The Wright laboratory's research is at the interface of cognitive neuroscience and genetics. We focuse on the neurobiological causes and modifiers of brain function, and especially brain disorders. A key aim is to determine whether there are particularly sensitive periods when genetic and environmental factors alter the developmental trajectory in adolescence, and mediate risk for mental illness. The group uses a combination of approaches to track adolescent brain development, including neuroimaging, genetic, behavioural, and neuropsychological.
Group leader
Associate Professor Margie Wright
+61 7 334 63112
margie.wright@uq.edu.au
UQ Researcher Profile
Imaging Genomics Group website
Queensland Twin Adolescent Brain (QTAB) project
Data collection 2017-2020
This project is enabled through NHMRC funding granted to Margie Wright (CIA), Greig de Zubicaray, Katie McMahon, and Paul Thompson. It will extend our understanding of normative brain changes during adolescence, including sex differences, the effects of puberty, and the role of genetic and environmental influences. Brain imaging and behavioural data will be collected longitudinally, allowing us to critically examine factors contributing to optimal cognitive and emotional functioning during this important transition period and to gain insights into vulnerabilities that may underlie brain disorders and mental illness.
Queensland Twin Imaging (QTIM) project
Data collection 2007-2012 – analyses ongoing
This collaborative project was initiated with NIH funding granted to Margie Wright (PI), Paul Thompson, Greig de Zubicaray, Nick Martin, Katie McMahon, and Arthur Toga (bringing together researchers from QIMR Berghofer Medical Research Institute, the University of Queensland, and the University of California, Los Angeles). Brain imaging was collected in a large genetically-informative population sample of young adults (N>1200) for whom a range of behavioural traits, including cognitive function, were already characterised (as a component of the Brisbane Adolescent Twin Study, QIMR Berghofer Medical Research Institute)). The project continues to add to our understanding of the genetic influences that determine variation in neuroanatomic structure, neural connectivity, and cognitive ability. Examining these relationships in a healthy cohort also provides insights into the role of genes associated with brain-related measures of neurological and psychiatric disease. In addition, the project joins with 50+ groups worldwide contributing data (>30,000 subjects) to the ENIGMA (Enhancing Neuroimaging Genetics through Meta-Analysis) Consortium, which pools data to maximise power and validate findings within the field of imaging genetics.
Memory, Attention, and Problem Solving (MAPS) project, also known as the Cognition Study, a component of the Brisbane Adolescent Twin Study
Data collection 1996-2012 – analyses ongoing
This long-running project was led by Margie Wright in collaboration with Nick Martin (QIMR Berghofer Medical Research Institute). Other researchers involved at different stages of the project include Gina Geffen, Laurie Geffen, Glen Smith, Michelle Luciano, Graham Halford, David Shum, Glenda Andrews, and Naomi Wray. Cognitive and behavioural data were collected from 16-year-old twin pairs and their siblings (N>2700). The broad aim of the project was, and is, to investigate individual differences in cognitive abilities, and in particular, the contribution of genetic and environmental factors. The data continue to contribute to worldwide initiatives exploring the genetics of cognitive function.
Older Australian Twin Study (OATS)
Data collection began in 2007 and is ongoing in New South Wales and Victoria (data collection ran 2007-2016 in Queensland, based at the QIMR Berghofer Medical Research Institute) – analyses ongoing
This project was initiated by Perminder Sachdev (School of Psychiatry, University of New South Wales) and expanded to include researchers in Queensland and Victoria. The OATS investigative team comprises David Ames, Bernhard Baune, Henry Brodaty, John Crawford, Teresa Lee, Nick Martin, Karen Mather, Christopher Rowe, Perminder Sachdev, Katherine Samaras, Peter Schofield, Julian Trollor, Wei Wen, and Margie Wright, who directed the Queensland arm of the study. The study is longitudinal in design and investigates healthy brain ageing in older twins (65+ years, N = 623 at baseline). Measures collected include brain imaging and cognitive function, as well as genotypes. The study has formed collaborative partnerships with other twin and/or imaging studies around the world, including the ENIGMA (Enhancing Neuroimaging Genetics through Meta-Analysis) Consortium.
“Imagine Cerebral Palsy” Genome and Connectome Study
Blood collection 2017-2018
This project was funded by the Research Foundation of Cerebral Palsy Alliance (Margie Wright, CI) with co-investigators Roslyn Boyd, Stephen Rose, Gai McMichael, and Michael Fahey). It builds on the PREDICT-CP Study (Roslyn Boyd, CI), in which children with cerebral palsy have been recruited for brain imaging and assessment of motor and cognitive function. The current project allows collection of a blood sample from 240 families (child and both parents) and subsequent whole exome sequencing for a subset of 40 families. This study expands on prior work by combining whole exome sequencing and brain imaging to identify rare/unique, and potentially highly penetrant, genetic variants in child-parent trios, with the aim of providing biological insights into the disease mechanisms of cerebral palsy.
ENIGMA (Enhancing Neuroimaging Genetics through Meta-Analysis) Consortium
This consortium was founded in 2009 and is led by Paul Thompson (University of Southern California). Margie Wright was a founding member and is one of a number of Australian researchers who continue to play a leading role in the consortium - now a global alliance of over 500 scientists from over 200 institutions in 35 countries with brain MRI data available for >30,000 individuals (approximately a third being patients with a range of psychiatric conditions). ENIGMA is organised into working groups that examine (i) normal variation in brain structure and function within the population, for example, as related to brain plasticity, ageing, and lateralization, (ii) disease-related variation in conditions such as depression, schizophrenia, and ADHD, (iii) genomics approaches such as genome-wide association analysis and epigenetic analyses, and (iv) protocol development. Large-scale collaborative consortia such as ENIGMA herald a new era in the field of imaging genetics in which the reliability of findings is paramount.
International
- Prof Timothy Bates (University of Edinburgh)
- Prof F. Xavier Castellanos (New York University) Prof Rhoschel Lenroot (University of New South Wales)
- Dr Michelle Luciano (University of Edinburgh)
- Dr Mike Milham (Centre for the Developing Brain, Child Mind Institute, New York)
- Prof Danielle Reed (Monell Chemical Senses Center, Philadelphia)
- Prof Paul Thompson (University of Southern California)
Domestic
- Prof Michael Breakspear (QIMR Berghofer Medical Research Institute)
- Prof Ian Hickie (Brain & Mind Centre, Sydney)
- Prof Rhoschel Lenroot (University of New South Wales)
- Prof Nick Martin (QIMR Berghofer Medical Research Institute)
- A/Prof Sarah Medland (QIMR Berghofer Medical Research Institute)
- Prof Perminder Sachdev (University of New South Wales)
- Prof Katharine Steinbeck (University of Sydney)
- Prof Greig de Zubicaray (Queensland University of Technology)
- A/Prof Katie McMahon (Queensland University of Technology)
University of Queensland
- Prof Roslyn Boyd (Child Health Research Centre, Faculty of Medicine, UQ)
- Prof Julie Henry (School of Psychology, UQ)
- Prof Naomi Wray (Program in Complex Trait Genetics, Institute for Molecular Bioscience, UQ)
- Prof Peter Visscher (Program in Complex Trait Genetics, Institute for Molecular Bioscience, UQ)
- Dr Brendan Zietsch (School of Psychology, UQ)
Strike, Lachlan T., Hansell, Narelle K., Thompson, Paul M., de Zubicaray, Greig I., McMahon, Katie L., Zietsch, Brendan P. and Wright, Margaret J. (2019)Absolute and relative estimates of genetic and environmental variance in brain structure volumes. Brain Structure and Function, . doi:10.1007/s00429-019-01931-8
Jiang, Jiyang, Thalamuthu, Anbupalam, Koch, Forrest C., Liu, Tao, Xu, Qun, Trollor, Julian N., Ames, David, Wright, Margaret J., Catts, Vibeke, Sachdev, Perminder S. and Wen, Wei (2019)Cerebral blood flow in community-based older twins is moderately heritable: an arterial spin labeling perfusion imaging study. Frontiers in Aging Neuroscience, 11 JUL: 169. doi:10.3389/fnagi.2019.00169
Hwang, Liang-Dar, Lin, Cailu, Gharahkhani, Puya, Cuellar-Partida, Gabriel, Ong, Jue-Sheng, An, Jiyuan, Gordon, Scott D., Zhu, Gu, MacGregor, Stuart, Lawlor, Deborah A., Breslin, Paul A. S., Wright, Margaret J., Martin, Nicholas G. and Reed, Danielle R. (2019)New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances. The American Journal of Clinical Nutrition, 109 6: 1724-1737. doi:10.1093/ajcn/nqz043
Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Böhmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kähönen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimäki, Terho, Li, Shu-Chen, Lill, Christina M., Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikäinen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumaré, Aïcha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, André, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stéphanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hägg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Räikkönen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Dan Rujescu,, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Bressler, Jan, Lencz, Todd and Deary, Ian J.(2019)Author correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications, 10 . doi:10.1038/s41467-019-10160-w
Hwang, Liang-Dar, Strike, Lachlan T, Couvy-Duchesne, Baptiste, de Zubicaray, Greig I, McMahon, Katie, Breslin, Paul A. S., Reed, Danielle R., Martin, Nicholas G. and Wright, Margaret J. (2019)Associations between brain structure and perceived intensity of sweet and bitter tastes. Behavioural Brain Research, 363 103-108. doi:10.1016/j.bbr.2019.01.046
Chen, Xu, Formisano, Elia, Blokland, Gabriëlla A. M., Strike, Lachlan T., McMahon, Katie L., Zubicaray, Greig I., Thompson, Paul M., Wright, Margaret J., Winkler, Anderson M., Ge, Tian and Nichols, Thomas E. (2019)Accelerated estimation and permutation inference for ACE modeling. Human Brain Mapping, 40 12: 3488-3507. doi:10.1002/hbm.24611
Lazaroo, Nikita K., Bates, Timothy C., Hansell, Narelle K., Wright, Margaret J., Martin, Nicholas G. and Luciano, Michelle (2019)Genetic structure of IQ, phonemic decoding skill, and academic achievement. Frontiers in Genetics, 10 . doi:10.3389/fgene.2019.00195
Kochunov, Peter, Patel, Binish, Ganjgahi, Habib, Donohue, Brian, Ryan, Meghann, Hong, Elliot L., Chen, Xu, Adhikari, Bhim, Jahanshad, Neda, Thompson, Paul M., Van't Ent, Dennis, den Braber, Anouk, de Geus, Eco J. C., Brouwer, Rachel M., Boomsma, Dorret, Pol, Hilleke E. Hulshoff, de Zubicaray, Greig, McMahon, Katie L., Martin, Nicholas G., Wright, Margaret J. and Nichols, Thomas E. (2019)Homogenizing estimates of heritability among SOLAR-Eclipse, OpenMx, APACE, and FPHI software packages in neuroimaging data. Frontiers in Neuroinformatics, 13 16. doi:10.3389/fninf.2019.00016
Mackey, Scott, Allgaier, Nicholas, Chaarani, Bader, Spechler, Philip, Orr, Catherine, Bunn, Janice, Allen, Nicholas B., Alia-Klein, Nelly, Batalla, Albert, Blaine, Sara, Brooks, Samantha, Caparelli, Elisabeth, Chye, Yann Ying, Cousijn, Janna, Dagher, Alain, Desrivieres, Sylvane, Feldstein-Ewing, Sarah, Foxe, John J., Goldstein, Rita Z., Goudriaan, Anna E., Heitzeg, Mary M., Hester, Robert, Hutchison, Kent, Korucuoglu, Ozlem, Li, Chiang-Shan R., London, Edythe, Lorenzetti, Valentina, Luijten, Maartje, Martin-Santos, Rocio, May, April, Momenan, Reza, Morales, Angelica, Paulus, Martin P., Pearlson, Godfrey, Rousseau, Marc-Etienne, Salmeron, Betty Jo, Schluter, Renée, Schmaal, Lianne, Schumann, Gunter, Sjoerds, Zsuzsika, Stein, Dan J., Stein, Elliot A., Sinha, Rajita, Solowij, Nadia, Tapert, Susan, Uhlmann, Anne, Veltman, Dick, Van Holst, Ruth, Whittle, Sarah, Wright, Margaret J., Yücel, Murat, Zhang, Sheng, Yurgelun-Todd, Deborah, Hibar, Derrek P., Jahanshad, Neda, Evans, Alan, Thompson, Paul M., Glahn, David C., Conrod, Patricia, Garavan, Hugh and ENIGMA Addiction Working Group (2019)Mega-analysis of gray matter volume in substance dependence: general and substance-specific regional effects. American Journal of Psychiatry, 176 2: 119-128. doi:10.1176/appi.ajp.2018.17040415
Chauhan, Ganesh, Adams, Hieab H. H., Satizabal, Claudia L., Bis, Joshua C., Teumer, Alexander, Sargurupremraj, Muralidharan, Hofer, Edith, Trompet, Stella, Hilal, Saima, Smith, Albert Vernon, Jian, Xueqiu, Malik, Rainer, Traylor, Matthew, Pulit, Sara L., Amouyel, Philippe, Mazoyer, Bernard, Zhu, Yi-Cheng, Kaffashian, Sara, Schilling, Sabrina, Beecham, Gary W., Montine, Thomas J., Schellenberg, Gerard D., Kjartansson, Olafur, Gudnason, Vilmundur, Knopman, David S., Griswold, Michael E., Windham, B. Gwen, Gottesman, Rebecca F., Mosley, Thomas H., Schmidt, Reinhold, Saba, Yasaman, Schmidt, Helena, Takeuchi, Fumihiko, Yamaguchi, Shuhei, Nabika, Toru, Kato, Norihiro, Rajan, Kumar B., Aggarwal, Neelum T., De Jager, Philip L., Evans, Denis A., Psaty, Bruce M., Rotter, Jerome I., Rice, Kenneth, Lopez, Oscar L., Liao, Jiemin, Chen, Christopher, Cheng, Ching-Yu, Wong, Tien Y., Ikram, Mohammad K., van der Lee, Sven J., Amin, Najaf, Chouraki, Vincent, DeStefano, Anita L., Aparicio, Hugo J., Romero, Jose R., Maillard, Pauline, DeCarli, Charles, Wardlaw, Joanna M., Hernandez, Maria del C. Valdes, Luciano, Michelle, Liewald, David, Deary, Ian J., Starr, John M., Bastin, Mark E., Maniega, Susana Munoz, Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, Uh, Hae-Won, Lemmens, Robin, Brodaty, Henry, Wright, Margaret J., Ames, David, Boncoraglio, Giorgio B., Hopewell, Jemma C., Beecham, Ashley H., Blanton, Susan H., Wright, Clinton B., Sacco, Ralph L., Wen, Wei, Thalamuthu, Anbupalam, Armstrong, Nicola J., Chong, Elizabeth, Schofield, Peter R., Kwok, John B., van der Grond, Jeroen, Stott, David J., Ford, Ian, Jukema, J. Wouter, Vernooij, Meike W., Hofman, Albert, Uitterlinden, Andre G., van der Lugt, Aad, Wittfeld, Katharina, Grabe, Hans J., Hosten, Norbert, von Sarnowski, Bettina, Voelker, Uwe, Levi, Christopher, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie L. M., Rosand, Jonathan, Woo, Daniel, Cole, John W., Meschia, James F., Slowik, Agnieszka, Thijs, Vincent, Lindgren, Arne, Melander, Olle, Grewal, Raji P., Rundek, Tatjana, Rexrode, Kathy, Rothwell, Peter M., Arnett, Donna K., Jern, Christina, Johnson, Julie A., Benavente, Oscar R., Wasssertheil-Smoller, Sylvia, Lee, Jin-Moo, Wong, Quenna, Mitchell, Braxton D., Rich, Stephen S., McArdle, Patrick F., Geerlings, Mirjam I., van der Graaf, Yolanda, de Bakker, Paul I. W., Asselbergs, Folkert W., Srikanth, Velandai, Thomson, Russell, McWhirter, Rebekah, Moran, Chris, Callisaya, Michele, Thanh Phan,, Rutten-Jacobs, Loes C. A., Bevan, Steve, Tzourio, Christophe, Mather, Karen A., Sachdev, Perminder S., van Duijn, Cornelia M., Worrall, Bradford B., Dichgans, Martin, Kittner, Steven J., Markus, Hugh S., Ikram, Mohammad A., Fornage, Myriam, Launer, Lenore J., Seshadri, Sudha, Longstreth, W. T. and Debette, Stephanie (2019)Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology, 92 5: E486-E503. doi:10.1212/WNL.0000000000006851
Bates, Timothy C., Maher, Brion S., Colodro-Conde, Lucía, Medland, Sarah E., McAloney, Kerrie, Wright, Margaret J., Hansell, Narelle K., Okbay, Aysu, Kendler, Kenneth S., Martin, Nicholas G. and Gillespie, Nathan A. (2019)Social competence in parents increases children's educational attainment: Replicable genetically-mediated effects of parenting revealed by non-transmitted DNA. Twin Research and Human Genetics, . doi:10.1017/thg.2018.75
Duffy, David L., Zhu, Gu, Li, Xin, Sanna, Marianna, Iles, Mark M., Jacobs, Leonie C., Evans, David M., Yazar, Seyhan, Beesley, Jonathan, Law, Matthew H., Kraft, Peter, Visconti, Alessia, Taylor, John C., Liu, Fan, Wright, Margaret J., Henders, Anjali K., Bowdler, Lisa, Glass, Dan, Ikram, M. Arfan, Uitterlinden, André G., Madden, Pamela A., Heath, Andrew C., Nelson, Elliot C., Green, Adele C., Chanock, Stephen, Barrett, Jennifer H., Brown, Matthew A., Hayward, Nicholas K., MacGregor, Stuart, Sturm, Richard A., Hewitt, Alex W., Kayser, Manfred, Hunter, David J., Newton Bishop, Julia A., Spector, Timothy D., Montgomery, Grant W., Mackey, David A., Smith, George Davey, Nijsten, Tamar E., Bishop, D. Timothy, Bataille, Veronique, Falchi, Mario, Han, Jiali and Martin, Nicholas G. (2019)Publisher correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nature Communications, 10 1: 299. doi:10.1038/s41467-018-08078-w
Demontis, Ditte, Walters, Raymond K., Martin, Joanna, Mattheisen, Manuel, Als, Thomas D., Agerbo, Esben, Baldursson, Gísli, Belliveau, Rich, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Churchhouse, Claire, Dumont, Ashley, Eriksson, Nicholas, Gandal, Michael, Goldstein, Jacqueline I., Grasby, Katrina L., Grove, Jakob, Gudmundsson, Olafur O., Hansen, Christine S., Hauberg, Mads Engel, Hollegaard, Mads V., Howrigan, Daniel P., Huang, Hailiang, Maller, Julian B., Martin, Alicia R., Martin, Nicholas G., Moran, Jennifer, Pallesen, Jonatan, Palmer, Duncan S., Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Poterba, Timothy, Poulsen, Jesper Buchhave, Ripke, Stephan, Robinson, Elise B., Satterstrom, F. Kyle, Stefansson, Hreinn, Stevens, Christine, Turley, Patrick, Walters, G. Bragi, Won, Hyejung, Wright, Margaret J., Andreassen, Ole A., Asherson, Philip, Burton, Christie L., Boomsma, Dorret I., Cormand, Bru, Dalsgaard, Søren, Franke, Barbara, Gelernter, Joel, Geschwind, Daniel, Hakonarson, Hakon, Haavik, Jan, Kranzler, Henry R., Kuntsi, Jonna, Langley, Kate, Lesch, Klaus-Peter, Middeldorp, Christel, Reif, Andreas, Rohde, Luis Augusto, Roussos, Panos, Schachar, Russell, Sklar, Pamela, Sonuga-Barke, Edmund J. S., Sullivan, Patrick F., Thapar, Anita, Tung, Joyce Y., Waldman, Irwin D., Medland, Sarah E., Stefansson, Kari, Nordentoft, Merete, Hougaard, David M., Werge, Thomas, Mors, Ole, Mortensen, Preben Bo, Daly, Mark J., Faraone, Stephen V., Børglum, Anders D., Neale, Benjamin M., Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium, Trzaskowski, Maciej , Evans, David M. and Kemp, John P. (2019)Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics, 51 1: 63-75. doi:10.1038/s41588-018-0269-7
Couvy-Duchesne, Baptiste, Strike, Lachlan T., McMahon, Katie L., de Zubicaray, Greig I., Thompson, Paul M., Martin, Nicholas G., Medland, Sarah E. and Wright, Margaret J. (2018)A fast method for estimating statistical power of multivariate GWAS in real case scenarios: examples from the field of imaging genetics. Behavior Genetics, 49 1: 112-121. doi:10.1007/s10519-018-9936-9
Ong, Jue-Sheng, Hwang, Liang-Dar, Zhong, Victor W., An, Jiyuan, Gharahkhani, Puya, Breslin, Paul A. S., Wright, Margaret J., Lawlor, Deborah A., Whitfield, John, MacGregor, Stuart, Martin, Nicholas G. and Cornelis, Marilyn C.(2018)Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization. Scientific Reports, 8 1: . doi:10.1038/s41598-018-34713-z
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Meier, Madeline H., Gillespie, Nathan A., Hansell, Narelle K., Hewitt, Alex W., Hickie, Ian B., Lu, Yi, MacGregor, Stuart, Medland, Sarah E., Sun, Cong, Wong, Tien Y., Wright, Margaret J., Zhu, Gu, Martin, Nicholas G. and Mackey, David A.(2014)Associations between depression and anxiety symptoms and retinal vessel caliber in adolescents and young adults. Psychosomatic Medicine, 76 9: 732-738. doi:10.1097/PSY.0000000000000117
Rentería, M. E., Hansell, N. K., Strike, L. T., McMahon, K. L., de Zubicaray, G. I., Hickie, Ian B., Thompson, Paul M., Martin, N. G., Medland, S. E. and Wright, M. J. (2014)Genetic architecture of subcortical brain regions: common and region-specific genetic contributions. Genes, Brain and Behavior, 13 8: 821-830. doi:10.1111/gbb.12177
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The Coffee and Caffeine Genetics Consortium, Cornelis, M. C., Byrne, E. M., Esko, T., Nalls, M. A., Ganna, A., Paynter, N., Monda, K. L., Amin, N., Fischer, K., Renstrom, F., Ngwa, J. S., Huikari, V., Cavadino, A., Nolte, I. M., Teumer, A., Yu, K., Marques-Vidal, P., Rawa, R., Manichaikul, A., Wojczynski, M. K., Vink, J.,M., Zhao, J. H., Burlutsky, G., Lahti, J., Mikkila, V., Lemaitre,R. N., Eriksson, J., Musani, S. K., Tanaka, T., Geller, F., Luan, J., Hui, J., Magi,R., Dimitriou, M., Garcia M. E., Ho, W.-K., Wright ,M. J., Rose, L. M., Magnusson, P. K. E., Pedersen, N. L., Couper, D., Oostra, B. A., Hofman, A., Ikram, M. A., Tiemeier, H. W., Uitterlinden, A. G., van Rooij, F. J. A., Barroso, I., Johansson, I., Xue, L., Kaakinen, M., Milani, L., Power, C., Snieder, H., Stolk, R. P., Baumeister, S. E., Biffar, R., Gu, F., Bastardot, F., Kutalik, Z., Jacobs Jnr, D. R., Forouhi, N. G., Mihailov, E., Lind, L., Lindgren, C., MichaeLsson, K., Morris, A., Jensen, M., Khaw, K. -T., Luben, R. N., Wang, J. J., MaNnisto, S., PeraLa, M. -M., Kahonen, M., LehtimaKi, T., Viikari, J., Mozaffarian, D., Mukamal, K., Psaty, B. M., Doring, A., Heath, A. C., Montgomery, G. W., Dahmen, N., Carithers, T., Tucker, K. L., Ferrucci, L., Boyd, H. A., Melbye, M., Treur, J. L., Mellstrom, D., Hottenga, J. J., Prokopenko, I., Tonjes, A., Deloukas, P., Kanoni, S., Lorentzon, M., Houston, D. K., Liu, Y., Danesh, J., Rasheed, A., Mason, M. A., Zonderman, A. B., Franke, L., Kristal, B. S., Karjalainen, J., Reed, D. R., Westra, H. -J., Evans, M. K., Saleheen, D., Harris, T. B., Dedoussis, G., Curhan, G., Stumvoll, M., Beilby, J., Pasquale, L. R., Feenstra, B., Bandinelli, S., Ordovas, J. M., Chan, A. T., Peters, U., Ohlsson, C., Gieger, C., Martin, N. G., Waldenberger, M., Siscovick, D. S., Raitakari, O., Eriksson, J. G., Mitchell, P., Hunter, D. J., Kraft, P., Rimm, E. B., Boomsma, D. I., Borecki, I. B., Loos, R. J. F., Wareham, N. J., Vollenweider, P., Caporaso, N., Grabe, H. J., Neuhouser, M. L., Wolffenbuttel, B. H. R., Hu, F. B., Hypponen, E., Jarvelin, M. -R., Cupples, L. A., Franks, P. W., Ridker, P. M., van Duijn, C. M., Heiss, G., Metspalu, A., North, K. E., Ingelsson, E., Nettleton, J. A., van Dam, R. M., Chasman, D. I., International Parkinson's Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC) and UK Brain Expression Consortium (UKBEC) (2014)Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry, 20 5: 647-656. doi:10.1038/mp.2014.107
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Dennis, Emily L., Jahanshad, Neda, McMahon, Katie L., de Zubicaray, Greig I., Martin, Nicholas G., Hickie, Ian B., Toga, Arthur W., Wright, Margaret J. and Thompson, Paul M. (2014)Development of insula connectivity between ages 12 and 30 revealed by high angular resolution diffusion imaging. Human Brain Mapping, 35 4: 1790-1800. doi:10.1002/hbm.22292
Roussotte, Florence F., Jahanshad, Neda, Hibar, Derrek P., Sowell, Elizabeth R., Kohannim, Omid, Barysheva, Marina, Hansell, Narelle K., McMahon, Katie L., de Zubicaray, Greig I., Montgomery, Grant W., Martin, Nicholas G., Wright, Margaret J., Toga, Arthur W., Jack Jr, Clifford R., Weiner, Michael W., Thompson, Paul M. and ADNI (2014)A commonly carried genetic variant in the delta opioid receptor gene, OPRD1, is associated with smaller regional brain volumes: replication in elderly and young populations. Human Brain Mapping, 35 4: 1226-1236. doi:10.1002/hbm.22247
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Shan, Zuyao Y., Wright, Margaret J., Thompson, Paul M., McMahon, Katie L., Blokland, Gabriella G. A. M., de Zubicaray, Greig I., Martin, Nicholas G., Vinkhuyzen, Anna A. E. and Reutens, David C. (2014)Modeling of the hemodynamic responses in block design fMRI studies. Journal of Cerebral Blood Flow and Metabolism, 34 2: 316-324. doi:10.1038/jcbfm.2013.200
Benyamin, B., St Pourcain, B., Davis, O. S., Davies, G., Hansell, N. K., Brion, M. J., Kirkpatrick, R. M., Cents, R. A. M., Franic, S., Miller, M. B., Haworth, C. M. A., Meaburn, E., Price, T. S., Evans, D. M., Timpson, N., Kemp, J., Ring, S., McArdle, W., Medland, S. E., Yang, J., Harris, S. E., Liewald, D. C., Scheet, P., Xiao, X., Hudziak, J. J., de Geus, E. J. C., Wellcome Trust Case Control Consortium 2 (WTCCC2), Jaddoe, V. W. V., Starr, J. M., Verhulst, F. C., Pennell, C., Tiemeier, H., Iacono, W. G., Palmer, L. J., Montgomery, G. W., Martin, N. G., Boomsma, D. I., Posthuma, D., McGue, M., Wright, M. J., Davey Smith, G., Deary, I. J., Plomin, R. and Visscher, P. M. (2014)Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Molecular Psychiatry, 19 2: 253-258. doi:10.1038/mp.2012.184
Blokland, Gabriëlla A. M., McMahon, Katie L., Thompson, Paul M., Hickie, Ian B., Martin, Nicholas G., de Zubicaray, Greig I. and Wright, Margaret J. (2014)Genetic effects on the cerebellar role in working memory: same brain, different genes?. NeuroImage, 86392-403. doi:10.1016/j.neuroimage.2013.10.006
Jahanshad, Neda, Kochunov, Peter V., Sprooten, Emma, Mandl, Rene C., Nichols, Thomas E., Almasy, Laura, Blangero, John, Brouwer, Rachel M., Curran, Joanne E., de Zubicaray, Greig I., Duggirala, Ravi, Fox, Peter T., Hong, L. Elliot, Landman, Bennett A., Martin, Nicholas G., McMahon, Katie L., Medland, Sarah E., Mitchell, Braxton D., Olvera, Rene L., Peterson, Charles P., Starr, John M., Sussmann, Jessika E., Toga, Arthur W., Wardlaw, Joanna M., Wright, Margaret J., Pol, Hilleke E. Hulshoff, Bastin, Mark E., McIntosh, Andrew M., Deary, Ian J., Thompson, Paul M. and Glahn, David C. (2014)Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA-DTI working group (vol 81, pg 455, 2013). Neuroimage, 90 470-471. doi:10.1016/j.neuroimage.2013.12.053
Hill, W. D., Davies, G., Van De Lagemaat, L. N., Christoforou, A., Marioni, R. E., Fernandes, C. P. D., Liewald, D. C., Croning, M. D. R., Payton, A., Craig, L. C. A., Whalley, L. J., Horan, M., Ollier, W., Hansell, N. K., Wright, M. J., Martin, N. G., Montgomery, G. W., Steen, V. M., Le Hellard, S., Espeseth, T., Lundervold, A. J., Reinvang, I., Starr, J. M., Pendleton, N., Grant, S. G. N., Bates, T. C. and Deary, I. J. (2014)Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins. Translational Psychiatry, 4 1: 1-8. doi:10.1038/tp.2013.114
Lee, Anthony J., Mitchem, Dorian G., Wright, Margaret J., Martin, Nicholas G., Keller, Matthew C. and Zietsch, Brendan P. (2014)Genetic factors that increase male facial masculinity decrease facial attractiveness of female relatives. Psychological Science, 25 2: 476-484. doi:10.1177/0956797613510724
Li, M., Luo, X-j, Rietschel, M., Lewis, C. M., Mattheisen, M., Mueller-Myhsok, B., Jamain, S., Leboyer, M., Landen, M., Thompson, P. M., Cichon, S., Noethen, M. M., Schulze, T. G., Sullivan, P. F., Bergen, S. E., Donohoe, G., Morris, D. W., Hargreaves, A., Gill, M., Corvin, A., Hultman, C., Toga, A. W., Shi, L., Lin, Q., Shi, H., Gan, L., Meyer-Lindenberg, A., Czamara, D., Henry, C., Etain, B., Bis, J. C., Ikram, M. A., Fornage, M., Debette, S., Launer, L. J., Seshadri, S., Erk, S., Walter, H., Heinz, A., Bellivier, F., Stein, J. L., Medland, S. E., Vasquez, A. Arias, Hibar, D. P., Franke, B., Martin, N. G., Wright, M. J. and Su, B. (2014)Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility. Molecular Psychiatry, 19 4: 452-461. doi:10.1038/mp.2013.37
Prasad, Gautam, Joshi, Shantanu H., Jahanshad, Neda, Villalon-Reina, Julio, Aganj, Iman, Lenglet, Christophe, Guillermo Sapiro, McMahon, Katie L., de Zubicaray, Greig I., Martin, Nicholas G., Wright, Margaret J., Toga, Arthur W.and Thompson, Paul M. (2014)Automatic clustering and population analysis of white matter tracts using maximum density paths. NeuroImage, 97 284-295. doi:10.1016/j.neuroimage.2014.04.033
Cetingul, H. Ertan, Wright, Margaret J., Thompson, Paul M. and Vidal, René (2014)Segmentation of high angular resolution diffusion MRI using sparse riemannian manifold clustering. IEEE Transactions on Medical Imaging, 33 2: 301-317. doi:10.1109/TMI.2013.2284360
Couvy-Duchesne, Baptiste, Blokland, Gabriëlla A.M., Hickie, Ian B., Thompson, Paul M., Martin, Nicholas G., de Zubicaray, Greig I., McMahon, Katie L. and Wright, Margaret J. (2014)Heritability of head motion during resting state functional MRI in 462 healthy twins. Neuroimage, 102 2: 424-434. doi:10.1016/j.neuroimage.2014.08.010
Braskie, Meredith N., Kohannim, Omid, Jahanshad, Neda, Chiang, Ming-Chang, Barysheva, Marina, Toga, Arthur W., Ringman, John M., Montgomery, Grant W., McMahon, Katie L., de Zubicaray, Greig I., Martin, Nicholas G., Wright, Margaret J. and Thompson, Paul M. (2013)Relation between variants in the neurotrophin receptor gene, NTRK3, and white matter integrity in healthy young adults. Neuroimage, 82 146-153. doi:10.1016/j.neuroimage.2013.05.095
Sletten, Tracey L., Rajaratnam, Shantha M. W., Wright, Margaret J., Zhu, Gu, Naismith, Sharon, Martin, Nicholas G.and Hickie, Ian (2013)Genetic and environmental contributions to sleep-wake behavior in 12-year-old twins. Sleep, 36 11: 1715-1722. doi:10.5665/sleep.3136
Schutte, Nienke M., Hansell, Narelle K., de Geus, Eco J. C., Martin, Nicholas G., Wright, Margaret J. and Smit, Dirk J. A. (2013)Heritability of resting state EEG functional connectivity patterns. Twin Research and Human Genetics, 16 5: 962-969. doi:10.1017/thg.2013.55
Brant, Angela M., Munakata, Yuko, Boomsma, Dorret I., DeFries, John C., Haworth, Claire M. A., Keller, Matthew C., Martin, Nicholas G., McGue, Matthew, Petrill, Stephen A., Plomin, Robert, Wadsworth, Sally J., Wright, Margaret J.and Hewitt, John K. (2013)The nature and nurture of high IQ: an extended sensitive period for intellectual development. Psychological Science, 24 8: 1487-1495. doi:10.1177/0956797612473119
Ritchie, Stuart J., Luciano, Michelle, Hansell, Narelle K., Wright, Margaret J. and Bates, Timothy C. (2013)The relationship of reading ability to creativity: positive, not negative associations. Learning and Individual Differences, 26 171-176. doi:10.1016/j.lindif.2013.02.009
Lee, Teresa, Lipnicki, Darreb M., Crawford, John D., Henry, Julie D., Trollnor, Julian N., Ames, David and Wright, Margaret J. (2013)Leisure activity, health, and medical correlates of neurocognitive performance among monzygotic twins: The Older Australian Twins Study. The Journals of Gerontology. Series B: Psychological Sciences and Social Sciences, 69 4: 514-522. doi:10.1093/geronb/gbt031
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Molenaar, Dylan, van der Sluis, Sophie, Boomsma, Dorret I., Haworth, Claire M. A., Hewitt, John K., Martin, Nicholas G., Plomin, Robert, Wright, Margaret J. and Dolan, Conor V. (2013)Genotype by environment interactions in cognitive ability: a survey of 14 studies from four countries covering four age groups. Behavior Genetics, 43 3: 208-219. doi:10.1007/s10519-012-9581-7
Keller, Matthew C., Garver-Apgar, Christine E., Wright, Margaret J., Martin, Nicholas G., Corley, Robin P., Stallings, Michael C., Hewitt, John K. and Zietsch, Brendan P. (2013)The genetic correlation between height and IQ: shared genes or assortative mating?. PLoS Genetics, 9 4: e1003451.1-e1003451.10. doi:10.1371/journal.pgen.1003451
Jahanshad, Neda, Rajagopalan, Priya, Hua, Xue, Hibar, Derrek P., Nir, Talia M., Toga, Arthur W., Jack, Jr, Clifford R., Saykin, Andrew J., Green, Robert C., Weiner, Michael W., Medland, Sarah E., Montgomery, Grant W., Hansell, Narelle K., McMahon, Katie L., de Zubicaray, Greig I., Martin, Nicholas G., Wright, Margaret J., Thompson, Paul M. and The Alzheimer’s Disease Neuroimaging Initiative (2013)Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Proceedings of the National Academy of Sciences of the United States of America, 110 12: 4768-4773. doi:10.1073/pnas.1216206110
Luciano, M., Evans, D. M., Hansell, N. K., Medland, S. E., Montgomery, G. W., Martin, N. G., Wright, M. J. and Bates, T. C. (2013)A genome-wide association study for reading and language abilities in two population cohorts. Genes, Brain and Behavior, 12 6: 645-652. doi:10.1111/gbb.12053
Hibar, Derrek P., Stein, Jason L., Ryles, April B., Kohannim, Omid, Jahanshad, Neda, Medland, Sarah E., Hansell, Narelle K., McMahon, Katie L., de Zubicaray, Greig I., Montgomery, Grant W., Martin, Nicholas G., Wright, Margaret J., Saykin, Andrew J., Jack, lifford R., Weiner, Michael W., Toga, Arthur W. and Thompson, Paul M. (2013)Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects. Brain Imaging and Behavior, 7 2: 102-115. doi:10.1007/s11682-012-9199-7
Gillespie, Nathan A., Henders, Anjali K., Davenport, Tracy A., Hermens, Daniel F., Wright, Margie J., Martin, Nicholas G. and Hickie, Ian B. (2013)The Brisbane Longitudinal Twin Study: pathways to cannabis use, abuse, and dependence project - current status, preliminary results, and future directions. Twin Research and Human Genetics, 16 1: 21-33. doi:10.1017/thg.2012.111
Ebejer, Jane L., Duffy, David L., van der Werf, Julius, Wright, Margaret J., Montgomery, Grant, Gillespie, Nathan A., Hickie, Ian B., Martin, Nicholas G. and Medland, Sarah E. (2013)Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits. Twin Research and Human Genetics, 16 2: 560-574. doi:10.1017/thg.2013.12
Amin, Najaf, Hottenga, Jouke-Jan, Hansell, Narelle K., Janssens, A. Cecile J. W., de Moor, Marleen H. M., Madden, Pamela A. F., Zorkoltseva, Irina V., Penninx, Brenda W., Terracciano, Antonio, Uda, Manuela, Tanaka, Toshiko, Esko, Tonu, Realo, Anu, Ferrucci, Luigi, Luciano, Michelle, Davies, Gail, Metspalu, Andres, Abecasis, Goncalo R., Deary, Ian J., Raikkonen, Katri, Bierut, Laura J., Costa, Paul T., Saviouk, Viatcheslav, Zhu, Gu, Kirichenko, Anatoly V., Isaacs, Aaron, Aulchenko, Yurii S., Willemsen, Gonneke, Heath, Andrew C., Pergadia, Michele L., Medland, Sarah E., Axenovich, Tatiana I., de Geus, Eco, Montgomery, Grant W., Wright, Margaret J., Oostra, Ben A., Martin, Nicholas G., Boomsma, Dorret I. and van Duijn, Cornelia M. (2013)Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions. European Journal of Human Genetics, 21 8: 876-882. doi:10.1038/ejhg.2012.263
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