Dehorter Lab

The Dehorter Group aims to determine how interneurons shape neuronal networks activity and contribute to circuits balance in health and disease.

While early genetic specification seems to drive the cardinal properties of the interneurons, it is increasingly recognized that their final features are subject to regulation by experience. We seek to identify genetic programs triggered by neuronal activity that lead to the remarkable diversity of neuronal subclasses.

We want to address fundamental questions:

  • How do interneurons adapt their activity to the environment and transmit appropriate information to the rest of the neuronal circuit?

  • How these adaptive processes shape emergent networks and modulate inhibitory circuits in normal condition and in pathology?

  • Can we detect early signs of interneuron dysfunction in pathologies such as Parkinson’s disease, schizophrenia or autism and restore normal activity to alleviate or block consequent deleterious symptoms?

To achieve our goals, we will take advantage of a multi-disciplinary approach, employing state of the art molecular biology, genetics, in vitro/ in vivo imaging and electrophysiological techniques.

Ahmed, Noorya YasminKnowles, RhysLiu, LixinyuYan, YimingLi, XiaohanSchumann, UlrikeWang, YumengSontani, YovinaReynolds, NathanNatoli, RiccardoWen, JiayuDel Pino, IsabelMi, Da and Dehorter, Nathalie (2023).Developmental deficits of MGE-derived interneurons in the Cntnap2 knockout mouse model of autism spectrum disorder. Frontiers in Cell and Developmental Biology, 11. doi: 10.3389/fcell.2023.1112062

Barettino, CandelaBallesteros-Gonzalez, ÁlvaroAylón, AndrésSoler-Sanchis, XavierOrtí, LeticiaDíaz, SeleneReillo, IsabelGarcía-García, FranciscoIborra, Francisco JoséLai, CaryDehorter, NathalieLeinekugel, XavierFlames, Nuria and Del Pino, Isabel (2021).Developmental disruption of Erbb4 in Pet1+ neurons impairs serotonergic sub-system connectivity and memory formation. Frontiers in Cell and Developmental Biology, 9 770458, 1-17. doi: 10.3389/fcell.2021.770458

Knowles, RhysDehorter, Nathalie and Ellender, Tommas (2021).From progenitors to progeny: shaping striatal circuit development and function. The Journal of Neuroscience, 41 (46), 9483-9502. doi: 10.1523/JNEUROSCI.0620-21.2021

Al Abed, A. ShaamReynolds, Nathan J. and Dehorter, Nathalie (2021).A second wave for the Neurokinin Tac2 pathway in brain research. Biological Psychiatry, 90 (3), 156-164. doi: 10.1016/j.biopsych.2021.02.016

Ahmed, Noorya YasminRanjbar-Slamloo, YadollahAl Abed, Alice ShaamGao, LingxiaoSontani, YovinaRCom-H'cheo-Gauthier, AlexandreArabzadeh, Ehsan and Dehorter, Nathalie (2021).Er81 transcription factor fine-tunes striatal cholinergic interneuron activity and drives habit formation. The Journal of Neuroscience, 41 (20), 4392-4409. doi: 10.1523/JNEUROSCI.0967-20.2021

Dehorter, Nathalie and Del Pino, Isabel (2020).Shifting developmental trajectories during critical periods of brain formation. Frontiers in Cellular Neuroscience, 14 283, 1-14. doi: 10.3389/fncel.2020.00283

Ahmed, Noorya YasminKnowles, Rhys and Dehorter, Nathalie (2019).New insights into cholinergic neuron diversity. Frontiers in Molecular Neuroscience, 12 204, 1-12. doi: 10.3389/fnmol.2019.00204

Scott, RicardoSánchez-Aguilera, AlbertoVan Elst, KimLim, LynetteDehorter, NathalieBae, Sung EunBartolini, GiorgiaPeles, EliorKas, Martien J HBruining, Hilgo and Marín, Oscar (2019).Loss of Cntnap2 causes axonal excitability deficits, developmental delay in cortical myelination, and abnormal stereotyped motor behavior. Cerebral Cortex, 29 (2), 586-597. doi: 10.1093/cercor/bhx341

Dehorter, NathalieMarichal, NicolásMarín, Oscar and Berninger, Benedikt (2017).Tuning neural circuits by turning the interneuron knob. Current Opinion in Neurobiology, 42, 144-151. doi: 10.1016/j.conb.2016.12.009

Dehorter, NathalieCiceri, GabrieleBartolini, GiorgiaLim, LynetteDel Pino, Isabel and Marín, Oscar (2015).Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch. Science, 349 (6253), 1216-1220. doi: 10.1126/science.aab3415

Dehorter, Nathalie and Hammond, Constance (2014).Giant GABAA receptor mediated currents in the striatum, a common signature of Parkinson's disease in pharmacological and genetic rodent models. Basal Ganglia, 3 (4), 197-201. doi: 10.1016/j.baga.2013.10.001

Ciceri, Gabriele and Dehorter, Nathalie (2014).Organization of interneurons lineages in the cerebral cortex Organisation des lignées d'interneurones du cortex cérébral. Medecine/Sciences, 30 (2), 144-146. doi: 10.1051/medsci/20143002010

delPino, IsabelGarcía-Frigola, CristinaDehorter, NathalieBrotons-Mas, JorgeR.Alvarez-Salvado, EfrénMartínezdeLagrán, MaríaCiceri, GabrieleGabaldón, MaríaVictoriaMoratal, DavidDierssen, MaraCanals, SantiagoMarín, Oscar and Rico, Beatriz (2013).Erbb4 Deletion from Fast-Spiking Interneurons Causes Schizophrenia-like Phenotypes. Neuron, 79 (6), 1152-1168. doi: 10.1016/j.neuron.2013.07.010

Ciceri, GabrieleDehorter, NathalieSols, IgnasiHuang, Z JoshMaravall, Miguel and Marín, Oscar (2013).Lineage-specific laminar organization of cortical GABAergic interneurons. Nature Neuroscience, 16 (9), 1199-1210. doi: 10.1038/nn.3485

Dehorter, NathalieLozovaya, NataliaJulius Mdzomba, B.Michel, François J.Lopez, CatherineTsintsadze, VeraTsintsadze, TimurKlinkenberg, MichaelGispert, SuzannaAuburger, Georg and Hammond, Constance (2012).Subthalamic lesion or levodopa treatment rescues giant GABAergic currents of PINK1-deficient striatum. Journal of Neuroscience, 32 (50), 18047-18053. doi: 10.1523/JNEUROSCI.2474-12.2012

Dehorter, N.Vinay, L.Hammond, C. and Ben-Ari, Y. (2012).Timing of developmental sequences in different brain structures: Physiological and pathological implications. European Journal of Neuroscience, 35 (12), 1846-1856. doi: 10.1111/j.1460-9568.2012.08152.x

Ferrari, Diana C.Mdzomba, Baya J.Dehorter, NathalieLopez, CatherineMichel, François J.Libersat, Frédéric and Hammond, Constance (2012).Midbrain dopaminergic neurons generate calcium and sodium currents and release dopamine in the striatum of pups. Frontiers in Cellular Neuroscience (MARCH) 7, 1-9. doi: 10.3389/fncel.2012.00007

Dehorter, NathalieMichel, François J.Marissal, ThomasRotrou, YannMatrot, BorisLopez, CatherineHumphries, Mark D. and Hammond, Constance (2011).Onset of pup locomotion coincides with loss of NR2C/D-mediated cortico-striatal EPSCs and dampening of striatal network immature activity. Frontiers in Cellular Neuroscience (NOVEMBER), 1-14. doi: 10.3389/fncel.2011.00024

Gelman, DiegoGriveau, AmélieDehorter, NathalieTeissier, AnneVarela, CarolinaPla, RamónPierani, Alessandra and Marín, Oscar (2011).A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area. Journal of Neuroscience, 31 (46), 16570-16580. doi: 10.1523/JNEUROSCI.4068-11.2011

Dehorter, NathalieGuigoni, CelineLopez, CatherineHirsch, JuneEusebio, AlexandreBen-Ari, Yehezkel and Hammond, Constance (2009).Dopamine-deprived striatal GABAergic interneurons burst and generate repetitive gigantic IPSCs in medium spiny neurons. Journal of Neuroscience, 29 (24), 7776-7787. doi: 10.1523/JNEUROSCI.1527-09.2009

Bouvier, JulienAutran, SandraDehorter, NathalieKatz, David M.Champagnat, JeanFortin, Gilles and Thoby-Brisson, Muriel (2008).Brain-derived neurotrophic factor enhances fetal respiratory rhythm frequency in the mouse preBötzinger complex in vitro. European Journal of Neuroscience, 28 (3), 510-520. doi: 10.1111/j.1460-9568.2008.06345.x

  • JCSMR Gender Equity Award (2017)
  • FENS Travel Grant Milan, Italy
  • European Molecular Biology Organization (EMBO) long-term fellowship
  • PhD grant from France Parkinson Association
  • PhD grant from « région PACA », France
  • Consequences of impaired neuronal activity during development in a mouse model of autism
  • Molecular Control of the Interneuron Integration and Synapse Formation
  • Presymptomatic Signatures of Interneuron Dysfunction in Mice Models of Striatum-Related Pathologies

Group leader

Dr Natalie Dehorter

Dr Natalie Dehorter

Senior Research Fellow