Professor Bruno van Swinderen
Professorial Research Fellow - GL
Queensland Brain Institute
+61 7 334 66332
Professor Bruno van Swinderen: Drosophila behaviour and cognition
Our long-term vision is to understand how a brain produces subjective awareness. To achieve this long-term goal, we have focussed on understanding three brain states where awareness can be lost: general anaesthesia, sleep, and selective attention. During selective attention, we become unaware of objects outside our focus. How does that work? During sleep, the outside world is more broadly suppressed. Why is this necessary? Finally, during general anaesthesia, a bewildering array of drugs achieve the same, but deeper. By studying these three ways in which consciousness is lost, we hope to arrive at a better understanding on what is necessary for consciousness to exist – in any animal.
Researcher biography
Professor Bruno van Swinderen received his PhD in Evolutionary and Population Biology in 1998 from Washington University in St. Louis, Missouri. His graduate work was on general anesthesia in a Caenorhabditis elegans model, applying both quantitative genetics and molecular genetic approaches. For his postdoc at The Neurosciences Institute (NSI) in San Diego, California (1999-2003), he switched to Drosophila melanogaster to develop methods of studying perception in the fruit-fly model. He ran a lab at NSI from 2003 to late 2007.
Professor van Swinderen established a new laboratory at the Queensland Brain Institute in February 2008.
Bruno van Swinderen's group use Drosophila as a genetic model system to study mechanisms of perception in the brain and are interested in three phenomena: selective attention, sleep, and general anesthesia. Their focus is on visual perception and how it is affected by these different arousal states. Their current effort is in understanding how sleep regulates selective attention and predictive processing. Toward this goal, they use various novel visual paradigms in a Drosophila molecular genetics context. The lab is also focussed on understanding presynaptic mechamisms of general anaesthesia, with a view to uncovering new strategies to improve recovery from this common medical procedure.
Publications
Book Chapters
Kirszenblat, Leonie and van Swinderen, Bruno (2019). Sleep in Drosophila. Handbook of Sleep Research. (pp. 333-347) edited by Hans C. Dringenberg. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-813743-7.00022-0
Karunanithi, Shanker, Troup, Michael and van Swinderen, Bruno (2018). Using Drosophila to understand general anesthesia: from synapses to behavior. Chemical and biochemical approaches for the study of anesthetic function, Part A. (pp. 153-176) edited by Roderick G. Eckenhoff and Ivan J. Dmochowski. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.mie.2018.02.003
van Swinderen, B. (2010). Visual learning and perception in Drosophila. Drosophila neurobiology: A laboratory manual. (pp. 411-427) edited by Bing Zhang, Marc R. Freeman and Scott Waddell. New York , U.S.A: Cold Spring Harbor Laboratory Press.
van Swinderen, B. (2006). Sleep in Invertebrates. Evolution of Nervous Systems, Volume 1: Theories, Development, Invertebrates. (pp. 451-456) edited by Jon H. Kaas. Oxford: Academic Press. doi: 10.1016/B0-12-370878-8/00185-3
Journal Articles
Tainton-Heap, Lucy, Troup, Michael, Van De Poll, Matthew and van Swinderen, Bruno (2024). Whole-Brain Calcium Imaging in Drosophila during Sleep and Wake. Cold Spring Harbor Protocols, 2024 (9) top108394. doi: 10.1101/pdb.prot108419
Van De Poll, Matthew and van Swinderen, Bruno (2024). Whole-Brain Electrophysiology in Drosophila during Sleep and Wake. Cold Spring Harbor Protocols, 2024 (9), 1-2. doi: 10.1101/pdb.prot108418
Hines, Adam D., Kewin, Amber B., Van De Poll, Matthew N., Anggono, Victor, Bademosi, Adekunle T. and van Swinderen, Bruno (2024). Synapse-specific trapping of SNARE machinery proteins in the anesthetized Drosophila brain. The Journal of Neuroscience, 44 (24) e0588232024, 1-18. doi: 10.1523/jneurosci.0588-23.2024
Cylinder, Drew M., van Zundert, André A. J., Solt, Ken and van Swinderen, Bruno (2024). Time to wake up! The ongoing search for general anesthetic reversal agents. Anesthesiology, 140 (3), 610-627. doi: 10.1097/aln.0000000000004846
Jagannathan, Sridhar R., Jeans, Travis, Van De Poll, Matthew N. and van Swinderen, Bruno (2024). Multivariate classification of multichannel long-term electrophysiology data identifies different sleep stages in fruit flies. Science Advances, 10 (8) eadj4399, eadj4399. doi: 10.1126/sciadv.adj4399
Anthoney, Niki, Tainton-Heap, Lucy, Luong, Hang, Notaras, Eleni, Kewin, Amber B., Zhao, Qiongyi, Perry, Trent, Batterham, Philip, Shaw, Paul J. and van Swinderen, Bruno (2023). Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila. eLife, 12 RP88198. doi: 10.7554/elife.88198
Troup, Michael, Tainton-Heap, Lucy A L and van Swinderen, Bruno (2023). Neural ensemble fragmentation in the anesthetized Drosophila brain. The Journal of Neuroscience, 43 (14), 2537-2551. doi: 10.1523/jneurosci.1657-22.2023
Anthoney, Niki, Tainton-Heap, Lucy A. L., Luong, Hang, Notaras, Eleni, Zhao, Qiongyi, Perry, Trent, Batterham, Philip, Shaw, Paul J. and van Swinderen, Bruno (2023). Experimentally induced active and quiet sleep engage non-overlapping transcriptomes in Drosophila. eLife, 12. doi: 10.7554/eLife.88198.1
Dissel, Stephane, Klose, Markus K., van Swinderen, Bruno, Cao, Lijuan, Ford, Melanie, Periandri, Erica M., Jones, Joseph D., Li, Zhaoyi and Shaw, Paul J. (2022). Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands. PLoS Biology, 20 (9) e3001797, 1-25. doi: 10.1371/journal.pbio.3001797
van Swinderen, Bruno and Kelz, Max B. (2022). Anesthesia: Synaptic power failure. Current Biology, 32 (14), R781-R783. doi: 10.1016/j.cub.2022.06.043
Van De Poll, Matthew N. and van Swinderen, Bruno (2021). Balancing prediction and surprise: A role for active sleep at the dawn of consciousness?. Frontiers in Systems Neuroscience, 15 768762, 768762. doi: 10.3389/fnsys.2021.768762
Hines, Adam D. and van Swinderen, Bruno (2021). Tracking single molecule dynamics in the adult Drosophila brain. eNeuro, 8 (3) ENEURO.0057-21.2021, ENEURO.0057-21.2021. doi: 10.1523/eneuro.0057-21.2021
Melnattur, Krishna, Kirszenblat, Leonie, Morgan, Ellen, Militchin, Valentin, Sakran, Blake, English, Denis, Patel, Rushi, Chan, Dorothy, van Swinderen, Bruno and Shaw, Paul J. (2021). A conserved role for sleep in supporting Spatial Learning in Drosophila. Sleep, 44 (3) zsaa197, 1-14. doi: 10.1093/sleep/zsaa197
Leung, Angus, Cohen, Dror, Van Swinderen, Bruno and Tsuchiya, Naotsugu (2021). Integrated information structure collapses with anesthetic loss of conscious arousal in Drosophila melanogaster. PLoS Computational Biology, 17 (2) e1008722, e1008722. doi: 10.1371/JOURNAL.PCBI.1008722
Tainton-Heap, Lucy A.L., Kirszenblat, Leonie C., Notaras, Eleni T., Grabowska, Martyna J., Jeans, Rhiannon, Feng, Kai, Shaw, Paul J. and van Swinderen, Bruno (2021). A paradoxical kind of sleep in Drosophila melanogaster. Current Biology, 31 (3), 578-590.e6. doi: 10.1016/j.cub.2020.10.081
van Alphen, Bart, Semenza, Evan R., Yap, Melvyn, van Swinderen, Bruno and Allada, Ravi (2021). A deep sleep stage in Drosophila with a functional role in waste clearance. Science Advances, 7 (4) eabc2999, 1-10. doi: 10.1126/sciadv.abc2999
Grabowska, Martyna J., Jeans, Rhiannon, Steeves, James and Van Swinderen, Bruno (2020). Oscillations in the central brain of Drosophila are phase locked to attended visual features. Proceedings of the National Academy of Sciences of the United States of America, 117 (47), 29925-29936. doi: 10.1073/pnas.2010749117
Karunanithi, Shanker, Lin, Yong Qi, Odierna, G. Lorenzo, Menon, Hareesh, Gonzalez, Juan Mena, Neely, G Gregory, Noakes, Peter G., Lavidis, Nickolas A., Moorhouse, Andrew J. and van Swinderen, Bruno (2020). Activity-dependent global downscaling of evoked neurotransmitter release across glutamatergic inputs in Drosophila. The Journal of Neuroscience, 40 (42), 8025-8041. doi: 10.1523/JNEUROSCI.0349-20.2020
van Swinderen, Bruno and Hines, Adam D. (2020). Turning to Drosophila for help in resolving general anesthesia. Proceedings of the National Academy of Sciences, 117 (40), 24627-24628. doi: 10.1073/pnas.2012131117
Ertekin, Deniz, Kirszenblat, Leonie, Faville, Richard and van Swinderen, Bruno (2020). Down-regulation of a cytokine secreted from peripheral fat bodies improves visual attention while reducing sleep in Drosophila. PLOS Biology, 18 (8) 3000548, e3000548. doi: 10.1371/journal.pbio.3000548
Muñoz, Roberto N., Leung, Angus, Zecevik, Aidan, Pollock, Felix A., Cohen, Dror, Van Swinderen, Bruno, Tsuchiya, Naotsugu and Modi, Kavan (2020). General anesthesia reduces complexity and temporal asymmetry of the informational structures derived from neural recordings in Drosophila. Physical Review Research, 2 (2) 023219. doi: 10.1103/PhysRevResearch.2.023219
Karunanithi, Shanker, Cylinder, Drew, Ertekin, Deniz, Zalucki, Oressia H., Marin, Leo, Lavidis, Nickolas A., Atwood, Harold L. and van Swinderen, Bruno (2020). Proportional downscaling of glutamatergic release sites by the general anesthetic propofol at Drosophila motor nerve terminals. eNeuro, 7 (1) ENEURO.0422-19.2020, ENEURO.0422-14. doi: 10.1523/eneuro.0422-19.2020
Dissel, Stephane, Morgan, Ellen, Duong, Vincent, Chan, Dorothy, van Swinderen, Bruno, Shaw, Paul and Zars, Troy (2020). Sleep restores place learning to the adenylyl cyclase mutant rutabaga. Journal of Neurogenetics, 34 (1), 83-91. doi: 10.1080/01677063.2020.1720674
Carter, Olivia, van Swinderen, Bruno, Leopold, David A., Collin, Shaun P. and Maier, Alexander (2020). Perceptual rivalry across animal species. Journal of Comparative Neurology, 528 (17) cne.24939, 3123-3133. doi: 10.1002/cne.24939
Troup, Michael, Zalucki, Oressia H., Kottler, Benjamin D., Karunanithi, Shanker, Anggono, Victor and van Swinderen, Bruno (2019). Syntaxin1A neomorphic mutations promote rapid recovery from isoflurane anesthesia in Drosophila melanogaster. Anesthesiology, 131 (3), 555-568. doi: 10.1097/ALN.0000000000002850
Kirszenblat, Leonie, Yaun, Rebecca and van Swinderen, Bruno (2019). Visual experience drives sleep need in Drosophila. Sleep, 42 (7) zsz102. doi: 10.1093/sleep/zsz102
Grabowska, Martyna J., Steeves, James, Alpay, Julius, van de Poll, Matthew, Ertekin, Deniz and van Swinderen, Bruno (2018). Innate visual preferences and behavioral flexibility in Drosophila. The Journal of Experimental Biology, 221 (23) jeb185918, jeb185918. doi: 10.1242/jeb.185918
Kirszenblat, Leonie, Ertekin, Deniz, Goodsell, Joseph, Zhou, Yanqiong, Shaw, Paul J. and van Swinderen, Bruno (2018). Sleep regulates visual selective attention in Drosophila. The Journal of Experimental Biology, 221 (24) jeb191429, jeb.191429. doi: 10.1242/jeb.191429
Troup, Michael, Yap, Melvyn H. W., Rohrscheib, Chelsie, Grabowska, Martyna J, Ertekin, Deniz, Randeniya, Roshini, Kottler, Benjamin, Larkin, Oife, Munro, Kelly, Shaw, Paul J and van Swinderen, Bruno (2018). Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness. eLife, 7 e37105. doi: 10.7554/eLife.37105
Bademosi, Adekunle T., Lauwers, Elsa, Amor, Rumelo, Verstreken, Patrik, van Swinderen, Bruno and Meunier, Frédéric A (2018). In vivo single-molecule tracking at the Drosophila presynaptic motor nerve terminal. Journal of Visualized Experiments, 2018 (131) e56952. doi: 10.3791/56952
Bademosi, Adekunle T. , Steeves, James, Karunanithi, Shanker, Zalucki, Oressia H, Gormal, Rachel S, Liu, Shu, Lauwers, Elsa, Verstreken, Patrik, Anggono, Victor, Meunier, Frederic A and van Swinderen, Bruno (2018). Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic. Cell reports, 22 (2), 427-440. doi: 10.1016/j.celrep.2017.12.054
Cohen, Dror, van Swinderen, Bruno and Tsuchiya, Naotsugu (2018). Isoflurane impairs low-frequency feedback but leaves high-frequency feedforward connectivity intact in the fly brain. eNeuro, 5 (1) e0329-17.2018, ENEURO.0329-17.2018. doi: 10.1523/ENEURO.0329-17.2018
Yap, Melvyn H. W., Grabowska, Martyna J., Rohrscheib, Chelsie, Jeans, Rhiannon, Troup, Michael, Paulk, Angelique C., van Alphen, Bart, Shaw, Paul J. and van Swinderen, Bruno (2017). Oscillatory brain activity in spontaneous and induced sleep stages in flies. Nature Communications, 8 (1) 1815, 1815. doi: 10.1038/s41467-017-02024-y
Rohrscheib, Chelsie E., Frentiu, Francesca D., Horn, Emilie, Ritchie, Fiona K., van Swinderen, Bruno, Weible, Michael W., O'Neill, Scott L. and Brownlie, Jeremy C. (2017). Response to: comment on Rohrscheib et al. 2016 "Intensity of mutualism breakdown is determined by temperature not amplification of Wolbachia genes". PLoS Pathogens, 13 (9) e1006521, e1006521. doi: 10.1371/journal.ppat.1006521
Ferguson, Lachlan, Petty, Alice, Rohrscheib, Chelsie, Troup, Michael, Kirszenblat, Leonie, Eyles, Darryl W. and van Swinderen, Bruno (2017). Transient dysregulation of dopamine signaling in a developing drosophila arousal circuit permanently impairs behavioral responsiveness in adults. Frontiers in Psychiatry, 8 (FEB) 22, 22. doi: 10.3389/fpsyt.2017.00022
Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, van Swinderen, Bruno and Meunier, Frédéric A (2017). Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters. Nature Communications, 8 (1) 14492. doi: 10.1038/ncomms14492
Dissel, Stephane, Klose, Markus, Donlea, Jeff, Cao, Lijuan, English, Denis, Winsky-Sommerer, Raphaelle, van Swinderen, Bruno and Shaw, Paul J. (2017). Enhanced sleep reverses memory deficits and underlying pathology in drosophila models of Alzheimer's disease. Neurobiology of Sleep and Circadian Rhythms, 2, 15-26. doi: 10.1016/j.nbscr.2016.09.001
Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, Van Swinderen, Bruno and Meunier, Frederic A. (2016). In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters. Nature Communications, 7 (1) 13660, 13660. doi: 10.1038/ncomms13660
Wang, Tong, Martin, Sally, Nguyen, Tam H., Harper, Callista B., Gormal, Rachel S., Martinez-Marmol, Ramon, Karunanithi, Shanker, Coulson, Elizabeth J., Glass, Nick R., Cooper-White, Justin J., Van Swinderen, Bruno and Meunier, Frederic A. (2016). Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB. Nature Communications, 7 (1) 12976, 12976. doi: 10.1038/ncomms12976
Rohrscheib, Chelsie E., Frentiu, Francesca D., Horn, Emilie, Ritchie, Fiona K., van Swinderen, Bruno, Weible, Michael W., O'Neill, Scott L. and Brownlie, Jeremy C. (2016). Intensity of mutualism breakdown is determined by temperature not amplification of Wolbachia genes. PLoS Pathogens, 12 (9) e1005888, e1005888. doi: 10.1371/journal.ppat.1005888
Zalucki, Oressia and Van Swinderen, Bruno (2016). What is unconsciousness in a fly or a worm? A review of general anesthesia in different animal models. Consciousness and Cognition, 44, 72-88. doi: 10.1016/j.concog.2016.06.017
Cohen, Dror, Zalucki, Oressia H., van Swinderen, Bruno and Tsuchiya, Naotsugu (2016). Local versus global effects of isoflurane anesthesia on visual processing in the fly brain. eNeuro, 3 (4), 876-880. doi: 10.1523/ENEURO.0116-16.2016
De Bivort, Benjamin L. and Van Swinderen, Bruno (2016). Evidence for selective attention in the insect brain. Current Opinion in Insect Science, 15, 9-15. doi: 10.1016/j.cois.2016.02.007
Van De Poll, Matthew N., Zajaczkowski, Esmi L., Taylor, Gavin J., Srinivasan, Mandyam V. and van Swinderen, Bruno (2015). Using an abstract geometry in virtual reality to explore choice behaviour: visual flicker preferences in honeybees. Journal of Experimental Biology, 218 (21), 3448-3460. doi: 10.1242/jeb.125138
Larkin, Aoife, Chen, Ming-Yu, Kirszenblat, Leonie, Reinhard, Judith, van Swinderen, Bruno and Claudianos, Charles (2015). Neurexin-1 regulates sleep and synaptic plasticity in Drosophila melanogaster. European Journal of Neuroscience, 42 (7), 2455-2466. doi: 10.1111/ejn.13023
Taylor, Gavin J., Paulk, Angelique C., Pearson, Thomas W., Moore, Richard J. D., Stacey, Jacqui A., Ball, David, van Swinderen, Bruno and Srinivasan, Mandyam V. (2015). Insects modify their behaviour depending on the feedback sensor used when walking on a trackball in virtual-reality. Journal of Experimental Biology, 218 (19), 3118-3127. doi: 10.1242/jeb.125617
Paulk, Angelique C., Kirszenblat, Leonie, Zhou, Yanqiong and van Swinderen, Bruno (2015). Closed-loop behavioral control increases coherence in the fly brain. Journal of Neuroscience, 35 (28), 10304-10315. doi: 10.1523/JNEUROSCI.0691-15.2015
Rohrscheib, Chelsie E., Bondy, Elizabeth, Josh, Peter, Riegler, Markus, Eyles, Darryl, van Swinderen, Bruno, Weible, Michael W. and Brownlie, Jeremy C. (2015). Wolbachia influences the production of octopamine and affects Drosophila male aggression. Applied and Environmental Microbiology, 81 (14), 4573-4580. doi: 10.1128/AEM.00573-15
Bosch, Danny S., van Swinderen, Bruno and Millard, S. Sean (2015). Dscam2 affects visual perception in Drosophila melanogaster. Frontiers in Behavioral Neuroscience, 9 (June) A149, 1-13. doi: 10.3389/fnbeh.2015.00149
Zalucki, Oressia H., Menon, Hareesh, Kottler, Benjamin, Faville, Richard, Day, Rebecca, Bademosi, Adekunle T., Lavidis, Nickolas, Karunanithi, Shanker and van Swinderen, Bruno (2015). Syntaxin1A-mediated resistance and hypersensitivity to isoflurane in Drosophila melanogaster. Anesthesiology, 122 (5), 1060-1074. doi: 10.1097/ALN.0000000000000629
Faville, R., Kottler, B., Goodhill, G. J., Shaw, P. J. and van Swinderen, B. (2015). How deeply does your mutant sleep? Probing arousal to better understand sleep defects in Drosophila. Scientific Reports, 5 (1) 8454, 1-13. doi: 10.1038/srep08454
Zalucki, Oressia, Day, Rebecca, Kottler, Benjamin, Karunanithi, Shanker and van Swinderen, Bruno (2015). Behavioral and electrophysiological analysis of general anesthesia in 3 background strains of Drosophila melanogaster. Fly, 9 (1), 7-15. doi: 10.1080/19336934.2015.1072663
Kirszenblat, Leonie and van Swinderen, Bruno (2015). The yin and yang of sleep and attention. Trends in Neurosciences, 38 (12), 776-786. doi: 10.1016/j.tins.2015.10.001
Dissel, Stepane, Angadi, Veena, Kirszenblat, Leonie, Suzuki, Yasuko, Donlea, Jeff, Klose, Markus, Koch, Zachary, English, Denis, Winsky-Sommerer, Raphaelle, van Swinderen, Bruno and Shaw, Paul J. (2015). Sleep Restores Behavioral Plasticity to Drosophila Mutants. Current Biology, 25 (10), 1270-1281. doi: 10.1016/j.cub.2015.03.027
Kottler, Benjamin and Van Swinderen, Bruno (2014). Taking a new look at how flies learn. Elife, 3 e03978, e03978.1-e03978.3. doi: 10.7554/eLife.03978
Sun, Fei, Wang, YiJin, Zhou, YanQiong, Van Swinderen, Bruno, Gong, ZheFeng and Liu, Li (2014). Identification of neurons responsible for feeding behavior in the Drosophila brain. Science China-Life Sciences, 57 (4), 391-402. doi: 10.1007/s11427-014-4641-2
Paulk, Angelique C., Stacey, Jacqueline A., Pearson, Thomas W. J., Taylor, Gavin J., Moore, Richard J. D., Srinivasan, Mandyam V. and Van Swinderen, Bruno (2014). Selective attention in the honeybee optic lobes precedes behavioral choices. Proceedings of the National Academy of Sciences of the United States of America, 111 (13), 5006-5011. doi: 10.1073/pnas.1323297111
Moore, Richard J. D., Taylor, Gavin J., Paulk, Angelique C., Pearson, Thomas, van Swinderen, Bruno and Srinivasan, Mandyam V. (2014). FicTrac: A visual method for tracking spherical motion and generating fictive animal paths. Journal of Neuroscience Methods, 225, 106-119. doi: 10.1016/j.jneumeth.2014.01.010
van Swinderen, Bruno and Kottler, Benjamin (2014). Explaining general anesthesia: A two-step hypothesis linking sleep circuits and the synaptic release machinery. BioEssays, 36 (4), 372-381. doi: 10.1002/bies.201300154
Paulk, Angelique C., Zhou, Yanqiong, Stratton, Peter, Liu, Li and van Swinderen, Bruno (2013). Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation. Journal of Neurophysiology, 110 (7), 1703-1721. doi: 10.1152/jn.00414.2013
van Alphen, Bart, Yap, Melvyn H. W., Kirszenblat, Leonie, Kottler, Benjamin and van Swinderen, Bruno (2013). A dynamic deep sleep stage in Drosophila. Journal of Neuroscience, 33 (16), 6917-6927. doi: 10.1523/JNEUROSCI.0061-13.2013
Kottler, Benjamin, Bao, Hong, Zalucki, Oressia, Imlach, Wendy, Troup, Michael, van Alphen, Bart, Paulk, Angelique, Zhang, Bing and van Swinderen, Bruno (2013). A sleep/wake circuit controls isoflurane sensitivity in Drosophila. Current Biology, 23 (7), 594-598. doi: 10.1016/j.cub.2013.02.021
van Alphen, Bart and van Swinderen, Bruno (2013). Drosophila strategies to study psychiatric disorders. Brain Research Bulletin, 92, 1-11. doi: 10.1016/j.brainresbull.2011.09.007
Calcagno, B., Eyles, D., van Alphen, B. and van Swinderen, B. (2013). Transient activation of dopaminergic neurons during development modulates visual responsiveness, locomotion and brain activity in a dopamine ontogeny model of schizophrenia. Translational Psychiatry, 3 (1), e206.1-e206.10. doi: 10.1038/tp.2012.139
Paulk, Angelique, Millard, S. Sean and van Swinderen, Bruno (2013). Vision in Drosophila: seeing the world through a model's eyes. Annual Review of Entomology, 58 (1), 313-332. doi: 10.1146/annurev-ento-120811-153715
van Swinderen, Bruno (2012). Competing visual flicker reveals attention-like rivalry in the fly brain. Frontiers in Integrative Neuroscience, 6 (OCTOBER 2012), 96.1-96.2. doi: 10.3389/fnint.2012.00096
Miller, Steven Mark, Ngo, Trung Thanh and van Swinderen, Bruno (2012). Attentional switching in humans and flies: rivalry in large and miniature brains. Frontiers in Human Neuroscience, 5 (JANUARY 2012) ARTN 188, 1-17. doi: 10.3389/fnhum.2011.00188
van Swinderen, Bruno (2011). Single fly tethered paradigms. Cold Spring Harbor Protocol, 2011 (12), 1488-1491. doi: 10.1101/pdb.prot066910
van Swinderen, Bruno (2011). The optomotor maze: a population assay for visual perception in Drosophila. Cold Spring Harbor Protocols, 6 (11), 1337-1339. doi: 10.1101/pdb.prot066530
van Swinderen, Bruno (2011). Conditioning to colors: a population assay for visual learning in Drosophila. Cold Spring Harbor Protocols, 6 (11), 1334-1336. doi: 10.1101/pdb.prot066522
van Swinderen. Bruno (2011). The aversive phototaxic suppression assay for individual adult Drosophila. Cold Spring Harbor Protocols, 6 (10), 1203-1205. doi: 10.1101/pdb.prot065896
van Swinderen, Bruno (2011). An assay for visual learning in individual Drosophila larvae. Cold Spring Harbor Protocols, 6 (10), 1200-1202. doi: 10.1101/pdb.prot065888
van Swinderen, Bruno (2011). Attention in drosophila. International Review of Neurobiology, 99, 51-85. doi: 10.1016/B978-0-12-387003-2.00003-3
Karunanithi, Shanker and van Swinderen, Bruno (2011). Slamdance: Seizing a fly model for epilepsy. Journal of Neurophysiology, 106 (1), 15-17. doi: 10.1152/jn.00382.2011
Evans, Oliver, Paulk, Angelique C. and van Swinderen, Bruno (2011). An automated paradigm for drosophila visual psychophysics. PLOS ONE, 6 (6) e21619, Article number e21619. doi: 10.1371/journal.pone.0021619
Burne, T. H. J., Scott, E., van Swinderen, B., Hilliard, M., Reinhard, J., Claudianos, C., Eyles, D. W. and McGrath, J. J. (2011). Big ideas for small brains: What can psychiatry learn from worms, flies, bees and fish?. Molecular Psychiatry, 16 (1), 7-16. doi: 10.1038/mp.2010.35
van Swinderen, Bruno and Brembs, Bjoern (2010). Attention-like deficit and hyperactivity in a Drosophila memory mutant. Journal of Neuroscience, 30 (3), 1003-1014. doi: 10.1523/JNEUROSCI.4516-09.2010
van Swinderen, Bruno (2009). Fly memory: a mushroom body story in parts. Current Biology, 19 (18), R855-R857. doi: 10.1016/j.cub.2009.07.064
van Swinderen, Bruno, McCartney, Amber, Kauffman, Sarah, Flores, Kris, Agrawal, Kunal, Wagner, Jenee and Paulk, Angelique (2009). Shared visual attention and memory systems in the Drosophila brain. PLoS One, 4 (6 Article e5989) e5989, 1-13. doi: 10.1371/journal.pone.0005989
van Swinderen, Bruno (2007). The attention-span of a fly. Fly, 1 (3), 187-189.
van Swinderen, Bruno (2007). Attention-like processes in Drosophila Require Short-term Memory Genes. Science, 315 (5818), 1590-1593. doi: 10.1126/science.1137931
van Swinderen, Bruno and Flores, Kristopher A. (2007). Attention-like processes underlying optomotor performance in a Drosophila Choice Maze. Journal of Neurobiology, 67 (2), 129-145. doi: 10.1002/dneu.20334
van Swinderen, Bruno (2006). A succession of anesthetic endpoints in the Drosophila brain. Journal of Neurobiology, 66 (11), 1195-1211. doi: 10.1002/neu.20300
Andretic, Rozi, van Swinderen, Bruno and Greenspan, Ralph J. (2005). Dopaminergic modulation of arousal in Drosophila. Current Biology, 15 (13), 1165-1175. doi: 10.1016/j.cub.2005.05.025
van Swinderen, Bruno and Greenspan, Ralph J. (2005). Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster. Genetics, 169 (4), 2151-2163. doi: 10.1534/genetics.103.023341
van Swinderen, B (2005). The remote roots of consciousness in fruit-fly selective attention?. Bioessays, 27 (3), 321-330. doi: 10.1002/bies.20195
Greenspan, Ralph J. and van Swinderen, Bruno (2004). Cognitive consonance: complex brain functions in the fruit fly and its relatives. Trends in Neurosciences, 27 (12), 707-711. doi: 10.1016/j.tins.2004.10.002
van Swinderen, B., Nitz, D.A. and Greenspan, R.J. (2004). Uncoupling of brain activity from movement defines arousal states in Drosophila. Current Biology, 14 (2), 81-87. doi: 10.1016/j.cub.2003.12.057
van Swinderen, Bruno and Andretic Rozi (2003). Arousal in Drosophila. Behavioural Processes, 64 (2), 133-144. doi: 10.1016/S0376-6357(03)00131-1
van Swinderen, Bruno and Greenspan, Ralph J. (2003). Salience modulates 20-30 Hz brain activity in Drosophila. Nature Neuroscience, 6 (6), 579-586. doi: 10.1038/nn1054
Nitz, Douglas A., van Swinderen, Bruno, Tononi, Giulio and Greenspan, Ralph J. (2002). Electrophysiological correlates of rest and activity in Drosophila melanogaster. Current Biology, 12 (22), 1934-1940. doi: 10.1016/S0960-9822(02)01300-3
Van Swinderen B., Metz L.B., Shebester L.D., Mendel J.E., Sternberg P.W. and Crowder C.M. (2001). Goα regulates volatile anesthetic action in Caenorhabditis elegans., 158 (2), 643-655.
Van Swinderen B., Saifee O., Shebester L., Roberson R., Nonet M.L. and Crowder C.M. (1999). A neomorphic syntaxin mutation blocks volatile-anesthetic action in Caenorhabditis elegans. Proceedings of the National Academy of Sciences, 96 (5), 2479-2484. doi: 10.1073/pnas.96.5.2479
Van Swinderen B., Galifianakis A. and Crowder C.M. (1998). Common genetic determinants of halothane and isoflurane potencies in Caenorhabditis elegans. Anesthesiology, 89 (6), 1509-1517. doi: 10.1097/00000542-199812000-00030
Van Swinderen B., Shook D.R., Ebert R.H., Cherkasova V.A., Johnson T.E., Reis R.J. and Crowder C.M. (1997). Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans. Proceedings of the National Academy of Sciences, 94 (15), 8232-8237. doi: 10.1073/pnas.94.15.8232
Cheverud J.M., Routman E.J., Duarte F.A.M., Van Swinderen B., Cothran K. and Perel C. (1996). Quantitative trait loci for murine growth., 142 (4), 1305-1319.
Chandrashekar, R., Vanswinderen, B., Taylor, H. R. and Weil, G. J. (1995). Effect of ivermection prophylaxis on antibody responses to Onchocerca volvulus recombinant antigens in experimentally infected chimpanzees. International Journal for Parasitology, 25 (8), 983-988. doi: 10.1016/0020-7519(95)00011-P
van Swinderen B. and Hall J.C. (1995). Analysis of conditioned courtship in dusky-Andante rhythm mutants of Drosophila.., 2 (2), 49-61.
Conference Papers
Kottler, B., Zalucki, O., Zhang, B. and Van Swinderen, B. (2012). Converging bioaminergic pathways controlling general anaesthesia and sleep in Drosophila. 2012 European Fly Neurobiology Meeting, Padua, Italy, 3-7 September 2012. Philadelphia, PA, United States: Informa Healthcare.
Van Swinderen, Bruno and Andretic, Rozi (2011). Dopamine in Drosophila: Setting arousal thresholds in a miniature brain. London, United Kingdom: The Royal Society Publishing. doi: 10.1098/rspb.2010.2564
Eyles, Darryl, Calcagno, B., Formella, I., Van Swinderen, B., Scott, E., Burne, T. and McGrath, J. (2011). Modeling schizophrenia, dopamine ontogeny and the small brain. 13th International Congress on Schizophrenia Research (ICOSR), Colorado Springs CO, United States, 2-6 April 2011. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/schbul/sbq173
Van Alphen, B., Burne, T. H. J., Eyles, D. W., Mattingley, J., McGrath, J. J. and van Swinderen, B. (2010). A high-throughput assay to measure sensorimotor gating (PPI) in Drosophila. ANS/AuPS 2010 – the 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society, Sydney, NSW, Australia, 31 January - 2 February 2010.
Evans O., Paulk, A. C. and van Swinderen, B. (2010). Learning and memory pathways in the Drosophila mushroom bodies affect motion response to visual stimuli. ANS/AuPS 2010 – 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society, Sydney, NSW Australia, 31 January - 2 February 2010.
van Swinderen, B. and Paulk, A. C. (2010). Steady-state visually evoked potentials (SSVEPs) reveal attention-like behaviour in the fruitfly Drosophila melanogaster. ANS/AuPS 2010: 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society, Sydney, NSW,` Australia, 31 January - 2 February 2010.
van Swinderen, B. (2009). Oscillations, attention, and timing in the fly brain. BCN Symposium: Clocks in the brain and concepts of time, Groningen, The Netherlands, June, 2009.
van Swinderen, B. and Brembs, B. (2009). A short attention span in the memory consolidation mutant radish. Australian Neuroscience Society 29th Annual Meeting, Canberra, ACT Australia, 27 - 30January, 2009.
Evans, O., Paulk, A. and van Swinderen, B. (2009). The optomotor maze paradigm: a high-throughput assay to study visual perception in Drosophila mutants. Janelia Farm Research Conference on Visual Processing in Insects: From Anatomy to Behavior, Janelia Farm, Virginia, USA, 17 - 20 May, 2009.
van Swinderen, Bruno (2008). Neural correlates of visual attention in Drosophila melanogaster. Asia-Pacific Conference on Vision, Brisbane, Australia, 18 - 21 July, 2008.
van Swinderen, B. (2008). Attention in the Drosophila Brain. 23rd Australian Insect Molecular Biology conference, Melbourne, Victoria, July, 2008.
van Swinderen, Bruno (2007). Attention-like processes in the Drosophila brain. Janelia Farm Research Conference on Insect Behavior: Small Brains, Big Functions, Janelia Farm, Virginia, USA, 13 - 15 March, 2007.
van Swinderen, Bruno (2007). The Standard Matrix: A novel approach to exploring genetic effects on behavior in Drosophila. 9th Annual Meeting of the International Behavioural and Neural Genetics Society (IBANGS), Doorwerth, The Netherlands, 21-25 May, 2007.
van Swinderen, Bruno (2007). Neurobiology of Drosophila summer lab course and lecture, Visual Learning Section. Neurobiology of Drosophila 2007, New York, USA, 3-7 October, 2007.
van Swinderen, Bruno (2006). Neurobiology of Drosophila summer lab course and lecture, Visual Learning Section. Neurobiology of Drosophila 2006, New York, USA, July, 2006.
van Swinderen, Bruno (2006). Genes modulating selective attention and associated Local Field Potentials in Drosophila. Computational and Systems Neuroscience workshop on oscillations 2006, Park City, Utah, USA, March, 2006.
van Swinderen, B. (2006). How to study consciousness on the fly: insights from brain recordings during sleep, general anesthesia, and selective attention in Drosophila. 11th European Drosophila Neurobiology Conference, Leuven, Belgium, 2 - 6 September, 2006.
van Swinderen, B. (2006). Learning and Memory Genes Modulate Selective Attention in Drosophila. Gordon Research Conference on Genes and Behavior, Ventura, California, U.S.A, January, 2006.
van Swinderen, B., Dierick, H., Andretic, R., Wagner, J., Kyriacou, C. and Greenspan, R. J. (2006). The Standard Matrix: A novel approach to exploring genetic effects on behavior in Drosophila. 11th European Drosophila Neurobiology Conference, Leuven, Belgium, 2 - 6 September, 2006.
van Swinderen, Bruno (2005). Studying fruit-fly selective attention with frequency-tagged visual stimuli. Computational and Systems Neuroscience workshop on oscillations 2005, Snowbird, Utah, USA, March, 2005.
van Swinderen, Bruno (2005). Neurobiology of Drosophila summer lab course and lecture, Visual Learning Section. Neurobiology of Drosophila 2005, New York, USA, 5 - 9 October, 2005.
van Swinderen, B. (2004). Fruit fly approaches to studying consciousness-related variables. The Eighth Conference of the Association for the Scientific Study of Consciousness, Antwerp, Belgium, 24 - 28 June, 2004.
van Swinderen, B. (2003). Local Field Potential recordings and visually evoked responses in Drosophila. Neurobiology of Drosophila 2001, United States, 3-7 October, 2001. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory.
van Swinderen, B. (2003). Uncoupling brain activity and arousal from movement in Drosophila. Neurobiology of Drosophila 2003, United States, 1 - 5 October, 2003. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory.
van Swinderen, B. and Greenspan, R. J. (2002). Physiology and neuroanatomy of selective attention in the brain of Drosophila. Society for Neuroscience Annual Meeting 2002, Orlando, Florida, 2-7 November, 2002.
van Swinderen, B. and Greenspan, R. J. (2002). Physiology and neuroanatomy of selective attention in the brain of Drosophila. Neurofly 2002, Dijon, France, 7 - 11 September, 2002.
van Swinderen, B, Galifianakis, A and Crowder, CM (1998). A quantitative genetic approach towards volatile anesthetic mechanisms in C. elegans. 5th International Conference on Molecular and Cellular Mechanisms of Anaesthesia, Calgary Canada, Jun 18-20, 1997. doi: 10.1016/S0378-4274(98)00200-8
Data Collections
Hines, Adam, van Swinderen, Bruno and Kewin, Amber (2022). Isoflurane-mediated trapping of Syntaxin1a into nanoclusters in excitatory but not inhibitory synapses reveals a presynaptic mechanism of general anesthesia. The University of Queensland. (Dataset) doi: 10.48610/1c00586
Hines, Adam and van Swinderen, Bruno (2021). PALM Imaging and analysis. The University of Queensland. (Dataset) doi: 10.14264/2124384
Hines, Adam D and van Swinderen, Bruno (2021). Tracking single molecule dynamics in the adult Drosophila brain. The University of Queensland. (Dataset) doi: 10.14264/2059dcb
Grabowska, Martyna and van Swinderen, Bruno (2020). Oscillations in the central brain of Drosophila are phase locked to attended visual features. The University of Queensland. (Dataset) doi: 10.14264/43fb51f
van Swinderen, Bruno (2019). Drosophila Sleep Multichannel. The University of Queensland. (Dataset) doi: 10.48610/6b03a7c
Generic Documents
van Swinderen, B. (2008). Fly psychology.