‘2B, or Not 2B’ – Subunit-specific Regulation of NMDA Receptor Trafficking
Speaker: Associate Professor Victor Anggono
Queensland Brain Institute
University of Queensland
‘2B, or Not 2B’ – Subunit-specific Regulation of NMDA Receptor Trafficking
Abstract: The ability of mammalian neurons to dynamically adjust their synaptic strength and connectivity, known as synaptic plasticity, provides the cellular basis for learning and memory. Most forms of structural and functional plasticity are mediated by calcium-dependent signalling through N-methyl-D-aspartate (NMDA)-type glutamate receptors (NMDARs). The expression of synaptic NMDARs is regulated during development and by neuronal activity, as they undergo a change in their subunit composition, specifically involving the glutamate-binding GluN2A and GluN2B subunits. Due to their differing biophysical properties, the activity-dependent switch in NMDAR subunit composition has significant implications for dendritic integration, circuit refinement, metaplasticity, learning, and memory. In this presentation, I will discuss our research aimed at elucidating the molecular mechanisms that govern the trafficking of GluN2B-containing NMDARs during two distinct forms of neuronal plasticity.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details.
