Cognitive neurology

About

Professor Nestor is a clinician-scientist and joined the Queensland Brain Institute in October/2017. He also has a conjoint appointment at Mater Misericordiae Ltd (Mater Hospital).

He aims to relate the neuropsychological and behavioural profiles of degenerative dementias, such as Alzheimer's disease and frontotemporal dementia, to regional brain damage through neuroimaging (MRI and PET) and histopathological analysis. His particular interest is the pathological landscape of incipient dementia (so-called mild cognitive impairment).

By studying patients in this category he hopes to develop a greater understanding of the regions of highest vulnerability to neurodegeneration in different pathologies. Identification of such regions may potentially lead to a better understanding of what makes these regions vulnerable in the first place. His research ultimately aims to improve diagnostic certainty and prognostic markers of decline - both of which are relevant to therapeutic development.

To this end, a major focus of his is on developing novel approaches to MR imaging for single subject pathological diagnoses that can be exported into the everyday clinical setting; this has included to date diffusion imaging (Sajjadi et al, 2013) and quantitative susceptibility mapping (Acosta-Cabornero et al, 2013).

Patient Referrals

Professor Nestor’s memory clinic is located at Mater Public Hospital, South Brisbane. Specialists wishing to refer patients to this service should send the referral to Mater Memory Clinic, details of which can be found by clicking here.

Contact

  +61 7 344 32505

   nestor.research@uq.edu.au


Group Publications

Research Areas

  • Dementia
  • Neurodegeneration
  • Neuropsychology
  • Neuroimaging
  • Alzheimer's disease
  • Frontotemporal Lobar Degeneration

Group Leader

Research Members

  • Dr Soo Lee

    Dr Soo Lee

    Clinical Research Coordinator
    Queensland Brain Institute

Support Staff

MRI Bio-Marker Study

Data Collection: 2019 – 2024

Currently, magnetic resonance imaging (MRI) scans used in standard medical practice often offer only limited information for the diagnosis of different forms of degenerative brain diseases. The overall aim of this study is to improve the ability of MRI to make disease-specific diagnoses of the major neurodegenerative disease patients (eg., Alzheimer’s Disease, frontotemporal dementias, Parkinson’s Disease, amyotrophic lateral sclerosis and related disorders) using advanced MRI methods. In addition to improved diagnosis, it is hoped that these new MRI methods may also offer new insights into how these diseases affect the brain and, therefore, potentially identify new targets for treatment.