Book Chapter
Akefe, Isaac O., Osborne, Shona L., Matthews, Benjamin, Wallis, Tristan P. and Meunier, Frédéric A. (2023). Lipids and Secretory Vesicle Exocytosis. Advances in Neurobiology. (pp. 357-397) Cham, Switzerland: Springer. doi: 10.1007/978-3-031-34229-5_14
Journal Articles
Jekimovs, Lachlan J., Akefe, Isaac O., Wallis, Tristan P., Young, Reuben S.E., Brydon, Samuel C., Meunier, Frédéric A., Poad, Berwyck L.J. and Blanksby, Stephen J. (2024). Making OzID go FFASTer: Combining stable-isotope tagging with ozone-induced dissociation to uncover changes in fatty acid unsaturation within neurosecretory cells. International Journal of Mass Spectrometry, 506 117342, 117342. doi: 10.1016/j.ijms.2024.117342
Fisher, Andre Lara, Arora, Kabir, Maehashi, Saki, Schweitzer, Daniel and Akefe, Isaac Oluwatobi (2024). Unveiling the neurolipidome of obsessive-compulsive disorder: a scoping review navigating future diagnostic and therapeutic applications. Neuroscience and Biobehavioral Reviews, 166 105885. doi: 10.1016/j.neubiorev.2024.105885
Maehashi, Saki, Arora, Kabir, Fisher, Andre Lara, Schweitzer, Daniel Rab and Akefe, Isaac Oluwatobi (2024). Neurolipidomic insights into anxiety disorders: Uncovering lipid dynamics for potential therapeutic advances. Neuroscience and Biobehavioral Reviews, 163 105741, 105741. doi: 10.1016/j.neubiorev.2024.105741
Akefe, Isaac O, Saber, Saber H., Matthews, Benjamin, Venkatesh, Bharat G., Gormal, Rachel S., Blackmore, Daniel G., Alexander, Suzy, Sieriecki, Emma, Gambin, Yann, Bertran-Gonzalez, Jesus, Vitale, Nicolas, Humeau, Yann, Gaudin, Arnaud, Ellis, Sevannah A., Michaels, Alysee A., Xue, Mingshan, Cravatt, Benjamin, Joensuu, Merja, Wallis, Tristan P. and Meunier, Frédéric A. (2024). The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids. The EMBO Journal, 43 (4), 533-567. doi: 10.1038/s44318-024-00030-7
Harakeh, Steve, Akefe, Isaac, Saber, Saber H., alamri, Turki, Al-Raddadi, Rajaa, Al-Jaouni, Soad, Tashkandi, Hanaa, Qari, Mohammed, Moulay, Mohammed, Aldahlawi, Alia, Abd Elmageed, Zakariya Y. and Mousa, Shaker (2024). Nanoformulated 3′-diindolylmethane modulates apoptosis, migration, and angiogenesis in breast cancer cells. Heliyon, 10 (1) e23553, 1-12. doi: 10.1016/j.heliyon.2023.e23553
Harakeh, Steve, Saber, Saber H., alamri, Turki, Al-Raddadi, Rajaa, Al-Jaouni, Soad, Tashkandi, Hanaa, Qari, Mohammed, Qari, Yousef, Akefe, Isaac O., Abd Elmageed, Zakariya Y., Haque, Shafiul, Hashem, Anwar M, Albajri, Eram and Mousa, Shaker (2023). Novel 3’-diindolylmethane nanoformulation induces apoptosis, and reduces migration and angiogenesis in liver cancer cells. Journal of King Saud University - Science, 35 (8) 102864, 1-9. doi: 10.1016/j.jksus.2023.102864
Ubah, Simon A., Agbonu, Oluwa A., Columbus, Philemon K., Abah, Kenneth O., Chibuogwu, Ijeoma C., Bankole, Abayomi S., Enem, Simon I., Ejiofor, Charles E., Akefe, Isaac O. and Ajayi, Itopa E. (2023). Cypermethrin toxicity-induced infertility: an assessment of longitudinal transfer of protective potentials of date fruit extracts in Wister rats. Recent Patents on Biotechnology, 17 (2), 176-185. doi: 10.2174/1872208316666220817092827
Philip, Ameh Matthew, Ofemile, Yusuf, Oluwatobi, Akefe Isaac, Gabriel, Ada, Ejiofor, Ugwoke Peter and Aske, Omar (2023). Medicinal plants used for the neutralization of snake venom in Northern Nigeria of West Africa. Recent Patents on Biotechnology, 17 (1), 3-8. doi: 10.2174/1872208316666220426120228
Yusuf, P.O., Dahiru, S., Ameh, M.P., Oyetunde, J.S., Ada, G., Idoga, E.S., Akefe, I.O., Attah, C.U. and Ajagun, E. (2023). Embryonated eggs as an alternative to animals in the determination of median lethal dose (LD50) in bitis venom. Sokoto Journal of Veterinary Sciences, 21 (1), 43-46. doi: 10.4314/sokjvs.v21i1.5
Qari, Mohammed, Harakeh, Steve, Akefe, Isaac O., Saber, Saber H., Al-Raddadi, Rajaa, Abd Elmageed, Zakaria Y., Alamri, Turki, El-Shitany, Nagla, Ali, Soad S., Almuhayawi, Mohammed S. and Mousa, Shaker (2023). Pomegranate nanoparticle mitigates cisplatin-induced testicular toxicity and improves cisplatin anti-cancer efficacy in Ehrlich carcinoma model. Journal of King Saud University - Science, 35 (4) 102631, 1-8. doi: 10.1016/j.jksus.2023.102631
Akefe, Isaac Oluwatobi, Nyan, Ezekiel Stephen, Adegoke, Victoria Aderonke, Lamidi, Ibrahim Yusuf, Ameh, Matthew Phillip, Chidiebere, Uchendu, Ubah, Simon Azubuike and Ajayi, Itopa Etudaye (2023). Myrtenal improves memory deficits in mice exposed to radiofrequency-electromagnetic radiation during gestational and neonatal development via enhancing oxido-inflammatory, and neurotransmitter functions. Heliyon, 9 (4) e15321, 1-12. doi: 10.1016/j.heliyon.2023.e15321
Eneojo Abalaka, Samson, Azubuike Ubah, Simon, Clara Asibor, Victory, Kehinde Ogundana, Ebenezer, Iyojo, Itodo Joy, Adikpe Agbonu, Oluwa, Kwinjoh Columbus, Philemon, Owoicho Abah, Kenneth, Ese Obudu, Christopher, Akefe Isaac, Oluwatobi and Adaoma Ezinwo, Prisca (2023). Gonadotropic activity of pituitary extract of African catfish, Clarias gariepinus, in mammals using immature wistar rats as models. Recent Patents on Biotechnology, 17 (1), 84-92. doi: 10.2174/1872208317666230313153832
Alamri, T., Harakeh, S., Saber, S. H., Akefe, I. O., Ali, Soad Shaker, Naseeb, Manal, Alkuwaity, K., Niyazi, Hatoon A., Niyazi, Hanouf A., Mokhtar, Jawaher A., Rath, M., Niedzwiecki, Aleksandra and Zgool, T. (2023). Protective and therapeutic potential of a novel phytobiological formulation of nutrients in the treatment of indomethacin-induced gastric ulcer. Indian Journal of Pharmaceutical Sciences, 85, 103-111.
Obeta, Sylvester Sunday, Ubah, Simon Azubuike, Ejiofor, Charles Ejike, Agbonu, Oluwa Adikpe, Columbus, Philemon Kwinjoh, Abah, Kenneth Owoicho, Ikpe, Alapa Baba, Bankole, Abayomi Samuel, Ezinwo, Prisca Adaoma, Itodo, Joy Iyojo, Akefe, Issac Oluwatobi, Uba, Charles Amaechi and Mailafia, Samuel (2023). The clinical effect of experimental infection with Trypanosoma congolense on Dutch belted rabbits. Parasitology Research, 122 (1), 113-116. doi: 10.1007/s00436-022-07702-5
Harakeh, Steve, Saber, Saber H., Akefe, Isaac O., Shaker, Soad, Barkaat Hussain, Muhammad, Saad Almasaudi, Arwa, Saleh, Shaimaa M.M. and Almasaudi, Saad (2022). Saudi honey alleviates indomethacin-induced gastric ulcer via improving antioxidant and anti-inflammatory responses in male albino rats. Saudi Journal of Biological Sciences, 29 (4), 3040-3050. doi: 10.1016/j.sjbs.2022.01.031
Otolorin, Gbeminiyi R., Oluwatobi, Akefe I., Olufemi, Olaolu T., Esonu, Daniel O., Dunka, Hassana I., Adanu, Williams A., Danjuma, Friday A., Abiayi, David C., Adegoke, Victoria A., Omoniwa, David O., Oghenefega, Ovwighose N. and Mshelbwala, Philip P. (2022). COVID-19 pandemic and its impacts on the environment: a global perspective. Narra J, 2 (1) e72, 1-13. doi: 10.52225/narra.v2i1.72
Harakeh, Steve, Almuhayawi, Mohammed S., Akefe, Isaac O., Saber, Saber H., Al Jaouni, Soad K., Alzughaibi, Torki, Almehmadi, Yousef, Ali, Soad Shaker, Bharali, Dhruba J. and Mousa, Shaker (2022). Novel pomegranate-nanoparticles ameliorate cisplatin-induced nephrotoxicity and improves cisplatin anti-cancer efficacy in Ehrlich carcinoma mice model. Molecules, 27 (5) 1605, 1605. doi: 10.3390/molecules27051605
Akefe, Isaac Oluwatobi, Adegoke, Victoria Aderonke, Lamidi, Ibrahim Yusuf, Ameh, Matthew Phillip, Idoga, Enokela Shaibu, Ubah, Simon Azubuike and Ajayi, Itopa Etudaye (2022). Myrtenal mitigates streptozotocin-induced spatial memory deficit via improving oxido inflammatory, cholinergic and neurotransmitter functions in mice. Current Research in Pharmacology and Drug Discovery, 3 100106, 1-9. doi: 10.1016/j.crphar.2022.100106
Akefe, Isaac Oluwatobi, Ayo, Joseph Olusegun and Sinkalu, Victor Olusegun (2021). Assortment of kaempferol and zinc gluconate improves noise-induced biochemical imbalance and deficits in body weight gain. Experimental Results, 2 e37, 1-13. doi: 10.1017/exp.2021.30
Nwosu, Rachel A., Suleiman, Mohammed M., Makun, Hussaina J., Ameh, Matthew P., Shetshak, Manji A. and Akefe, Isaac O. (2021). In vitro anthelmintic activity of Dennettia tripetala G. Baker (Annonaceae) Fruits against Haemonchus contortus. Journal of Parasitic Diseases, 54 (1) 2, 220-229. doi: 10.1007/s12639-021-01438-2
Zakari, Friday Ocheja, Akefe, Isaac Oluwatobi and Uchendu, Chidiebere (2021). Comparison of diurnal rectal and body surface temperatures in large white piglets during the hot-dry season in a tropical Guinea savannah. Journal of Thermal Biology, 99 102953, 1-12. doi: 10.1016/j.jtherbio.2021.102953
Shetshak, M. A., Suleiman, M. M., Jatau, I. D., Ameh, M. P. and Akefe, I. O. (2021). Anticoccidial efficacy of Garcinia kola (Heckel H.) against experimental Eimeria tenella infection in chicks. Journal of Parasitic Diseases, 45 (4), 1-15. doi: 10.1007/s12639-021-01389-8
Lamidi, Ibrahim Yusuf, Mikail, Hudu Garba, Adamu, Sani, Akefe, Isaac Oluwatobi, Tijjani, Mohammed Bashir, Salihu, Sabo Isa, Olatunji, Aisha Omobolanle, Hassan, Abdussalam, Daniel, Nubwa and Adegoke, Victoria Aderonke (2021). Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats. Toxicological Research, 37 (4), 473-484. doi: 10.1007/s43188-020-00084-9
Richard, Otolorin Gbeminiyi, Oluwatobi, Akefe Isaac, Tosin, Olufemi Olaolu, Obinna, Esonu Daniel, Isaac, Dunka Hassana, Adanu, Adanu Williams, Audu, Danjuma Friday, Nok, Kia Grace Sabo, Oghenefega, Ovwighose Naomi and Paul, Mshelbwala Philip (2021). COVID-19 Pandemic: A concise appraisal of the current status. International Journal of Tropical Disease and Health, 42 (4) IJTDH.66588, 1-9. doi: 10.9734/ijtdh/2021/v42i430446
Shetshak, Manji Amos, Jatau, Isa Danladi, Suleiman, Muhammed Musa, Ameh, Matthew Philip, Gabriel, Ada and Akefe, Isaac O. (2021). In vitro anticoccidial activities of the extract and fractions of Garcinia kola (Heckel h.) against Eimeria tenella oocyst. Recent Patents on Biotechnology, 15 (1), 76-84. doi: 10.2174/1872208315666210129095213
Gabriel, Ada, Mohammed, Mamman, Magaji, Mohammed Garba, Ofemile, Yusuf Peter, Matthew, Ameh Philip and Akefe, Isaac (2020). In vitro and in vivo neutralizing activity of Uvaria chamae leaves fractions on the venom of Naja nigricollis in albino rat and bovine blood. Recent Patents on Biotechnology, 14 (4), 295-311. doi: 10.2174/1872208314666200903152129
Akefe, Isaac Oluwatobi, Ayo, Joseph Olusegun and Sinkalu, Victor Olusegun (2020). Kaempferol and zinc gluconate mitigate neurobehavioral deficits and oxidative stress induced by noise exposure in Wistar rats. PloS One, 15 (7) e0236251, 1-12. doi: 10.1371/journal.pone.0236251
Lamidi, Ibrahim Yusuf, Hudu, Mikail Garba, Akefe, Isaac Oluwatobi, Adamu, Sani and Salihu, Sabo Isa (2020). Sub-chronic administration of flavonoid fraction Daflon improve lead-induced alterations in delta-aminolevulinic acid dehydratase activity, erythrocytic parameters, and erythrocyte osmotic fragility in Wistar rats. Comparative Clinical Pathology, 29 (5), 955-963. doi: 10.1007/s00580-020-03144-6
Ameh, Matthew P., Mohammed, Mamman, Ofemile, Yusuf P., Mohammed, Magaji G., Gabriel, Ada and Isaac, Akefe O. (2020). Detoxifying action of aqueous extracts of Mucuna pruriens seed and Mimosa pudica root against venoms of Naja nigricollis and Bitis arietans. Recent Patents on Biotechnology, 14 (2), 134-144. doi: 10.2174/1872208313666191025110019
Aderonke, Adegoke Victoria, Aliyu, Haruna Dede, Akefe, Isaac Oluwatob and Nyan, Ezekiel Stephen (2019). Role of Nickel (II) Salicylhydroxamic Acid and its Aniline Adduct as an Antimicrobial Substitute. Biomedical Journal of Scientific & Technical Research, 18 (1). doi: 10.26717/bjstr.2019.18.003098
Ameh, M.P., Jatau, I. D., Akefe, I. O. and Ada, G. (2019). Hematological and Biological Changes in Different Routes of Experimental Trypanosoma BruceiInfection in Albino Rats. Biomedical Journal of Scientific & Technical Research, 13 (5). doi: 10.26717/bjstr.2019.13.002465
Akefe, Isaac O., Yusuf, Ibrahim L. and Adegoke, Victoria A. (2019). C-glycosyl flavonoid orientin alleviates learning and memory impairment by radiofrequency electromagnetic radiation in mice via improving antioxidant defence mechanism. Asian Pacific Journal of Tropical Biomedicine, 9 (12), 518-523. doi: 10.4103/2221-1691.271725
Akefe, I. O. (2017). Pathophysiological mechanism of intestinal gas production. Biomedical Journal of Scientific and Technical Research, 1 (7). doi: 10.26717/bjstr.2017.01.000606
AO, Isaac, AO, Joseph, SO, Victor, YI, Lamidi and AM, Andrew (2017). Ameliorative Effects of Kaempferol and Zinc Gluconate on Erythrocyte Osmotic Fragility and Haematological Parameters in Wistar Rats Exposed to Noise Stress. Insights in Biomedicine, 02 (03). doi: 10.21767/2572-5610.10031
Adamu, Andrew, Dung, Edward, Abraham, Solomon, Akefe, Isaac and Yusuf, Ibrahim (2017). The cortisol steroid levels as a determinant of health status in animals. Journal of Proteomics and Bioinformatics, 10 (11). doi: 10.4172/jpb.1000452
Akefe, Isaac O., OA, Joseph and OS, Victor (2017). Mitigative Effects of Antioxidants in Noise Stress. Journal of Clinical Nutrition & Dietetics, 03 (03). doi: 10.4172/2472-1921.100056
Data Collection
Meunier, F A, Akefe, I O, Saber, S H, Matthews, B, Venkatesh, B V, Gormal, R S, Blackmore, D G, Alexander, S, Sieriecki, E, Gambin, Y, Bertran-Gonzalez, J, Vitale, N, Humeau, Y, Gaudin, A, Ellis, S A, Michaels, A A, Xue, M, Cravatt, B, Joensuu, M and Wallis, T P (2023). Quantified behavioural and lipidomic data in response to memory acquisition in mice. The University of Queensland. (Dataset) doi: 10.48610/4a44503
Thesis
Akefe, Isaac (2022). Identifying key changes in brain free fatty acids associated with memory in health, ageing and disease: A mechanistic study. PhD Thesis, Queensland Brain Institute, The University of Queensland. doi: 10.14264/a5c754a