• GWAS analyses in Indian and Sarawak populations, comparing the results with the latest results for European-ancestry schizophrenia from the Psychiatric Genomics Consortium.
     
  • Phase 2 Indian schizophrenia GWAS using additional samples from India and UK Biobank.
     
  • Targeted resequencing analyses of a previously identified chromosomal region in an Indian sample.
     
  • Identification of de novo and transmitted mutations using whole exome sequence data from Indian family based schizophrenia cohort.
     
  • Functional characterisation of top Indian GWAS locus in zebrafish and cellular models.
     
  • Investigation of top Indian locus in NAD pathway using Indian plasma samples.
     
  • In silico Investigation of the impact of schizophrenia GWAS loci during human brain development using spatio-temporal brain gene expression data.
     
  • Using deep learning to predict disease mechanisms from GWAS in psychiatric disorders.
     
  • Developing deep learning models to predict differential binding of regulators in schizophrenia-associated loci.
     
  • Generating disease specific genetic interaction data investigate relationships between genotype and phenotype using genome-wide GWAS data.
     
  • Investigating the normal and pathogenic in vivo role of genes recently associated with brain disorders and schizophrenia in particular, using the zebrafish as research model (PhD Projects available)
     
  • Identifying new neuroactive drugs using national and international chemical libraries and the zebrafish as a screening tool  (PhD Projects available).
     
  • Understanding the cellular and molecular effect of current anti-psychotic drugs using the zebrafish and state-of-the-art microscopy technologies (PhD Projects available).