Emeritus Professor Joseph Lynch: Molecular neuroscience

The Lynch laboratory’s major research interest concerns the molecular structure and function of the glycine and GABAA receptor (GABAAR) chloride channels that mediate inhibitory neurotransmission in the brain. The GABAAR is an important therapeutic target for sedative and anxiolytic drugs and the glycine receptor (GlyR) has recently emerged as a therapeutic target for pain, spasticity, epilepsy and tinnitus. The Lynch laboratory is discovering new drugs active at these receptors and the molecular mechanisms by which their structures and functions are disrupted in hereditary neurological disorders.

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