Nerve cell survival

About

The Coulson laboratory is investigating how and why certain neurons die in neurodegenerative diseases including Alzheimer’s disease (AD) and motor neuron disease (MND). Their work focusses on the p75 neurotrophin receptor (p75NTR) and its role in neuronal loss, particularly the nerve cell degeneration that occurs in cholinergic neurons in the brain and spinal cord.

Cholinergic neurons in the basal forebrain are important for learning and memory, and post-mortem studies show that they can be selectively lost in AD. The current treatment for AD patients targets the function of these cholinergic neurons. However, significant loss of these neurons has already occurred in the majority of AD patients prior to treatment, and because these drugs are only efficacious while the neurons are alive, these treatments are of limited value to most patients. Better drugs are needed. Similarly, cholinergic neurons in the spinal cord selectively die in MND, causing loss of muscle tone and paralysis. No treatments are effective in treating the underlying cell loss in this debilitating condition.

The Coulson group has developed a candidate therapy (called c29) to try to stop the p75NTR death signalling pathway and promote cholinergic neuron survival. They have had success in a mouse model of MND, showing that a three-month c29 infusion could keep dying motor neurons alive for longer, and that treatment delayed disease onset. They further demonstrated that when mice were given the early-version drug, a cell survival signalling pathway was activated, and the cell death signalling pathway used by the p75 protein to kill dying motor neurons was blocked. In addition, collaborators from the University of Adelaide found that a by-product of p75 was found in high levels in people with MND, and could be measured in urine and blood. The c29 treated mice also showed less of this by-product, indicating that motor neuron degeneration was not being activated to the same extent.

Contact

  +61 (0)7 334 66392

  e.coulson@uq.edu.au


Group Publications

Research Areas

  • Neurodegenerative disease
  • Nerve cell survival
  • p75NTR biology
  • Regulation of neurodegeneration


Apply for a PhD

Group Leader


Research Members

  • Dr Lei Qian

    Postdoctoral Research Fellow
    School of Biomedical Sciences
    Postdoctoral Research Fellow
    Queensland Brain Institute
  • Michael Milne

    Mr Michael Milne

    Research Assistant
    School of Biomedical Sciences

Students

  • Miss Sonja Meier

    PhD Student
    Queensland Brain Insitute
    BIOL3006 Demonstrator & BIOC3003 Demonstrator & BIOL2202 Demonstrator
    School of Chemistry and Molecular Biosciences
  • Mrs Lacey Atkins

    MPhil Student
    Queensland Brain Insitute
  • Chai Chee Ng

    Ms Chai Chee Ng

    MPhil Student
    Queensland Brain Institute

Visiting Academics


Unravelling the mechanism coupling synaptic activity with neurotrophin signaling in the nervous system
(2017–2019) NHMRC Project Grant

Predicting cholinesterase inhibitor response in patients with dementia
(2016–2018) Metro North Hospital and Health Service

A novel approach to enhance cognitive function and promote synaptic plasticity
(2016–2017) Alzheimer's Australia Dementia Research Foundation - Cromwell Property Group Foundation Project Grant


Cholinergic basal forebrain lesion decreases neurotrophin signaling without affecting tau hyperphosphorylation in genetically susceptible mice

Turnbull, Marion T. and Coulson, Elizabeth J. (2017) Cholinergic basal forebrain lesion decreases neurotrophin signaling without affecting tau hyperphosphorylation in genetically susceptible mice. Journal of Alzheimer's Disease,55 3: 1141-1154. doi:10.3233/JAD-160805

Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB

Wang, Tong, Martin, Sally, Nguyen, Tam H., Harper, Callista B., Gormal, Rachel S., Martinez-Marmol, Ramon, Karunanithi, Shanker, Coulson, Elizabeth J., Glass, Nick R., Cooper-White, Justin J., Van Swinderen, Bruno and Meunier, Frederic A. (2016) Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB. Nature Communications7 . doi:10.1038/ncomms12976

Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment

Matusica, Dusan, Alfonsi, Fabienne, Turner, Bradley J., Butler, Tim J., Shepheard, Stephanie R., Rogers, Mary-Louise, Skeldal, Sune, Underwood, Clare K., Mangelsdorf, Marie and Coulson, Elizabeth J. (2016) Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment. Journal of Cell Science129 3: 517-530. doi:10.1242/jcs.173864

The A-B-C for SORting APP

Coulson, Elizabeth J. and Andersen, Olav M. (2015) The A-B-C for SORting APP. Journal of Neurochemistry135 1: 1-3. doi:10.1111/jnc.13231

Basal forebrain atrophy contributes to allocentric navigation impairment in Alzheimer's disease patients

Kerbler, Georg M., Nedelska, Zuzana, Fripp, Jurgen, Laczo, Jan, Vyhnalek, Martin, Lisy, Jiri, Hamlin, Adam S., Rose, Stephen, Hort, Jakub and Coulson, Elizabeth J. (2015) Basal forebrain atrophy contributes to allocentric navigation impairment in Alzheimer's disease patients. Frontiers in Aging Neuroscience7 185: 1-11. doi:10.3389/fnagi.2015.00185

Basal forebrain atrophy correlates with amyloid beta burden in Alzheimer's disease

Kerbler, Georg M., Fripp, Jürgen, Rowe, Christopher C., Villemagne, Victor L., Salvado, Olivier, Rose, Stephen, Coulson, Elizabeth J. and Alzheimer's Disease Neuroimaging Initiative (2015) Basal forebrain atrophy correlates with amyloid beta burden in Alzheimer's disease. NeuroImage: Clinical7 105-113. doi:10.1016/j.nicl.2014.11.015

Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease

Edwards, Stephen R., Hamlin, Adam S., Marks, Nicola, Coulson, Elizabeth J. and Smith, Maree T. (2014) Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease. Clinical and Experimental Pharmacology and Physiology41 10: 798-806. doi:10.1111/1440-1681.12277

The role of p75NTR in cholinergic basal forebrain structure and function

Boskovic, Zoran, Alfonsi, Fabienne, Rumballe, Bree A., Fonseka, Sachini, Windels, Francois and Coulson, Elizabeth J. (2014) The role of p75NTR in cholinergic basal forebrain structure and function. Journal of Neuroscience34 39: 13033-13038. doi:10.1523/JNEUROSCI.2364-14.2014

Local versus long-range neurotrophin receptor signalling: Endosomes are not just carriers for axonal transport

Matusica, Dusan and Coulson, Elizabeth J. (2014) Local versus long-range neurotrophin receptor signalling: Endosomes are not just carriers for axonal transport. Seminars in Cell and Developmental Biology31 57-63. doi:10.1016/j.semcdb.2014.03.032

A role for SNAREs in neuronal survival?

Harper, Callista B., Bademosi, Adekunle T., Coulson, Elizabeth J. and Meunier, Frederic A. (2014) A role for SNAREs in neuronal survival?. Journal of Neurochemistry129 5: 753-755. doi:10.1111/jnc.12699

Effect of donepezil in alzheimer disease can be measured by a computerized human analog of the morris water maze

Hort, J., Andel, R., Mokrisova, I., Gazova, I., Amlerova, J., Valis, M., Coulson, E. J., Harrison, J., Windisch, M. and Laczo, J. (2014) Effect of donepezil in alzheimer disease can be measured by a computerized human analog of the morris water maze. Neurodegenerative Diseases13 2-3: 192-196. doi:10.1159/000355517

Spatial navigation in young versus older adults

Gazova, Ivana, Laczo, Jan, Rubinova, Eva, Mokrisova, Ivana, Hyncicova, Eva, Andel, Ross, Vyhnalek, Martin, Sheardova, Katerina, Coulson, Elizabeth J. and Hort, Jakub (2013) Spatial navigation in young versus older adults.Frontiers in Aging Neuroscience5 DEC: 94.1-94.8. doi:10.3389/fnagi.2013.00094

Up-regulation of sortilin mediated by amyloid-beta and p75NTR: safety lies in the middle course

Coulson, Elizabeth J and Nykjaer, Anders (2013) Up-regulation of sortilin mediated by amyloid-beta and p75NTR: safety lies in the middle course. Journal of Neurochemistry127 2: 149-151. doi:10.1111/jnc.12389

An intracellular domain fragment of the p75 neurotrophin receptor (p75 NTR) enhances tropomyosin receptor kinase A(TrkA) receptor function

Matusica, Dusan, Skeldal, Sune, Sykes, Alex M., Palstra, Nickless, Sharma, Aanchal and Coulson, Elizabeth J. (2013) An intracellular domain fragment of the p75 neurotrophin receptor (p75 NTR) enhances tropomyosin receptor kinase A(TrkA) receptor function. Journal of Biological Chemistry288 16: 11144-11154. doi:10.1074/jbc.M112.436469

Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

Martin, Sally, Harper, Callista B., May, Linda M., Coulson, Elizabeth J., Meunier, Frederic A. and Osborne, Shona L. (2013) Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death. PLoS One8 3: e60152.1-e60152.14. doi:10.1371/journal.pone.0060152

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Ghai, Rajesh, Bugarcic, Andrea, Liu, Huadong, Norwood, Suzanne J., Skeldal, Sune, Coulson, Elizabeth J., Li, Shawn Shun-Cheng, Teasdale, Rohan D. and Collins, Brett M. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proceedings of the National Academy of Sciences of the United States of America110 8: E643-E652. doi:10.1073/pnas.1216229110

Lesions of the basal forebrain cholinergic system in mice disrupt idiothetic navigation

Hamlin, Adam S., Windels, Francois, Boskovic, Zoran, Sah, Pankaj and Coulson, Elizabeth J. (2013) Lesions of the basal forebrain cholinergic system in mice disrupt idiothetic navigation. PLoS ONE8 1: e53472.1-e53472.9. doi:10.1371/journal.pone.0053472

The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase

Sykes, Alex M., Palstra, Nick, Abankwa, Daniel, Hill, Justine M., Skeldal, Sune, Matusica, Dusan, Venkatraman, Prahatha, Hancock, John F. and Coulson, Elizabeth J. (2012) The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase. Journal of Biological Chemistry287 52: 43810-43824. doi:10.1074/jbc.M112.382903

Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model

Kerbler, Georg M., Hamlin, Adam S., Pannek, Kerstin, Kurniawan, Nyoman D., Keller, Marianne D., Rose, Stephen E. and Coulson, Elizabeth J. (2012) Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model. NeuroImage, 133-141. doi:10.1016/j.neuroimage.2012.10.075

Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis

Skeldal, Sune, Sykes, Alex M., Glerup, Simon, Matusica, Dusan, Palstra, Nickless, Autio, Henri, Boskovic, Zoran, Madsen, Peder, Castrén, Eero, Nykjaer, Anders and Coulson, Elizabeth J. (2012) Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis. Journal of Biological Chemistry287 52: 43798-43809. doi:10.1074/jbc.M112.374710

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR)

Skeldal, Sune, Matusica, Dusan, Nykjaer, Anders and Coulson, Elizabeth J. (2011) Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR). BioEssays33 8: 614-625. doi:10.1002/bies.201100036

Post-synaptic scaffolding protein interactions with glutamate receptors in synaptic dysfunction and Alzheimer's disease

Proctor, Dustin T., Coulson, Elizabeth J. and Dodd, Peter R. (2011) Post-synaptic scaffolding protein interactions with glutamate receptors in synaptic dysfunction and Alzheimer's disease. Progress in Neurobiology93 4: 509-521. doi:10.1016/j.pneurobio.2011.02.002

Reduction in post-synaptic scaffolding PSD-95 and SAP-102 protein levels in the Alzheimer inferior temporal cortex is correlated with disease pathology

Proctor, Dustin T., Coulson, Elizabeth J. and Dodd, Peter R. (2010) Reduction in post-synaptic scaffolding PSD-95 and SAP-102 protein levels in the Alzheimer inferior temporal cortex is correlated with disease pathology. Journal of Alzheimer's Disease21 3: 795-811. doi:10.3233/JAD-2010-100090

Aβ₁₋₄₂ stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor

Sotthibundhu, Areechun, Li, Qiao-Xin, Thangnipon, Wipawan and Coulson, Elizabeth J. (2009) Aβ₁₋₄₂ stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor. Neurobiology of Aging30 12: 1975-1985. doi:10.1016/j.neurobiolaging.2008.02.004

p75 neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis

Colditz, Michael J., Catts, Vibeke S., Al-menhali, Noura, Osborne, Geoffrey W., Bartlett, Perry F. and Coulson, Elizabeth J. (2009) p75 neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis.Experimental Brain Research200 2: 161-167. doi:10.1007/s00221-009-1947-6

The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease

Coulson, Elizabeth, May, Linda, Sykes, Alexander and Hamlin, Adam (2009) The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease. Neuroscientist15 4: 317-323. doi:10.1177/1073858408331376

The p75 neurotrophin receptor regulates hippocampal neurogenesis and related behaviours

Catts, Vibeke, Al-Minhali, Noura, Burne, Thomas H.J., Colditz, Michael and Coulson, Elizabeth (2008) The p75 neurotrophin receptor regulates hippocampal neurogenesis and related behaviours. European Journal of Neuroscience28 5: 883-892. doi:10.1111/j.1460-9568.2008.06390.x

β-amyloid1-42 induces neuronal death through the p75 neurotrophin receptor

Sotthibundhu, Areechun, Sykes, Alex M., Fox, Briony, Underwood, Clare K., Thangnipon, Wipawan and Coulson, Elizabeth, J. (2008) β-amyloid1-42 induces neuronal death through the p75 neurotrophin receptor. The Journal of Neuroscience28 15: 3941-3946. doi:10.1523/JNEUROSCI.0350-08.2008

Palmitoylation of the C-terminal fragment of p75NTR regulates death signaling and is required for subsequent cleavage by gamma-secretase

Underwood, Clare K., Reid, Kate, May, Linda M., Bartlett, Perry F. and Coulson, Elizabeth J. (2008) Palmitoylation of the C-terminal fragment of p75NTR regulates death signaling and is required for subsequent cleavage by gamma-secretase. Molecular and Cellular Neuroscience37 2: 346-358. doi:10.1016/j.mcn.2007.10.005

p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate

Coulson, E. J., May, L. M., Osborne, S. L., Reid, K., Underwood, C. K., Meunier, F. A., Bartlett, P. F. and Sah, P. (2008) p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate. Journal of Neuroscience28 1: 315-324. doi:10.1523/JNEUROSCI.2699-07.2008

The p75 neurotrophin receptor

Underwood, Clare K. and Coulson, Elizabeth J. (2008) The p75 neurotrophin receptor. The International Journal of Biochemistry and Cell Biology40 9: 1664-1668. doi:10.1016/j.biocel.2007.06.010

Copper induced oxidation of serotonin: analysis of products and toxicity

Jones, C. E., Underwood, C. K., Coulson, E. J. and Taylor, P. J. (2007) Copper induced oxidation of serotonin: analysis of products and toxicity. Journal of Neurochemistry102 4: 1035-1043. doi:10.1111/j.1471-4159.2007.04602.x

Zinc-mediated neuronal death is dependent on Trk activation

Morley, Samuel N., Power, John M., Coulson, Elizabeth J. and Bartlett, Perry F. (2007) Zinc-mediated neuronal death is dependent on Trk activation. Experimental Neurology205 2: 360-366. doi:10.1016/j.expneurol.2007.02.006

p75 Neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells

Young, K. M., Merson, T. D., Sotthibundhu, A., Coulson, E. J. and Bartlett, P. F. (2007) p75 Neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells. Journal of Neuroscience27 19: 5146-5155. doi:10.1523/JNEUROSCI.0654-07.2007

Apoptosis and schizophrenia: a pilot study based on dermal fibroblast cell lines

Catts, Vibeke Sorensen, Catts, Stanley Victor, McGrath, John Joseph, Feron, Francois, McLean, Duncan, Coulson, Elizabeth Jane and Lutze-Mann, Louise Helen (2006) Apoptosis and schizophrenia: a pilot study based on dermal fibroblast cell lines. Schizophrenia Research84 1: 20-28. doi:10.1016/j.schres.2006.03.016

Does the p75 neurotrophin receptor mediate A beta-induced toxicity in Alzheimer's disease?

Coulson, Elizabeth J. (2006) Does the p75 neurotrophin receptor mediate A beta-induced toxicity in Alzheimer's disease?. Journal of Neurochemistry98 3: 654-660. doi:10.1111/j.1471-4159.2006.03905.x

Neural progenitor number is regulated by nuclear factor-kappa B p65 and p50 subunit-dependent proliferation rather than cell survival

Young, Kaylene M., Bartlett, Perry F. and Coulson, Elizabeth J. (2006) Neural progenitor number is regulated by nuclear factor-kappa B p65 and p50 subunit-dependent proliferation rather than cell survival. Journal of Neuroscience Research83 1: 39-49. doi:10.1002/jnr.20702

Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner

Kanjhan, R., Coulson, E. J., Adams, D. J. and Bellingham, M. C. (2005) Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner. Journal of Pharmacology And Experimental Therapeutics,314 3: 1353-1361. doi:10.1124/jpet.105.085928

A microarray study of post-mortem mRNA degradation in mouse brain tissue

Catts, V. S., Catts, S. V., Fernandez, H. R., Taylor, J. M., Coulson, E. J. and Lutze-Mann, L. H. (2005) A microarray study of post-mortem mRNA degradation in mouse brain tissue. Molecular Brain Research138 2: 164-177. doi:10.1016/j.molbrainres.2005.04.017

Low-affinity neurotrophin receptor with targeted mutation of exon 3 is capable of mediating the death of axotomized neurons

Murray, SS, Bartlett, PF, Lopes, EC, Coulson, EJ, Greferath, U and Cheema, SS (2003) Low-affinity neurotrophin receptor with targeted mutation of exon 3 is capable of mediating the death of axotomized neurons. Clinical And Experimental Pharmacology And Physiology30 4: 217-222. doi:10.1046/j.1440-1681.2003.03827.x

The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis

Jabbour, AM, Ekert, PG, Coulson, EJ, Knight, MJ, Ashley, DM and Hawkins, CJ (2002) The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. Cell Death And Differentiation,9 12: 1311-1320. doi:10.1038/sj.cdd.4401135

Systemic administration of antisense p75(NTR) oligodeoxynucleotides rescues axotomised spinal motor neurons

Lowry, KS, Murray, SS, Coulson, EJ, Epa, R, Bartlett, PF, Barrett, G and Cheema, SS (2001) Systemic administration of antisense p75(NTR) oligodeoxynucleotides rescues axotomised spinal motor neurons. Journal of Neuroscience Research64 1: 11-17. doi:10.1002/jnr.1048

Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death

Coulson, E. J., Reid, K., Baca, M., Shipham, K. A., Hulett, S. M., Kilpatrick, T. J. and Bartlett, P. F. (2000) Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death. Journal of Biological Chemistry275 39: 30537-30545. doi:10.1074/jbc.M005214200

Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury

Coulson, E. J., Reid, K., Murray, S. S., Cheema, S. S. and Bartlett, P. F. (2000) Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury. Clinical And Experimental Pharmacology And Physiology27 7: 537-541. doi:10.1046/j.1440-1681.2000.03295.x

What the evolution of the amyloid protein precursor supergene family tells us about its function

Coulson, EJ, Paliga, K, Beyreuther, K and Masters, CL (2000) What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochemistry International36 3: 175-184. doi:10.1016/S0197-0186(99)00125-4

Signaling of neuronal cell death by the p75NTR neurotrophin receptor

Coulson, E. J., Reid, K. and Bartlett, P. F. (1999) Signaling of neuronal cell death by the p75NTR neurotrophin receptor. Molecular Neurobiology20 1: 29-44. doi:10.1007/BF02741363

p75 neurotrophin receptor-mediated neuronal death is promoted by Bcl-2 and prevented by Bcl-x(L)

Coulson, E. J., Reid, K., Barrett, G. L. and Bartlett, P. F. (1999) p75 neurotrophin receptor-mediated neuronal death is promoted by Bcl-2 and prevented by Bcl-x(L). Journal of Biological Chemistry274 23: 16387-16391. doi:10.1074/jbc.274.23.16387

Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts

Uren, AG, Coulson, EJ and Vaux, DL (1998) Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts. Trends In Biochemical Sciences23 5: 159-162. doi:10.1016/S0968-0004(98)01198-0

Enhanced downregulation of the p75 nerve growth factor receptor by cholesteryl and bis-cholesteryl antisense oligonucleotides

Epa, WR, Rong, P, Bartlett, PF, Coulson, EJ and Barrett, GL (1998) Enhanced downregulation of the p75 nerve growth factor receptor by cholesteryl and bis-cholesteryl antisense oligonucleotides. Antisense & Nucleic Acid Drug Development8 6: 489-498. doi:10.1089/oli.1.1998.8.489

Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata

Coulson, EJ, Barrett, GL, Storey, E, Bartlett, PF, Beyreuther, K and Masters, CL (1997) Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata. Brain Research770 1-2: 72-80. doi:10.1016/S0006-8993(97)00757-9

 

 


Project 1: The role of cleavage of p75 neurotrophin receptor in neurotrophic function (cell biology)

Proejct 2: The role of neurotrophins in regulating the synaptic function of cholinergic basal forebrain neurons (mouse studies: electrophysiology, behaviour, fMRI, in vivo genetic manipulation)

Project 3: Studying basal forebrain function in Alzheimer’s disease and sleep apnea (human MRI and PET analysis)

Project 4: Developing optimised peptides for treating neurotrophic dysfunction in neurodegenerative disease (biochemistry)

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