1. Understanding the pathophysiological mechanisms of treatment resistance, particularly the role of stress, inflammation, and metabolic dysfunction;
  2. Defining the therapeutic mechanisms of novel pharmaceutical agents and brain stimulation technologies with the ultimately goal of identifying specific biomarkers of treatment response;
  3. Establishing translational behavioural paradigms that can be effectively used across species (rodent to human) to quantify specific neural correlates of disease pathophysiology and treatment response;
  4. Developing novel technologies for brain stimulation;
  5. Translating novel treatment approaches and neuromodulation technologies to the clinic.