Speaker:

Dr Tara Walker
Senior Research Associate, Kempermann Group
Center for Regenerative Therapies, Dresden, Germany

Title: "Cell death in adult hippocampal neurogenesis is ferroptotic and rescued by selenium"

Abstract: Apoptotic cell death is a key mechanism controlling the generation of new neurons in the adult hippocampus, a brain region important for learning and memory. We show here that ferroptosis, a recently-discovered form of programmed cell death with as yet unknown physiological functions, explains the first wave of cell death at the precursor cell stage of neurogenesis. Reduction of ferroptosis by exogenous selenium increased neurogenesis in the hippocampus but not the subventricular zone, another adult neural stem cell niche. This suggests a mechanism whereby external stimuli including physical activity increase hippocampal but not subventricular zone neurogenesis. We propose that ferroptotic elimination maintains an expandable reservoir of neural precursor cells that is sensitive to the environmental regulation of adult hippocampal neurogenesis.

 

 

About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

The scheduled QBI Neuroscience Seminar series are held on Wednesdays from 11am-12pm in the Level 7 Auditorium of the Queensland Brain Institute, Building 79, St Lucia Campus, The University of Queensland. Additional seminars may be held at other times as listed below.

 

Neuroscience Seminars archive 2005-2016