Professor Elizabeth Coulson
Head of School
School Biomedical Science
Professor and Professorial Research Fellow
Queensland Brain Institute
Affiliate of Clem Jones Centre for Ageing and Dementia Research
Clem Jones Centre for Ageing Dementia Research
+61 7 336 52905
+61 7 336 59022
Professor Elizabeth Coulson: Neurotrophins in Alzheimer’s disease
The Coulson laboratory is investigating how and why certain neurons die in neurodegenerative diseases including Alzheimer’s disease (AD) and motor neuron disease (MND). Their work focusses on the p75 neurotrophin receptor (p75NTR) and its role in neuronal loss, particularly the nerve cell degeneration that occurs in cholinergic neurons in the brain and spinal cord.
Researcher biography
Professor Elizabeth (Lizzie) Coulson did her undergraduate Honours degree at the University of Melbourne, majoring in Genetics and Biochemistry. Her PhD (1997) in the Department of Pathology, University of Melbourne, with Professor Colin Masters, was on the normal function of the amyloid precursor protein of Alzheimer's disease. Following a year at the ZMBH, University of Heidelberg, Germany, she pursued postdoctoral work studying neuronal cell death in neurodegeneration and development at the Walter and Eliza Hall Institute with Professor Perry Bartlett before being recruited in 2003 to the University of Queensland as a founding member of the Queensland Brain Institute. She was appointed Professor in 2015, joining the School of Biomedical Sciences and becoming Deputy Head of School in 2016/7 and 2019 and Head of School in 2020. She maintains a 20% Queensland Brain Institutes appointment and is a member of the Clem Jones Centre for Ageing Dementia Research.
Her Lab webpage is: Coulson Lab - Neurotrophin - School of Biomedical Sciences ...
Book Chapters
Skeldal, S. and Coulson, E.J. (2023). Signaling and function of death receptors of the tumor necrosis factor receptor superfamily. Encyclopedia of cell biology. (pp. 85-94) Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-821618-7.30011-6
Skeldal, S. and Coulson, E. J. (2016). Signaling and function of death receptors of the tumor necrosis factor receptor superfamily. Encyclopedia of cell biology. (pp. 67-75) edited by Ralph A. Bradshaw and Philip D. Stahl. Waltham, MA United States: Academic Press. doi: 10.1016/B978-0-12-394447-4.30011-6
Hawkins, Christine J., Coulson, Elizabeth J. and Vaux, David L. (2005). Baculoviral lessons in apoptosis. Signalling pathways in apoptosis. (pp. 196-209) edited by Dianne Watters and Martin Lavin. Abingdon, United Kingdom: Taylor & Francis. doi: 10.4324/9780203303658_chapter_7
Journal Articles
Xia, Ying, Dore, Vincent, Fripp, Jurgen, Bourgeat, Pierrick, Laws, Simon M., Fowler, Christopher J., Rainey-Smith, Stephanie R., Martins, Ralph N., Rowe, Christopher, Masters, Colin L., Coulson, Elizabeth J. and Maruff, Paul (2024). Association of Basal Forebrain Atrophy With Cognitive Decline in Early Alzheimer Disease. Neurology, 103 (2) ARTN e209626. doi: 10.1212/WNL.0000000000209626
Madrid, Lidia I., Hafey, Katelyn, Bandhavkar, Saurabh, Bodea, Gabriela O., Jimenez-Martin, Javier, Milne, Michael, Walker, Tara L., Faulkner, Geoffrey J., Coulson, Elizabeth J. and Jhaveri, Dhanisha J. (2024). Stimulation of the muscarinic receptor M4 regulates neural precursor cell proliferation and promotes adult hippocampal neurogenesis. Development, 151 (1) dev201835, 1-13. doi: 10.1242/dev.201835
Xia, Ying, Maruff, Paul, Doré, Vincent, Bourgeat, Pierrick, Laws, Simon M., Fowler, Christopher, Rainey-Smith, Stephanie R., Martins, Ralph N., Villemagne, Victor L., Rowe, Christopher C., Masters, Colin L., Coulson, Elizabeth J. and Fripp, Jurgen (2023). Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease. Neurobiology of Aging, 132, 120-130. doi: 10.1016/j.neurobiolaging.2023.09.002
Martínez‐Mármol, Ramón, Chai, YeJin, Conroy, Jacinta N., Khan, Zahra, Hong, Seong‐Min, Kim, Seon Beom, Gormal, Rachel S., Lee, Dae Hee, Lee, Jae Kang, Coulson, Elizabeth J., Lee, Mi Kyeong, Kim, Sun Yeou and Meunier, Frédéric A. (2023). Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to
ERK1
/2 signaling enhancing spatial memory. Journal of Neurochemistry, 165 (6), 791-808. doi: 10.1111/jnc.15767
Qian, Lei, Rawashdeh, Oliver, Kasas, Leda, Milne, Michael R., Garner, Nicholas, Sankorrakul, Kornraviya, Marks, Nicola, Dean, Matthew W., Kim, Pu Reum, Sharma, Aanchal, Bellingham, Mark C. and Coulson, Elizabeth J. (2022). Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease. Nature Communications, 13 (1) 6543, 1-18. doi: 10.1038/s41467-022-33624-y
Pearson, Ella, Siskind, Dan, Hubbard, Ruth, Gordon, Emily, Coulson, Elizabeth, Arnautovska, Urska and Warren, Nicola (2022). Frailty and Treatment-Resistant Schizophrenia: A Retrospective Cohort Study. Community Mental Health Journal, 59 (1), 1-5. doi: 10.1007/s10597-022-00998-8
Zhou, Xiaoqing Alice, Ngiam, Grace, Qian, Lei, Sankorrakul, Kornraviya, Coulson, Elizabeth J. and Chuang, Kai-Hsiang (2022). The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer's Disease mouse model. Neurobiology of Aging, 117, 24-32. doi: 10.1016/j.neurobiolaging.2022.03.017
Xia, Ying, Eeles, Eamonn, Fripp, Jurgen, Pinsker, Donna, Thomas, Paul, Latter, Melissa, Doré, Vincent, Fazlollahi, Amir, Bourgeat, Pierrick, Villemagne, Victor L., Coulson, Elizabeth J. and Rose, Stephen (2022). Reduced cortical cholinergic innervation measured using [18F]-FEOBV PET imaging correlates with cognitive decline in mild cognitive impairment. NeuroImage: Clinical, 34 102992, 102992. doi: 10.1016/j.nicl.2022.102992
Shen, Wei-Yun, Luo, Cong, Hurtado, Plinio Reinaldo, Liu, Xiao-Jing, Luo, Ru-Yi, Li, Hui, Hu, Zhao-Lan, Xu, Jun-Mei, Coulson, Elizabeth J., Zhao, Ming, Zhou, Xin-Fu and Dai, Ru-Ping (2022). Up-regulation of proBDNF/p75NTR signaling in antibody-secreting cells drives systemic lupus erythematosus. Science Advances, 8 (3) eabj2797, eabj2797. doi: 10.1126/sciadv.abj2797
Hunt, Jeremy, Coulson, Elizabeth J., Rajnarayanan, Rajendram, Oster, Henrik, Videnovic, Aleksandar and Rawashdeh, Oliver (2022). Sleep and circadian rhythms in Parkinson’s disease and preclinical models. Molecular Neurodegeneration, 17 (1) 2, 2. doi: 10.1186/s13024-021-00504-w
Pearson, Ella, Siskind, Dan, Hubbard, Ruth E., Gordon, Emily H., Coulson, Elizabeth and Warren, Nicola (2022). Frailty and severe mental illness: A systematic review and narrative synthesis. Journal of Psychiatric Research, 147, 166-175. doi: 10.1016/j.jpsychires.2022.01.014
Conroy, Jacinta N. and Coulson, Elizabeth J. (2022). High-affinity TrkA and p75 neurotrophin receptor complexes: a twisted affair. Journal of Biological Chemistry, 298 (3) 101568, 101568. doi: 10.1016/j.jbc.2022.101568
Sankorrakul, Kornraviya, Qian, Lei, Thangnipon, Wipawan and Coulson, Elizabeth J (2021). Is there a role for the p75 neurotrophin receptor in mediating degeneration during oxidative stress and after hypoxia?. Journal of Neurochemistry, 158 (6) jnc.15451, 1-15. doi: 10.1111/jnc.15451
Conroy, Jacinta N., Jhaveri, Dhanisha J. and Coulson, Elizabeth J. (2021). Fast-Trk(B)ing the mechanism of antidepressants. Neuron, 109 (10), 1593-1595. doi: 10.1016/j.neuron.2021.04.027
Madrid, Lidia I., Jimenez-Martin, Javier, Coulson, Elizabeth J. and Jhaveri, Dhanisha J. (2021). Cholinergic regulation of adult hippocampal neurogenesis and hippocampus-dependent functions. The International Journal of Biochemistry & Cell Biology, 134 105969, 1-6. doi: 10.1016/j.biocel.2021.105969
Zhao, Yan, Coulson, Elizabeth J., Su, Xingli, Zhang, Junfeng, Sha, Baoyong, Xu, Hao, Deng, Yating, Chen, Yulong, Cao, Jian, Wang, Yunpeng and Wang, Shuang (2021). Identification of 14-3-3 epsilon as a regulator of the neural apoptotic pathway for chronic-stress-induced depression. iScience, 24 (2) 102043, 1-16. doi: 10.1016/j.isci.2021.102043
Kumar, Vinod, Lee, John D., Coulson, Elizabeth J. and Woodruff, Trent M. (2020). A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models. Journal of Neurochemistry, 158 (3) jnc.15119, 807-817. doi: 10.1111/jnc.15119
Edwards, Stephen R., Khan, Nemat, Coulson, Elizabeth J. and Smith, Maree T. (2020). Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease. Clinical and Experimental Pharmacology and Physiology, 47 (10) 1440-1681.13363, 1740-1750. doi: 10.1111/1440-1681.13363
Qin, Zuoheng, Gonsalvez, David G., Wood, Rhiannon J., Daemi, Fatemeh, Yoo, Sangwon, Ivanusic, Jason J., Coulson, Elizabeth J., Murray, Simon S. and Xiao, Junhua (2020). Partial deletion of p75NTR in large-diameter DRG neurons exerts no influence upon the survival of peripheral sensory neurons in vivo. Journal of Neuroscience Research, 98 (10) jnr.24665, 1987-1998. doi: 10.1002/jnr.24665
Groves, Natalie, O’Keeffe, Imogen, Lee, Wendy, Toft, Alexandra, Blackmore, Daniel, Bandhavkar, Saurabh, Coulson, Elizabeth J., Bartlett, Perry F. and Jhaveri, Dhanisha J. (2020). Blockade of TrkB but not p75 NTR activates a subpopulation of quiescent neural precursor cells and enhances neurogenesis in the adult mouse hippocampus. Developmental Neurobiology, 79 (9-10) dneu.22729, 868-879. doi: 10.1002/dneu.22729
Meier, Sonja, Alfonsi, Fabienne, Kurniawan, Nyoman D., Milne, Michael R., Kasherman, Maria A., Delogu, Alessio, Piper, Michael and Coulson, Elizabeth J. (2019). The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex. Development, 146 (18) dev181933, dev.181933. doi: 10.1242/dev.181933
Martínez-Mármol, Ramón, Mohannak, Nika, Qian, Lei, Wang, Tong, Gormal, Rachel S, Ruitenberg, Marc J, Vanhaesebroeck, Bart, Coulson, Elizabeth J and Meunier, Frédéric A (2019). p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model. Journal of Neuroscience, 39 (40), 7976-7991. doi: 10.1523/JNEUROSCI.0674-19.2019
Lee, Hsu-Lei, Li, Zengmin, Coulson, Elizabeth J. and Chuang, Kai-Hsiang (2019). Ultrafast fMRI of the rodent brain using simultaneous multi-slice EPI. NeuroImage, 195, 48-58. doi: 10.1016/j.neuroimage.2019.03.045
Goncalves, Nadia P., Mohseni, Simin, El Soury, Marwa, Ulrichsen, Maj, Richner, Mette, Xiao, Junhua, Wood, Rhiannon J., Andersen, Olav M., Coulson, Elizabeth J., Raimondo, Stefania, Murray, Simon S. and Vaegter, Christian B. (2019). Peripheral Nerve Regeneration Is Independent From Schwann Cell p75(NTR) Expression. Frontiers in Cellular Neuroscience, 13 235, 235. doi: 10.3389/fncel.2019.00235
Milne, Michael R., Qian, Lei, Turnbull, Marion T., Kinna, Genevieve, Collins, Brett M., Teasdale, Rohan D. and Coulson, Elizabeth J. (2019). Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model. Neurobiology of Aging, 77, 144-153. doi: 10.1016/j.neurobiolaging.2019.01.011
Boskovic, Zoran, Meier, Sonja, Wang, Yunpeng, Milne, Michael R., Onraet, Tessa, Tedoldi, Angelo and Coulson, Elizabeth J. (2019). Regulation of cholinergic basal forebrain development, connectivity, and function by neurotrophin receptors. Neuronal Signaling, 3 (1), NS20180066. doi: 10.1042/ns20180066
Boskovic, Zoran, Milne, Michael R., Qian, Lei, Clifton, Hamish D., McGovern, Alice E., Turnbull, Marion T., Mazzone, Stuart B. and Coulson, Elizabeth J. (2018). Cholinergic basal forebrain neurons regulate fear extinction consolidation through p75 neurotrophin receptor signaling. Translational Psychiatry, 8 (1) 199, 199. doi: 10.1038/s41398-018-0248-x
Qian, Lei, Milne, Michael R., Shepheard, Stephanie, Rogers, Mary-Louise, Medeiros, Rodrigo and Coulson, Elizabeth J. (2018). Removal of p75 neurotrophin receptor expression from cholinergic basal forebrain neurons reduces amyloid-β plaque deposition and cognitive impairment in aged APP/PS1 mice. Molecular Neurobiology, 56 (7), 4639-4652. doi: 10.1007/s12035-018-1404-2
Turnbull, Marion T., Boskovic, Zoran and Coulson, Elizabeth J. (2018). Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-beta Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion. Frontiers in Molecular Neuroscience, 11 51, 1-13. doi: 10.3389/fnmol.2018.00051
May, Linda M., Anggono, Victor, Gooch, Helen M., Jang, Se E., Matusica, Dusan, Kerbler, Georg M., Meunier, Frederic A., Sah, Pankaj and Coulson, Elizabeth J. (2017). G-protein-coupled inwardly rectifying potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid beta toxicity. Frontiers in Neuroscience, 11 (455) 455. doi: 10.3389/fnins.2017.00455
Coulson, Elizabeth J. and Bartlett, Perry F. (2017). An exercise path to preventing Alzheimer's disease : An Editorial Highlight on 'Exercise and BDNF reduce Ab production by enhancing alpha-secretase processing of APP'. Journal of Neurochemistry, 142 (2), 191-193. doi: 10.1111/jnc.14038
Turnbull, Marion T. and Coulson, Elizabeth J. (2017). Cholinergic basal forebrain lesion decreases neurotrophin signaling without affecting tau hyperphosphorylation in genetically susceptible mice. Journal of Alzheimer's Disease, 55 (3), 1141-1154. doi: 10.3233/JAD-160805
Wang, Tong, Martin, Sally, Nguyen, Tam H., Harper, Callista B., Gormal, Rachel S., Martinez-Marmol, Ramon, Karunanithi, Shanker, Coulson, Elizabeth J., Glass, Nick R., Cooper-White, Justin J., Van Swinderen, Bruno and Meunier, Frederic A. (2016). Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB. Nature Communications, 7 (1) 12976, 12976. doi: 10.1038/ncomms12976
Matusica, Dusan, Alfonsi, Fabienne, Turner, Bradley J., Butler, Tim J., Shepheard, Stephanie R., Rogers, Mary-Louise, Skeldal, Sune, Underwood, Clare K., Mangelsdorf, Marie and Coulson, Elizabeth J. (2016). Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment. Journal of Cell Science, 129 (3), 517-530. doi: 10.1242/jcs.173864
Coulson, Elizabeth J. and Andersen, Olav M. (2015). The A-B-C for SORting APP. Journal of Neurochemistry, 135 (1), 1-3. doi: 10.1111/jnc.13231
Kerbler, Georg M., Nedelska, Zuzana, Fripp, Jurgen, Laczo, Jan, Vyhnalek, Martin, Lisy, Jiri, Hamlin, Adam S., Rose, Stephen, Hort, Jakub and Coulson, Elizabeth J. (2015). Basal forebrain atrophy contributes to allocentric navigation impairment in Alzheimer's disease patients. Frontiers in Aging Neuroscience, 7 (185) 185, 1-11. doi: 10.3389/fnagi.2015.00185
Kerbler, Georg M., Fripp, Jürgen, Rowe, Christopher C., Villemagne, Victor L., Salvado, Olivier, Rose, Stephen, Coulson, Elizabeth J. and Alzheimer's Disease Neuroimaging Initiative (2015). Basal forebrain atrophy correlates with amyloid beta burden in Alzheimer's disease. NeuroImage: Clinical, 7, 105-113. doi: 10.1016/j.nicl.2014.11.015
Edwards, Stephen R., Hamlin, Adam S., Marks, Nicola, Coulson, Elizabeth J. and Smith, Maree T. (2014). Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease. Clinical and Experimental Pharmacology and Physiology, 41 (10), 798-806. doi: 10.1111/1440-1681.12277
Boskovic, Zoran, Alfonsi, Fabienne, Rumballe, Bree A., Fonseka, Sachini, Windels, Francois and Coulson, Elizabeth J. (2014). The role of p75NTR in cholinergic basal forebrain structure and function. Journal of Neuroscience, 34 (39), 13033-13038. doi: 10.1523/JNEUROSCI.2364-14.2014
Matusica, Dusan and Coulson, Elizabeth J. (2014). Local versus long-range neurotrophin receptor signalling: Endosomes are not just carriers for axonal transport. Seminars in Cell and Developmental Biology, 31, 57-63. doi: 10.1016/j.semcdb.2014.03.032
Harper, Callista B., Bademosi, Adekunle T., Coulson, Elizabeth J. and Meunier, Frederic A. (2014). A role for SNAREs in neuronal survival?. Journal of Neurochemistry, 129 (5), 753-755. doi: 10.1111/jnc.12699
Hort, J., Andel, R., Mokrisova, I., Gazova, I., Amlerova, J., Valis, M., Coulson, E. J., Harrison, J., Windisch, M. and Laczo, J. (2014). Effect of donepezil in alzheimer disease can be measured by a computerized human analog of the morris water maze. Neurodegenerative Diseases, 13 (2-3), 192-196. doi: 10.1159/000355517
Gazova, Ivana, Laczo, Jan, Rubinova, Eva, Mokrisova, Ivana, Hyncicova, Eva, Andel, Ross, Vyhnalek, Martin, Sheardova, Katerina, Coulson, Elizabeth J. and Hort, Jakub (2013). Spatial navigation in young versus older adults. Frontiers in Aging Neuroscience, 5 (DEC) Article 94, 94.1-94.8. doi: 10.3389/fnagi.2013.00094
Coulson, Elizabeth J and Nykjaer, Anders (2013). Up-regulation of sortilin mediated by amyloid-beta and p75NTR: safety lies in the middle course. Journal of Neurochemistry, 127 (2), 149-151. doi: 10.1111/jnc.12389
Matusica, Dusan, Skeldal, Sune, Sykes, Alex M., Palstra, Nickless, Sharma, Aanchal and Coulson, Elizabeth J. (2013). An intracellular domain fragment of the p75 neurotrophin receptor (p75 NTR) enhances tropomyosin receptor kinase A(TrkA) receptor function. Journal of Biological Chemistry, 288 (16), 11144-11154. doi: 10.1074/jbc.M112.436469
Martin, Sally, Harper, Callista B., May, Linda M., Coulson, Elizabeth J., Meunier, Frederic A. and Osborne, Shona L. (2013). Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death. PLoS One, 8 (3) e60152, e60152.1-e60152.14. doi: 10.1371/journal.pone.0060152
Ghai, Rajesh, Bugarcic, Andrea, Liu, Huadong, Norwood, Suzanne J., Skeldal, Sune, Coulson, Elizabeth J., Li, Shawn Shun-Cheng, Teasdale, Rohan D. and Collins, Brett M. (2013). Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proceedings of the National Academy of Sciences of the United States of America, 110 (8), E643-E652. doi: 10.1073/pnas.1216229110
Hamlin, Adam S., Windels, Francois, Boskovic, Zoran, Sah, Pankaj and Coulson, Elizabeth J. (2013). Lesions of the basal forebrain cholinergic system in mice disrupt idiothetic navigation. PLoS ONE, 8 (1) e53472, e53472.1-e53472.9. doi: 10.1371/journal.pone.0053472
Sykes, Alex M., Palstra, Nick, Abankwa, Daniel, Hill, Justine M., Skeldal, Sune, Matusica, Dusan, Venkatraman, Prahatha, Hancock, John F. and Coulson, Elizabeth J. (2012). The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase. Journal of Biological Chemistry, 287 (52), 43810-43824. doi: 10.1074/jbc.M112.382903
Kerbler, Georg M., Hamlin, Adam S., Pannek, Kerstin, Kurniawan, Nyoman D., Keller, Marianne D., Rose, Stephen E. and Coulson, Elizabeth J. (2012). Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model. NeuroImage, 66, 133-141. doi: 10.1016/j.neuroimage.2012.10.075
Skeldal, Sune, Sykes, Alex M., Glerup, Simon, Matusica, Dusan, Palstra, Nickless, Autio, Henri, Boskovic, Zoran, Madsen, Peder, Castrén, Eero, Nykjaer, Anders and Coulson, Elizabeth J. (2012). Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis. Journal of Biological Chemistry, 287 (52), 43798-43809. doi: 10.1074/jbc.M112.374710
Skeldal, S., Matusica, D., Nykjaer, A. and Coulson, E. J. (2012). Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling? (vol 33, pg 614, 2011). Bioessays, 34 (6), 521-521. doi: 10.1002/bies.201110036
Skeldal, Sune, Matusica, Dusan, Nykjaer, Anders and Coulson, Elizabeth J. (2011). Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR). BioEssays, 33 (8), 614-625. doi: 10.1002/bies.201100036
Proctor, Dustin T., Coulson, Elizabeth J. and Dodd, Peter R. (2011). Post-synaptic scaffolding protein interactions with glutamate receptors in synaptic dysfunction and Alzheimer's disease. Progress in Neurobiology, 93 (4), 509-521. doi: 10.1016/j.pneurobio.2011.02.002
Proctor, Dustin T., Coulson, Elizabeth J. and Dodd, Peter R. (2010). Reduction in post-synaptic scaffolding PSD-95 and SAP-102 protein levels in the Alzheimer inferior temporal cortex is correlated with disease pathology. Journal of Alzheimer's Disease, 21 (3), 795-811. doi: 10.3233/JAD-2010-100090
Sotthibundhu, Areechun, Li, Qiao-Xin, Thangnipon, Wipawan and Coulson, Elizabeth J. (2009). Aβ₁₋₄₂ stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor. Neurobiology of Aging, 30 (12), 1975-1985. doi: 10.1016/j.neurobiolaging.2008.02.004
Colditz, Michael J., Catts, Vibeke S., Al-menhali, Noura, Osborne, Geoffrey W., Bartlett, Perry F. and Coulson, Elizabeth J. (2009). p75 neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis. Experimental Brain Research, 200 (2), 161-167. doi: 10.1007/s00221-009-1947-6
Coulson, Elizabeth, May, Linda, Sykes, Alexander and Hamlin, Adam (2009). The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease. Neuroscientist, 15 (4), 317-323. doi: 10.1177/1073858408331376
Catts, Vibeke, Al-Minhali, Noura, Burne, Thomas H.J., Colditz, Michael and Coulson, Elizabeth (2008). The p75 neurotrophin receptor regulates hippocampal neurogenesis and related behaviours. European Journal of Neuroscience, 28 (5), 883-892. doi: 10.1111/j.1460-9568.2008.06390.x
Sotthibundhu, Areechun, Sykes, Alex M., Fox, Briony, Underwood, Clare K., Thangnipon, Wipawan and Coulson, Elizabeth, J. (2008). β-amyloid1-42 induces neuronal death through the p75 neurotrophin receptor. The Journal of Neuroscience, 28 (15), 3941-3946. doi: 10.1523/JNEUROSCI.0350-08.2008
Underwood, Clare K., Reid, Kate, May, Linda M., Bartlett, Perry F. and Coulson, Elizabeth J. (2008). Palmitoylation of the C-terminal fragment of p75NTR regulates death signaling and is required for subsequent cleavage by gamma-secretase. Molecular and Cellular Neuroscience, 37 (2), 346-358. doi: 10.1016/j.mcn.2007.10.005
Coulson, E. J., May, L. M., Osborne, S. L., Reid, K., Underwood, C. K., Meunier, F. A., Bartlett, P. F. and Sah, P. (2008). p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate. Journal of Neuroscience, 28 (1), 315-324. doi: 10.1523/JNEUROSCI.2699-07.2008
Underwood, Clare K. and Coulson, Elizabeth J. (2008). The p75 neurotrophin receptor. The International Journal of Biochemistry and Cell Biology, 40 (9), 1664-1668. doi: 10.1016/j.biocel.2007.06.010
Jones, C. E., Underwood, C. K., Coulson, E. J. and Taylor, P. J. (2007). Copper induced oxidation of serotonin: analysis of products and toxicity. Journal of Neurochemistry, 102 (4), 1035-1043. doi: 10.1111/j.1471-4159.2007.04602.x
Morley, Samuel N., Power, John M., Coulson, Elizabeth J. and Bartlett, Perry F. (2007). Zinc-mediated neuronal death is dependent on Trk activation. Experimental Neurology, 205 (2), 360-366. doi: 10.1016/j.expneurol.2007.02.006
Young, K. M., Merson, T. D., Sotthibundhu, A., Coulson, E. J. and Bartlett, P. F. (2007). p75 Neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells. Journal of Neuroscience, 27 (19), 5146-5155. doi: 10.1523/JNEUROSCI.0654-07.2007
Catts, Vibeke Sorensen, Catts, Stanley Victor, McGrath, John Joseph, Feron, Francois, McLean, Duncan, Coulson, Elizabeth Jane and Lutze-Mann, Louise Helen (2006). Apoptosis and schizophrenia: a pilot study based on dermal fibroblast cell lines. Schizophrenia Research, 84 (1), 20-28. doi: 10.1016/j.schres.2006.03.016
Coulson, Elizabeth J. (2006). Does the p75 neurotrophin receptor mediate A beta-induced toxicity in Alzheimer's disease?. Journal of Neurochemistry, 98 (3), 654-660. doi: 10.1111/j.1471-4159.2006.03905.x
Young, Kaylene M., Bartlett, Perry F. and Coulson, Elizabeth J. (2006). Neural progenitor number is regulated by nuclear factor-kappa B p65 and p50 subunit-dependent proliferation rather than cell survival. Journal of Neuroscience Research, 83 (1), 39-49. doi: 10.1002/jnr.20702
Kanjhan, R., Coulson, E. J., Adams, D. J. and Bellingham, M. C. (2005). Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner. Journal of Pharmacology And Experimental Therapeutics, 314 (3), 1353-1361. doi: 10.1124/jpet.105.085928
Catts, V. S., Catts, S. V., Fernandez, H. R., Taylor, J. M., Coulson, E. J. and Lutze-Mann, L. H. (2005). A microarray study of post-mortem mRNA degradation in mouse brain tissue. Molecular Brain Research, 138 (2), 164-177. doi: 10.1016/j.molbrainres.2005.04.017
Murray, SS, Bartlett, PF, Lopes, EC, Coulson, EJ, Greferath, U and Cheema, SS (2003). Low-affinity neurotrophin receptor with targeted mutation of exon 3 is capable of mediating the death of axotomized neurons. Clinical And Experimental Pharmacology And Physiology, 30 (4), 217-222. doi: 10.1046/j.1440-1681.2003.03827.x
Jabbour, AM, Ekert, PG, Coulson, EJ, Knight, MJ, Ashley, DM and Hawkins, CJ (2002). The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. Cell Death And Differentiation, 9 (12), 1311-1320. doi: 10.1038/sj.cdd.4401135
Verhagen, A. M., Coulson, E. J. and Vaux, D. L. (2001). Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biology, 2 (7) 3009
Lowry, KS, Murray, SS, Coulson, EJ, Epa, R, Bartlett, PF, Barrett, G and Cheema, SS (2001). Systemic administration of antisense p75(NTR) oligodeoxynucleotides rescues axotomised spinal motor neurons. Journal of Neuroscience Research, 64 (1), 11-17. doi: 10.1002/jnr.1048
Coulson, E. J., Reid, K., Baca, M., Shipham, K. A., Hulett, S. M., Kilpatrick, T. J. and Bartlett, P. F. (2000). Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death. Journal of Biological Chemistry, 275 (39), 30537-30545. doi: 10.1074/jbc.M005214200
Coulson, E. J., Reid, K., Murray, S. S., Cheema, S. S. and Bartlett, P. F. (2000). Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury. Clinical And Experimental Pharmacology And Physiology, 27 (7), 537-541. doi: 10.1046/j.1440-1681.2000.03295.x
Coulson, EJ, Paliga, K, Beyreuther, K and Masters, CL (2000). What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochemistry International, 36 (3), 175-184. doi: 10.1016/S0197-0186(99)00125-4
Coulson, E. J., Reid, K. and Bartlett, P. F. (1999). Signaling of neuronal cell death by the p75NTR neurotrophin receptor. Molecular Neurobiology, 20 (1), 29-44. doi: 10.1007/BF02741363
Coulson, E. J., Reid, K., Barrett, G. L. and Bartlett, P. F. (1999). p75 neurotrophin receptor-mediated neuronal death is promoted by Bcl-2 and prevented by Bcl-x(L). Journal of Biological Chemistry, 274 (23), 16387-16391. doi: 10.1074/jbc.274.23.16387
Epa, WR, Rong, P, Bartlett, PF, Coulson, EJ and Barrett, GL (1998). Enhanced downregulation of the p75 nerve growth factor receptor by cholesteryl and bis-cholesteryl antisense oligonucleotides. Antisense & Nucleic Acid Drug Development, 8 (6), 489-498. doi: 10.1089/oli.1.1998.8.489
Uren, AG, Coulson, EJ and Vaux, DL (1998). Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts. Trends In Biochemical Sciences, 23 (5), 159-162. doi: 10.1016/S0968-0004(98)01198-0
Coulson, EJ, Barrett, GL, Storey, E, Bartlett, PF, Beyreuther, K and Masters, CL (1997). Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata. Brain Research, 770 (1-2), 72-80. doi: 10.1016/S0006-8993(97)00757-9
Conference Papers
Xia, Ying, Maruff, Paul, Dore, Vincent, Bourgeat, Pierrick, Villemagne, Victor L., Rowe, Christopher C., Coulson, Elizabeth J. and Fripp, Jurgen (2023). The effect of basal forebrain atrophy on the rate of cognitive decline in older adults without dementia. Alzheimer’s Association International Conference AAIC 2023, Amsterdam, Netherlands, 16-20 July 2023. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/alz.079648
Xia, Ying, Maruff, Paul, Bourgeat, Pierrick, Dore, Vincent, Villemagne, Victor L., Rowe, Christopher C., Coulson, Elizabeth J. and Fripp, Jurgen (2023). Longitudinal basal forebrain atrophy in association with amyloid‐β positivity and dementia severity. Alzheimer's Association International Conference (AAIC) 2022, San Diego, CA United States, 31 July - 4 August 2022. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/alz.064027
Xia, Ying, Eeles, Eamonn, Fripp, Jurgen, Pinsker, Donna, Thomas, Paul, Latter, Melissa, Dore, Vincent, Fazlollahi, Amir, Bourgeat, Pierrick, Villemagne, Victor L., Coulson, Elizabeth J. and Rose, Stephen (2023). Reduced cortical cholinergic innervation correlates with cognitive decline in mild cognitive impairment. Alzheimer's Association International Conference (AAIC) 2022, San Diego, CA United States, 31 July - 4 August 2022. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/alz.063527
Adams, R., Georgeson, T., Szollosi, I. and Coulson, E. (2022). CPAP therapy compliance and changes in cognitive function in patients with obstructive sleep apnoea. 33rd annual scientific meeting of Australasian Sleep Association (ASA) & Australian and New Zealand Sleep Science Association (ANZSSA), Brisbane, QLD, Australia, 8-11 November 2022. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/sleepadvances/zpac029.075
Lerch, O., Pannek, K., Laczo, J., Nedelska, Z., Fripp, J., Hort, J. and Coulson, E. (2018). Impairment of basal forebrain projections contributes to hippocampal atrophy in subjects at risk of Alzheimer's disease. 4th Congress of the European Academy of Neurology, Lisbon, Portugal, 16-19 June 2018. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ene.13700
Coulson, E. (2017). Cholinergic dysfunction may explain the link between obstructive sleep apnea and sporadic Alzheimer's disease. ISN-ESN Meeting 2017, Paris, France, 20-24 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.14089
Hearn, Nathan, Dore, Vincent, Fripp, Jurgen, Grothe, Michel J., Teipel, Stefan J., Masters, Colin L., Rowe, Christopher C., Coulson, Elizabeth and Villemagne, Victor L.L. (2017). Global tau burden correlates with basal forebrain atrophy in healthy aging subjects. *, *, *. Elsevier BV. doi: 10.1016/j.jalz.2017.06.1565
Turnbull, M., Goetz, J. and Coulson, E. (2015). Neurotrophin regulation of Alzheimer's disease pathology. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188
Coulson, E. (2015). Disruption to long-range anterograde neurotrophin signalling in alzheimer's disease. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13185
Qian, L., Marks, N., Sharma, A., Bellingham, M. and Coulson, E. (2015). Cholinergic dysfunction of mesopontine tegmentum is involved in the development of Alzheimer's disease. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD, Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13189
Camara, M. Iou, Matusica, D., Qian, L., Bredy, T., Nykjaer, A. and Coulson, E. (2015). Enhancing TRK mediated trophic signalling to augment cognitive processes. 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD, Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13189
Coulson, E. J. and Matusica, D. (2012). Regulation of neuronal survival and death by the cleaved fragments of p75 neurotrophin receptor. HOBOKEN: WILEY-BLACKWELL.
Kerbler, Georg, Hamlin, Adam, Keller, Marianne D., Kurniawan, Nyoman D., Brereton, Ian M. and Coulson, Elizabeth (2011). Imaging the loss of cholinergic basal forebrain neurons in a mouse model of Alzheimer’s disease by tractography. 10th International Conference on Alzheimer's and Parkinson Diseases, Barcelona, Spain, 9-13 March 2011.
Georg Kerbler, Hamlin, Adam, Keller, Marianne D., Kurniawan, Nyoman D., Brereton, Ian M. and Coulson, Elizabeth (2010). Imaging the loss of cholinergic basal forebrain neurons in a mouse model of Alzheimer’s disease by tractography. 3rd Brain Plasticity Symposium, Brisbane, Australia, 14-16 September 2010.
Edwards, Stephen R., Coulson, Elizabeth J. and Smith, Maree T. (2010). A behavioural study assessing memory deficits in the APP/PS1 double transgenic mouse model of Alzheimer’s disease using the Morris water maze.. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) 44th Annual Scientific Meeting 2010, Melbourne, Australia, 28 November-1 December 2010. Melbourne, Australia: ASCEPT.
Keller, Marianne D., Kerbler, Georg, Hamlin, Adam S., Brereton, Ian and Coulson, Elizabeth J. (2010). Tractography in a Saporine Alzheimer's Disease mouse model. World Molecular Imaging Conference in Kyoto, Japan, Kyoto, Japan, 8-11 September 2010. United States: Springer New York LLC.
Kurniawan, N. D., Fox , B., Rogers, F., Butler, T., Li, L., Wallace, R., Cowin, G., Rose, S., Coulson, E., Galloway, G., Bartlett, P. F. and Brereton, I. M. (2006). Magnetic resonance neuroimaging at 16.4T. UWS Symposium and Workshop on NMR Imaging and Diffusion, Sydney, Australia, 21-22 October 2006.
Kurniawan, N., Fox, B., Xu, Z., Li, L., Rogers, F., Lu, G., Galloway, G., Rose, S., Bartlett, P. F. and Coulson, E. J. (2006). Magnetic resonance micro-imaging at the University of Queensland. The 2nd Pacific Rim Brain Conference, Sunshine Coast, Australia, 14-16 August 2006. Brisbane, Australia: Queensland Brain Institute.
Kurniawan, N., Rogers, F., Li, L., Fox, B., Xu. G., Bartlett, P. F., Coulson, E. and Rose, S. (2005). Development of contrast agents for magnetic resonance microimaging. The Queensland Brain Institute Brain Plasticity Symposium, Brisbane, Australia, 12-15 September, 2005.
Catts, V. S., Catts, S., McGrath, J. J., Mackay-Sim, A., Feron, F., McLean, D., Coulson, E. J. and Lutze-Mann, L. H. (2005). Apoptotic markers in fibroblast cultures from patients with schizophrenia, bipolar disorder and non-affected controls. The Royal Aust & NZ College of Psychiatrists 40th Congress, Sydney, 22-26 May, 2005. Melbourne, Australia: Blackwell.
Coulson, E., Reid, K. M., Shipham, K. M., Morley, S. N., Kilpatrick, T. J. and Bartlett, P. F. (2004). The role of neurotransmission and the Chopper domain in p75 neurotrophin receptor death signaling. 7th International Conference on NGF and Related Molecules, Modena, Italy, 15-19 May, 2002. Amsterdam Netherlands: Elsevier. doi: 10.1016/S0079-6123(03)46003-2
Morley, S. N., Coulson, E. and Bartlett, P. F. (2004). Zinc neurotoxicity is promoted by nerve growth factor but is prevented by leukaemia inhibitor factor. Society for Neuroscience 34th Annual Meeting, San Diego, 23-27 October. Washington DC: Society for Neuroscience.
Coulson, E., Sah, P., May, L. M., Morley, S. N. and Bartlett, P. F. (2004). Stimulation of Girk channel activity by P75 neurotrophin receptor (p 75NTR) promotes neuronal death. Society for Neuroscience 34th Annual Meeting, San Diego, 23-27 October, 2004. Washington DC: Society for Neuroscience.
Young, K. M., Coulson, E. and Bartlett, P. F. (2004). p75NTR: The first positive marker for neural stem cell selection and its role in cell fate determination. Australian Neuroscience Society 24th Annual Meeting, Melbourne Convention Centre, 27-30 January. Melbourne: Australian Neuroscience Society.
Catts, V. S., Catts, S., Fernandez, H.R., Taylor, J., Coulson, E. and Lutzemann, L.H. (2004). A microarray study of postmortem mRNA degradation in mouse brain tissue. Australian Neuroscience Society 24th Annual Meeting, Melbourne Convention Centre, 27-30 January 2004. Melbourne: Australian Neuroscience Society.
Whyte, S, Jones, L, Coulson, EJ, Moir, RD, Bush, AI, Beyreuther, K and Masters, CL (1997). The metabolism of the amyloid precursor protein of Alzheimer's disease and dietary zinc. 5th International Conference on Alzheimers Disease and Related Disorders, Osaka Japan, Jul 24-29, 1996. CHICHESTER: JOHN WILEY & SONS LTD.
Whyte, S., Currie, J., Maruff, P., Malone, V., Coulson, E.J., Beyreuther, K. and Masters, C.L. (1996). The effect of oral zinc supplementation on the amyloid precursor protein of Alzheimer's disease in human plasma and rat brain. The Fifth International Conference on Alzheimer's Disease and Related Disorders, Osaka, Japan, 1996. Philadelphia, PA, United States: Elsevier. doi: 10.1016/s0197-4580(96)80326-5
Data Collection
Coulson, Elizabeth, Qian, Lei, Bellingham, Mark, Georgeson, Thomas, Garner, Nicholas and Dean, Matthew (2022). Cholinergic basal forebrain degeneration due to sleep-disordered breathing project source data. The University of Queensland. (Dataset) doi: 10.48610/81462a6