Blood clues tell of gene targets for brain diseases

12 Jun 2018



Blood clues tell of gene targets for brain diseases

Our blood can be used to uncover genetic secrets inside the brain, according to new research by Professor Jian Yang from UQ’s Institute for Molecular Bioscience (IMB) and QBI, and Dr Ting Qi  from IMB.

They led a team who discovered blood samples can be used to identify gene targets for brain-related traits such as IQ and diseases such as schizophrenia.

Professor Yang said this discovery will open up new avenues of research and improve our ability to unravel the complexity of brain disease.   

“Identifying gene targets for brain diseases is an essential part of understanding disease risk and developing treatment and prevention strategies,” he said.

“But the effects of individual genes on brain traits are often very small, meaning we require large numbers of samples to find the gene targets, and there are only a few hundred brain samples available in most databases.”

“We wondered whether we could overcome this issue by using blood samples, which are much easier to give and therefore number in tens of thousands, to identify gene targets for brain-related complex traits and diseases.”

Professor Yang, Dr Qi and the team found that the local genetic controls of gene expression in brain are very similar to those in blood.

This discovery provides strong justification for using genetic data from blood samples as a proxy for those in the brain to boost the power of research studies to identify the genes involved in brain traits and disorders, Dr Qi said.

“Using blood data enabled us to find 97 genes associated with IQ, schizophrenia, years of education and cigarette smoking, compared to 61 using brain data alone,” he said

Professor Yang last year won the Frank Fenner Prize for Life Scientist of the Year at the Prime Minister’s Prizes for Science, and this year alone has made several significant discoveries, including on using genetic data to identify modifiable disease risk factors, pinpointing the genes and epigenetic factors linked to specific diseases, natural selection and evolution.

The study was published overnight in international scientific journal Nature Communications, and was funded by the Australian Research Council, the Australian National Health and Medical Research Council, the US National Institutes of Health and the Sylvia & Charles Viertel Charitable Foundation.