Professor Helen Cooper
Interim Director, Queensland Brain Institute
Queensland Brain Institute
+61 7 334 66354
Professor Helen Cooper: Neural migration
Current research in the Cooper laboratory explores the fundamental cellular and molecular mechanisms governing the development of the neocortex. The group has identified unexpected, novel roles for the axon guidance receptors Neogenin (a netrin receptor) and Ryk (a Wnt receptor) in neural stem cell biology, neurogenesis, dendrite outgrowth and synaptogenesis. The Cooper group has shown that loss of these receptors in the mouse leads to cortical malformations which are equivalent to those seen in humans.
Researcher biography
Helen obtained her PhD in the Department of Biochemistry and Molecular Biology at the University of Melbourne. She completed her postdoctoral fellowship at the Scripps Research Institute (San Diego) before being recruited to the Ludwig Institute for Cancer Research (Melbourne) and then the Walter and Eliza Hall Institute to establish her own laboratory. In 2003 she joined The University of Queensland as an inaugural Group Leader and Head of the Neural Migration Laboratory at the Queensland Brain Institute. Her research explores the fundamental cellular and molecular mechanisms governing the development of the neocortex.
Book Chapter
Cooper, Helen M. and Paterson, Yvonne (2008). Production of polyclonal antisera. Current protocols in molecular biology. (pp. 11.12.1-11.12.10) edited by Frederick M. Ausubel, Roger Brent, Robert E. Kingston, David D. Moore, J. G. Seidman and Kevin Struhl. New York, U.S.: John Wiley. doi: 10.1002/0471142727.mb1112s81
Journal Articles
Shohayeb, Belal, Sempert, Kai, Wallis, Tristan P., Meunier, Frédéric A., Durisic, Nela, O'Brien, Elizabeth A., Flores, Cecilia and Cooper, Helen M. (2024). BDNF-dependent nano-organization of Neogenin and the WAVE regulatory complex promotes actin remodeling in dendritic spines. iScience, 27 (9) 110621, 110621. doi: 10.1016/j.isci.2024.110621
Sempert, Kai, Shohayeb, Belal, Lanoue, Vanessa, O’Brien, Elizabeth A., Flores, Cecilia and Cooper, Helen M. (2023). RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling. Frontiers in Molecular Neuroscience, 16 1253801. doi: 10.3389/fnmol.2023.1253801
Martin, Sally, Poppe, Daniel, Olova, Nelly, O’Leary, Conor, Ivanova, Elena, Pflueger, Jahnvi, Dechka, Jennifer, Simmons, Rebecca K., Cooper, Helen M., Reik, Wolf, Lister, Ryan and Wolvetang, Ernst J. (2023). Embryonic stem cell-derived neurons as a model system for epigenome maturation during development. Genes, 14 (5) 957. doi: 10.3390/genes14050957
Shohayeb, Belal and Cooper, Helen M. (2023). The ups and downs of Pax6 in neural stem cells. Journal of Biological Chemistry, 299 (5) 104680, 104680. doi: 10.1016/j.jbc.2023.104680
Harkins, Danyon, Harvey, Tracey J., Atterton, Cooper, Miller, Ingrid, Currey, Laura, Oishi, Sabrina, Kasherman, Maria, Davila, Raul Ayala, Harris, Lucy, Green, Kathryn, Piper, Hannah, Parton, Robert G., Thor, Stefan, Cooper, Helen M. and Piper, Michael (2022). Hydrocephalus in Nfix−/− mice is underpinned by changes in ependymal cell physiology. Cells, 11 (15) 2377, 1-27. doi: 10.3390/cells11152377
Chau, Tevin CY., Baek, Sungmin, Coxam, Baptiste, Skoczylas, Renae, Rondon‐Galeano, Maria, Bower, Neil I., Wainwright, Elanor N., Stacker, Steven A., Cooper, Helen M., Koopman, Peter A., Lagendijk, Anne K., Harvey, Natasha L., François, Mathias and Hogan, Benjamin M. (2021). Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice. Developmental Dynamics, 251 (2) dvdy.390, 336-349. doi: 10.1002/dvdy.390
Shohayeb, Belal, Muzar, Zukhrofi and Cooper, Helen M. (2021). Conservation of neural progenitor identity and the emergence of neocortical neuronal diversity. Seminars in Cell and Developmental Biology, 118, 4-13. doi: 10.1016/j.semcdb.2021.05.024
Morcom, Laura, Gobius, Ilan, Marsh, Ashley P. L., Suárez, Rodrigo, Lim, Jonathan W. C., Bridges, Caitlin, Ye, Yunan, Fenlon, Laura R., Zagar, Yvrick, Douglass, Amelia M., Donahoo, Amber-Lee, Fothergill, Thomas, Shaikh, Samreen, Kozulin, Peter, Edwards, Timothy J., Cooper, Helen M., IRC5 Consortium, Sherr, Elliott H., Chédotal, Alain, Leventer, Richard J., Lockhart, Paul J. and Richards, Linda J. (2021). DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. eLife, 10 e61769, 1-35. doi: 10.7554/eLife.61769
Shohayeb, Belal and Cooper, Helen M. (2021). Mosaic synapses in epilepsy. Science, 372 (6539), 235-236. doi: 10.1126/science.abh3555
Cooper, Helen M. and Flores, Cecilia (2021). Mechanisms of cortical development: From the embryo to adulthood. Seminars in Cell and Developmental Biology, 118, 1-3. doi: 10.1016/j.semcdb.2021.08.012
Harkins, Danyon, Cooper, Helen M. and Piper, Michael (2020). The role of lipids in ependymal development and the modulation of adult neural stem cell function during aging and disease. Seminars in Cell and Developmental Biology, 112, 61-68. doi: 10.1016/j.semcdb.2020.07.018
Cuesta, Santiago, Nouel, Dominique, Reynolds, Lauren M., Morgunova, Alice, Torres-Berrío, Angélica, White, Amanda, Hernandez, Giovanni, Cooper, Helen M. and Flores, Cecilia (2020). Dopamine axon targeting in the nucleus accumbens in adolescence requires netrin-1. Frontiers in Cell and Developmental Biology, 8 487, 487. doi: 10.3389/fcell.2020.00487
Tawarayama, Hiroshi, Yamada, Hirohisa, Amin, Ruhul, Morita-Fujimura, Yuiko, Cooper, Helen M, Shinmyo, Yohei, Tanaka, Hideaki and Ikawa, Shuntaro (2020). Draxin-mediated regulation of granule cell progenitor differentiation in the postnatal hippocampal dentate gyrus. Neuroscience, 431, 184-192. doi: 10.1016/j.neuroscience.2020.02.005
Veeraval, Lenin, O’Leary, Conor J. and Cooper, Helen M. (2020). Adherens junctions: guardians of cortical development. Frontiers in Cell and Developmental Biology, 8 6, 6. doi: 10.3389/fcell.2020.00006
Langford, Michael B., O'Leary, Conor J., Veeraval, Lenin, White, Amanda, Lanoue, Vanessa and Cooper, Helen M. (2020). WNT5a regulates epithelial morphogenesis in the developing choroid plexus. Cerebral Cortex, 30 (6), 3617-3631. doi: 10.1093/cercor/bhz330
Chaturvedi, Vishal, Fournier-Level, Alexandre, Cooper, Helen M. and Murray, Michael J. (2019). Loss of Neogenin1 in human colorectal carcinoma cells causes a partial EMT and wound-healing response. Scientific Reports, 9 (1) 4110, 4110. doi: 10.1038/s41598-019-40886-y
Lanoue, Vanessa and Cooper, Helen M. (2019). Branching mechanisms shaping dendrite architecture. Developmental Biology, 451 (1), 16-24. doi: 10.1016/j.ydbio.2018.12.005
Chen, Weiyu, Zuo, Huali, Zhang, Enqi, Li, Li, Henrich-Noack, Petra, Cooper, Helen M., Qian, Yujin and Xu, Zhi Ping (2018). Brain targeting delivery facilitated by ligand-functionalized layered double hydroxide nanoparticles. ACS Applied Materials and Interfaces, 10 (24) acsami.8b04613, 20326-20333. doi: 10.1021/acsami.8b04613
Tawarayama, Hiroshi, Yamada, Hirohisa, Amin, Ruhul, Morita-Fujimura, Yuiko, Cooper, Helen M., Shinmyo, Yohei, Kawata, Masakado, Ikawa, Shuntaro and Tanaka, Hideaki (2018). Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis. Scientific Reports, 8 (1) 840, 1-10. doi: 10.1038/s41598-018-19346-6
Marsh, Ashley P. L., Edwards, Timothy J., Galea, Charles, Cooper, Helen M., Engle, Elizabeth C., Jamuar, Saumya S., Méneret, Aurélie, Moutard, Marie-Laure, Nava, Caroline, Rastetter, Agnès, Robinson, Gail, Rouleau, Guy, Roze, Emmanuel, Smith, Megan, Trouillard, Oriane, Billette de Villemeur, Thierry, Walsh, Christopher A., Yu, Timothy W., IRC5 Consortium, Heron, Delphine, Sherr, Elliott H., Richards, Linda J., Depienne, Christel, Leventer, Richard J. and Lockhart, Paul J. (2017). DCC mutation update: Congenital mirror movements, isolated agenesis of the corpus callosum, and developmental split brain syndrome. Human Mutation, 39 (1), 23-39. doi: 10.1002/humu.23361
Zuo, Huali, Chen, Weiyu, Li, Bei, Xu, Kewei, Cooper, Helen, Gu, Zi and Xu, Zhi Ping (2017). MnAl layered double hydroxide nanoparticles as a dual-functional platform for magnetic resonance imaging and siRNA delivery. Chemistry - A European Journal, 23 (57), 14299-14306. doi: 10.1002/chem.201702835
Lanoue, Vanessa, Langford, Michael, White, Amanda, Sempert, Kai, Fogg, Lily and Cooper, Helen M. (2017). The Wnt receptor Ryk is a negative regulator of mammalian dendrite morphogenesis. Scientific Reports, 7 (1) 5965, 5965.1-5965.11. doi: 10.1038/s41598-017-06140-z
O'Leary, Conor J., Nourse, Cathrin C., Lee, Natalie K., White, Amanda, Langford, Michael, Sempert, Kai, Cole, Stacey J. and Cooper, Helen M. (2017). Neogenin recruitment of the WAVE regulatory complex to ependymal and radial progenitor adherens junctions prevents hydrocephalus. Cell Reports, 20 (2), 370-383. doi: 10.1016/j.celrep.2017.06.051
Zuo, Huali, Chen, Weiyu, Cooper, Helen M. and Xu, Zhi Ping (2017). A facile way of modifying layered double hydroxide nanoparticles with targeting ligand-conjugated albumin for enhanced delivery to brain tumour cells. ACS Applied Materials & Interfaces, 9 (24), 20444-20453. doi: 10.1021/acsami.7b06421
Torres-Berrío, Angélica, Lopez, Juan Pablo, Bagot, Rosemary C., Nouel, Dominique, Dal Bo, Gregory, Cuesta, Santiago, Zhu, Lei, Manitt, Colleen, Eng, Conrad, Cooper, Helen M., Storch, Kai-Florian, Turecki, Gustavo, Nestler, Eric J. and Flores, Cecilia (2017). DCC confers susceptibility to depression-like behaviors in humans and mice and is regulated by miR-218. Biological Psychiatry, 81 (4), 306-315. doi: 10.1016/j.biopsych.2016.08.017
Lee, Natalie K., Fok, Ka Wai, White, Amanda, Wilson, Nicole H., O’Leary, Conor J., Cox, Hayley L., Michael, Magdalene, Yap, Alpha S. and Cooper, Helen M. (2016). Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension. Nature Communications, 7 (11082) 11082, 11082. doi: 10.1038/ncomms11082
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Validating Eaton's hypothesis: cubane as a benzene bioisostere. Angewandte Chemie (International Edition), 55 (11), 3580-3585. doi: 10.1002/anie.201510675
Zuo, Huali, Gu, Zi, Cooper, Helen and Xu, Zhi Ping (2015). Crosslinking to enhance colloidal stability and redispersity of layered double hydroxide nanoparticles. Journal of Colloid and Interface Science, 459, 10-16. doi: 10.1016/j.jcis.2015.07.063
O'Leary, Conor J., Bradford, DanaKai, Chen, Min, White, Amanda, Blackmore, Daniel G. and Cooper, Helen M. (2014). The Netrin/RGM receptor, neogenin, controls adult neurogenesis by promoting neuroblast migration and cell cycle exit. Stem Cells, 33 (2), 503-514. doi: 10.1002/stem.1861
Dong, Haiyan, Chen, Min, Rahman, Shafiur, Parekh, Harendra S., Cooper, Helen M. and Xu, Zhi Ping (2014). Engineering small MgAl-layered double hydroxide nanoparticles for enhanced gene delivery. Applied Clay Science, 100 (C), 66-75. doi: 10.1016/j.clay.2014.04.028
Clark, Charlotte E. J., Liu, Yaobo and Cooper, Helen M. (2014). The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration. Science China Life Sciences, 57 (4), 366-371. doi: 10.1007/s11427-014-4640-3
Chen, Xiang-Jun, Xu, Huan, Cooper, Helen M. and Liu, Yaobo (2014). Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases. Science China Life Sciences, 57 (4), 372-377. doi: 10.1007/s11427-014-4639-9
Clark, Charlotte E. J., Richards, , Linda J., Stacker, Steven A. and Cooper, Helen M. (2014). Wnt5a induces Ryk-dependent and -independent effects on callosal axon and dendrite growth. Growth Factors, 32 (1), 11-17. doi: 10.3109/08977194.2013.875544
Kim, Jee Hyun, Lavan, Doron, Chen, Nicola, Flores, Cecilia, Cooper, Helen and Lawrence, Andrew J. (2013). Netrin-1 receptor-deficient mice show age-specific impairment in drug-induced locomotor hyperactivity but still self-administer methamphetamine. Psychopharmacology, 230 (4), 607-616. doi: 10.1007/s00213-013-3187-5
Manitt C., Eng C., Pokinko M., Ryan R.T., Torres-Berrio A., Lopez J.P., Yogendran S.V., Daubaras M.J.J., Grant A., Schmidt E.R.E., Tronche F., Krimpenfort P., Cooper H.M., Pasterkamp R.J., Kolb B., Turecki G., Wong T.P., Nestler E.J., Giros B. and Flores C. (2013). Dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients. Translational Psychiatry, 3 (12) e105, e338-e338. doi: 10.1038/tp.2013.105
O'Leary, Conor, Cole, Stacey J., Langford, Michael, Hewage, Jayani, White, Amanda and Cooper, Helen M. (2013). RGMa regulates cortical interneuron migration and differentiation. PLoS One, 8 (11) e81711, e81711.1-e81711.12. doi: 10.1371/journal.pone.0081711
Reyes, Stefanie, Fu, Yuhong, Double, Kay L., Cottam, Veronica, Thompson, Lachlan H., Kirik, Deniz, Paxinos, George, Watson, Charles, Cooper, Helen M. and Halliday, Glenda M. (2013). Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease. Neurobiology of Aging, 34 (3), 873-886. doi: 10.1016/j.neurobiolaging.2012.07.019
Kee, Nigel, Wilson, Nicole, Key, Brian and Cooper, Helen (2013). Netrin-1 is required for efficient neural tube closure. Developmental Neurobiology, 73 (2), 176-187. doi: 10.1002/dneu.22051
Zhu, Yian, Li, Zhen, Chen, Min, Cooper, Helen, Lu, Gao Qing (Max) and Xu, Zhi Ping (2013). One-pot preparation of highly fluorescent cadmium telluride/cadmium sulfide quantum dots under neutral-pH condition for biological applications. Journal of Colloid and Interface Science, 390 (1), 3-10. doi: 10.1016/j.jcis.2012.08.003
Chen, Min, Helen Cooper, Zhou, Ji Zhi, Bartlett, Perry F. and Xu, Zhi Ping (2013). Reduction in the size of layered double hydroxide nanoparticles enhances the efficiency of siRNA delivery. Journal of Colloid and Interface Science, 390 (1), 275-281. doi: 10.1016/j.jcis.2012.09.033
Zhu, Yian, Li, Zhen, Chen, Min, Cooper, Helen M. and Xu, Zhi Ping (2013). Tuning core-shell SiO2@CdTe@SiO2 fluorescent nanoparticles for cell labeling. Journal of Materials Chemistry B, 1 (17), 2315-2323. doi: 10.1039/c3tb20202j
Unni, Divya K., Piper, Michael, Moldrich, Randal X., Gobius, Ilan, Liu, Sha, Fothergill, Thomas, Donahoo, Amber-Lee S., Baisden, John M., Cooper, Helen M. and Richards, Linda J. (2012). Multiple Slits regulate the development of midline glial populations and the corpus callosum. Developmental Biology, 365 (1), 36-49. doi: 10.1016/j.ydbio.2012.02.004
Clark, Charlotte E.J., Nourse, C. Cathrin and Cooper, Helen M. (2012). The tangled web of non-canonical Wnt signalling in neural migration. Neurosignals, 20 (3), 202-220. doi: 10.1159/000332153
Mo, Wei-chuan, Liu, Ying, Cooper, Helen M. and He, Rong-qiao (2012). Altered development of Xenopus embryos in a hypogeomagnetic field. Bioelectromagnetics, 33 (3), 238-246. doi: 10.1002/bem.20699
Wong, Yunyi, Cooper, Helen M., Zhang, Kai, Chen, Min, Bartlett, Perry and Xu, Zhi Ping (2012). Efficiency of layered double hydroxide nanoparticle-mediated delivery of siRNA is determined by nucleotide sequence. Journal of Colloid and Interface Science, 369 (1), 453-459. doi: 10.1016/j.jcis.2011.12.046
Zhu, Yian, Li, Zhen, Chen, Min, Cooper, Helen M., Lu, Gao Qing (Max) and Xu, Zhi Ping (2012). Synthesis of robust sandwich-like SiO2@CdTe@SiO2 fluorescent nanoparticles for cellular imaging. Chemistry of Materials, 24 (3), 421-423. doi: 10.1021/cm2033417
Chawengsaksophak, Kallayanee, Svingen, Terje, Ng, Ee Ting, Epp, Trevor, Spiller, Cassy M., Clark, Charlotte, Cooper, Helen and Koopman, Peter (2012). Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice. Biology of Reproduction, 86 (1) 4, 1-12. doi: 10.1095/biolreprod.111.095232
Beatus, Paul, Jhaveri, Dhanisha J., Walker, Tara L., Lucas, Peter G., Rietze, Rodney L., Cooper, Helen M., Morikawa, Yoshihiro and Bartlett, Perry F. (2011). Oncostatin M regulates neural precursor activity in the adult brain. Developmental Neurobiology, 71 (7), 619-633. doi: 10.1002/dneu.20871
Manitt, Colleen, Mimee, Andrea, Eng, Conrad, Pokinko, Matthew, Stroh, Thomas, Cooper, Helen M., Kolb, Bryan and Flores, Cecilia (2011). The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry. The Journal of Neuroscience, 31 (23), 8381-8394. doi: 10.1523/JNEUROSCI.0606-11.2011
Dave, Richa K., Ellis, Tammy, Toumpas, Melissa C., Robson, Jonathan P., Julian, Elaine, Adolphe, Christelle, Bartlett, Perry F., Cooper, Helen M., Reynolds, Brent A. and Wainwright, Brandon J. (2011). Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. PLoS One, 6 (2) e14680, e14680-1-e14680-13. doi: 10.1371/journal.pone.0014680
Wong, Yunyi, Markham, Kathryn, Xu, Zhi Ping, Chen, Min, Liu, Gao Qing (Max), Bartlett, Perry F. and Cooper, Helen M. (2010). Efficient delivery of siRNA to cortical neurons using layered double hydroxide nanoparticles. Biomaterials, 31 (33), 8770-8779. doi: 10.1016/j.biomaterials.2010.07.077
Bradford, D., Faull, R. L. M., Curtis, M. A. and Cooper, H. M. (2010). Characterization of the netrin/RGMa receptor neogenin in neurogenic regions of the mouse and human adult forebrain. Journal of Comparative Neurology, 518 (16), 3237-3253. doi: 10.1002/cne.22397
Chen, Apj, Muller, CC, Cooper, HM and Williams, CM (2010). Synthetic neovibsanes and their ability to induce neuronal differentiation in PC12 cells. Tetrahedron, 66 (34), 6842-6850. doi: 10.1016/j.tet.2010.06.056
Chen, Annette P. -J., Müller, C. Catharina, Cooper, Helen M. and Williams, Craig M. (2009). Total synthesis of (+/-)-4,5-Bis-epi-neovibsanin A and B: A neurite outgrowth comparison study. Organic Letters, 11 (16), 3758-3761. doi: 10.1021/ol901406j
Bradford, Dana, Cole, Stacey and Cooper, Helen M. (2009). Netrin-1: Diversity in development. International Journal of Biochemistry & Cell Biology, 41 (3), 487-493. doi: 10.1016/j.biocel.2008.03.014
Kee, Nigel, Wilson, Nicole, De Vries, Melissa, Bradford, DanaKai, Key, Brian and Cooper, Helen M. (2008). Neogenin and RGMa control neural tube closure and neuroepithelial morphology by regulating cell polarity. The Journal of Neuroscience, 28 (48), 12643-12653. doi: 10.1523/JNEUROSCI.4265-08.2008
Xu, Zhi Ping, Niebert, Marcus, Porazik, Katharina, Walker, Tara L., Cooper, Helen M., Middelberg, Anton P.J., Gray, Peter P., Bartlett, Perry F. and Lu, Gao Qing (Max) (2008). Subcellular compartment targeting of layered double hydroxide nanoparticles. Journal of Controlled Release, 130 (1), 86-94. doi: 10.1016/j.jconrel.2008.05.021
de Vries, Melissa and Cooper, Helen M. (2008). Emerging roles for neogenin and its ligands in CNS development. Journal Of Neurochemistry, 106 (4), 1483-1492. doi: 10.1111/j.1471-4159.2008.05485.x
Cooper, Helen M and Paterson, Yvonne (2008). Production of polyclonal antisera. Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.], Appendix 3 (SUPPL. 43). doi: 10.1002/0471142956.cya03is43
Cooper, Helen M and Paterson, Yvonne (2008). Production of polyclonal antisera. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.], Chapter 11
Fitzgerald, D. P., Bradford, D. and Cooper, H. M. (2007). Neogenin is expressed on neurogenic and gliogenic progenitors in the embryonic and adult central nervous system. Gene Expression Patterns, 7 (7), 784-792. doi: 10.1016/j.modgep.2007.05.004
Xu, Zhi Ping, Walker, Tara L., Liu, Kerh-lin, Cooper, Helen M., Lu, G. Q. Max and Bartlett, Perry F. (2007). Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA. International Journal of Nanomedicine, 2 (2), 163-174. doi: 10.2147/IJN.S
Cole, S. J., Bradford, D. and Cooper, H. M. (2007). Neogenin: A multi-functional receptor regulating diverse developmental processes. The International Journal of Biochemistry & Cell Biology, 39 (9), 1569-1575. doi: 10.1016/j.biocel.2006.11.009
Xu, Zhi Ping, Walker, Tara L., Liu, Kerh-lin, Cooper, Helen M., Lu, G. Q. Max and Bartlett, Perry F. (2007). Layered double hydroxide nanoparticles as cellular delivery vectors of supercoiled plasmid DNA. International Journal of Nanomedicine, 2 (2), 163-74.
Fitzgerald, D. P., Cole, S. J., Hammond, A., Seaman, C. and Cooper, H. M. (2006). Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain. Neuroscience, 142 (3), 703-716. doi: 10.1016/j.neuroscience.2006.06.041
Keeble, T. R., Halford, M., Seaman, C., Kee, N., Macheda, M., Andersen, R. B., Stacker, S. A. and Cooper, H. M. (2006). The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. Journal of Neuroscience, 26 (21), 5840-5848. doi: 10.1523/JNEUROSCI.1175-06.2006
Fitzgerald, D. P., Seaman, C. and Cooper, H. M. (2006). Localization of neogenin protein during morphogenesis in the mouse embryo. Developmental Dynamics, 235 (6), 1720-1725. doi: 10.1002/dvdy.20744
Emery, B., Cate, H. S., Marriottt, M., Merson, T., Binder, M. D., Snell, C., Soo, P. Y., Murray, S., Croker, B., Zhang, J. G., Alexander, W. S., Cooper, H., Butzkueven, H. and Kilpatrick, T. J. (2006). Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination. Proceedings of The National Academy of Sciences of The United States of America, 103 (20), 7859-7864. doi: 10.1073/pnas.0602574103
Keeble, T. R. and Cooper, H. M. (2006). Ryk: A novel Wnt receptor regulating axon pathfinding. International Journal of Biochemistry & Cell Biology, 38 (12), 2011-2017. doi: 10.1016/j.biocel.2006.07.005
Osborne, P. B., Halliday, G. M., Cooper, H. M. and Keast, J. R. (2005). Localization of immunoreactivity for deleted in colorectal cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents. Neuroscience, 131 (3), 671-681. doi: 10.1016/j.neuroscience.2004.11.043
Mawdsley, David J., Cooper, Helen M., Hogan, Benjamin M., Cody, Stephen H., Lieschke, Graham J. and Heath, Joan K. (2004). The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish. Developmental Biology, 269 (1), 302-315. doi: 10.1016/j.ydbio.2004.02.001
Petratos, S., Butzkueven, H., Shipham, K., Cooper, H., Bucci, T., Reid, K., Lopes, E., Emery, B., Cheema, S. S. and Kilpatrick, T. J. (2003). Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor. Journal of Neuropathology And Experimental Neurology, 62 (4), 398-411.
Cooper, H. M. (2002). Axon guidance receptors direct growth cone pathfinding: rivalry at the leading edge. International Journal of Developmental Biology, 46 (4), 621-631.
Seaman, Clare, Anderson, Richard, Emery, Ben and Cooper, Helen M. (2001). Localization of the netrin guidance receptor, DCC, in the developing peripheral and enteric nervous systems. Mechanisms of Development, 103 (1-2), 173-175. doi: 10.1016/S0925-4773(01)00350-1
Seaman, Clare and Cooper, Helen M. (2001). Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons. Mechanisms of Development, 101 (1-2), 245-248. doi: 10.1016/S0925-4773(00)00563-3
Hjorth, J. T., Gad, J., Cooper, H. and Key, B. (2001). A zebrafish homologue of deleted in colorectal cancer (zdcc) is expressed in the first neuronal clusters of the developing brain. Mechanisms of Development, 109 (1), 105-109. doi: 10.1016/S0925-4773(01)00513-5
Gad, Jacqueline M. , Keeling, Sharon L. , Shu, Tianzhi , Richards, Linda J. and Cooper, Helen M. (2000). The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina. Experimental Eye Research, 70 (6), 711-722. doi: 10.1006/exer.2000.0823
Shu, Tianzhi, Valentino, Kimberly M., Seaman, Clare, Cooper, Helen M. and Richards, Linda J. (2000). Expression of the netrin-1 receptor, deleted in colorectal cancer (DCC), is largely confined to projecting neurons in the developing forebrain. Journal of Comparative Neurology, 416 (2), 201-212. doi: 10.1002/(SICI)1096-9861(20000110)416:2<201::AID-CNE6>3.0.CO;2-Z
Anderson, R. B., Cooper, H. M., Jackson, S. C., Seaman, C. and Key, B. (2000). DCC plays a role in navigation of forebrain axons across the ventral midbrain commissure in embryonic Xenopus. Developmental Biology, 217 (2), 244-253. doi: 10.1006/dbio.1999.9549
Cooper, Helen M. (1999). The deleted in colorectal cancer netrin guidance system: a molecular strategy for neuronal navigation. Clinical and Experimental Pharmacology and Physiology, 26 (9), 749-751. doi: 10.1046/j.1440-1681.1999.03106.x
Gad, J. M., Keeling, S. L., Wilks, A. F., Tan, S. S. and Cooper, H. M. (1997). The expression patterns of guidance receptors, DCC and neogenin, are spatially and temporally distinct throughout mouse embryogenesis. Developmental Biology, 192 (2), 258-273. doi: 10.1006/dbio.1997.8756
Keeling, S. L., Gad, J. M. and Cooper, H. M. (1997). Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis. Oncogene, 15 (6), 691-700. doi: 10.1038/sj.onc.1201225
Cooper, H. M., Armes, P., Britto, J., Gad, J. and Wilks, A. F. (1995). Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo. Oncogene, 11 (11), 2243-2254.
Tamura, R. N., Cooper, H. M., Collo, G. and Quaranta, V. (1991). Cell type-specific integrin variants with alternative α chain cytoplasmic domains. Proceedings of the National Academy of Sciences, 88 (22), 10183-10187. doi: 10.1073/pnas.88.22.10183
Cooper, H. M., Tamura, R. N. and Quaranta, V. (1991). The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin. Journal of Cell Biology, 115 (3), 843-850. doi: 10.1083/jcb.115.3.843
Korhonen, M., Ylänne, J., Laitinen, L., Cooper, H. M., Quaranta, V. and Virtanen, I. (1991). Distribution of the alpha 1-alpha 6 integrin subunits in human developing and term placenta. Laboratory Investigation, 65 (3), 347-356.
Jones, Jonathan, C. R., Kurpakus, Michelle A., Cooper, Helen M. and Quaranta, Vito (1991). A function for the integrin α6β4 in the hemidesmosome. Cell Regulation, 2 (6), 427-438. doi: 10.1091/mbc.2.6.427
Tamura, R. N., Rozzo, C., Starr, L., Chambers, J., Reichardt, L. F., Cooper, H. M. and Quaranta, V. (1990). Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4. Journal of Cell Biology, 111 (4), 1593-1604. doi: 10.1083/jcb.111.4.1593
Cheresh, David A., Smith, Jeffrey W., Cooper, Helen M. and Quaranta, Vito (1989). A novel vitronectin receptor integrin (αvβx) is responsible for distinct adhesive properties of carcinoma cells. Cell, 57 (1), 59-69. doi: 10.1016/0092-8674(89)90172-4
Cooper, Helen M., Klinman, Norman R. and Paterson, Yvonne (1989). The autoantigenic response to rabbit cytochrome C. European Journal of Immunology, 19 (2), 315-322. doi: 10.1002/eji.1830190215
Cooper, H. M., Corradin, G. and Paterson, Y. (1988). The heme moiety of cytochrome c is an autoreactive Ir gene-restricted T cell epitope. Journal of Experimental Medicine, 168 (3), 1127-1143. doi: 10.1084/jem.168.3.1127
Cooper, Helen M., Jemmerson, Ronald, Hunt, Donald F., Griffin, Patrick R., Yates, John R. , Shabanowitz, Jeffrey, Zhu, Nian-Zhou and Paterson, Yvonne (1987). Site-directed Chemical Modification of Horse Cytochrome c Results in Changes in Antigenicity Due to Local and Long-range Conformational Perturbation. Journal of Biological Chemistry, 262 (24), 11591-11597.
Cooper, H.M., Todd, P.E.E. and Leach, S.J. (1986). Antibody response to the C-terminal peptide sequence in beef myoglobin. Molecular Immunology, 23 (12), 1289-1299. doi: 10.1016/0161-5890(86)90014-3
Cooper, H.M., Todd, P.E.E. and Leach, S.J. (1985). Original antigenic sin and the production of autoantibodies. Molecular Immunology, 22 (8), 921-927. doi: 10.1016/0161-5890(85)90078-1
Cooper, H.M., East, I.J., Todd, P.E.E. and Leach, S.J. (1984). Antibody response to myoglobins: effect of host species. Molecular Immunology, 21 (6), 479-487. doi: 10.1016/0161-5890(84)90063-4