Neuroimmunology and cognition

About

We have recently demonstrated that microglia can exert a dual and opposing influence over adult neurogenesis (the birth of new neurons) in the hippocampus under different physiological conditions, namely exercise and ageing, and that signalling through the chemokine receptor, CX3CR1, critically contributes towards this (Vukovic et al., 2012, J Neurosci). We have also generated novel evidence that ongoing neurogenesis in the adult hippocampus is critical for new learning but does not play a role in memory recall (Vukovic et al., 2013, J Neurosci).

Our goal is now to elucidate exactly how physiological changes associated with exercise, as well as ageing, influence microglial function and adult neurogenesis. The ultimate goal of our work is to link cellular events to altered behaviour, and to harness the regenerative potential of neural stem / progenitor cells to stimulate optimal cognitive function and treat conditions associated with learning and memory deficits such as dementia.

Contact

  +61 (0) 7 336 52818

  j.vukovic@uq.edu.au


Group Publications

Research Areas

  • Adult neurogenesis
  • Microglial function
  • Exercise and ageing


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Group Leader

  • Dr Jana Vukovic

    Research Fellow
    Queensland Brain Institute
    Lecturer in Biomedical Sciences (An
    School of Biomedical Sciences

Members


IVIg attenuates complement and improves spinal cord injury outcomes in mice

Brennan, Faith H., Kurniawan, Nyoman D., Vukovic, Jana, Bartlett, Perry F., Käsermann, Fabian, Arumugam, Thiruman V., Basta, Milan and Ruitenberg, Marc J. (2016) IVIg attenuates complement and improves spinal cord injury outcomes in mice. Annals of Clinical and Translational Neurology3 7: 495-511. doi:10.1002/acn3.318

Blockade of microglial KATP-channel abrogates suppression of inflammatory-mediated inhibition of neural precursor cells

Ortega, Francisco J., Vukovic, Jana, Rodriguez, Manuel J. and Bartlett, Perry F. (2014) Blockade of microglial KATP-channel abrogates suppression of inflammatory-mediated inhibition of neural precursor cells. GLIA62 2: 247-258. doi:10.1002/glia.22603

A novel fluorescent reporter CDy1 enriches for neural stem cells derived from the murine brain

Vukovic, Jana, Bedin, Anne-Sophie, Bartlett, Perry F. and Osborne, Geoffrey W. (2013) A novel fluorescent reporter CDy1 enriches for neural stem cells derived from the murine brain. Stem Cells and Development22 16: 2341-2345. doi:10.1089/scd.2012.0660

Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering

Vukovic, Jana, Borlikova, Gilyana G., Ruitenberg, Marc J., Robinson, Gregory J., Sullivan, Robert K. P., Walker, Tara L. and Bartlett, Perry F. (2013) Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering. Journal of Neuroscience33 15: 6603-6613. doi:10.1523/JNEUROSCI.3064-12.2013

GH mediates exercise-dependent activation of SVZ neural precursor cells in aged mice

Blackmore, Daniel G., Vukovic, Jana, Waters, Michael J. and Bartlett, Perry F. (2012) GH mediates exercise-dependent activation of SVZ neural precursor cells in aged mice. PLoS One7 11: e49912.1-e49912.7. doi:10.1371/journal.pone.0049912

Prolactin stimulates precursor cells in the adult mouse hippocampus

Walker, Tara L., Vukovic, Jana, Koudijs, Margaretha M., Blackmore, Daniel G., Mackay, Eirinn W., Sykes, Alex M., Overall, Rupert W., Hamlin, Adam S. and Bartlett, Perry F. (2012) Prolactin stimulates precursor cells in the adult mouse hippocampus. PLoS One7 9 Article No. e44371: . doi:10.1371/journal.pone.0044371

Microglia modulate hippocampal neural precursor activity in response to exercise and aging

Vukovic, Jana, Colditz, Michael J., Blackmore, Daniel G., Ruitenberg, Marc J. and Bartlett, Perry F. (2012) Microglia modulate hippocampal neural precursor activity in response to exercise and aging. Journal of Neuroscience32 19: 6435-6443. doi:10.1523/JNEUROSCI.5925-11.2012

Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscle

Chai, Ruth Jinfen, Vukovic, Jana, Dunlop, Sarah, Grounds, Miranda D. and Shavlakadze, Thea (2011) Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscle. PLoS One6 12: e28090.1-e28090.11. doi:10.1371/journal.pone.0028090

CX(3)CR1 deficiency exacerbates neuronal loss and impairs early regenerative responses in the target-ablated olfactory epithelium

Blomster, Linda, Vukovic, Jana, Hendrickx, Debbie A.E., Jung, Steffen, Harvey, Alan R., Filgueira, Luis and Ruitenberg, Marc J. (2011) CX(3)CR1 deficiency exacerbates neuronal loss and impairs early regenerative responses in the target-ablated olfactory epithelium. Molecular and Cellular Neuroscience48 3: 236-245. doi:10.1016/j.mcn.2011.08.004

Activation of neural precursors in the adult neurogenic niches

Vukovic, Jana, Blackmore, Daniel, Jhaveri, Dhanisha and Bartlett, Perry F. (2011) Activation of neural precursors in the adult neurogenic niches. Neurochemistry International59 3: 341-346. doi:10.1016/j.neuint.2011.04.003

Bone marrow chimeric mice reveal a role for CX3CR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium

Vukovic, J, Blomster, LV, Chinnery, HR, Weninger, W, Jung, S, McMenamin, PG and Ruitenberg, MJ (2010) Bone marrow chimeric mice reveal a role for CX3CR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium. Journal of Leukocyte Biology88 4: 645-654. doi:10.1189/jlb.0410194

Lack of fibulin-3 alters regenerative tissue responses in the primary olfactory pathway

Vukovic, Jana, Marmorstein, Lihua Y., McLaughlin, Precious J., Sasaki, Takako, Plant, Giles W., Harvey, Alan R. and Ruitenberg, Marc J. (2009) Lack of fibulin-3 alters regenerative tissue responses in the primary olfactory pathway.Matrix Biology28 7: 406-415. doi:10.1016/j.matbio.2009.06.001

The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheathing cells in vitro

Vukovic, Jana, Ruitenberg, Marc J., Roet, Kasper, Franssen, Elske, Arulpragasam, Ajanthy, Sasaki, Takako, Verhaagen, Joost, Harvey, Alan R., Busfield, Samantha J. and Plant, Giles W. (2009) The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheathing cells in vitro. Glia57 4: 424-443. doi:10.1002/glia.20771

CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium

Ruitenberg, Marc J., Vukovic, Jana, Blomster, Linda, Hall, Jarrad M, Jung, Steffen, Filgueira, Luis, McMenamin, Paul G. and Plant, Giles W. (2008) CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium. Journal of Neuroimmunology205 1-2: 80-85. doi:10.1016/j.jneuroim.2008.09.010

Promoting central nervous system regeneration: Lessons from cranial nerve I

Ruitenberg, Marc J. and Vukovic, Jana (2008) Promoting central nervous system regeneration: Lessons from cranial nerve I. Restorative Neurology and Neuroscience26 2-3: 183-196.

Influence of adult Schwann cells and olfactory ensheathing glia on axontarget cell interactions in the CNS a comparative analysis using a retinotectal cograft model

Vukovic, Jana, Plant, Giles W., Ruitenberg, Marc J. and Harvey, Alan R. (2007) Influence of adult Schwann cells and olfactory ensheathing glia on axontarget cell interactions in the CNS a comparative analysis using a retinotectal cograft model. Neuron Glia Biology3 2: 105-117. doi:10.1017/S1740925X07000671

Olfactory ensheathing cells: Characteristics, genetic engineering, and therapeutic potential

Ruitenberg, Marc J., Vukovic, Jana, Sarich, Julijana, Busfield, Samantha J. and Plant, Giles W. (2006) Olfactory ensheathing cells: Characteristics, genetic engineering, and therapeutic potential. Journal of Neurotrauma23 3-4: 468-478. doi:10.1089/neu.2006.23.468

Jana Vukovic is a neuroimmunologist who studies neurogenesis

Jana Vukovic: Neuroimmunology and adult neurogenesis

Neuroimmunologist Dr Jana Vukovic on her career