Dr Ramon Martinez-Marmol
Postdoctoral Research Fellow
Queensland Brain Institute
+61 7 334 66362
Journal Articles
Martínez-Mármol, Ramón, Mohannak, Nika, Qian, Lei, Wang, Tong, Gormal, Rachel S, Ruitenberg, Marc J, Vanhaesebroeck, Bart, Coulson, Elizabeth J and Meunier, Frédéric A (2019) p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model. Journal of Neuroscience, 39 40: 7976-7991. doi:10.1523/JNEUROSCI.0674-19.2019
Padmanabhan, Pranesh, Martínez-Mármol, Ramón, Xia, Di, Götz, Jürgen and Meunier, Frédéric A. (2019) Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife, 8 . doi:10.7554/elife.45040
Rosello-Busquets, Cristina, de la Oliva, Natalia, Martinez-Marmol, Ramon, Hernaiz-Llorens, Marc, Pascual, Marta, Muhaisen, Ashraf, Navarro, Xavier, del Valle, Jaume and Soriano, Eduardo (2019) Cholesterol depletion regulates axonal growth and enhances central and peripheral nerve regeneration. Frontiers in Cellular Neuroscience, 13 . doi:10.3389/fncel.2019.00040
Ros, Oriol, Jose Barrecheguren, Pablo, Cotrufo, Tiziana, Schaettin, Martina, Rosello-Busquets, Cristina, Vilchez-Acosta, Alba, Hernaiz-Llorens, Marc, Martinez-Marmol, Ramon, Ulloa, Fausto, Stoeckli, Esther T., Araujo, Sofia J. and Soriano, Eduardo (2018) A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse. PLoS Genetics, 14 6: e1007432. doi:10.1371/journal.pgen.1007432
Polanco, Juan Carlos, Li, Chuanzhou, Bodea, Liviu-Gabriel, Martinez-Marmol, Ramon, Meunier, Frederic A and Götz, Jürgen (2017) Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies. Nature reviews. Neurology, 14 1: 22-40. doi:10.1038/nrneurol.2017.162
Joensuu, Merja, Martinez-Marmol, Ramon, Padmanabhan, Pranesh, Glass, Nick R., Durisic, Nela, Pelekanos, Matthew, Mollazade, Mahdie, Balistreri, Giuseppe, Amor, Rumelo, Cooper-White, Justin J., Goodhill, Geoffrey J. and Meunier, Frederic A. (2017) Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules. Nature Protocols, 12 12: 2590-2622. doi:10.1038/nprot.2017.116
Martinez-Marmol, Ramón, Styrczewska, Katarzyna, Perez-Verdaguer, Mireia, Vallejo-Gracia, Albert, Comes, Núria, Sorkin, Alexander and Felipe, Antonio (2017) Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation. Scientific Reports, 7 1: 42395. doi:10.1038/srep42395
Sole, Laura, Roig, Sara R., Vallejo-Gracia, Albert, Serrano-Albarras, Antonio, Martinez-Marmol, Ramon, Tamkun, Michael M. and Felipe, Antonio (2016) The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit. Journal of Cell Science, 129 22: 4265-4277. doi:10.1242/jcs.191650
Martinez-Marmol, Ramón, Barneda-Zahonero, Bruna, Soto, David, Andres, Rosa Maria, Coccia, Elena, Gasull, Xavier, Planells-Ferrer, Laura, Moubarak, Rana S., Soriano, Eduardo and Comella, Joan X. (2016) FAIM-L regulation of XIAP degradation modulates synaptic long-term depression and axon degeneration. Scientific Reports, 6 . doi:10.1038/srep35775
Wang, Tong, Martin, Sally, Nguyen, Tam H., Harper, Callista B., Gormal, Rachel S., Martinez-Marmol, Ramon, Karunanithi, Shanker, Coulson, Elizabeth J., Glass, Nick R., Cooper-White, Justin J., Van Swinderen, Bruno and Meunier, Frederic A. (2016) Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB. Nature Communications, 7 12976. doi:10.1038/ncomms12976
Martínez-Mármol, Ramón, Salla-Martret, Mercè, Sastre, Daniel, Estadella, Irene and Felipe, Antonio (2016) EGF and the potassium channel Kv1.3 are promising pharmacological targets against neuro-degenerative diseases. Journal of Neurology and Neuromedicine, 1 5: .
Martinez-Marmol, Ramon, Comes, Nuria, Styrczewska, Katarzyna, Perez-Verdaguer, Mireia, Vicente, Ruben, Pujadas, Lluis, Soriano, Eduardo, Sorkin, Alexander and Felipe, Antonio (2016) Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis. Cellular and Molecular Life Sciences, 73 7: 1515-1528. doi:10.1007/s00018-015-2082-0
Perez-Verdaguer, Mireia, Capera, Jesusa, Martinez-Marmol, Ramon, Camps, Marta, Comes, Nuria, Tamkun, Michael M. and Felipe, Antonio (2016) Caveolin interaction governs Kv1.3 lipid raft targeting. Scientific Reports, 6 . doi:10.1038/srep22453
Ros, Oriol, Cotrufo, Tiziana, Martinez-Marmol, Ramon and Soriano, Eduardo (2015) Regulation of patterned dynamics of local exocytosis in growth cones by Netrin-1. Journal of Neuroscience, 35 13: 5156-5170. doi:10.1523/JNEUROSCI.0124-14.2015
Ulloa, Fausto, Gonzalez-Junca, Alba, Meffre, Delphine, Barrecheguren, Pablo Jose, Martinez-Marmol, Ramon, Pazos, Irene, Olive, Nuria, Cotrufo, Tiziana, Seoane, Joan and Soriano, Eduardo (2015) Blockade of the SNARE protein syntaxin 1 inhibits glioblastoma tumor growth. PLoS One, 10 3: . doi:10.1371/journal.pone.0119707
Martinez-Marmol, Ramon, Perez-Verdaguer, Mireia, Roig, Sara R., Vallejo-Gracia, Albert, Gotsi, Pelagia, Serrano-Albarras, Antonio, Isabel Bahamonde, Maria, Ferrer-Montiel, Antonio, Fernandez-Ballester, Gregorio, Comes, Nuria and Felipe, Antonio (2013) A non-canonical di-acidic signal at the C-terminus of Kv1.3 determines anterograde trafficking and surface expression. Journal of Cell Science, 126 24: 5681-5691. doi:10.1242/jcs.134825
Cotrufo, Tiziana, Maria Andres, Rosa, Ros, Oriol, Perez-Branguli, Francesc, Muhaisen, Ashraf, Fuschini, Giulia, Martinez, Ramon, Pascual, Marta, Comella, Joan X. and Soriano, Eduardo (2012) Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip. European Journal of Neuroscience, 36 9: 3152-3164. doi:10.1111/j.1460-9568.2012.08259.x
David, Miren, Macias, Alvaro, Moreno, Cristina, Prieto, Angela, Martinez-Marmol, Ramon, Vicente, Ruben, Gonzalez, Teresa, Felipe, Antonio, Tamkun, Michael M. and Valenzuela, Carmen (2012) Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome. Journal of Biological Chemistry, 287 25: 21416-21428. doi:10.1074/jbc.M111.328278
Martinez-Marmol, Ramon, Villalonga, Nuria, Sole, Laura, Vicente, Ruben, Tamkun, Michael M., Soler, Concepcio and Felipe, Antonio (2008) Multiple Kv1.5 targeting to membrane surface microdomains. Journal of Cellular Physiology, 217 3: 667-673. doi:10.1002/jcp.21538
Roura-Ferrer, Meritxell, Sole, Laura, Martinez-Marmol, Ramon, Villalonga, Nuria and Felipe, Antonio (2008) Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation. Biochemical and Biophysical Research Communications, 369 4: 1094-1097. doi:10.1016/j.bbrc.2008.02.152
Villalonga, Nuria, Martinez-Marmol, Ramon, Roura-Ferrer, Meritxell, David, Miren, Valenzuela, Carmen, Soler, Concepcio and Felipe, Antonio (2008) Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation. Biochimica Et Biophysica Acta-Molecular Cell Research, 1783 5: 728-736. doi:10.1016/j.bbamcr.2008.01.001
David, Miren, Martinez-Marmol, Ramon, Gonzalez, Teresa, Felipe, Antonio and Valenzuela, Carmen (2008) Differential regulation of Navβ subunits during myogenesis. Biochemical and Biophysical Research Communications, 368 3: 761-766. doi:10.1016/j.bbrc.2008.01.138
Martinez-Marmol, Ramon, David, Miren, Sanches, Rosario, Roura-Ferrer, Meritxell, Villalonga, Nuria, Sorianello, Eleonora, Webb, Susan M., Zorzano, Antonio, Guma, Anna, Valenzuela, Cannen and Felipe, Antonio (2007) Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair. Cardiovascular Research, 76 3: 430-441. doi:10.1016/j.cardiores.2007.08.009
Felipe, Antonio, Vicente, Ruben, Villalonga, Nuria, Roura-Ferrer, Meritxell, Martinez-Marmol, Ramon, Sole, Laura, Ferreres, Joan C. and Condom, Enric (2006) Potassium channels: new targets in cancer therapy. Cancer Detection and Prevention, 30 4: 375-385. doi:10.1016/j.cdp.2006.06.002
Conference Papers
Roig, Sara R., Sole, Laura, Vallejo-Gracia, Albert, Sastre, Daniel, Serrano-Albarras, Antonio, Serrano-Novillo, Clara, Martinez-Marmol, Ramon, Tamkun, Michael M. and Felipe, Antonio (2017). The C-Terminal Domain of Kv1.3 Interacts with KCNE4 to form Oligo-meric Channels. In: 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, (545A-545A). 15-19 February 2014. doi:10.1016/j.bpj.2016.11.2944
Styrczewska, Katarzyna, Martinez-Marmol, Ramon, Comes, Nuria, Estadella, Irene, Perez-Verdaguer, Mireia, Pujadas, Lluis, Soriano, Eduardo, Sorkin, Alexander and Felipe, Antonio (2017). ERK1/2 Mediates EGF-Dependent Kv1.3 Endocytosis. In: Biophysical Journal. 58th Annual Meeting of the Biophysical-Society, San Francisco Ca, (251A-252A). Feb 15-19, 2014. doi:10.1016/j.bpj.2016.11.1374
Perez-Verdaguer, Mireia, Capera, Jesusa, Martinez-Marmol, Ramon, Camps, Marta, Comes, Nuria, Tamkun, Michael M. and Felipe, Antonio (2017). Deciphering the Kv1.3/Caveolin Interaction. In: Biophysical Journal. 58th Annual Meeting of the Biophysical-Society, San Francisco Ca, (252A-252A). Feb 15-19, 2014. doi:10.1016/j.bpj.2016.11.1375
Martinez-Marmol, R., Perez-Verdaguer, M., Roig, S. R., Vallejo-Gracia, A., Capera, J., Serrano-Albarras, A., Serrano-Novillo, C., Ferrer-Montiel, A., Fernandez-Ballester, G., Comes, N. and Felipe, A. (2014). A DI-ACIDIC MOTIF IS RESPONSIBLE FOR Kv1.3 MEMBRANE SURFACE EXPRESSION VIA COPII-DEPENDENT MECHANISMS. In: Acta Physiologica. , , (47-47). .
Martinez-Marmol, Ramon, Perez-Verdaguer, Mireia, Roig, Sara R., Vallejo-Gracia, Albert, Gotsi, Pelagia, Serrano-Albarras, Antonio, Isabel Bahamonde, Ma, Ferrer-Montiel, Antonio, Fernandez-Ballester, Gregorio, Comes, Nuria and Felipe, Antonio (2014). A Non-Canonical Di-Acidic Signal at the C-Terminal of KV1.3 Determines Anterograde Trafficking and Surface Expression. In: 58th Annual Meeting of the Biophysical Society, San Francisco, CA United States, (739A-739A). 15-19 February 2014. doi:10.1016/j.bpj.2013.11.4072