Group leader
Professor Victor Anggono
QBI Director of Research
Affiliate of the Clem Jones Centre for Ageing Dementia Research
Affiliate of Centre for RNA in Neuroscience
ARC Professorial Future Fellow
+61 7 334 66390
Victor Anggono
v.anggono@uq.edu.au
Our research
The brain’s capacity for learning and memory relies on the precise, activity-dependent modulation of synaptic strength within highly interconnected neural circuits. This process, synaptic plasticity, is governed by tightly regulated molecular and cellular mechanisms that control how neurons respond to and encode experience.
Our focus:
Neuronal membrane trafficking: including pre- and post-synaptic pathways that regulate delivery, recycling, localisation of key synaptic proteins
Epitranscriptomic regulation: how RNA modifications shape activity-dependent gene expression during synaptic plasticity, learning, and memory
Synaptic signalling pathways: protein–protein interactions and post-translational modifications of critical synaptic molecules
Our approach
Our research combines biochemical, molecular, and cellular biology approaches across multiple experimental systems, including primary neuron cultures, cell lines, and mouse models.
We utilise a range of advanced technologies, including:
- Gene editing techniques
- Cutting-edge microscopy
- Proteomics
- Next-generation sequencing
- Behavioural analyses
This multidisciplinary approach allows us to dissect complex neuronal signalling cascades and understand how molecular changes translate into synaptic function, behaviour, and disease. Our goal is to determine how disruptions in these processes contribute to neurological disorders and neurodegenerative diseases, and to identify potential new targets for therapeutic intervention.
Latest news
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QBI researchers secure $3.2 million NHMRC funding
18 December 2023
Our approach
Our research combines biochemical, molecular and cellular biology in both cell culture (primary neurons and cell lines) and mouse models. We utilise gene editing technology, cutting-edge microscopy, proteomics, next-generation sequencing and behavioural analyses in our study. We are particularly interested in understanding the complex neuronal signalling cascades through protein-protein interactions and post-translational modifications of key synaptic molecules.
Research areas
- Neuronal trafficking
- Neuroepigenetics
- Neurodegenerative diseases