Associate Professor Susannah Tye
Principal Research Fellow - GL
Queensland Brain Institute
+61 7 344 32493
Associate Professor Susannah Tye: Functional neuromodulation and novel therapeutics
Our research is interdisciplinary, drawing on approaches and techniques from neuroscience, molecular biology, biochemistry, and neuroengineering. We are particularly interested in the potential to use key biomarkers of refractory illness to diagnose and inform treatment decisions, and the possibility that real-time feedback may be used to customise neuromodulatory treatments. Ongoing projects in the lab address both basic and translational neuroscience questions.
Researcher biography
Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic's Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.
Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.
Book Chapters
Tye, Susannah, Yates, Clarissa G. and Postorivo, Danielle (2022). Modeling treatment-resistant depression in the preclinical setting. Managing treatment-resistant depression: road to novel therapeutics. (pp. 61-80) edited by Joao Quevedo, Patricio Riva-Posse and William V. Bobo. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-824067-0.00005-0
Andreazza, Ana C., Kale, Rajas P., Duong, Angela, Molina, Fabio and Tye, Susannah J. (2019). Mitochondrial function and inflammation pathways in the neuroprogression of mental disorders. Neuroprogression in psychiatry. (pp. 35-62) Oxford, United Kingdom: Oxford University Press. doi: 10.1093/med/9780198787143.003.0004
Kim, Yesul, Wininger, Katheryn M. and Tye, Susannah J. (2017). Deep brain stimulation for treatment-resistant depression. Deep brain stimulation: indications and applications. (pp. 197-214) edited by Kendall H. Lee, Penelope S. Duffy and Allan J. Bieber. Singapore: Pan Stanford Publishing. doi: 10.1201/9781315364759-18
Journal Articles
Varela, Roger B., Boschen, Suelen L., Yates, Nathanael, Houghton, Tristan, Blaha, Charles D., Lee, Kendall H., Bennet, Kevin E., Kouzani, Abbas Z., Berk, Michael, Quevedo, João, Valvassori, Samira S. and Tye, Susannah J. (2024). Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine. Bipolar Disorders. doi: 10.1111/bdi.13423
Parikh, Sagar V., Vande Voort, Jennifer L., Yocum, Anastasia K., Achtyes, Eric, Goes, Fernando S., Nykamp, Louis, Singh, Balwinder, Lopez-Vives, Daniela, Sera, Cortney E., Maixner, Daniel, Tarnal, Vijay, Severe, Jennifer, Bartek, Steven, Tye, Susannah J., Rico, Jose, Stoppel, Cynthia J., Becerra, Alexis, Smart, LeAnn, Miller, Christina R., Frye, Mark A., Greden, John F. and Bobo, William V. (2024). Clinical outcomes in the biomarkers of ketamine (Bio-K) study of open-label IV ketamine for refractory depression. Journal of Affective Disorders, 348, 143-151. doi: 10.1016/j.jad.2023.12.033
Nuñez, Nicolas A., Coombes, Brandon J., Beaupre, Lindsay Melhuish, Ozerdem, Aysegul, Resendez, Manuel Gardea, Romo-Nava, Francisco, Bond, David J., Veldic, Marin, Singh, Balwinder, Moore, Katherine M., Betcher, Hannah K., Kung, Simon, Prieto, Miguel L., Fuentes, Manuel, Ercis, Mete, Miola, Alessandro, Sanchez Ruiz, Jorge A., Jenkins, Gregory, Batzler, Anthony, Leung, Jonathan G., Cuellar-Barboza, Alfredo, Tye, Susannah J., McElroy, Susan L., Biernacka, Joanna M. and Frye, Mark A. (2024). Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder. Translational Psychiatry, 14 (1) 93, 93. doi: 10.1038/s41398-024-02798-y
Corva, Dean M., Parke, Brenna, West, Alyssa, Doeven, Egan H., Adams, Scott D., Tye, Susannah J., Hashemi, Parastoo, Berk, Michael and Kouzani, Abbas Z. (2024). SmartStim: An Artificial Intelligence Enabled Deep Brain Stimulation Device. IEEE Transactions on Medical Robotics and Bionics, PP (99), 1-1. doi: 10.1109/tmrb.2024.3381341
Corva, Dean M., Doeven, Egan H., Parke, Brenna, Adams, Scott D., Tye, Susannah J., Hashemi, Parastoo, Berk, Michael and Kouzani, Abbas Z. (2024). SmartFSCV: An Artificial Intelligence Enabled Miniaturised FSCV Device Targeting Serotonin. IEEE Open Journal of Engineering in Medicine and Biology, PP (99), 1-12. doi: 10.1109/OJEMB.2024.3356177
Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Abulseoud, Osama A., Oesterle, Tyler S., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Oh, Yoonbae and Shin, Hojin (2023). Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation. Frontiers in Pharmacology, 14 1199655. doi: 10.3389/fphar.2023.1199655
Tye, Susannah, Price, Joshua, Walker, Adam, Sutor, Shari, Erhardt, Sophie, Schwieler, Lilly, Cullen, Kathryn, Voort, Jennifer Vande, Frye, Mark, Bobo, William and Shiroma, Paulo (2023). Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression. Biological Psychiatry, 93 (9), S24. doi: 10.1016/j.biopsych.2023.02.076
Voort, Jennifer Vande, Singh, Balwinder, Riva-Posse, Patricio, Erhardt, Sophie, Schwieler, Lilly, Pazdernik, Vanessa, Frye, Mark and Tye, Susannah (2023). Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression. Biological Psychiatry, 93 (9), S24. doi: 10.1016/j.biopsych.2023.02.077
Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Shin, Hojin and Oh, Yoonbae (2023). High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens. Frontiers in Neuroscience, 17 1061578, 1-12. doi: 10.3389/fnins.2023.1061578
Singh, Balwinder, Vande Voort, Jennifer L., Riva-Posse, Patricio, Pazdernik, Vanessa M., Frye, Mark A. and Tye, Susannah J. (2023). Ketamine-associated change in anhedonia and mTOR expression in treatment-resistant depression. Biological Psychiatry, 93 (12), e65-e68. doi: 10.1016/j.biopsych.2022.10.007
Gardea-Resendez, Manuel, Coombes, Brandon J., Veldic, Marin, Tye, Susannah J., Romo-Nava, Francisco, Ozerdem, Aysegul, Prieto, Miguel L., Cuellar-Barboza, Alfredo, Nunez, Nicolas A., Singh, Balwinder, Pendegraft, Richard S., Miola, Alessandro, McElroy, Susan L., Biernacka, Joanna M., Morava, Eva, Kozicz, Tamas and Frye, Mark A. (2022). Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania. Molecular Psychiatry, 28 (3), 1020-1026. doi: 10.1038/s41380-022-01888-x
Kruse, Jennifer L., Boyle, Chloe C., Olmstead, Richard, Breen, Elizabeth C., Tye, Susannah J., Eisenberger, Naomi I. and Irwin, Michael R. (2022). Interleukin-8 and depressive responses to an inflammatory challenge: secondary analysis of a randomized controlled trial. Scientific Reports, 12 (1) 12627, 1-9. doi: 10.1038/s41598-022-16364-3
Yuen, Jason, Kouzani, Abbas Z., Berk, Michael, Tye, Susannah J., Rusheen, Aaron E., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Shin, Hojin, Kim, Jee Hyun and Oh, Yoonbae (2022). Deep brain stimulation for addictive disorders—where are we now?. Neurotherapeutics, 19 (4), 1193-1215. doi: 10.1007/s13311-022-01229-4
Varela, Roger B., Cararo, José Henrique, Tye, Susannah J., Carvalho, Andre F., Valvassori, Samira S., Fries, Gabriel R. and Quevedo, João (2022). Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications. Neuroscience and Biobehavioral Reviews, 135 104579, 104579. doi: 10.1016/j.neubiorev.2022.104579
Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Oh, Yoonbae and Shin, Hojin (2022). Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens. Journal of Neurophysiology, 127 (3), 714-724. doi: 10.1152/jn.00420.2021
Tye, Susannah J., Borreggine, Kristin, Price, J. Blair, Sutor, Shari L., Cuéllar-Barboza, Alfredo B., McElroy, Susan L., Biernacka, Joanna M. and Frye, Mark A. (2022). Dynamic insulin-stimulated mTOR/GSK3 signaling in peripheral immune cells: preliminary evidence for an association with lithium response in bipolar disorder. Bipolar Disorders, 24 (1) bdi.13081, 1-9. doi: 10.1111/bdi.13081
Price, J. Blair, Yates, Clarissa G., Morath, Brooke A., Van De Wakker, Sam K., Yates, Nathanael J., Butters, Kim, Frye, Mark A., McGee, Sean L. and Tye, Susannah J. (2021). Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression. Translational Psychiatry, 11 (1) 598, 598. doi: 10.1038/s41398-021-01716-w
Yates, Clarissa, Kruse, Jennifer L., Price, J. Blair, Robertson, Avril A. B. and Tye, Susannah J. (2021). Modulating neuroplasticity: lessons learned from antidepressants and emerging novel therapeutics. Current Treatment Options in Psychiatry, 8 (4), 229-257. doi: 10.1007/s40501-021-00249-9
Kruse, Jennifer L., Olmstead, Richard, Hellemann, Gerhard, Breen, Elizabeth C., Tye, Susannah J., Brooks, John O., Wade, Benjamin, Congdon, Eliza, Espinoza, Randall, Narr, Katherine L. and Irwin, Michael R. (2021). Interleukin-8 and lower severity of depression in females, but not males, with treatment-resistant depression. Journal of Psychiatric Research, 140, 350-356. doi: 10.1016/j.jpsychires.2021.06.009
Kale, Rajas P., Nguyen, Thanh Thanh L., Price, J. Blair, Yates, Nathanael J., Walder, Ken, Berk, Michael, Sillitoe, Roy V., Kouzani, Abbas Z. and Tye, Susannah J. (2021). Mood regulatory actions of active and sham nucleus accumbens deep brain stimulation in antidepressant resistant rats. Frontiers in Human Neuroscience, 15 644921, 644921. doi: 10.3389/fnhum.2021.644921
Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Blaha, Charles D., Bennet, Kevin E., Jang, Dong-Pyo, Lee, Kendall H., Shin, Hojin and Oh, Yoonbae (2021). Cocaine-induced changes in tonic dopamine concentrations measured using multiple-cyclic square wave voltammetry in vivo. Frontiers in Pharmacology, 12 705254, 705254. doi: 10.3389/fphar.2021.705254
Lee, Stellina Y. H., Yates, Nathanael J. and Tye, Susannah J. (2021). Inflammatory mechanisms in Parkinson’s disease: from pathogenesis to targeted therapies. The Neuroscientist, 28 (5) ARTN 1073858421992265, 1073858421992265-506. doi: 10.1177/1073858421992265
Postorivo, Danielle and Tye, Susannah J. (2021). Novel antidepressant approaches for refractory depression. Current Treatment Options in Psychiatry, 8 (3), 141-157. doi: 10.1007/s40501-021-00246-y
Shiroma, Paulo R., Thuras, Paul, Wels, Joseph, Albott, C. Sophia, Erbes, Christopher, Tye, Susannah and Lim, Kelvin O. (2020). Neurocognitive performance of repeated versus single intravenous subanesthetic ketamine in treatment resistant depression. Journal of Affective Disorders, 277, 470-477. doi: 10.1016/j.jad.2020.08.058
Varela, Roger B., Resende, Wilson R., Dal-Pont, Gustavo C., Gava, Fernanda F., Nadas, Gabriella B., Tye, Susannah J., Andersen, Monica L., Quevedo, João and Valvassori, Samira S (2020). Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation. European Journal of Neuroscience, 53 (2) ejn.14922, 649-662. doi: 10.1111/ejn.14922
Shiroma, Paulo R., Thuras, Paul, Wels, Joseph, Albott, C Sophia, Erbes, Christopher, Tye, Susannah and Lim, Kelvin O. (2020). A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression. Translational Psychiatry, 10 (1) 206, 206. doi: 10.1038/s41398-020-00897-0
Varela, Roger B., Resende, Wilson R., Dal-Pont, Gustavo C., Gava, Fernanda F., Tye, Susannah J., Quevedo, João and Valvassori, Samira S. (2020). HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain. Pharmacology Biochemistry and Behavior, 193 172917, 172917. doi: 10.1016/j.pbb.2020.172917
Seshadri, Ashok, Clark, Matthew M., Kung, Simon, Fuller-Tyszkiewicz, Matthew, Sood, Amit, Dammen, Kristina C., Rico, Jose A., Tye, Susannah J., McGillivray, Jane and Frye, Mark A. (2020). Feasibility study of Stress Management and Resiliency Training (SMART) in patients with major depressive disorder. Primary Care Companion to CNS Disorders, 22 (3) 19m02556. doi: 10.4088/PCC.19m02556
Adams, Scott D., Doeven, Egan H., Tye, Susannah J., Bennet, Kevin E., Berk, Michael and Kouzani, Abbas Z. (2020). TinyFSCV: FSCV for the masses. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 28 (1) 8917694, 133-142. doi: 10.1109/TNSRE.2019.2956479
Roy, Abhrajeet V., Thai, Michelle, Klimes-Dougan, Bonnie, Westlund Schreiner, Mindy, Mueller, Bryon A., Albott, Christina Sophia, Lim, Kelvin O., Fiecas, Mark, Tye, Susannah J. and Cullen, Kathryn R. (2020). Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: preliminary evidence in adolescents with treatment-resistant depression. Journal of Psychopharmacology, 35 (2), 026988112092820-177. doi: 10.1177/0269881120928203
Walker, Adam J., Price, J. Blair, Borreggine, Kristin, Sutor, Shari L., Gogos, Andrea, McGillivray, Jane A., Frye, Mark A. and Tye, Susannah J. (2019). Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of antidepressant-resistance. Translational Psychiatry, 9 (1) 113, 113. doi: 10.1038/s41398-019-0434-5
Adams, Scott D., Bennet, Kevin E., Tye, Susannah J., Berk, Michael and Kouzani, Abbas Z. (2019). Development of a miniature device for emerging deep brain stimulation paradigms. PLoS ONE, 14 (2) e0212554, e0212554. doi: 10.1371/journal.pone.0212554
Valvassori, Samira S., Mariot, Edemilson, Varela, Roger B., Bavaresco, Daniela V., Dal-Pont, Gustavo C., Ferreira, Camila L., Andersen, Monica L., Tye, Susannah J. and Quevedo, João (2019). The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: implications to the animal model of bipolar disorder. Journal of Affective Disorders, 245, 1106-1113. doi: 10.1016/j.jad.2018.10.370
Cullen, K. R., Amatya, P., Roback, M. G., Albott, C. S., Westlund Schreiner, M., Ren, Y., Eberly, L. E., Carstedt, P., Samikoglu, A., Gunlicks-Stoessel, M., Reigstad, K., Horek, N., Tye, S., Lim, K. O. and Klimes-Dougan, B. (2019). Erratum: Intravenous ketamine for adolescents with treatment-resistant depression: An Open-Label Study, by Cullen KR, Amatya P, Roback MG, Albott CS, Westlund Schreiner M, Ren Y, Eberly LE, Carstedt P, Samikoglu A, Gunlicks-Stoessel M, Reigstad K, Horek N, Tye S, Lim KO, Klimes-Dougan B. (J Child Adolesc Psychopharmacol (2018) 28:7 (437-444) DOI: 10.1089/cap.2018.0030). Journal of Child and Adolescent Psychopharmacology, 29 (1), 77-77. doi: 10.1089/cap.2018.0030.correx
Ahmed, T. Ahmed, Frye, Mark A., Rush, A. John, Biernacka, Joanna M., Craighead, W. Edward, McDonald, William M., Bobo, William V., Riva-Posse, Patricio, Tye, Susannah J., Mayberg, Helen S., Hall-Flavin, Daniel K., Skime, Michelle K., Jenkins, Greg D., Wang, Liewei, Krishnan, Ranga Rama, Weinshilboum, Richard M., Kaddurah-Daouk, Rima and Dunlop, Boadie W. (2018). Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. Journal of Affective Disorders, 238, 1-7. doi: 10.1016/j.jad.2018.05.005
Nguyen, Thanh Thanh L., Chan, Lily C., Borreginne, Kristin, Kale, Rajas P., Hu, Chunling and Tye, Susannah J. (2018). A review of brain insulin signaling in mood disorders: from biomarker to clinical target. Neuroscience & Biobehavioral Reviews, 92, 7-15. doi: 10.1016/j.neubiorev.2018.05.014
Cullen, Kathryn R., Amatya, Palistha, Roback, Mark G., Albott, Christina Sophia, Westlund Schreiner, Melinda, Ren, Yanan, Eberly, Lynn E., Carstedt, Patricia, Samikoglu, Ali, Gunlicks-Stoessel, Meredith, Reigstad, Kristina, Horek, Nathan, Tye, Susannah, Lim, Kelvin O. and Klimes-Dougan, Bonnie (2018). Intravenous ketamine for adolescents with treatment-resistant depression: an open-label study. Journal of Child and Adolescent Psychopharmacology, 28 (7), 437-444. doi: 10.1089/cap.2018.0030
Vande Voort, Jennifer L., Morgan, Robert J., Kung, Simon, Rasmussen, Keith G., Rico, Jose, Palmer, Brian A., Schak, Kathryn M., Tye, Susannah J., Ritter, Matthew J., Frye, Mark A. and Bobo, William V. (2018). Corrigendum to “Continuation phase intravenous ketamine in adults with treatment-resistant depression” [J. Affect. Disord. 206 (2016) 300–304]. Journal of Affective Disorders, 236, 313-313. doi: 10.1016/j.jad.2017.09.024
Price, J. Blair, Bronars, Carrie, Erhardt, Sophie, Cullen, Kathyrn R., Schwieler, Lilly, Berk, Michael, Walder, Ken, McGee, Sean L., Frye, Mark A. and Tye, Susannah J. (2018). Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression. Neuroscience and Biobehavioral Reviews, 90, 212-220. doi: 10.1016/j.neubiorev.2018.04.002
Yang, Joanna, Lopez Cervera, Roberto, Tye, Susannah J., Ekker, Stephen C. and Pierret, Chris (2018). Adolescent mental health education InSciEd Out: a case study of an alternative middle school population. Journal of Translational Medicine, 16 (1) 84, 84. doi: 10.1186/s12967-018-1459-x
Adams, Scott D., Kouzani, Abbas Z., Tye, Susannah J., Bennet, Kevin E. and Berk, Michael (2018). An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction. Journal of NeuroEngineering and Rehabilitation, 15 (1) 8, 8. doi: 10.1186/s12984-018-0349-z
Edward, Epsy S, Kouzani, Abbas Z. and Tye, Susannah J (2018). Towards miniaturized closed-loop optogenetic stimulation devices. Journal of Neural Engineering, 15 (2) 021002, 021002. doi: 10.1088/1741-2552/aa7d62
Brimijoin, Stephen and Tye, Susannah (2018). Favorable impact on stress-related behaviors by modulating plasma Butyrylcholinesterase. Cellular and Molecular Neurobiology, 38 (1), 7-12. doi: 10.1007/s10571-017-0523-z
Morris, Gerwyn, Walder, Ken, Carvalho, André F., Tye, Susannah J., Lucas, Kurt, Berk, Michael and Maes, Michael (2018). The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases. Neuroscience and Biobehavioral Reviews, 84, 453-469. doi: 10.1016/j.neubiorev.2017.07.017
Kouzani, Abbas Z., Kale, Rajas P., Zarate-Garza, Pablo Patricio, Berk, Michael, Walder, Ken and Tye, Susannah J. (2017). Validation of a portable low-power deep brain stimulation device through anxiolytic effects in a laboratory rat model. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 25 (9) 7744659, 1365-1374. doi: 10.1109/TNSRE.2016.2628760
Veerabhadrappa, R., Bhatti, A., Berk, Michael, Tye, S. J. and Nahavandi, S. (2017). Hierarchical estimation of neural activity through explicit identification of temporally synchronous spikes. Neurocomputing, 249, 299-313. doi: 10.1016/j.neucom.2016.09.135
Luthar, Suniya S., Curlee, Alexandria, Tye, Susannah J., Engelman, Judith C. and Stonnington, Cynthia M. (2017). Fostering resilience among mothers under stress: "Authentic Connections Groups" for medical professionals. Women's Health Issues, 27 (3), 382-390. doi: 10.1016/j.whi.2017.02.007
Zarate-Garza, Pablo Patricio, Biggs, Bridget K, Croarkin, Paul, Morath, Brooke, Leffler, Jarrod, Cuellar-Barboza, Alfredo and Tye, Susannah J (2017). How well do we understand the long-term health implications of childhood bullying?. Harvard Review of Psychiatry, 25 (2), 89-95. doi: 10.1097/HRP.0000000000000137
Morris, Gerwyn, Walder, Ken, McGee, Sean L., Dean, Olivia M., Tye, Susannah J., Maes, Michael and Berk, Michael (2017). A model of the mitochondrial basis of bipolar disorder. Neuroscience and Biobehavioral Reviews, 74, 1-20. doi: 10.1016/j.neubiorev.2017.01.014
Patten, Christi A., Bronars, Carrie A., Vickers Douglas, Kristin S., Ussher, Michael H., Levine, James A., Tye, Susannah J., Hughes, Christine A., Brockman, Tabetha A., Decker, Paul A., DeJesus, Ramona S., Williams, Mark D., Olson, Thomas P., Clark, Matthew M. and Dieterich, Angela M. (2017). Supervised, vigorous intensity exercise intervention for depressed female smokers: a pilot study. Nicotine & Tobacco Research, 19 (1), 77-86. doi: 10.1093/ntr/ntw208
Vande Voort, Jennifer L., Morgan, Robert J., Kung, Simon, Rasmussen, Keith G., Rico, Jose, Palmer, Brian A., Schak, Kathryn M., Tye, Susannah J., Ritter, Matthew J., Frye, Mark A. and Bobo, William V. (2016). Continuation phase intravenous ketamine in adults with treatment-resistant depression. Journal of Affective Disorders, 206, 300-304. doi: 10.1016/j.jad.2016.09.008
Berk, Michael, Tye, Susannah, Walder, Ken and McGee, Sean (2016). Hyperthermia for major depressive disorder?. JAMA Psychiatry, 73 (10), 1095-1096. doi: 10.1001/jamapsychiatry.2016.1532
Bobo, William V., Voort, Jennifer L. Vande, Croarkin, Paul E., Leung, Jonathan G., Tye, Susannah J. and Frye, Mark A. (2016). Ketamine for treatment-resistant unipolar and bipolar major depression: critical review and implications for clinical practice. Depression and Anxiety, 33 (8), 698-710. doi: 10.1002/da.22505
Veerabhadrappa, R., Lim, C. P., Nguyen, T. T., Berk, M., Tye, S. J., Monaghan, P., Nahavandi, S. and Bhatti, A. (2016). Unified selective sorting approach to analyse multi-electrode extracellular data. Scientific Reports, 6 (1) 28533. doi: 10.1038/srep28533
Kim, Y., McGee, S., Czeczor, J. K., Walker, A. J., Kale, R. P., Kouzani, A. Z., Walder, K., Berk, M. and Tye, S. J. (2016). Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects. Translational Psychiatry, 6 (6) e842, e842-e842. doi: 10.1038/tp.2016.84
Kim, Yesul, Morath, Brooke, Hu, Chunling, Byrne, Linda K., Sutor, Shari L., Frye, Mark A. and Tye, Susannah J. (2016). Antidepressant actions of lateral habenula deep brain stimulation differentially correlate with CaMKII/GSK3/AMPK signaling locally and in the infralimbic cortex. Behavioural Brain Research, 306, 170-177. doi: 10.1016/j.bbr.2016.02.039
Abulseoud, Osama A., Kasasbeh, Aimen, Min, Hoon-Ki, Fields, Julie A., Tye, Susannah J., Goerss, Stephan, Knight, Emily J., Sampson, Shirlene M., Klassen, Bryan T., Matsumoto, Joseph Y., Stoppel, Cynthia, Lee, Kendall H. and Frye, Mark A. (2016). Stimulation-induced transient nonmotor psychiatric symptoms following subthalamic deep brain stimulation in patients with Parkinson's disease: association with clinical outcomes and neuroanatomical correlates. Stereotactic and Functional Neurosurgery, 94 (2), 93-101. doi: 10.1159/000445076
Adams, Scott, Kouzani, Abbas Z., Mohammed, Mazher, Usma, Clara and Tye, Susannah J. (2016). Fabrication of biocompatible enclosures for an electronic implant using 3D printing. International Journal of Rapid Manufacturing, 6 (1), 17-32. doi: 10.1504/ijrapidm.2016.078742
Frye, M. A., Nassan, M., Jenkins, G. D., Kung, S., Veldic, M., Palmer, B. A., Feeder, S. E., Tye, S. J., Choi, D. S. and Biernacka, J. M. (2015). Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders. Translational Psychiatry, 5 (12) e689, e689-e689. doi: 10.1038/tp.2015.185
Walker, Adam J., Foley, Brittany M., Sutor, Shari L., McGillivray, Jane A., Frye, Mark A. and Tye, Susannah J. (2015). Peripheral proinflammatory markers associated with ketamine response in a preclinical model of antidepressant-resistance. Behavioural Brain Research, 293, 198-202. doi: 10.1016/j.bbr.2015.07.026
Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah J., Samad, Mst Fateha, Kale, Rajas P., Bennet, Kevin E., Manciu, Felicia S. and Berk, Michael (2015). Radio frequency energy harvesting from a feeding source in a passive deep brain stimulation device for murine preclinical research. Medical Engineering and Physics, 37 (10), 1020-1026. doi: 10.1016/j.medengphy.2015.07.003
Kale, Rajas P., Kouzani, Abbas Z., Walder, Ken, Berk, Michael and Tye, Susannah J. (2015). Evolution of optogenetic microdevices. Neurophotonics, 2 (3) 031206, 031206. doi: 10.1117/1.NPh.2.3.031206
Frye, Mark A., Blier, Pierre and Tye, Susannah J. (2015). Concomitant benzodiazepine use attenuates ketamine response: implications for large scale study design and clinical development. Journal of Clinical Psychopharmacology, 35 (3), 334-6. doi: 10.1097/JCP.0000000000000316
Hosain, Md Kamal, Kouzani, Abbas Z., Samad, Mst Fateha and Tye, Susannah J. (2015). A miniature energy harvesting rectenna for operating a head-mountable deep brain stimulation device. IEEE Access, 3 7062898, 223-234. doi: 10.1109/ACCESS.2015.2414411
Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah, Kaynak, Akif and Berk, Michael (2015). RF rectifiers for EM power harvesting in a Deep Brain Stimulating device. Australasian Physical and Engineering Sciences in Medicine, 38 (1), 157-72. doi: 10.1007/s13246-015-0328-7
Davis, J., Maes, M., Andreazza, A., McGrath, J. J., Tye, S. J. and Berk, M. (2015). Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass. Molecular Psychiatry, 20 (2), 152-153. doi: 10.1038/mp.2014.139
Tye, Susannah, Van Voorhees, Elizabeth, Hu, Chunling and Lineberry, Timothy (2015). Preclinical perspectives on posttraumatic stress disorder criteria in DSM-5. Harvard Review of Psychiatry, 23 (1), 51-58. doi: 10.1097/HRP.0000000000000035
Frye, Mark A., Prieto, Miguel L., Bobo, William V., Kung, Simon, Veldic, Marin, Alarcon, Renato D., Moore, Katherine M., Choi, Doo-Sup, Biernacka, Joanna M. and Tye, Susannah J. (2014). Current landscape, unmet needs, and future directions for treatment of bipolar depression. Journal of Affective Disorders, 169 (S1), S17-S23. doi: 10.1016/S0165-0327(14)70005-9
Holland, Brendan J., Conlan, Xavier A., Stevenson, Paul G., Tye, Susannah, Reker, Ashlie, Barnett, Neil W., Adcock, Jacqui L. and Francis, Paul S. (2014). Determination of neurotransmitters and their metabolites using one- and two-dimensional liquid chromatography with acidic potassium permanganate chemiluminescence detection. Analytical and Bioanalytical Chemistry, 406 (23), 5669-5676. doi: 10.1007/s00216-013-7514-9
Walker, Adam J., Kim, Yesul, Price, J. Blair, Kale, Rajas P., McGillivray, Jane A., Berk, Michael and Tye, Susannah J. (2014). Stress, Inflammation, and Cellular Vulnerability during Early Stages of Affective Disorders: Biomarker Strategies and Opportunities for Prevention and Intervention. Frontiers in Psychiatry, 5 (APR) Article 34, 34. doi: 10.3389/fpsyt.2014.00034
Hosain, M. D. Kamal, Kouzani, Abbas Z., Tye, Susannah J., Abulseoud, Osama A., Amiet, Andrew, Galehdar, Amir, Kaynak, Akif and Berk, Michael (2014). Development of a compact rectenna for wireless powering of a head-mountable deep brain stimulation device. IEEE Journal of Translational Engineering in Health and Medicine, 2 1500113, 1500113-13. doi: 10.1109/JTEHM.2014.2313856
Broadbent, J., Sitka, N., Macfarlane, S. , McGillivray, J. and Tye, S. (2014). Informing Brain Health Behaviour Choices: The Efficacy of a High-School Brain Awareness Pilot Study. British Journal of Education, Society & Behavioural Science, 4 (6), 755-767. doi: 10.9734/bjesbs/2014/6694
Hosain, Md Kamal, Kouzani, Abbas and Tye, Susannah (2014). Closed loop deep brain stimulation: an evolving technology. Australasian Physical and Engineering Sciences in Medicine, 37 (4), 619-634. doi: 10.1007/s13246-014-0297-2
Tye, S. J., Miller, A. D. and Blaha, C. D. (2013). Ventral tegmental ionotropic glutamate receptor stimulation of nucleus accumbens tonic dopamine efflux blunts hindbrain-evoked phasic neurotransmission: implications for dopamine dysregulation disorders. Neuroscience, 252, 337-345. doi: 10.1016/j.neuroscience.2013.08.010
Kouzani, Abbas Z, Abulseoud, Osama A, Tye, Susannah J, Hosain, M D Kamal and Berk, Michael (2013). A low power micro deep brain stimulation device for murine preclinical research. IEEE Journal of Translational Engineering in Health and Medicine, 2, 1500109-1500109. doi: 10.1109/JTEHM.2013.2264093
Walker, Adam J., Burnett, Sandy A., Hasebe, Kyoko, McGillivray, Jane A., Gray, Laura J., McGee, Sean L., Walder, Ken, Berk, Michael and Tye, Susannah J. (2013). Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels. Behavioural Brain Research, 242 (1), 76-83. doi: 10.1016/j.bbr.2012.12.033
Anderson, Rodney J., Frye, Mark A., Abulseoud, Osama A., Lee, Kendall H., McGillivray, Jane A., Berk, Michael and Tye, Susannah J. (2012). Deep brain stimulation for treatment-resistant depression: efficacy, safety and mechanisms of action. Neuroscience and Biobehavioral Reviews, 36 (8), 1920-1933. doi: 10.1016/j.neubiorev.2012.06.001
Chopra, Amit, Tye, Susannah J., Lee, Kendall H., Sampson, Shirlene, Matsumoto, Joseph, Adams, Andrea, Klassen, Bryan, Stead, Matt, Fields, Julie A. and Frye, Mark A. (2012). Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature. Journal of Neuropsychiatry and Clinical Neurosciences, 24 (1), 102-110. doi: 10.1176/appi.neuropsych.10070109
Chopra, Amit, Tye, Susannah J., Lee, Kendall H., Matsumoto, Joseph, Klassen, Bryan, Adams, Andrea C., Stead, Matt, Sampson, Shirlene, Kall, Bruce A. and Frye, Mark A. (2011). Voltage-dependent mania after subthalamic nucleus deep brain stimulation in Parkinson's disease: a case report. Biological Psychiatry, 70 (2), e5-e7. doi: 10.1016/j.biopsych.2010.12.035
Griessenauer, Christoph J., Chang, Su-Youne, Tye, Susannah J., Kimble, Christopher J., Bennet, Kevin E., Garris, Paul A. and Lee, Kendall H. (2010). Wireless Instantaneous Neurotransmitter Concentration System: Electrochemical monitoring of serotonin using fast-scan cyclic voltammetry - A proof-of-principle study. Laboratory investigation. Journal of Neurosurgery, 113 (3), 656-665. doi: 10.3171/2010.3.JNS091627
Shon, Young-Min, Chang, Su-Youne, Tye, Susannah J., Kimble, Christopher J., Bennet, Kevin E., Blaha, Charles D. and Lee, Kendall H. (2010). Comonitoring of adenosine and dopamine using the wireless instantaneous neurotransmitter concentration system: Proof of principle: Laboratory investigation. Journal of Neurosurgery, 112 (3), 539-548. doi: 10.3171/2009.7.JNS09787
Tye, Susannah J, Miller, Anthony D and Blaha, Charles D (2009). Differential corticosteroid receptor regulation of mesoaccumbens dopamine efflux during the peak and nadir of the circadian rhythm: a molecular equilibrium in the midbrain?. Synapse (New York, N.Y.), 63 (11), 982-90. doi: 10.1002/syn.20682
Agnesi, Filippo, Tye, Susannah J., Bledsoe, Jonathan M., Griessenauer, Christoph J., Kimble, Christopher J., Sieck, Gary C., Bennet, Kevin E., Garris, Paul A., Blaha, Charles D. and Lee, Kendall H. (2009). Wireless Instantaneous Neurotransmitter Concentration System-based amperometric detection of dopamine, adenosine, and glutamate for intraoperative neurochemical monitoring: Laboratory investigation. Journal of Neurosurgery, 111 (4), 701-711. doi: 10.3171/2009.3.JNS0990
Tye, Susannah J., Covey, Dan P. and Griessenauer, Christoph J. (2009). A balancing act: D4 receptor activation and the neurobiological basis of emotional learning. Journal of Neuroscience, 29 (35), 10785-10787. doi: 10.1523/JNEUROSCI.2822-09.2009
Tye, Susannah J., Frye, Mark A. and Lee, Kendall H. (2009). Disrupting disordered neurocircuitry: Treating refractory psychiatric illness with neuromodulation. Mayo Clinic Proceedings, 84 (6), 522-532. doi: 10.4065/84.6.522
Conference Papers
Tye, Susannah (2023). Circuit-Based Manipulation of Striatal Dopamine: A State-Dependent and Mood Stabilizing Approach. 62nd Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Tampa Fl, Dec 03-06, 2023. LONDON: SPRINGERNATURE.
Voort, Jennifer Vande, Singh, Balwinder, Riva-Posse, Patricio, Erhardt, Sophie, Schwieler, Lilly, Pazdernik, Vanessa, Frye, Mark and Tye, Susannah (2023). Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression. NEW YORK: ELSEVIER SCIENCE INC.
Tye, S., Nasrallah, Fatima and Lim, Alex (2023). PRECISION PSYCHIATRY IN MILITARY MENTAL HEALTH CARE. LONDON: SAGE PUBLICATIONS LTD.
Tye, Susannah, Price, Joshua, Walker, Adam, Sutor, Shari, Erhardt, Sophie, Schwieler, Lilly, Cullen, Kathryn, Voort, Jennifer Vande, Frye, Mark, Bobo, William and Shiroma, Paulo (2023). Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression. NEW YORK: ELSEVIER SCIENCE INC.
Varella, R. B., Boschen, S. L., Blaha, C. D., Chye, N., Ghandi, K., Valvassori, S. S. and Tye, S. J. (2019). Antidepressant and antimanic effects of deep brain stimulation of the ventral tegmental area. 21st Annual ISBD Conference on Global Advances in Bipolar Disorder and Depression, Sydney Australia, Mar 20-23, 2019. HOBOKEN: WILEY. doi: 10.1111/bdi.12745
Blair, Joshua, Morath, Brooke, Butters, Kim, Frye, Mark, McGee, Sean and Tye, Susannah (2019). Molecular, cellular, and bioenergetic actions of ketamine and lithium combinatorial treatment in antidepressant resistant rats. 58th Annual Meeting of the American College of Neuropsychopharmacology , Orlando, Florida, 8-11 December 2019 . London, United Kingdom: Nature Publishing Group.
Adams, Scott, Kouzani, Abbas Z., Bennet, Kevin and Tye, Susannah J. (2017). Towards in-vivo ATP sensing. 2016 IEEE Region 10 Conference (TENCON), Singapore, 22-25 November 2016. Piscataway, NJ United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/TENCON.2016.7848474
Pfeiffer, John, Bustamante, Angela, Price, Joshua, Tye, Susannah and Uddin, Monica (2017). 501. Epigenetic modifications of stress-relevant genes as peripheral biomarkers of treatment-resistant depression. 72nd Annual Scientific Convention and Meeting, San Diego, CA, United States, 15 May 2017. NEW YORK: Elsevier BV. doi: 10.1016/j.biopsych.2017.02.1109
Kale, Rajas P., Kouzani, Abbas Z., Berk, Julian, Walder, Ken, Berk, Michael and Tye, Susannah J. (2016). Electrical resistance increases at the tissue-electrode interface as an early response to nucleus accumbens deep brain stimulation. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, FL, United States, 16-20 August 2016. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/EMBC.2016.7591071
Edward, Epsy S., Kouzani, Abbas Z., Kale, Rajas P. and Tye, Susannah J. (2016). Portable closed-loop optogenetic stimulation device. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, Florida, 16-20 August 2016 . Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/embc.2016.7591911
Edward, Epsy S., Kouzani, Abbas Z., Berk, Julian and Tye, Susannah J. (2016). A miniature neural recording device. IEEE International Conference on Industrial Technology, ICIT 2016, Taipei, Taiwan, 14-17 March 2016. Piscataway, NJ United States: IEEE. doi: 10.1109/icit.2016.7474892
Parastarfeizabadi, Mahboubeh, Kouzani, Abbas Z., Gibson, Ian and Tye, Susannah J. (2016). A miniature closed-loop deep brain stimulation device. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, Florida, 16-20 August 2016 . Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/embc.2016.7591064
Veerabhadrappa, Rakesh, Bhatti, Asim, Lim, Chee Peng, Nguyen, Thanh Thi, Tye, S. J., Monaghan, Paul and Nahavandi, Saeid (2015). Statistical modelling of artificial neural network for sorting temporally synchronous spikes. 22nd International Conference on Neural Information Processing, ICONIP 2015, Istanbul, Turkey, 9-12 November 2015. Heidelberg, 69121 Germany: Springer Verlag. doi: 10.1007/978-3-319-26555-1_30
Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah J., Abulseoud, Osama A. and Berk, Michael (2013). Design and analysis of an antenna for wireless energy harvesting in a head-mountable DBS device. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 3-7 July 2013. Piscataway, NJ, United States: IEEE. doi: 10.1109/EMBC.2013.6610191
Hosain, Md. Kamal, Kouzani, Abbas Z., Tye, Susannah, Walder, Ken and Kong, Lingxue (2012). Design of a miniature UHF PIFA for DBS implants. 6th International Conference on Complex Medical Engineering, CME 2012, Kobe, Japan, 1-4 July 2012. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/ICCME.2012.6275746
Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah, Mortazavi, Daryoush and Kaynak, Akif (2012). Compact stacked planar inverted-F antenna for passive deep brain stimulation implants. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, CA USA, 28 August-1 September 2012. doi: 10.1109/EMBC.2012.6346065
Hosain, Md Kamal, Kouzani, Abbas and Tye, Susannah (2012). Multi-layer implantable antenna for closed loop deep brain stimulation system. 2012 International Symposium on Communications and Information Technologies, ISCIT 2012, Gold Coast, QLD, Australia, 2-5 October 2012. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/ISCIT.2012.6380979
Kouzani, Abbas Z., Tye, Susannah, Walder, Ken and Kong, Lingxue (2011). A head mountable deep brain stimulation device for laboratory animals. 2011 International Conference on Computer, Communication, Control and Automation, 3CA 2011, , , November 19, 2011-November 20, 2011. doi: 10.1007/978-3-642-25541-0_36
Kimble, Christopher J., Johnson, David M., Winter, Bruce A., Whitlock, Sidney V., Kressin, Kenneth R., Horne, April E., Robinson, Justin C., Bledsoe, Jonathan M., Tye, Susannah J., Chang, Su-Youne, Agnesi, Filippo, Griessenauer, Christoph J., Covey, Daniel, Shon, Young-Min, Bennet, Kevin E., Garris, Paul A. and Lee, Kendall H. (2009). Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 2- 6 September, 2009. Piscataway, NJ, United States: IEEE Computer Society. doi: 10.1109/IEMBS.2009.5332773
Data Collection
Tye, Susannah (2019). Manipulating ghrelin tone for stress resilience. The University of Queensland. (Dataset) doi: 10.48610/7a58088