Cognitive neurology

Professor Nestor is a clinician-scientist and joined the Queensland Brain Institute in October/2017. He also has a conjoint appointment at Mater Misericordiae Ltd (Mater Hospital).

He aims to relate the neuropsychological and behavioural profiles of degenerative dementias, such as Alzheimer's disease and frontotemporal dementia, to regional brain damage through neuroimaging (MRI and PET) and histopathological analysis. His particular interest is the pathological landscape of incipient dementia (so-called mild cognitive impairment).

By studying patients in this category he hopes to develop a greater understanding of the regions of highest vulnerability to neurodegeneration in different pathologies. Identification of such regions may potentially lead to a better understanding of what makes these regions vulnerable in the first place. His research ultimately aims to improve diagnostic certainty and prognostic markers of decline - both of which are relevant to therapeutic development.

To this end, a major focus of his is on developing novel approaches to MR imaging for single subject pathological diagnoses that can be exported into the everyday clinical setting; this has included to date diffusion imaging (Sajjadi et al, 2013) and quantitative susceptibility mapping (Acosta-Cabornero et al, 2013).

Patient Referrals

Professor Nestor’s memory clinic is located at Mater Public Hospital, South Brisbane. Specialists wishing to refer patients to this service should send the referral to Mater Memory Clinic, details of which can be found by clicking here.

Group leader

Professor Peter Nestor

Professor Peter Nestor

Professor in Neuroscience, Queensland Brain Institute

  +61 7 344 32505
  nestor.research@uq.edu.au
  UQ Researcher Profile

MRI Bio-Marker Study

Data Collection: 2019 – 2024

Currently, magnetic resonance imaging (MRI) scans used in standard medical practice often offer only limited information for the diagnosis of different forms of degenerative brain diseases. The overall aim of this study is to improve the ability of MRI to make disease-specific diagnoses of the major neurodegenerative disease patients (eg., Alzheimer’s Disease, frontotemporal dementias, Parkinson’s Disease, amyotrophic lateral sclerosis and related disorders) using advanced MRI methods. In addition to improved diagnosis, it is hoped that these new MRI methods may also offer new insights into how these diseases affect the brain and, therefore, potentially identify new targets for treatment.

 

Cognitive Test Development and Normative Data Collection Study

Data Collection: 2019 – 2024

In order to know if a mental ability is not normal in brain diseases that cause dementia, we first have to define normal! This involves testing healthy people in the same age range as those who develop dementias. We therefore need the help of healthy people over the age of 50 to do these tests so that we can create a normal range of performance. Some of these tests are already in use around the world and we need to create a normal range for the local population; sometimes we develop completely new tests that we hope will be more useful in diagnosing and understanding dementias than those that already exist.

To volunteer for this study, please click on this link and go to “Cognitive Test Development.”

 

The Australian Frontotemporal Dementia (FTD) Gene-Carrier Longitudinal Study

Data Collection: 2019 - Ongoing

FTD usually occurs spontaneously in single individuals, however, it can sometimes run in a family (meaning that multiple relatives are affected). Examples of these family forms of FTD include those caused by abnormalities in the C9orf72 gene, the progranulin (PGRN) gene or the tau gene. In this study, we are trying to better understand how the FTD disease process emerges by studying healthy first degree relatives from such families. The study involves a blood test, MRI scanning and tests of mental abilities. It is hoped that with a better understanding of how the disease emerges, methods of prevention might be developed in the future.

To volunteer for this study, please click on this link and go to “The FLAG Study”.

Original research articles

  • Müller S, Preische O, Göpfert JC, Yañez VAC, Joos TO, Boecker H, Düzel E, Falkai P, Priller J, Buerger K, Catak C, Janowitz D, Heneka MT, Brosseron F, Nestor P, Peters O, Menne F, Schipke CG, Schneider A, Spottke A, Fließbach K, Kilimann I, Teipel S, Wagner M, Wiltfang J, Jessen F, Laske C. Tau plasma levels in subjective cognitive decline: Results from the DELCODE study. Sci Rep. 2017; 7: 9529.
  • Hoffman P, Sajjadi SA, Patterson K, Nestor PJ. Data-driven classification of patients with primary progressive aphasia. Brain Lang. 2017; 174: 86-93.
  • Shebani Z, Patterson K, Nestor PJ, Diaz-de-Grenu LZ, Dawson K, Pulvermüller F. Semantic word category processing in semantic dementia and posterior cortical atrophy. Cortex. 2017; 93: 92-106
  • Respondek G, Kurz C, Arzberger T, Compta Y, Englund E, Ferguson LW, Gelpi E, Giese A, Irwin DJ, Meissner WG, Nilsson C, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Whitwell JL, Antonini A, Bhatia KP, Bordelon Y, Corvol JC, Colosimo C, Dodel R, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris H, Nestor P, Oertel WH, Rabinovici GD, Rowe JB, van Eimeren T, Wenning GK, Boxer A, Golbe LI, Litvan I, Stamelou M, Höglinger GU; Movement Disorder Society-Endorsed PSP Study Group. Which ante mortem clinical features predict progressive supranuclear palsy pathology? Mov Disord. 2017; 32: 995-1005.
  • Cole JH, Annus T, Wilson LR, Remtulla R, Hong YT, Fryer TD, Acosta-Cabronero J, Cardenas-Blanco A, Smith R, Menon DK, Zaman SH, Nestor PJ, Holland AJ. Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline. Neurobiol Aging. 2017; 56: 41-49.
  • Schreiber S, Debska-Vielhaber G, Abdulla S, Machts J, Schreiber F, Kropf S, Körtvelyessy P, Körner S, Kollewe K, Petri S, Dengler R, Kunz WS, Nestor PJ, Vielhaber S. Peripheral nerve atrophy together with higher CSF progranulin indicate axonal damage in ALS. Muscle Nerve. In press.
  • Smith BN, Topp SD, Fallini C, Shibata H, Chen HJ, Troakes C, King A, Ticozzi N, Kenna KP, Soragia-Gkazi A, Miller JW, Sato A, Dias DM, Jeon M, Vance C, Wong CH, de Majo M, Kattuah W, Mitchell JC, Scotter EL, Parkin NW, Sapp PC, Nolan M, Nestor PJ, Simpson M, Weale M, Lek M, Baas F, Vianney de Jong JM, Ten Asbroek ALMA, Redondo AG, Esteban-Pérez J, Tiloca C, Verde F, Duga S, Leigh N, Pall H, Morrison KE, Al-Chalabi A, Shaw PJ, Kirby J, Turner MR, Talbot K, Hardiman O, Glass JD, De Belleroche J, Maki M, Moss SE, Miller C, Gellera C, Ratti A, Al-Sarraj S, Brown RH Jr, Silani V, Landers JE, Shaw CE. Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis. Sci Transl Med. 2017; 9 (388).
  • Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I; Movement Disorder Society-endorsed PSP Study Group. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Mov Disord. 2017; 32: 853-864.
  • Costa A, Bak T, Caffarra P, Caltagirone C, Ceccaldi M, Collette F, Crutch S, Della Sala S, Démonet JF, Dubois B, Duzel E, Nestor P, Papageorgiou SG, Salmon E, Sikkes S, Tiraboschi P, van der Flier WM, Visser PJ, Cappa SF. The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group. Alzheimers Res Ther. 2017; 9: 27.
  • Sajjadi SA, Sheikh-Bahaei N, Cross J, Gillard JH, Scoffings D, Nestor PJ. Can MRI Visual Assessment Differentiate the Variants of Primary-Progressive Aphasia? AJNR Am J Neuroradiol. 2017; 38: 954-960.
  • Crutch SJ, Schott JM, Rabinovici GD, Murray M, Snowden JS, van der Flier WM, Dickerson BC, Vandenberghe R, Ahmed S, Bak TH, Boeve BF, Butler C, Cappa SF, Ceccaldi M, de Souza LC, Dubois B, Felician O, Galasko D, Graff-Radford J, Graff-Radford NR, Hof PR, Krolak-Salmon P, Lehmann M, Magnin E, Mendez MF, Nestor PJ, Onyike CU, Pelak VS, Pijnenburg Y, Primativo S, Rossor MN, Ryan NS, Scheltens P, Shakespeare TJ, Suárez González A, Tang-Wai DF, Yong KX, Carrillo M, Fox NC; Alzheimer's Association ISTAART Atypical Alzheimer's Disease and Associated Syndromes Professional Interest Area. Consensus classification of posterior cortical atrophy. Alzheimers Dement. 2017; 13: 870-884.
  • Annus T, Wilson LR, Acosta-Cabronero J, Cardenas-Blanco A, Hong YT, Fryer TD, Coles JP, Menon DK, Zaman SH, Holland AJ, Nestor PJ. The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis. Neurobiol Aging. 2017; 53: 11-19.
  • Acosta-Cabronero J, Cardenas-Blanco A, Betts MJ, Butryn M, Valdes-Herrera JP, Galazky I, Nestor PJ. The whole-brain pattern of magnetic susceptibility perturbations in Parkinson's disease. Brain. 2017; 140: 118-131.
  • Betts MJ, Acosta-Cabronero J, Cardenas-Blanco A, Nestor PJ, Düzel E. High-resolution characterisation of the aging brain using simultaneous quantitative susceptibility mapping (QSM) and R2* measurements at 7T. Neuroimage, 2016; 138: 43-63.
  • Cardenas-Blanco A, Machts J, Acosta-Cabronero J, Kaufmann J, Abdulla S, Kollewe K, Petri S, Schreiber S, Heinze HJ, Dengler R, Vielhaber S, Nestor PJ. Structural and diffusion imaging versus clinical assessment to monitor amyotrophic lateral sclerosis. Neuroimage Clin, 2016; 11: 408-414.
  • Brueggen K, Grothe MJ, Dyrba M, Fellgiebel A, Fischer F, Filippi M, Agosta F, Nestor P, Meisenzahl E, Blautzik J, Frölich L, Hausner L, Bokde AL, Frisoni G, Pievani M, Klöppel S, Prvulovic D, Barkhof F, Pouwels PJ, Schröder J, Hampel H, Hauenstein K, Teipel S. The European DTI Study on Dementia - a multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment. Neuroimage, 2017; 144: 305-308.
  • Acosta-Cabronero J, Betts MJ, Cardenas-Blanco A, Yang S, Nestor PJ. In Vivo MRI Mapping of Brain Iron Deposition across the Adult Lifespan. J Neurosci, 2016; 36: 364-74.
  • Annus T, Wilson LR, Hong YT, Acosta-Cabronero J, Fryer TD, Cardenas-Blanco A, Smith R, Boros I, Coles JP, Aigbirhio FI, Menon DK, Zaman SH, Nestor PJ, Holland AJ. The pattern of amyloid accumulation in the brains of adults with Down syndrome. Alzheimers Dement, 2016; 12: 538-545.
  • Schreiber S, Dannhardt-Stieger V, Henkel D, Debska-Vielhaber G, Machts J, Abdulla S, Kropf S, Kollewe K, Petri S, Heinze HJ, Dengler R, Nestor PJ, Vielhaber S. Quantifying disease progression in ALS using peripheral nerve sonography. Muscle Nerve, 2016; 54: 391-397.
  • Billette OV, Sajjadi SA, Patterson K, Nestor PJ. SECT and MAST: new tests to assess grammatical abilities in primary progressive aphasia. Aphasiology, 2015; 29: 1135-1151.
  • Körtvelyessy P, Krägeloh-Mann I, Mawrin C, Heinze H-J, Bittner D, Wieland I, Zenker M, Nestor, P. Hereditary diffuse leukoencephalopathy with spheroids (HDLS) with a novel CSF1R mutation and spinal cord involvement. J Neurol Sci, 2015; 358: 515-517
  • Brueggen K, Dyrba M, Barkhof F, Hausner L, Filippi M, Nestor PJ, Hauenstein K, Klöppel S, Grothe MJ, Kasper E, Teipel SJ. Basal Forebrain and Hippocampus as Predictors of Conversion to Alzheimer's Disease in Patients with Mild Cognitive Impairment - A Multicenter DTI and Volumetry Study. J Alzheimer's Dis, 2015; 48: 197-204.
  • Gruslys A, Acosta-Cabronero J, Nestor PJ, Williams GB, Ansorge RE. A new fast accurate nonlinear medical image registration program including surface preserving regularization. IEEE Trans Med Imaging. 2014; 33: 2118-2127.
  • Schreiber S, Abdulla S, Debska-Vielhaber G, Machts J, Dannhardt-Stieger V, Feistner H, Oldag A, Goertler M, Petri S, Kollewe K, Kropf S, Schreiber F, Heinze HJ, Dengler R, Nestor PJ, Vielhaber S. Peripheral nerve ultrasound in ALS phenotypes. Muscle Nerve, 2015; 51: 669-675.
  • Cardenas-Blanco A, Machts J, Acosta-Cabronero J, Kaufmann J, Abdulla S, Kollewe K, Petri S, Heinze HJ, Dengler R, Vielhaber S, Nestor PJ. Central white matter degeneration in bulbar- and limb-onset amyotrophic lateral sclerosis. J Neurol, 2014; 261: 1961-1967.
  • Diaz-de-Grenu L, Acosta-Cabronero J, Williams GB, Nestor PJ. Comparing voxel-based iterative sensitivity and voxel-based morphometry to detect abnormalities in T2-weighted MRI. NeuroImage, 2014; 100: 379-384.
  • Abdulla S, Machts J, Kaufmann J, Patrick K, Kollewe K, Dengler R, Heinze H-J, Petri S, Vielhaber S, Nestor PJ. Hippocampal degeneration in amyotrophic lateral sclerosis. Neurobiol Aging, 2014; 35: 2639-45.
  • Sajjadi SA, Patterson K, Nestor PJ. Logopenic, mixed or Alzheimer-related aphasia. Neurology 2014; 82: 1127-1131.
  • Diaz-de-Grenu LZ, Acosta-Cabronero J, Chong YF, Pereira JM, Sajjadi SA, Williams GB, Nestor PJ. A Brief History of Voxel-Based Grey Matter Analysis in Alzheimer's Disease. J Alzheimers Dis 2014; 38: 647-659.
  • Alexander SK, Brown JM, Graham A, Nestor PJ. CADASIL presenting with a behavioural variant frontotemporal dementia phenotype. J Clin Neurosci 2014; 21: 165-167.
  • Acosta-Cabronero J, Williams GB, Cardenas-Blanco A, Arnold RJ, Lupson V, Nestor PJ. In vivo quantitative susceptibility mapping (QSM) in Alzheimer’s disease. PLoS One 2013; 8: e81093.
  • Pereira JMS, Acosta-Cabronero J, Pengas G, Xiong L, Nestor PJ, Williams GB. VBM with viscous fluid registration of gray matter segments in SPM. Front Aging Neurosci 2013; 5: 30.
  • Sajjadi SA, Acosta-Cabronero J, Patterson K, Diaz-de-Grenu LZ, Williams GB, Nestor PJ. Diffusion tensor magnetic resonance imaging for single subject diagnosis in neurodegenerative diseases. Brain 2013; 136: 253-61.
  • Nathan PJ, Boardley R, Scott N, Berges A, Maruff P, Sivananthan T, Upton N, Lowy MT, Nestor PJ, Lai R. The safety, tolerability, pharmacokinetics and cognitive effects of GSK239512, a selective histamine H₃ receptor antagonist in patients with mild to moderate Alzheimer's disease: a preliminary investigation. Curr Alzheimer Res, 2013; 10: 240-51.
  • Smith BN, Newhouse S, Shatunov A, Vance C, Topp S, Johnson L, Miller J, Lee Y, Troakes C, Scott KM, Jones A, Gray I, Wright J, Hortobagyi T, Al-Sarraj S, Rogelj B, Powell J, Lupton M, Lovestone S, Sapp PC, Weber M, Nestor PJ, Schelhaas HJ, Asbroek AALM, Silani V, Gellera C, Taroni F, Ticozzi N, Van den Berg L, Veldink J, Van Damme P, Robberecht W, Shaw PJ, Kirby J, Pall H, Morrison KE, Morris A, de Belleroche J, Vianney de Jong JMB, Baas F, Andersen PM, Landers J, Brown Jr RH, Weale ME, Al-Chalabi A, Shaw CE. The C9ORF72 expansion mutation is a common cause of ALS +/- FTD in Europe and has a single founder. Eur J Hum Gen, 2013; 21: 102-108.
  • Acosta-Cabronero J, Alley S, Williams GB, Pengas G, Nestor PJ. Diffusion tensor metrics as biomarkers in Alzheimer's disease. PLoS One, 2012; 7: e49072
  • Filippi M, Agosta F, Barkhof F, Dubois B, Fox NC, Frisoni GB, Jack CR, Johannsen P, Miller BL, Nestor PJ, Scheltens P, Sorbi S, Teipel S, Thompson PM, Wahlund LO. EFNS task force: the use of neuroimaging in the diagnosis of dementia. Eur J Neurol 2012; 19: 1487-1501.
  • Sajjadi SA, Patterson K, Tomek M, Nestor PJ. Abnormalities of connected speech in the non-semantic variants of primary progressive aphasia. Aphasiology, 2012; 26: 1219-1237.
  • Pengas G, Williams GB, Acosta-Cabronero J, Ash TW, Hong YT, Izquierdo-Garcia D, Fryer TD, Hodges JR, Nestor PJ. The relationship of topographical memory performance to regional neurodegeneration in Alzheimer's disease. Front Aging Neurosci. 2012; 4: 17.
  • Sajjadi SA, Patterson K, Arnold RJ, Watson PC, Nestor PJ. Primary progressive aphasia: a tale of two syndromes and the rest. Neurology 2012; 78: 1670-1677.
  • Nestor PJ. Reversal of abnormal eating and drinking behaviour in a frontotemporal lobar degeneration patient using low-dose topiramate. J Neurol, Neurosurg, Psychiatry 2012; 83: 349-350.
  • Sajjadi SA, Patterson K, Tomek M, Nestor PJ. Abnormalities of connected speech in semantic dementia vs. Alzheimer’s disease. Aphasiology 2012; 26: 847-866.
  • Hughes LE, Nestor PJ, Hodges JR, Rowe JB. Magnetoencephalography of frontotemporal dementia: spatiotemporally localized changes during semantic decisions. Brain 2011; 134: 2513-2522.
  • Acosta-Cabronero J, Patterson K, Fryer TD, Hodges JR, Pengas G, Williams GB, Nestor PJ. Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story. Brain 2011; 134: 2025-2035.
  • Irish M, Hornberger M, Lah S, Miller L, Pengas G, Nestor PJ, Hodges JR, Piguet O. Profiles of recent autobiographical memory retrieval in semantic dementia, behavioural-variant frontotemporal dementia, and Alzheimer's disease. Neuropsychologia 2011; 49: 2694-2702.
  • Diaz-de-Grenu LZ, Acosta-Cabronero J, Pereira JMS, Pengas G, Williams GB, Nestor PJ. MRI detection of tissue pathology beyond atrophy in Alzheimer’s disease: introducing T2-VBM. NeuroImage 2011; 56: 1946-1953.
  • de Rover M, Pironti VA, McCabe JA, Acosta-Cabronero J, Arana FS, Morein-Zamir S, Hodges JR, Robbins TW, Fletcher PC, Nestor PJ,  Sahakian BJ. Hippocampal dysfunction in patients with mild cognitive impairment: a functional neuroimaging study of a visuospatial paired associates learning task. Neuropsychologia 2011; 49: 2060-2070.
  • Malone IB, Ansorge RE, Williams GB, Nestor PJ, Carpenter TA, Fryer TD. Attenuation correction methods suitable for brain imaging with a PET/MRI scanner: A comparison of tissue atlas and template attenuation map approaches. J Nucl Med 2011; 52: 1142-1149.
  • Xiong L, Xuereb JH, Spillantini MG, Patterson K, Hodges JR, Nestor PJ. Clinical comparison of progressive aphasia associated with Alzheimer versus FTD-spectrum pathology. J Neurol Neurosurg Psychiatry 2011; 82: 254-260.
  • Pengas G, Patterson K, Arnold RJ, Bird CM, Burgess N, Nestor PJ. Lost and found: bespoke memory testing for Alzheimer's disease and semantic dementia. J Alzheimers Dis 2010; 21: 1347-1365.
  • Mion M, Patterson K, Acosta-Cabronero J, Pengas G, Izquierdo- Garcia D, Hong YT, Fryer TD, Williams GB, Hodges JR, Nestor PJ. What the left and right anterior fusiform gyri tell us about semantic memory. Brain, 2010; 133: 3256-3268.
  • Acosta-Cabronero J, Williams GB, Pengas G, Nestor PJ. Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease. Brain 2010; 133: 529-539.
  • Pengas G, Hodges JR, Watson P, Nestor PJ. Focal posterior cingulate atrophy in incipient Alzheimer’s disease. Neurobiol Aging2010; 31: 25-33.
  • Hodges JR, Mitchell J, Dawson K, Spillantini MG, Xuereb JH, McMonagle P, Nestor PJ, Patterson K. Semantic dementia: demography, familial factors and survival in a consecutive series of 100 cases. Brain 2010; 133: 300-306.
  • Hornberger M, Piguet O, Graham AJ, Nestor PJ, Hodges JR. How preserved is episodic memory in behavioral variant frontotemporal dementia? Neurology 2010; 74: 472-479.
  • Pereira JM, Xiong L, Acosta-Cabronero J, Pengas G, Williams GB, Nestor PJ. Registration accuracy for VBM studies varies according to region and degenerative disease grouping. NeuroImage 2010; 49: 2205-2215.
  • Pulvermüller F, Pye E, Dine C, Hauk O, Nestor PJ, Patterson K. The word processing deficit in semantic dementia: all categories are equal but some categories are more equal than others. J Cogn Neurosci, 2010; 22: 2027-2041.
  • Butler CR, Bhaduri A, Acosta-Cabronero J, Nestor PJ, Kapur N, Graham KS, Hodges JR, Zeman AZ. Transient epileptic amnesia: regional brain atrophy and its relationship to memory deficits. Brain, 2009; 132: 357-368.
  • Garcin B, Lillo P, Hornberger M, Piguet O, Dawson K, Nestor PJ, Hodges JR. Determinants of survival in behavioral variant frontotemporal dementia. Neurology 2009; 73: 1656-1661.
  •  Kipps CM, Hodges JR, Fryer TD, Nestor PJ. Combined magnetic resonance imaging and positron emission tomography brain imaging in behavioural variant frontotemporal degeneration: refining the clinical phenotype. Brain 2009; 132: 2566-2578.
  • Kipps CM, Nestor PJ, Acosta-Cabronero J, Arnold R, Hodges JR. Understanding social dysfunction in the behavioural variant of frontotemporal dementia: the role of emotion and sarcasm processing. Brain, 2009; 132: 592-603.
  • Mitchell J, Arnold R, Dawson K, Nestor PJ, Hodges JR. Outcome in subgroups of mild cognitive impairment (MCI) is highly predictable using a simple algorithm. J Neurol 2009; 256: 1500-1509.
  • Pengas G, Pereira JMS, Williams GB, Nestor PJ. Comparative reliability of Total Intracranial Volume estimation methods and the influence of atrophy in a longitudinal semantic dementia cohort. J Neuroimaging, 2009, 19: 37-46.
  • Pereira JMS, Williams GB, Acosta-Cabronero J, Pengas G, Spillantini MG, Xuereb JH, Hodges JR, Nestor PJ. Atrophy patterns in histological versus clinical groupings of frontotemporal lobar degeneration. Neurology, 2009; 72: 1653-1660.
  • Shinagawa S, Ikeda M, Nestor PJ, Shigenobu K, Fukuhara R, Nomura M, Hodges JR. Characteristics of abnormal eating behaviours in frontotemporal lobar degeneration: a cross-cultural survey. J Neurol Neurosurg Psychiatry 2009; 80: 1413-1414.
  • Acosta-Cabronero J, Williams GB, Pereira JMS, Pengas G, Nestor PJ. The impact of skull-stripping and radio-frequency bias correction on grey-matter segmentation for voxel-based morphometry. NeuroImage, 2008, 39: 1654-1665.
  • Ahmed S, Mitchell J, Arnold R, Dawson K, Nestor PJ, Hodges JR. Memory Complaints in Mild Cognitive Impairment, Worried Well, and Semantic Dementia Patients. Alzheimer Dis Assoc Disord, 2008, 22: 227-235.
  • Ahmed S, Mitchell J, Arnold R, Nestor PJ, Hodges JR. Predicting Rapid Clinical Progression in Amnestic Mild Cognitive Impairment. Dement Geriatr Cogn Disord, 2008, 25:170-177.
  • Kipps CM, Nestor PJ, Dawson CE, Mitchell J, Hodges JR.
 Measuring Progression in Frontotemporal Dementia: Implications for therapeutic trials. Neurology, 2008, 70: 2046-52.
  • Pereira JMS, Nestor PJ, Williams GB. Impact of inconsistent resolution on VBM studies. NeuroImage, 2008, 40: 1711-7.
  • Alladi S, Xuereb J, Bak T, Nestor P, Knibb J, Patterson K, Hodges JR. Focal cortical presentations of Alzheimer's disease. Brain, 2007, 130: 2636-45.
  • Kipps CM, Nestor PJ, Fryer TD, Hodges JR. Behavioural variant frontotemporal dementia: not all it seems? Neurocase, 2007, 13: 237-47.
  • Nestor PJ, Balan K, Choew HK, Fryer TD, Knibb JA, Xuereb JH, Hodges JR. Nuclear imaging can predict pathological diagnosis in progressive non-fluent aphasia. Neurology,  2007, 68: 238-239.
  • Adlam A-L, Patterson K, Rogers T, Nestor PJ, Salmond C, Acosta-Cabronero J, Hodges JR. Semantic dementia and fluent primary progressive aphasia: two sides of the same coin? Brain,  2006, 129: 3066-3080.
  • Bak TH, Yancopoulou D, Nestor PJ, Xuereb J, Spillantini MG, Pulvermüller F, Hodges JR. Clinical, imaging and pathological correlates of a hereditary deficit in verb and action processing. Brain, 2006, 129: 321-332.
  • Mori T, Ikeda M, Fukuhara R, Nestor PJ, Tanabe H. Correlation of visual hallucinations with occipital rCBF changes by donepezil in DLB. Neurology, 2006, 66:935-937.
  • Mori T, Ikeda M, Fukuhara R, Sugawara Y, Nakata S, Matsumoto N, Nestor PJ, Tanabe H. Regional cerebral blood flow change in a case of Alzheimer's disease with musical hallucinations. Eur Arch Psychiatry Clin Neurosci, 2006, 256: 236-239.
  • Alladi S, Arnold R, Mitchell J, Nestor PJ, Hodges JR. Mild cognitive impairment: applicability of research criteria in a memory clinic and characterisation of cognitive profile. Psychological Medicine2006, 36: 507-15.
  • Nestor PJ, Fryer TD, Hodges JR. Declarative memory impairments in Alzheimer's disease and semantic dementia. NeuroImage2006, 30: 1010-1020.
  • Rahman S, Robbins TW, Hodges JR, Mehta MA, Nestor PJ, Clark L, Sahakian BJ. Methylphenidate ('Ritalin') can ameliorate abnormal risk-taking behavior in the frontal variant of frontotemporal dementia. Neuropsychopharmacology, 2006, 31: 651-658.
  • Williams GB, Nestor PJ and Hodges JR. Neural correlates of semantic and behavioural deficits in frontotemporal dementia. NeuroImage, 2005, 24: 1042-1051.
  • Deakin JB, Rahman S, Nestor PJ, Hodges JR, Sahakian BJ. Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial. Psychopharmacology, 2004, 172: 400-408.
  • Ho AK, Nestor PJ, Williams GB, Bradshaw JL, Sahakian BJ, Robbins TW, Barker RA. Pseudo-neglect in Huntington's disease correlates with decreased angular gyrus density. Neuroreport, 2004, 15:1061-1064.
  • Piguet O, Brooks WS, Halliday GM, Schofield PR, Stanford PM, Kwok JBJ, Spillanini MG, Yancopoulou D, Nestor PJ, Broe GA, Hodges JR. Similar early clinical presentations in familial and non-familial frontotemporal dementia. J Neurol, Neurosurg, Psychiatry 2004, 75: 1743-1745.
  • Ho AK, Manly T, Nestor PJ, Sahakian BJ, Bak TH, Robbins TW, Rosser AE and Barker RA. A case of unilateral neglect in Huntington's disease. Neurocase 2003, 9: 261-273.
  • Nestor PJ, Fryer TD, Ikeda M, Hodges JR. Retrosplenial cortex (BA 29/30) hypometabolism in mild cognitive impairment (prodromal Alzheimer's disease). Eur J Neurosci 2003, 18: 2663-2667.
  • Nestor PJ, Graham NL, Fryer TD, Williams GB, Patterson K and Hodges JR. Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula. Brain 2003, 126: 2406-2418.
  • Nestor PJ, Caine D, Fryer TD, Clarke J, and Hodges JR. The topography of metabolic deficits in posterior cortical atrophy (the visual variant of Alzheimer's disease) with FDG-PET. J Neurol, Neurosurg, Psychiatry 2003, 74: 1521-1529.
  • Nestor PJ, Fryer TD, Smielewski P, and Hodges JR. Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment. Annals of Neurology 2003, 54: 343-351.
  • Nestor PJ, Graham KS, Bozeat S, Simons JS, and Hodges JR. Memory consolidation and the hippocampus: Further evidence from studies of autobiographical memory in semantic dementia and frontal variant frontotemporal dementia. Neuropsychologia 2002, 40: 633-654.
  • Mathuranath PS, Nestor PJ, Berrios GE, Rakowicz W, Hodges JR. A brief cognitive test battery to differentiate Alzheimer's disease and frontotemporal dementia. Neurology 2000, 55(11): 1613-20.
  • Dartnell JGA, Anderson RP, Chohan V, Galbraith KJ, Lyon MEH, Nestor PJ, Moulds RFW. Hospitalisation for adverse events related to drug therapy: incidence, avoidability and costs. Medical Journal of Australia 1996; 164: 659-662.
  • Nestor P, Dennett X, Day B. Proximal myotonic myopathy: a report of a kindred. Journal of Clinical Neuroscience 1998, 5(2): 218-220.
  • Nestor PJ, Stark RJ. Vitamin B12 myeloneuropathy precipitated by nitrous oxide anaesthesia. Medical Journal of Australia 1996; 165: 174.

Reveiws, chapters and commentary

  • Nestor PJ. Frontotemporal Dementia. In: Dementia 5th Ed. eds: Ames D, O’Brien JT, Burns A. CRC Press, In press.
  • Sajjadi SA and Nestor PJ. Bedside assessment of cognition. In: Oxford Textbook of Cognitive Neurology and Dementia. eds. Husain M and Schott JM. OUP, Oxford 2016.
  • Acosta-Cabronero J and Nestor PJ. Diffusion tensor imaging in Alzheimer's disease: insights into the limbic-diencephalic network and methodological considerations. Front Aging Neurosci. 2014, 2; 6: 266. doi: 10.3389/fnagi.2014.00266.
  • Nestor PJ. Degenerator tau/TDP43: rise of the machines (editorial). J Neurol Neurosurg Psychiatry, 2013; 84: 945.
  • Nestor PJ. Dementia in Lewy body syndromes—a battle between hearts and minds (editorial). Neurology 2010, 74: 872-873.
  • Nestor P and Hodges JR. Disturbances of higher cerebral function. In: The Oxford textbook of medicine 5th Ed. eds. Warrell DA, Cox TM, Firth JD. OUP, Oxford 2010.
  • Patterson K, Nestor PJ, Rogers TT. Where do you know what you know? The representation of semantic knowledge in the human brain. Nat Rev Neurosci 2007, 8: 976-87.
  • Nestor PJ. Dopamine transporter brain imaging - can it improve the differential diagnosis of dementia with Lewy bodies? Nature Clinical Practice Neurology 2007, 3: 602-603.
  • Nestor PJ. The Lewy body, the hallucination, the atrophy and the physiology. Brain 2007, 130: e81.
  • Nestor PJ. Neuroimaging and other investigative findings. In: Frontotemporal Dementia Syndromes ed: Hodges JR, Cambridge University Press, 2007.
  • Nestor PJ. Don't forget cortical Lewy bodies. Journal of Clinical Neuroscience 2007; 14: 296.
  • Nestor PJ and Hodges JR. Limbic metabolic changes in Alzheimer’s disease. In: Research progress in Alzheimer’s disease ed: Miao-Kun Sun. Nova science publishers, Inc. 2006.
  • Nestor PJ. Disorders of memory. In: Neurology:  Basic and Clinical Neurosciences ed: Schapira, AHV. Mosby, Inc., New York,  2007.
  • Nestor PJ, Scheltens P and Hodges JR. Advances in the early detection of Alzheimer’s disease. Nature Medicine. 2004; 10: S34-41.
  • Self-Assessment Colour Review of Clinical Neurology and Neurosurgery eds: Kitchen ND, Manji H, McKhann, GM. Manson Publishing Ltd, 2003.
  • Thompson SA, Nestor PJ and Hodges JR. Advances in early diagnosis and differentiation of the dementias. In: Disorders of brain and mind II eds. Ron MA and Robbins TW. CUP, Cambridge 2003.
  • Nestor P and Hodges J. New concepts in Alzheimer's disease research. Advances in Clinical Neuroscience and Rehabilitation  2001, 1(3): 8-10.
  • Nestor P and Hodges JR. Disturbances of higher cerebral function. In: The Oxford textbook of medicine 4th Ed. eds. Warrell DA, Cox TM, Firth JD and Benz EJ. OUP, Oxford 2003.
  • Nestor P and Hodges J. The clinical approach to assessing patients with early-onset dementia. In: Early-onset dementia: a multidisciplinary approach. ed. Hodges JR. OUP, Oxford 2001.
  • Nestor P and Hodges J. Non-Alzheimer dementias. In: Seminars in Neurology ed. H. Branch Coslett. 2000, 20(4) 439-446.
  • Nestor PJ and Hodges JR. Cognitive testing. Medicine 2000, 28(4): 37-40.

The Cognitive Neurology Group (Professor Peter Nestor) at the Queensland Brain Institute (QBI) conducts research on improving early detection and accurate diagnosis for different types of dementia.

Part of this involves developing better tests of memory, language and thinking abilities. In order to develop new tests and interpret performance of people with dementia, we also need the help of healthy people. This is where we need your help!

YOU NEED TO

  • Be over the age of 50 years.
  • Have English as your first language.
  • Be in reasonably good health with no previous history of significant brain diseases.
  • Be available for three hours (maximum) to attend an appointment at the QBI, UQ (St Lucia).

WHERE

Queensland Brain Institute (Building #79), The University of Queensland, St Lucia Qld.

YOUR COMMITMENT

You will be asked to complete a series of pen-and-paper and computerised tests that are designed to assess mental abilities, such as memory, thinking, language and how our eyes scan the world.

WILL I GET PAID?

There is no payment for participating.

INTERESTED?

If you meet the requirements and are interested in participating, or you would like further information, please email Dr Soo Lee (nestor.research@uq.edu.au), phone (07) 3443 2615, or visit the Nestor Lab website.

Research Areas

  • Dementia
  • Neurodegeneration
  • Neuropsychology
  • Neuroimaging
  • Alzheimer's disease
  • Frontotemporal Lobar Degeneration

Our team

Group Leader

Research Members

Students

Support Staff