Synaptic neurobiology

About

Billions of neurons in the human brain are organised into highly interconnected neural circuits for efficient processing of sensory information. Communication between nerve cells depends on transmission of chemical signals, which occurs at specialised structures called synapses. The ability of neurons to modulate the strength of their synaptic connections, known as synaptic plasticity, forms the cellular basis of learning and memory. How neurons dynamically modulate their synaptic strength is one of the outstanding and most fascinating questions in modern neuroscience.

The Anggono Lab are studying molecular mechanisms that regulate the trafficking of presynaptic vesicles and postsynaptic glutamate receptors in neurons, as well as the mechanisms underlying activity-dependent gene transcriptions during synaptic plasticity, learning and memory. Ultimately, we aim to understand how dysregulation of these cellular processes contributes to neurological disorders and neurodegenerative diseases. 

Group Publications

Research Areas

  • Neuronal trafficking
  • Neuroepigenetics
  • Glutamate receptors
  • Synaptic vesicle recycling
  • Endosomal sorting
  • Neurodegenerative diseases


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Group Leader

  • Dr Victor Anggono

    Group Leader in Dementia Reseach
    Clem Jones Centre for Ageing Dementia Research

Research Members


Students

Research Articles

Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic

Bademosi, Adekunle T. , Steeves, James, Karunanithi, Shanker, Zalucki, Oressia H, Gormal, Rachel S, Liu, Shu, Lauwers, Elsa, Verstreken, Patrik, Anggono, Victor, Meunier, Frederic A and van Swinderen, Bruno (2018) Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic. Cell reports22 2: 427-440. doi:10.1016/j.celrep.2017.12.054

The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons

Tan, Men C., Widagdo, Jocelyn, Chau, Yu Q., Zhu, Tianyi, Wong, Justin J.-L, Cheung, Allen and Anggono, Victor (2017) The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons. Frontiers in Cellular Neuroscience11 124.1-124.12. doi:10.3389/fncel.2017.00124

GluA1 subunit ubiquitination mediates amyloid-beta-induced loss of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

Guntupalli, Sumasri, Jang, Se Eun, Zhu, Tianyi, Huganir, Richard L., Widagdo, Jocelyn and Anggono, Victor (2017) GluA1 subunit ubiquitination mediates amyloid-beta-induced loss of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.Journal of Biological Chemistry292 20: 8186-8194. doi:10.1074/jbc.M116.774554

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex

Clairfeuille, Thomas, Mas, Caroline, Chan, Audrey S. M., Yang, Zhe, Tello-Lafoz, Maria, Chandra, Mintu, Wigagdo, Jocelyn, Kerr, Markus, Blessy, Paul, Merida, Isabel, Teasdale, Rohan D., Pavlos, Nathan J., Anggono, Victor and Collins, Brett (2016) A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex. Nature Structural and Molecular Biology23 10: 921-932. doi:10.1038/nsmb.3290

Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice

Widagdo, Jocelyn, Zhao, Qiong-Yi, Kempen, Marie-Jeanne, Tan, Men Chee, Ratnu, Vikram S., Wei, Wei, Leighton, Laura, Spadaro, Paola A., Edson, Janette, Anggono, Victor and Bredy, Timothy W. (2016) Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice. Journal of Neuroscience3625: 6771-6777. doi:10.1523/JNEUROSCI.4053-15.2016

Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation

Widagdo, Jocelyn, Chai, Ye Jin, Ridder, Margreet C, Chau, Yu Qian, Johnson, Richard C, Sah, Pankaj, Huganir, Richard L and Anggono, Victor (2015) Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation. Cell Reports,10 5: 783-795. doi:10.1016/j.celrep.2015.01.015

PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression

Anggono, Victor, Koc-Schmitz, Yeliz, Widagdo, Jocelyn, Kormann, Jan, Quan, Annie, Chen, Chih-Ming, Robinson, Phillip J., Choi, Se-Young, Linden, David J., Plomann, Markus and Huganir, Richard L. (2013) PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proceedings of the National Academy of Sciences of the United States of America110 34: 13976-13981. doi:10.1073/pnas.1312467110

Regulation of AMPA receptor function by the human memory-associated gene KIBRA

Makuch, Lauren, Volk, Lenora, Anggono, Victor, Johnson, Richard C., Yu, Yilin, Duning, Kerstin, Kremerskothen, Joachim, Xia, Jun, Takamiya, Kogo and Huganir, Richard L. (2011) Regulation of AMPA receptor function by the human memory-associated gene KIBRA.Neuron71 6: 1022-1029. doi:10.1016/j.neuron.2011.08.017

PICK1 Loss of Function Occludes Homeostatic Synaptic Scaling

Anggono, Victor, Clem, Roger L. and Huganir, Richard L. (2011) PICK1 Loss of Function Occludes Homeostatic Synaptic Scaling. Journal of Neuroscience31 6: 2188-2196. doi:10.1523/JNEUROSCI.5633-10.2011

Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis

Anggono, V, Smillie, KJ, Graham, ME, Valova, VA, Cousin, MA and Robinson, PJ (2006) Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Nature Neuroscience9 6: 752-760. doi:10.1038/nn1695

Review Articles

The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity

Widagdo, Jocelyn and Anggono, Victor (2018) The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity. Journal of Neurochemistry, . doi:10.1111/jnc.14481

Regulation of AMPA receptor trafficking by protein ubiquitination

Widagdo, Jocelyn, Guntupalli, Sumasri, Jang, Se E. and Anggono, Victor (2017) Regulation of AMPA receptor trafficking by protein ubiquitination. Frontiers in Molecular Neuroscience,10 . doi:10.3389/fnmol.2017.00347

Amyloid-β-induced dysregulation of AMPA receptor trafficking

Guntupalli, Sumasri, Widagdo, Jocelyn and Anggono, Victor (2016) Amyloid-β-induced dysregulation of AMPA receptor trafficking. Neural Plasticity2016 1-12. doi:10.1155/2016/3204519

Regulation of AMPA receptor trafficking and synaptic plasticity

Anggono, Victor and Huganir, Richard L. (2012) Regulation of AMPA receptor trafficking and synaptic plasticity. Current Opinion in Neurobiology22 3: 461-469. doi:10.1016/j.conb.2011.12.006

Dr Victor Anggono

  • Young Scientist Award, The Federation of Asian and Oceanian Biochemists and Molecular Biologists (2015) 
  • Science to Art Award, NHMRC (2015)
  • Boomerang Award, Australian Society for Biochemistry and Molecular Biology (2011)

Dr Iris Wang

  • ARC Discovery Early Career Researcher Award (2017-2019)
  • JG Russell Award, Australian Academy of Science (2017)
  • Best Paper Award, Clem Jones Centre for Ageing Dementia Research (2016)
  • University of Queensland Postdoctoral Research Fellowship (2013-2015)

Dr Jocelyn Widagdo

  • ARC Discovery Early Career Researcher Award (2017-2019)
  • Young Investigator Travel Grant, International Society for Neurochemistry (2017)
  • The Ian Potter Foundation Travel Award (2013)
  • The Lorne Genome Travel Grant (2013)


  • Prof. Richard L. Huganir, Johns Hopkins University School of Medicine, Baltimore, USA
  • Prof. Michael A. Cousin, University of Edinburgh, UK
  • A/Prof. Melanie A. Woodin, University of Toronto, Canada
  • Prof. John McGrath, University of Queensland
  • A/Prof. Brett Collins, University of Queensland
  • A/Prof. Bruno van Swinderen, University of Queensland
  • A/Prof. Thomas Fath, University of New South Wales

 

 

 

 

 

 

 

 

 


Project 1: Regulation of postsynaptic glutamate receptor dynamics by intracellular scaffolding and signalling molecules.

Project 2: Mechanisms underlying dysregulation of postsynaptic glutamate receptor trafficking in neurodegenerative diseases.

Project 3: Regulation of synaptic function by post-translational modifications, including phosphorylation, ubiquitination and palmitoylation.

Project 4: Regulation of presynaptic vesicle recycling by BAR domain-containing proteins.

Project 5: Epitranscriptomic mechanisms of synaptic plasticity, learning and memory.

Project 6: The roles of non-coding RNAs (miRNAs and lncRNAs) in synaptic plasticity, learning and memory.

How to apply