Robert D., Talman, Paul, Mathers, Susan, Bellgard, Matthew, Aoun, Samar, Birks, Carol, Thomas, Gethin, Hansen, Catherine, Thomas, Geoff, Hogden, Anne, Needham, Merrilee, Schultz, David, Soulis, Tina, Sheean, Bec, Milne, Jane, Rowe, Dominic, Zoing, Margie and Kiernan, Matthew C (2021). MiNDAUS partnership: a roadmap for the cure and management of motor Neurone disease. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 23 (5-6), 1-8. doi: 10.1080/21678421.2021.1980889
Visscher, Peter M., Yengo, Loic, Cox, Nancy J. and Wray, Naomi R. (2021). Discovery and implications of polygenicity of common diseases. Science, 373 (6562), 1468-1473. doi: 10.1126/science.abi8206
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Nichles, Alissa, Zmicerevska, Natalia, Song, Yun Ju Christine, Wilson, Chloe, McHugh, Catherine, Hamilton, Blake, Crouse, Jacob, Rohleder, Cathrin, Carpenter, Joanne Sarah, Ho, Nicholas, Hermens, Daniel F., Wray, Naomi, Scott, Jan, Merikangas, Kathleen R., Leweke, F. Markus, Koethe, Dagmar, Iorfino, Frank, Naismith, Sharon L., Guastella, Adam J., Scott, Elizabeth M. and Hickie, Ian B (2021). Neurobiology Youth Follow-up Study: Protocol to establish a longitudinal and prospective research database using multimodal assessments for current and past mental health treatment-seeking young people within an early intervention service. BMJ Open, 11 (6) e044731, 1-8. doi: 10.1136/bmjopen-2020-044731
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Chauquet, Solal, Zhu, Zhihong, O'Donovan, Michael C., Walters, James T. R., Wray, Naomi R. and Shah, Sonia (2021). Association of antihypertensive drug target genes with psychiatric disorders: a Mendelian randomization study. JAMA Psychiatry, 78 (6), 623-631. doi: 10.1001/jamapsychiatry.2021.0005
Mehta, Divya, Grewen, Karen, Pearson, Brenda, Wani, Shivangi, Wallace, Leanne, Henders, Anjali K., Binder, Elisabeth B., Frokjaer, Vibe G., Meltzer-Brody, Samantha, Wray, Naomi R. and Stuebe, Alison M. (2021). Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape. Translational Psychiatry, 11 (1) 155, 155. doi: 10.1038/s41398-021-01270-5
Zeng, Jian, Xue, Angli, Jiang, Longda, Lloyd-Jones, Luke R., Wu, Yang, Wang, Huanwei, Zheng, Zhili, Yengo, Loic, Kemper, Kathryn E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2021). Widespread signatures of natural selection across human complex traits and functional genomic categories. Nature Communications, 12 (1) 1164, 1-12. doi: 10.1038/s41467-021-21446-3
Wu, Yeda, Murray, Graham K., Byrne, Enda M., Sidorenko, Julia, Visscher, Peter M. and Wray, Naomi R. (2021). GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression. Nature Communications, 12 (1) 1146, 1-17. doi: 10.1038/s41467-021-21280-7
Kemper, Kathryn E., Yengo, Loic, Zheng, Zhili, Abdellaoui, Abdel, Keller, Matthew C., Goddard, Michael E., Wray, Naomi R., Yang, Jian and Visscher, Peter M. (2021). Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals. Nature Communications, 12 (1) 1050, 1050. doi: 10.1038/s41467-021-21283-4
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Murray, Graham K., Lin, Tian, Austin, Jehannine, McGrath, John J., Hickie, Ian B. and Wray, Naomi R. (2021). Could polygenic risk scores be useful in psychiatry? a review. JAMA Psychiatry, 78 (2), 210-219. doi: 10.1001/jamapsychiatry.2020.3042
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Baselmans, Bart M.L., Yengo, Loic, van Rheenen, Wouter and Wray, Naomi R. (2021). Risk in relatives, heritability, SNP-based heritability and genetic correlations in psychiatric disorders: a review. Biological Psychiatry, 89 (1), 11-19. doi: 10.1016/j.biopsych.2020.05.034
Crouse, Jacob J., Carpenter, Joanne S., Iorfino, Frank, Lin, Tian, Ho, Nicholas, Byrne, Enda M., Henders, Anjali K., Wallace, Leanne, Hermens, Daniel F., Scott, Elizabeth M., Wray, Naomi R. and Hickie, Ian B. (2021). Schizophrenia polygenic risk scores in youth mental health: preliminary associations with diagnosis, clinical stage and functioning. BJPsych Open, 7 (2) e58, e58. doi: 10.1192/bjo.2021.14
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Wray, Naomi R., Lin, Tian, Austin, Jehannine, McGrath, John J., Hickie, Ian B., Murray, Graham K. and Visscher, Peter M. (2021). From basic science to clinical application of polygenic risk scores : a primer. JAMA Psychiatry, 78 (1), 101-109. doi: 10.1001/jamapsychiatry.2020.3049
Banos, Daniel Trejo, McCartney, Daniel L., Patxot, Marion, Anchieri, Lucas, Battram, Thomas, Christiansen, Colette, Costeira, Ricardo, Walker, Rosie M., Morris, Stewart W., Campbell, Archie, Zhang, Qian, Porteous, David J., McRae, Allan F., Wray, Naomi R., Visscher, Peter M., Haley, Chris S., Evans, Kathryn L., Deary, Ian J., McIntosh, Andrew M., Hemani, Gibran, Bell, Jordana T., Marioni, Riccardo E. and Robinson, Matthew R. (2020). Author Correction: Bayesian reassessment of the epigenetic architecture of complex traits (Nature Communications, (2020), 11, 1, (2865), 10.1038/s41467-020-16520-1). Nature Communications, 11 (1) 5186, 5186. doi: 10.1038/s41467-020-19099-9
Shen, Xueyi, Howard, David M., Adams, Mark J., Hill, W. David, Clarke, Toni-Kim, Adams, Mark J., Clarke, Toni-Kim, McIntosh, Andrew M., Deary, Ian J., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard ... McIntosh, Andrew M. (2020). A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. Nature Communications, 11 (1) 2301. doi: 10.1038/s41467-020-16022-0
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Garton, Fleur C., Trabjerg, Betina B., Wray, Naomi R. and Agerbo, Esben (2020). Cardiovascular disease, psychiatric diagnosis and sex‐differences in the multi‐step hypothesis of ALS. European Journal of Neurology, 28 (2) ene.14554, 421-429. doi: 10.1111/ene.14554
Zhang, Qian, Sidorenko, Julia, Couvy-Duchesne, Baptiste, Marioni, Riccardo E., Wright, Margaret J., Goate, Alison M., Marcora, Edoardo, Huang, Kuan-lin, Porter, Tenielle, Laws, Simon M., Australian Imaging Biomarkers and Lifestyle (AIBL) Study, Sachdev, Perminder S., Mather, Karen A., Armstrong, Nicola J., Thalamuthu, Anbupalam, Brodaty, Henry, Yengo, Loic, Yang, Jian, Wray, Naomi R., McRae, Allan F. and Visscher, Peter M. (2020). Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture. Nature Communications, 11 (1) 4799, 1-11. doi: 10.1038/s41467-020-18534-1
Hammerschlag, Anke R., Byrne, Enda M., Bartels, Meike, Wray, Naomi R., Middeldorp, Christel M., eQTLGen Consortium, BIOS Consortium, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexis, Beutner, Frank, Bonder, Marc Jan, Boomsma, Dorret I., Christiansen, Mark, Claringbould, Annique, Deelen, Patrick, Esko, Tõnu, Favé, Marie-Julie, Franke, Lude, Frayling, Timothy, Gharib, Sina A., Gibson, Gregory, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette ... Agbessi, Mawussé (2020). Refining attention-deficit/hyperactivity disorder and autism spectrum disorder genetic loci by integrating summary data from genome-wide association, gene expression and DNA methylation studies. Biological Psychiatry, 88 (6), 470-479. doi: 10.1016/j.biopsych.2020.05.002
Costilla, Roy, Kemper, Kathryn E., Byrne, Enda M., Porto-Neto, Laercio R., Carvalheiro, Roberto, Purfield, Deirdre C., Doyle, Jennifer L., Berry, Donagh P., Moore, Stephen S., Wray, Naomi R. and Hayes, Ben J. (2020). Genetic control of temperament traits across species: association of autism spectrum disorder risk genes with cattle temperament. Genetics Selection Evolution, 52 (1) 51, 51. doi: 10.1186/s12711-020-00569-z
McCombe, Pamela A., Garton, Fleur C., Katz, Matthew, Wray, Naomi R. and Henderson, Robert D. (2020). What do we know about the variability in survival of patients with amyotrophic lateral sclerosis?. Expert Review of Neurotherapeutics, 20 (9), 921-941. doi: 10.1080/14737175.2020.1785873
Colicino, Elena, Marioni, Riccardo, Ward-Caviness, Cavin, Gondalia, Rahul, Guan, Weihua, Chen, Brian, Tsai, Pei-Chien, Huan, Tianxiao, Xu, Gao, Golareh, Agha, Schwartz, Joel, Vokonas, Pantel, Just, Allan, Starr, John M., McRae, Allan F., Wray, Naomi R., Visscher, Peter M., Bressler, Jan, Zhang, Wen, Tanaka, Toshiko, Moore, Ann Zenobia, Pilling, Luke C., Zhang, Guosheng, Stewart, James D., Li, Yun, Hou, Lifang, Castillo-Fernandez, Juan, Spector, Tim, Kiel, Douglas P. ... Baccarelli, Andrea (2020). Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals. Aging, 12 (14), 14092-14124. doi: 10.18632/aging.103408
Couvy‐Duchesne, Baptiste, Strike, Lachlan T., Zhang, Futao, Holtz, Yan, Zheng, Zhili, Kemper, Kathryn E., Yengo, Loic, Colliot, Olivier, Wright, Margaret J., Wray, Naomi R., Yang, Jian and Visscher, Peter M. (2020). A unified framework for association and prediction from vertex‐wise grey‐matter structure. Human Brain Mapping, 41 (14) hbm.25109, 4062-4076. doi: 10.1002/hbm.25109
Hagenaars, Saskia P., Coleman, Jonathan R. I., Choi, Shing Wan, Gaspar, Héléna, Adams, Mark J., Howard, David M., Hodgson, Karen, Traylor, Matthew, Air, Tracy M., Andlauer, Till F. M., Arolt, Volker, Baune, Bernhard T., Binder, Elisabeth B., Blackwood, Douglas H. R., Boomsma, Dorret I., Campbell, Archie, Cearns, Micah, Czamara, Darina, Dannlowski, Udo, Domschke, Katharina, de Geus, Eco J. C., Hamilton, Steven P., Hayward, Caroline, Hickie, Ian B., Hottenga, Jouke Jan, Ising, Marcus, Jones, Ian, Jones, Lisa, Kutalik, Zoltan ... Lewis, Cathryn M. (2020). Genetic comorbidity between major depression and cardio‐metabolic traits, stratified by age at onset of major depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 183 (6) ajmg.b.32807, 309-330. doi: 10.1002/ajmg.b.32807
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Katz, Matthew, Davis, Mark, Garton, Fleur C., Henderson, Robert, Bharti, Vanda, Wray, Naomi and McCombe, Pamela (2020). Mutations in heat shock protein beta-1 (HSPB1) are associated with a range of clinical phenotypes related to different patterns of motor neuron dysfunction: a case series. Journal of the Neurological Sciences, 413 116809, 116809. doi: 10.1016/j.jns.2020.116809
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