Synaptic Plasticity

About

The Sah laboratory uses electrophysiology and molecular techniques, in conjunction with behavioural studies, to understand the neural circuitry that underpins learning and memory formation. Using animal models, the laboratory focusses on the part of the brain called the amygdala, and a Pavlovian learning paradigm called fear conditioning. The group uses viruses to deliver optogenetic constructs to neurons in defined regions, and then records the electrical activity in acute brain slices to study the neural circuits and the properties of these connections. The group is mapping the circuits that provide auditory and noxious information to the amygdala, and is in interested in the circuits that connect the amygdala with the prefrontal cortex and hippocampus. This information is then used to understand the role of these circuits in behaviour.

In collaboration with Professor Joe Lynch at QBI, the group is exploring the molecular identity of receptors at inhibitory connections in the amygdala. In the last year this work has concentrated on the properties of synaptic γ-aminobutyric (GABA) receptors that contain γ1 subunits. These receptors are enriched in specific circuits in the amygdala and could be targets for the development of new anxiolytic drugs.

The animal studies are complemented by electrophysiological recordings in humans. For these studies, Professor Sah collaborates with Professor Peter Silburn and Dr Terry Coyne who together are part of the Asia–Pacific Centre for Neuromodulation (APCN), to study neural activity in the human brain in patients undergoing neurosurgery for deep brain stimulation. These recordings are revealing the activity in the human brain in a range of movement disorders, such as Parkinson’s disease, essential tremor and Tourette syndrome. In 2016, the group will be involved in a clinical trial for the treatment of obsessive compulsive disorder.

Contact

  @pankajqbi

  +61 7 334 66311

  pankaj.sah@uq.edu.au


Group Publications

Research Areas

  • Electrophysiology and molecular techniques
  • Neural circuitry underpinning learning and memory formation
  • The amygdala and fear conditioning 
  • Deep brain stimulation (DBI)


Apply for a PhD

Group Leader


Research Members


Students

  • Mr Shanzhi Yan

    PhD Student
    Queensland Brain Insitute
  • Ms Cong Wang

    PhD Student
    Queensland Brain Insitute
    Casual Phys/Pharm Academic
    School of Biomedical Sciences
  • Mr Amu Faiz

    PhD Student
    Queensland Brain Insitute
    Casual Academic Phys/Pharm
    School of Biomedical Sciences
  • Mr Andrea Giorni

    PhD Student
    Queensland Brain Insitute

Support Staff


Ivermectin-activated, cation-permeable glycine receptors for the chemogenetic control of neuronal excitation

Islam, Robiul, Keramidas, Angelo, Xu, Li, Durisic, Nela, Sah, Pankaj and Lynch, Joseph W. (2016) Ivermectin-activated, cation-permeable glycine receptors for the chemogenetic control of neuronal excitation. ACS Chemical Neuroscience7 12: 1647-1657. doi:10.1021/acschemneuro.6b00168

Neuroscience and education: mind the gap

Morris, John and Sah, Pankaj (2016) Neuroscience and education: mind the gap. Australian Journal of Education60 2: 146-156. doi:10.1177/0004944116652913

Auditory tones and foot-shock recapitulate spontaneous sub-threshold activity in basolateral amygdala principal neurons and interneurons

Windels, Francois, Yan, Shanzhi, Stratton, Peter G., Sullivan, Robert, Crane, James W. and Sah, Pankaj (2016) Auditory tones and foot-shock recapitulate spontaneous sub-threshold activity in basolateral amygdala principal neurons and interneurons. PLoS ONE11 5: . doi:10.1371/journal.pone.0155192

Integrating neuroscience and learning: now’s the time

Sah, Pankaj, Fanselow, Michael, Hattie, John, Magsamen, Susan, Mattingley, Jason, Quirk, Gregory and Williams, Stephen (2016) Integrating neuroscience and learning: now’s the time. n p j Science of Learning1 . doi:10.1038/npjscilearn.2016.7

IK1 channels do not contribute to the slow after hyperpolarization in pyramidal neurons

Wang, Kang, Mateos-Aparicio, Pedro, Honigsperger, Christoph, Raghuram, Vijeta, Wu, Wendy W., Ridder, Margreet C., Sah, Pankaj, Mayile, Jim, Storm, Johan F. and Adelman, John P. (2016) IK1 channels do not contribute to the slow after hyperpolarization in pyramidal neurons. eLife5 e11206: 1-16. doi:10.7554/eLife.11206

Development and physiology of GABAergic feedback excitation in parvalbumin expressing interneurons of the mouse basolateral amygdala

Spampanato, Jay, Sullivan, Robert K. P., Perumal, Madhusoothanan B. and Sah, Pankaj (2016) Development and physiology of GABAergic feedback excitation in parvalbumin expressing interneurons of the mouse basolateral amygdala. Physiological Reports4 e12664: 1-15. doi:10.14814/phy2.12664

Regulating anxiety with extrasynaptic inhibition

Botta, Paolo, Demmou, Lynda, Kasugai, Yu, Markovic, Milica, Xu, Chun, Fadok, Jonathan P., Lu, Tingjia, Poe, Michael M., Xu, Li, Cook, James M., Rudolph, Uwe, Sah, Pankaj, Ferraguti, Francesco and Luthi, Andreas (2015) Regulating anxiety with extrasynaptic inhibition. Nature Neuroscience18 10: 1493-1500. doi:10.1038/nn.4102

Dendritic organization of olfactory inputs to medial amygdala neurons

Keshavarzi, Sepideh, Power, John M., Albers, Eva H.H., Sullivan, Robert K.S. and Sah, Pankaj (2015) Dendritic organization of olfactory inputs to medial amygdala neurons. Journal of Neuroscience35 38: 13020-13028. doi:10.1523/JNEUROSCI.0627-15.2015

Norepinephrine and Corticotropin-Releasing Hormone: Partners in the Neural Circuits that Underpin Stress and Anxiety

Sun, Yajie, Hunt, Sarah and Sah, Pankaj (2015) Norepinephrine and Corticotropin-Releasing Hormone: Partners in the Neural Circuits that Underpin Stress and Anxiety. Neuron87 3: 468-470. doi:10.1016/j.neuron.2015.07.022

Where and what is the PPN and what is its role in locomotion?

Windels, Francois, Thevathasan, Wesley, Silburn, Peter and Sah, Pankaj (2015) Where and what is the PPN and what is its role in locomotion?. Brain138 5: 1133-1134. doi:10.1093/brain/awv059

Vitamin D and the brain: key questions for future research

Cui, Xiaoying, Gooch, Helen, Groves, Natalie J., Sah, Pankaj, Burne, Thomas H., Eyles, Darryl W. and McGrath, John J. (2015) Vitamin D and the brain: key questions for future research. The Journal of Steroid Biochemistry and Molecular Biology148 305-309. doi:10.1016/j.jsbmb.2014.11.004

Prefrontal and Auditory Input to Intercalated Neurons of the Amygdala

Strobel, Cornelia, Marek, Roger, Gooch, Helen, Sullivan, Robert K. P. and Sah, Pankaj (2015) Prefrontal and Auditory Input to Intercalated Neurons of the Amygdala. Cell Reports10 9: 1435-1442. doi:10.1016/j.celrep.2015.02.008

Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation

Widagdo, Jocelyn, Chai, Ye Jin, Ridder, Margreet C, Chau, Yu Qian, Johnson, Richard C, Sah, Pankaj, Huganir, Richard L and Anggono, Victor (2015) Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation. Cell Reports10 5: 783-795. doi:10.1016/j.celrep.2015.01.015

Dendritic spine heterogeneity and calcium dynamics in basolateral amygdala principal neurons

Power, John M. and Sah, Pankaj P. (2014) Dendritic spine heterogeneity and calcium dynamics in basolateral amygdala principal neurons. Journal of Neurophysiology112 7: 1616-1627. doi:10.1152/jn.00770.2013

Balanced interhemispheric cortical activity is required for correct targeting of the corpus callosum

Suarez, Rodrigo, Fenlon, Laura R., Marek, Roger, Avitan, Lilach A, Sah, Pankaj, Goodhill, Geoffrey J. and Richards, Linda J. (2014) Balanced interhemispheric cortical activity is required for correct targeting of the corpus callosum.Neuron82 6: 1289-1298. doi:10.1016/j.neuron.2014.04.040

Emotional regulation of pain: the role of noradrenaline in the amygdala

Strobel, Cornelia, Hunt, Sarah, Sullivan, Robert, Sun, Jian and Sah, Pankaj (2014) Emotional regulation of pain: the role of noradrenaline in the amygdala. Science China Life Sciences57 4: 384-390. doi:10.1007/s11427-014-4638-x

GABAa receptor α and γ subunits shape synaptic currents via different mechanisms

Dixon, Christine, Sah, Pankaj, Lynch, Joseph W. and Keramidas, Angelo (2014) GABAa receptor α and γ subunits shape synaptic currents via different mechanisms. Journal of Biological Chemistry289 9: 5399-5411. doi:10.1074/jbc.M113.514695

Rodent scope: A user-configurable digital wireless telemetry system for freely behaving animals

Ball, David, Kliese, Russell, Windels, Francois, Nolan, Christopher, Stratton, Peter, Sah, Panjkaj and Wiles, Janet (2014) Rodent scope: A user-configurable digital wireless telemetry system for freely behaving animals. PLoS One9 2: e89949.1-e89949.10. doi:10.1371/journal.pone.0089949

Mechanisms of heterosynaptic metaplasticity

Hulme, Sarah R., Jones, Owen D., Raymond, Clarke R., Sah, Pankaj and Abraham, Wickliffe C. (2014) Mechanisms of heterosynaptic metaplasticity. Philosophical Transactions of the Royal Society B: Biological Sciences369 1633: 1633.1-1633.8. doi:10.1098/rstb.2013.0148

Functional properties and projections of neurons in the medial amygdala

Keshavarzi, Sepideh, Sullivan, Robert K. P., Ianno, Damian J. and Sah, Pankaj (2014) Functional properties and projections of neurons in the medial amygdala. Journal of Neuroscience34 26: 8699-8715. doi:10.1523/JNEUROSCI.1176-14.2014

Imagined gait modulates neuronal network dynamics in the human pedunculopontine nucleus

Tattersall, Timothy L., Stratton, Peter G., Coyne, Terry J., Cook, Raymond, Silberstein, Paul, Silburn, Peter A., Windels, Francois and Sah, Pankaj (2014) Imagined gait modulates neuronal network dynamics in the human pedunculopontine nucleus. Nature Neuroscience17 3: 449-454. doi:10.1038/nn.3642

The amygdala and medial prefrontal cortex: partners in the fear circuit

Marek, Roger, Strobel, Cornelia, Bredy, Timothy W. and Sah, Pankaj (2013) The amygdala and medial prefrontal cortex: partners in the fear circuit. Journal of Physiology591 10: 2381-2391. doi:10.1113/jphysiol.2012.248575

Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits

Delaney, Andrew J., Sedlak, Petra L., Autuori, Eleonora, Power, John M. and Sah, Pankaj (2013) Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits. Journal of Neurophysiology109 5: 1391-1402. doi:10.1152/jn.00176.2012

Lesions of the basal forebrain cholinergic system in mice disrupt idiothetic navigation

Hamlin, Adam S., Windels, Francois, Boskovic, Zoran, Sah, Pankaj and Coulson, Elizabeth J. (2013) Lesions of the basal forebrain cholinergic system in mice disrupt idiothetic navigation. PLoS ONE8 1: e53472.1-e53472.9. doi:10.1371/journal.pone.0053472

Properties of doublecortin expressing neurons in the adult mouse dentate gyrus

Spampanato, Jay, Sullivan, Robert K., Turpin, Fabrice R., Bartlett, Perry F. and Sah, Pankaj (2012) Properties of doublecortin expressing neurons in the adult mouse dentate gyrus. PLoS One7 9: e41029-1-e41029-12. doi:10.1371/journal.pone.0041029

p300/CBP-associated factor selectively regulates the extinction of conditioned fear

Wei, Wei, Coelho, Carlos M., Li, Xiang, Marek, Roger, Yan, Shanzhi, Anderson, Shawn, Meyers, David, Mukherjee, Chandrani, Sbardella, Gianluca, Castellano, Sabrina, Milite, Ciro, Rotili, Dante, Mai, Antonello, Cole, Philip A., Sah, Pankaj, Kobor, Michael S. and Bredy, Timothy W. (2012) p300/CBP-associated factor selectively regulates the extinction of conditioned fear. Journal of Neuroscience32 35: 11930-11941. doi:10.1523/JNEUROSCI.0178-12.2012

Targeted ablation of oligodendrocytes induces axonal pathology independent of overt demyelination

Oluich, Laura-Jane, Stratton, Jo Anne S., Xing, Yao Lulu, Ng, Sze Woei, Cate, Holly S., Sah, Pankaj, Windels, Francois, Kilpatrick, Trevor J. and Merson, Tobias D. (2012) Targeted ablation of oligodendrocytes induces axonal pathology independent of overt demyelination. The Journal of Neuroscience32 24: 8317-8330. doi:10.1523/JNEUROSCI.1053-12.2012

Action potential waveform variability limits multi-unit separation in freely behaving rats

Stratton, Peter, Cheung, Allen, Wiles, Janet H., Kiyatkin, E., Sah, Pankaj and Windels, Francois (2012) Action potential waveform variability limits multi-unit separation in freely behaving rats. PLoS One7 6: e38482.1-e38482.16. doi:10.1371/journal.pone.0038482

An introduction to a symposium dedicated to the scientific achievements of Roger Nicoll

Jahr, Craig, Perkel, David and Sah, Pankaj (2012) An introduction to a symposium dedicated to the scientific achievements of Roger Nicoll. Journal of Physiology590 10: 2201-2202. doi:10.1113/jphysiol.2012.230896

Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels

Delaney, Andrew J., Power, John M. and Sah, Pankaj (2012) Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels. Journal of Neurophysiology107 6: 1571-1575. doi:10.1152/jn.01066.2011

Small-conductance Ca(2+)-activated K(+) channels: form and function

Adelman, John P., Maylie, James and Sah, Pankaj (2012) Small-conductance Ca(2+)-activated K(+) channels: form and function. Annual Review of Physiology74 245-269. doi:10.1146/annurev-physiol-020911-153336

Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300

Marek, Roger, Coelho, Carlos M., Sullivan, Robert K. P., Baker-Andresen, Danay, Li, Xiang, Ratnu, Vikram, Dudley, Kevin J., Meyers, David, Mukherjee, Chandrani, Cole, Philip A., Sah, Pankaj and Bredy, Timothy W. (2011) Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300. Journal of Neuroscience31 20: 7486-7491. doi:10.1523/JNEUROSCI.0133-11.2011

Interneurons in the basolateral amygdala

Spampanato, Jay, Polepalli, Jai and Sah, Pankaj (2011) Interneurons in the basolateral amygdala.Neuropharmacology60 5: 765-773. doi:10.1016/j.neuropharm.2010.11.006

Location and function of the slow afterhyperpolarization channels in the basolateral amygdala

Power, John M., Bocklisch, Christina, Curby, Peter and Sah, Pankaj (2011) Location and function of the slow afterhyperpolarization channels in the basolateral amygdala. Journal of Neuroscience31 2: 526-537. doi:10.1523/JNEUROSCI.1045-10.2011

Inhibition dominates the early phase of up-states in the basolateral amygdala

Windels, Francois, Crane, James W. and Sah, Pankaj (2010) Inhibition dominates the early phase of up-states in the basolateral amygdala. Journal of Neurophysiology104 6: 3433-3438. doi:10.1152/jn.00531.2010

A Specific class of interneuron mediates inhibitory plasticity in the lateral amygdala

Polepalli, Jai S., Sullivan, Robert K. P., Yanagawa, Yuchio and Sah, Pankaj (2010) A Specific class of interneuron mediates inhibitory plasticity in the lateral amygdala. Journal of Neuroscience30 44: 14619-14629. doi:10.1523/JNEUROSCI.3252-10.2010

Differential expression of glycine receptor subunits in the rat basolateral and central amygdala

Delaney, A. J., Esmaeili, A., Sedlak, Petra L., Lynch, J. W. and Sah, P. (2010) Differential expression of glycine receptor subunits in the rat basolateral and central amygdala. Neuroscience Letters469 2: 237-242. doi:10.1016/j.neulet.2009.12.003

Oscillations in the basolateral amygdala: aversive stimulation is state dependent and resets the oscillatory phase

Crane, James W., Windels, Francois and Sah, Pankaj (2009) Oscillations in the basolateral amygdala: aversive stimulation is state dependent and resets the oscillatory phase. Journal Neurophysiology102 3: 1379-1387. doi:10.1152/jn.00438.2009

GABAᴀ receptors containing gamma 1 subunits contribute to inhibitory transmission in the central amygdala

Esmaeili, Abolghasem, Lynch, Joseph W. and Sah, Pankaj (2009) GABAᴀ receptors containing gamma 1 subunits contribute to inhibitory transmission in the central amygdala. Journal of Neurophysiology101 1: 341-349. doi:10.1152/jn.90991.2008

The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres

Crane, James W., Baiquni, Gilang P., Sullivan, Robert K. P., Lee, John D, Sah, Pankaj, Taylor, Stephen M, Noakes, Peter G. and Woodruff, Trent (2009) The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres. Journal of Neuroinflammation6 34: 34.1-34.10. doi:10.1186/1742-2094-6-34

Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala

Faber, Elizabeth S. L., Delaney, Andrew J., Power, John M., Sedlak, Petra, Crane, James W. and Sah, Pankaj (2008) Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala. Journal of Neuroscience28 43: 10803-10813. doi:10.1523/JNEUROSCI.1796-08.2008

Behavioural neuroscience: The circuit of fear

Sah, Pankaj and Westbrook, R. Federick (2008) Behavioural neuroscience: The circuit of fear. Nature454 7204: 589-590. doi:10.1038/454589a

Fear Conditioning and Long-term Potentiation in the Amygdala What Really Is the Connection?

Sah, Pankaj, Westbrook, R. F. and Luthi, A. (2008) Fear Conditioning and Long-term Potentiation in the Amygdala What Really Is the Connection?. Annals of the New York Academy of Science1129 88-95. doi:10.1196/annals.1417.020

Latent stem and progenitor cells in the hippocampus are activated by neural excitation

Walker, Tara L., White, Amanda, Black, Debra M., Wallace, Robyn H., Sah, Pankaj and Bartlett, Perry F. (2008) Latent stem and progenitor cells in the hippocampus are activated by neural excitation. Journal of Neuroscience28 20: 5240-5247. doi:10.1523/JNEUROSCI.0344-08.2008

Competition between Calcium-Activated K⁺ Channels Determines Cholinergic Action on Firing Properties of Basolateral Amygdala Projection Neurons

Power, John M. and Sah, Pankaj (2008) Competition between Calcium-Activated K⁺ Channels Determines Cholinergic Action on Firing Properties of Basolateral Amygdala Projection Neurons. Journal of Neuroscience28 12: 3209-3220. doi:10.1523/JNEUROSCI.4310-07.2008

p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate

Coulson, E. J., May, L. M., Osborne, S. L., Reid, K., Underwood, C. K., Meunier, F. A., Bartlett, P. F. and Sah, P. (2008) p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate. Journal of Neuroscience28 1: 315-324. doi:10.1523/JNEUROSCI.2699-07.2008

Inhibition and synchronization of basal amygdala principal neuron spiking by parvalbumin-positive interneurons

Woodruff, Alan R. and Sah, Pankaj (2007) Inhibition and synchronization of basal amygdala principal neuron spiking by parvalbumin-positive interneurons. Journal of Neurophysiology98 5: 2956-2961. doi:10.1152/jn.00739.2007

Distribution of IP3-mediated calcium responses and their role in nuclear signalling in rat basolateral amygdala neurons

Power, John M. and Sah, Pankaj (2007) Distribution of IP3-mediated calcium responses and their role in nuclear signalling in rat basolateral amygdala neurons. Journal of Physiology580 3: 835-857. doi:10.1113/jphysiol.2006.125062

Bidirectional synaptic plasticity at nociceptive afferents in the rat central amygdala

Lopez de Armentia, M. and Sah, P. (2007) Bidirectional synaptic plasticity at nociceptive afferents in the rat central amygdala. Journal of Physiology581 3: 961-970. doi:10.1113/jphysiol.2007.101822

Functions of SK channels in central neurons

Faber, E. S. L. and Sah, P. (2007) Functions of SK channels in central neurons. Clinical and Experimental Pharmacology and Physiology34 10: 1077-1083. doi:10.1111/j.1440-1681.2007.04725.x

Networks of parvalbumin-positive interneurons in the basolateral amygdala

Woodruff, Alan R. and Sah, Pankaj (2007) Networks of parvalbumin-positive interneurons in the basolateral amygdala. Journal of Neuroscience27 3: 553-563. doi:10.1523/JNEUROSCI.3686-06.2007

Noradrenaline modulates transmission at a central synapse by a presynaptic mechanism

Delaney, Andrew J., Crane, James W. and Sah, Pankaj (2007) Noradrenaline modulates transmission at a central synapse by a presynaptic mechanism. Neuron56 5: 880-892. doi:10.1016/j.neuron.2007.10.022

Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons

Gunnersen, J. M., Kim, M. H., Fuller, S. J., De Silva, M., Britto, J. M., Hammond, V. E., Davies, P. J., Petrou, S., Faber, E. S. L., Sah, P. and Tan, S. S. (2007) Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons. Neuron56 4: 621-639. doi:10.1016/j.neuron.2007.09.018

Canonical organization of opioid modulation of nociceptive circuits. Focus on "mu opioid receptor activation inhibits GABAergic inputs to basolateral amygdala neurons through Kv1.1/Kv1.2 channels"

Sah, Pankaj (2006) Canonical organization of opioid modulation of nociceptive circuits. Focus on "mu opioid receptor activation inhibits GABAergic inputs to basolateral amygdala neurons through Kv1.1/Kv1.2 channels". Journal of Neurophysiology95 4: 2029-2030. doi:10.1152/jn.01259.2005

Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator

Graham, B. A., Schofield, P. R., Sah, P., Margrie, T. W. and Callister, R. J. (2006) Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator. Journal of Neuroscience26 18: 4880-4890. doi:10.1523/JNEUROSCI.3991-05.2006

GABAergic excitation in the basolateral amygdala

Woodruff, Alan R., Monyer, Hannah and Sah, Pankaj (2006) GABAergic excitation in the basolateral amygdala.Journal of Neuroscience26 46: 11881-11887. doi:10.1523/JNEUROSCI.3389-06.2006

Synaptic activation of transient receptor potential channels by metabotropic glutamate receptors in the lateral amygdala

Faber, E. S. L., Sedlak, P., Vidovic, M. and Sah, P. (2006) Synaptic activation of transient receptor potential channels by metabotropic glutamate receptors in the lateral amygdala. Neuroscience137 3: 781-794. doi:10.1016/j.neuroscience.2005.09.027

Independent roles of calcium and voltage-dependent potassium currents in controlling spike frequency adaptation in lateral amygdala pyramidal neurons

Faber, E. S. L. and Sah, P. (2005) Independent roles of calcium and voltage-dependent potassium currents in controlling spike frequency adaptation in lateral amygdala pyramidal neurons. European Journal of Neuroscience22 7: 1627-1635. doi:10.1111/j.1460-9568.2005.04357.x

Intracellular calcium store filling by an L-type calcium current in the basolateral amygdala at subthreshold membrane potentials

Power, J. M. and Sah, P. (2005) Intracellular calcium store filling by an L-type calcium current in the basolateral amygdala at subthreshold membrane potentials. Journal of Physiology562 2: 439-453. doi:10.1113/jphysiol.2004.076711

SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala

Faber, E. S., Delaney, A. J. and Sah, P. (2005) SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala. Nature Neuroscience8 5: 635-641. doi:10.1038/nn1450

Firing properties and connectivity of neurons in the rat lateral central nucleus of the amygdala

De Armentia, Mikel Lopez and Sah, Pankaj (2004) Firing properties and connectivity of neurons in the rat lateral central nucleus of the amygdala. Journal of Neurophysiology92 3: 1285-1294. doi:10.1152/jn.00211.2004

Opioids Inhibit Lateral Amygdala Pyramidal Neurons by Enhancing A Dendritic Potassium Current

Faber, E. S. L. and Sah, P. (2004) Opioids Inhibit Lateral Amygdala Pyramidal Neurons by Enhancing A Dendritic Potassium Current. Journal of Neuroscience24 12: 3031-3039. doi:10.1523/JNEUROSCI.4496-03.2004

Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice

Graham, BA, Schofield, PR, Sah, P and Callister, RJ (2003) Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice. Journal of Physiology-london551 3: 905-916. doi:10.1113/jphysiol.2003.049064

Ca2+-activated K+(BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala

Faber, E. S. L. and Sah, P. (2003) Ca2+-activated K+(BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala. Journal of Physiology552 2: 483-497. doi:10.1113/jphysiol.2003.050120

Calcium-activated potassium channels: Multiple contributions to neuronal function

Faber, ESL and Sah, P (2003) Calcium-activated potassium channels: Multiple contributions to neuronal function.Neuroscientist9 3: 181-194. doi:10.1177/107385840325673

Development and subunit composition of synaptic NMDA receptors in the amygdala: NR2B Synapses in the adult central amygdala

De Armentia, Mikel Lopez and Sah, Pankaj (2003) Development and subunit composition of synaptic NMDA receptors in the amygdala: NR2B Synapses in the adult central amygdala. Journal of Neuroscience23 17: 6876-6883.

Excitatory synaptic transmission in the lateral and central amygdala

Sah, P. and De Armentia, M. L. (2003) Excitatory synaptic transmission in the lateral and central amygdala. Annals of New York Academy of Sciences985 THE AMYGDALA IN BRAIN FUNCTION Basic and Clinical Approaches: 67-77. doi:10.1111/j.1749-6632.2003.tb07072.x

The amygdaloid complex: Anatomy and physiology

Sah, P, Faber, ESL, De Armentia, ML and Power, J (2003) The amygdaloid complex: Anatomy and physiology.Physiological Reviews83 3: 803-834. doi:10.1152/physrev.00002.2003

Channels underlying neuronal calcium-activated potassium currents

Sah, P and Faber, ESL (2002) Channels underlying neuronal calcium-activated potassium currents. Progress In Neurobiology66 5: 345-353. doi:10.1016/S0301-0082(02)00004-7

Neurobiology - Never fear, cannabinoids are here

Sah, P (2002) Neurobiology - Never fear, cannabinoids are here. Nature418 6897: 488-489. doi:10.1038/418488b

Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons

Power, JM and Sah, P (2002) Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons. Journal of Neuroscience22 9: 3454-3462.

Physiological role of calcium-activated potassium currents in the rat lateral amygdala

Faber, ESL and Sah, P (2002) Physiological role of calcium-activated potassium currents in the rat lateral amygdala.Journal of Neuroscience22 5: 1618-1628.

Morphological and electrophysiological properties of principal neurons in the rat lateral amygdala in vitro

Faber, ESL, Callister, RJ and Sah, P (2001) Morphological and electrophysiological properties of principal neurons in the rat lateral amygdala in vitro. Journal of Neurophysiology85 2: 714-723.

Pathway-specific targeting of GAB(A) a receptor subtypes to somatic and dendritic synapses in the central amygdala

Delaney, A. J. and Sah, P. (2001) Pathway-specific targeting of GAB(A) a receptor subtypes to somatic and dendritic synapses in the central amygdala. Journal of Neurophysiology86 2: 717-723.

Calcium-activated potassium currents in mammalian neurons

Sah, P and Davies, P (2000) Calcium-activated potassium currents in mammalian neurons. Clinical And Experimental Pharmacology And Physiology27 9: 657-663. doi:10.1046/j.1440-1681.2000.03317.x

Inhibition of transmitter release and long-term depression in the avian hippocampus

Margrie, TW, Rostas, JAP and Sah, P (2000) Inhibition of transmitter release and long-term depression in the avian hippocampus. Neuroscience Letters284 1-2: 17-20. doi:10.1016/S0304-3940(00)00992-7

Excitatory synaptic inputs to pyramidal neurons of the lateral amygdala

Mahanty, NK and Sah, P (1999) Excitatory synaptic inputs to pyramidal neurons of the lateral amygdala. European Journal of Neuroscience11 4: 1217-1222. doi:10.1046/j.1460-9568.1999.00528.x

GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala

Delaney, AJ and Sah, P (1999) GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala. Journal of Neuroscience19 22: 9698-9704.

Molecular studies of synaptic neurotran fission: Development of transgenic animal models

Morgan, B, Callister, R, Handford, C, Walker, S, Sah, P and Schofield, P (1999) Molecular studies of synaptic neurotran fission: Development of transgenic animal models. Journal of Neurochemistry73 S88-S88.

Photolytic manipulation of [Ca2+](i) reveals slow kinetics of potassium channels underlying the afterhyperpolarization in hipppocampal pyramidal neurons

Sah, P and Clements, JD (1999) Photolytic manipulation of [Ca2+](i) reveals slow kinetics of potassium channels underlying the afterhyperpolarization in hipppocampal pyramidal neurons. Journal of Neuroscience19 10: 3657-3664.

Use of murine mutants to study glycine receptor function

Callister, RJ, Schofield, PR and Sah, P (1999) Use of murine mutants to study glycine receptor function. Clinical And Experimental Pharmacology And Physiology26 11: 929-931. doi:10.1046/j.1440-1681.1999.03148.x

Are there functional P2X receptors on cell bodies in intact dorsal root ganglia of rats?

Stebbing, MJ, McLachlan, EM and Sah, P (1998) Are there functional P2X receptors on cell bodies in intact dorsal root ganglia of rats?. Neuroscience86 4: 1235-1244. doi:10.1016/S0306-4522(98)00127-4

Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala

Mahanty, Nishith K. and Sah, Pankaj (1998) Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala. Nature394 6694: 683-687. doi:10.1038/29312

Long-term potentiation of synaptic transmission in the avian hippocampus

Margrie, TW, Rostas, JAP and Sah, P (1998) Long-term potentiation of synaptic transmission in the avian hippocampus. Journal of Neuroscience18 4: 1207-1216.

Neuroplasticity and psychiatry

Gynther, BD, Calford, MB and Sah, P (1998) Neuroplasticity and psychiatry. Australian And New Zealand Journal of Psychiatry32 1: 119-128. doi:10.3109/00048679809062718

Presynaptic long-term depression at a central glutamatergic synapse: a role for CaMKII

Margrie, TW, Rostas, JAP and Sah, P (1998) Presynaptic long-term depression at a central glutamatergic synapse: a role for CaMKII. Nature Neuroscience1 5: 378-383.

Ca2+-activated K+ channels in rat otic ganglion cells: Role of Ca2+ entry via Ca2+ channels and nicotinic receptors

Callister, RJ, Keast, JR and Sah, P (1997) Ca2+-activated K+ channels in rat otic ganglion cells: Role of Ca2+ entry via Ca2+ channels and nicotinic receptors. Journal of Physiology-london500 3: 571-582.

NMDA receptor independent long-term potentiation in the avian hippocampus

Margrie, TW, Rostas, JAP and Sah, P (1997) NMDA receptor independent long-term potentiation in the avian hippocampus. Journal of Neurochemistry69 S66-S66.

The removal of acetylcholine by diffusion at nicotinic synapses in the rat otic ganglion

Callister, Robert J. and Sah, Pankaj (1997) The removal of acetylcholine by diffusion at nicotinic synapses in the rat otic ganglion. Journal of Physiology505 1: 165-175. doi:10.1111/j.1469-7793.1997.165bc.x

Apical dendritic location of slow afterhyperpolarization current in hippocampal pyramidal neurons: Implications for the integration of long-term potentiation

Sah, P and Bekkers, JM (1996) Apical dendritic location of slow afterhyperpolarization current in hippocampal pyramidal neurons: Implications for the integration of long-term potentiation. Journal of Neuroscience16 15: 4537-4542.

Ca2+-activated K+ currents in neurones: Types, physiological roles and modulation

Sah, P (1996) Ca2+-activated K+ currents in neurones: Types, physiological roles and modulation. Trends in Neurosciences19 4: 150-154. doi:10.1016/S0166-2236(96)80026-9

Properties of Channels Mediating the Apamin-Insensitive Afterhyperpolarization in Vagal Motoneurons

Sah, P (1995) Properties of Channels Mediating the Apamin-Insensitive Afterhyperpolarization in Vagal Motoneurons.Journal of Neurophysiology74 4: 1772-1776.

Channels Underlying the Slow Afterhyperpolarization in Hippocampal Pyramidal Neurons - Neurotransmitters Modulate the Open Probability

Sah, P and Isaacson, JS (1995) Channels Underlying the Slow Afterhyperpolarization in Hippocampal Pyramidal Neurons - Neurotransmitters Modulate the Open Probability. Neuron15 2: 435-441. doi:10.1016/0896-6273(95)90047-0

Membrane-Properties and Synaptic Potentials in Rat Sympathetic Preganglionic Neurons Studied in Horizontal Spinal-Cord Slices In-Vitro

Sah, P and McLachlan, EM (1995) Membrane-Properties and Synaptic Potentials in Rat Sympathetic Preganglionic Neurons Studied in Horizontal Spinal-Cord Slices In-Vitro. Journal of the Autonomic Nervous System53 1: 1-15. doi:10.1016/0165-1838(94)00161-C

Different Calcium Channels Are Coupled to Potassium Channels with Distinct Physiological Roles in Vagal Neurons

Sah, P (1995) Different Calcium Channels Are Coupled to Potassium Channels with Distinct Physiological Roles in Vagal Neurons. Proceedings of the Royal Society B-Biological Sciences260 1357: 105-111. doi:10.1098/rspb.1995.0066

Subcellular-Distribution of Ryanodine Receptor-Like and Calcium Atpase-Like Immunoreactivity in Brain-Stem and Cerebellar Neurons of Rat and Guinea-Pig

Sah, P, Dulhunty, A, Junankar, P and Stanhope, C (1994) Subcellular-Distribution of Ryanodine Receptor-Like and Calcium Atpase-Like Immunoreactivity in Brain-Stem and Cerebellar Neurons of Rat and Guinea-Pig. Neuroscience Letters166 2: 143-148. doi:10.1016/0304-3940(94)90471-5

Distribution of Ryanodine Receptor-Like Immunoreactivity in Mammalian Central-Nervous-System Is Consistent with its Role in Calcium-Induced Calcium Release

Sah, P, Francis, K, McLachlan, EM and Junankar, P (1993) Distribution of Ryanodine Receptor-Like Immunoreactivity in Mammalian Central-Nervous-System Is Consistent with its Role in Calcium-Induced Calcium Release.Neuroscience54 1: 157-165. doi:10.1016/0306-4522(93)90391-R

Calcium Induced Calcium Release Is Involved in the Afterhyperpolarization in One Class of Guinea-Pig Sympathetic Neuron

Jobling, P, McLachlan, EM and Sah, P (1993) Calcium Induced Calcium Release Is Involved in the Afterhyperpolarization in One Class of Guinea-Pig Sympathetic Neuron. Journal of the Autonomic Nervous System42 3: 251-257. doi:10.1016/0165-1838(93)90370-A

Differences in Electrophysiological Properties Between Neurons of the Dorsal Motor Nucleus of the Vagus in Rat and Guinea-Pig

Sah, P and McLachlan, EM (1993) Differences in Electrophysiological Properties Between Neurons of the Dorsal Motor Nucleus of the Vagus in Rat and Guinea-Pig. Journal of the Autonomic Nervous System42 2: 89-98. doi:10.1016/0165-1838(93)90041-R

Role of Calcium Influx and Buffering in the Kinetics of a Ca-2+-Activated K+ Current in Rat Vagal Motoneurons

Sah, P (1992) Role of Calcium Influx and Buffering in the Kinetics of a Ca-2+-Activated K+ Current in Rat Vagal Motoneurons. Journal of Neurophysiology68 6: 2237-2247.

Potassium Currents Contributing to Action-Potential Repolarization and the Afterhyperpolarization in Rat Vagal Motoneurons

Sah, Paj and McLachlan, EM (1992) Potassium Currents Contributing to Action-Potential Repolarization and the Afterhyperpolarization in Rat Vagal Motoneurons. Journal of Neurophysiology68 5: 1834-1841.

A Slow Voltage-Activated Potassium Current in Rat Vagal Neurons

Sah, P and McLachlan, EM (1992) A Slow Voltage-Activated Potassium Current in Rat Vagal Neurons. Proceedings of the Royal Society B-Biological Sciences249 1324: 71-76. doi:10.1098/rspb.1992.0085

Ca2+-Activated K+-Currents Underlying the Afterhyperpolarization in Guinea-Pig Vagal Neurons - a Role for Ca2+-Activated Ca2+ Release

Sah, P and McLachlan, EM (1991) Ca2+-Activated K+-Currents Underlying the Afterhyperpolarization in Guinea-Pig Vagal Neurons - a Role for Ca2+-Activated Ca2+ Release. Neuron7 2: 257-264. doi:10.1016/0896-6273(91)90264-Z

Mechanisms Underlying Potentiation of Synaptic Transmission in Rat Anterior Cingulate Cortex Invitro

Sah, P and Nicoll, RA (1991) Mechanisms Underlying Potentiation of Synaptic Transmission in Rat Anterior Cingulate Cortex Invitro. Journal of Physiology-London433 615-630.

Properties of Excitatory Postsynaptic Currents Recorded Invitro From Rat Hippocampal Interneurons

Sah, P, Hestrin, S and Nicoll, RA (1990) Properties of Excitatory Postsynaptic Currents Recorded Invitro From Rat Hippocampal Interneurons. Journal of Physiology-London430 605-616.

Mechanisms Generating the Time Course of Dual Component Excitatory Synaptic Currents Recorded in Hippocampal Slices

Hestrin, S, Sah, P and Nicoll, RA (1990) Mechanisms Generating the Time Course of Dual Component Excitatory Synaptic Currents Recorded in Hippocampal Slices. Neuron5 3: 247-253. doi:10.1016/0896-6273(90)90162-9

Excitatory Synaptic Currents in Purkinje-Cells

Perkel, DJ, Hestrin, S, Sah, P and Nicoll, RA (1990) Excitatory Synaptic Currents in Purkinje-Cells. Proceedings of the Royal Society B-Biological Sciences241 1301: 116-121. doi:10.1098/rspb.1990.0074

A Voltage-Dependent Persistent Sodium Current in Mammalian Hippocampal-Neurons

French, CR, Sah, P, Buckett, KJ and Gage, PW (1990) A Voltage-Dependent Persistent Sodium Current in Mammalian Hippocampal-Neurons. Journal of General Physiology95 6: 1139-1157. doi:10.1085/jgp.95.6.1139

Analysis of Excitatory Synaptic Action in Pyramidal Cells Using Whole-Cell Recording From Rat Hippocampal Slices

Hestrin, S, Nicoll, RA, Perkel, DJ and Sah, P (1990) Analysis of Excitatory Synaptic Action in Pyramidal Cells Using Whole-Cell Recording From Rat Hippocampal Slices. Journal of Physiology-London422 203-225.

Physiological-Properties of Excitatory Synaptic Transmission in the Central-Nervous-System

Hestrin, S, Perkel, DJ, Sah, P, Manabe, T, Renner, P and Nicoll, RA (1990) Physiological-Properties of Excitatory Synaptic Transmission in the Central-Nervous-System. Cold Spring Harbor Symposia On Quantitative Biology55 87-93.

Tonic Activation of Nmda Receptors by Ambient Glutamate Enhances Excitability of Neurons

Sah, P, Hestrin, S and Nicoll, RA (1989) Tonic Activation of Nmda Receptors by Ambient Glutamate Enhances Excitability of Neurons. Science246 4931: 815-818. doi:10.1126/science.2573153

Potassium Current Activated by Depolarization of Dissociated Neurons From Adult Guinea-Pig Hippocampus

Sah, P, Gibb, AJ and Gage, PW (1988) Potassium Current Activated by Depolarization of Dissociated Neurons From Adult Guinea-Pig Hippocampus. Journal of General Physiology92 2: 263-278. doi:10.1085/jgp.92.2.263

The Sodium Current Underlying Action-Potentials in Guinea-Pig Hippocampal Ca1 Neurons

Sah, P, Gibb, AJ and Gage, PW (1988) The Sodium Current Underlying Action-Potentials in Guinea-Pig Hippocampal Ca1 Neurons. Journal of General Physiology91 3: 373-398. doi:10.1085/jgp.91.3.373

Effects of Noradrenaline On Some Potassium Currents in Ca1 Neurons in Rat Hippocampal Slices

Sah, P, French, CR and Gage, PW (1985) Effects of Noradrenaline On Some Potassium Currents in Ca1 Neurons in Rat Hippocampal Slices. Neuroscience Letters60 3: 295-300. doi:10.1016/0304-3940(85)90593-2

Postsynaptic Effects of Some Central Stimulants At the Neuromuscular-Junction

Gage, PW and Sah, P (1982) Postsynaptic Effects of Some Central Stimulants At the Neuromuscular-Junction. British Journal of Pharmacology75 3: 493-502.

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