Dr Ramon Martinez-Marmol
Research Fellow
Queensland Brain Institute
+61 7 334 66362
Book Chapters
Small, Christopher, Martínez-Mármol, Ramon, Amor, Rumelo, Meunier, Frederic A. and Joensuu, Merja (2021). Combining single molecule super-resolution imaging techniques to unravel the nanoscale organization of the presynapse. Exocytosis and endocytosis. (pp. 265-286) edited by Florence Niedergang, Nicolas Vitale and Stéphane Gasman. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1044-2_18
Joensuu, Merja, Martínez-Mármol, Ramon, Mollazade, Mahdie, Padmanabhan, Pranesh and Meunier, Frédéric A. (2020). Single-molecule imaging of recycling synaptic vesicles in live neurons. Single molecule microscopy in neurobiology. (pp. 81-114) edited by Nobuhiko Yamamoto and Yasushi Okada. New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-0532-5_5
Journal Articles
Hernaiz-Llorens, Marc, Martínez-Mármol, Ramón, Roselló-Busquets, Cristina and Soriano, Eduardo (2021). One raft to guide them all, and in axon regeneration inhibit them. International Journal of Molecular Sciences, 22 (9) 5009, 5009. doi: 10.3390/ijms22095009
Hernaiz-Llorens, Marc, Roselló-Busquets, Cristina, Durisic, Nela, Filip, Adam, Ulloa, Fausto, Martínez-Mármol, Ramón and Soriano, Eduardo (2020). Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors. Cellular and Molecular Life Sciences, 78 (6), 2797-2820. doi: 10.1007/s00018-020-03663-z
Harper, Callista B., Small, Christopher, Davenport, Elizabeth C., Low, Darryl W., Smillie, Karen J., Martínez-Mármol, Ramón, Meunier, Frédéric A. and Cousin, Michael A. (2020). An epilepsy-associated SV2A mutation disrupts Synaptotagmin-1 expression and activity-dependent trafficking. The Journal of Neuroscience, 40 (23), 4586-4595. doi: 10.1523/jneurosci.0210-20.2020
Roselló-Busquets, Cristina, Hernaiz-Llorens, Marc, Soriano, Eduardo and Martínez-Mármol, Ramon (2020). Nystatin regulates axonal extension and regeneration by modifying the levels of nitric oxide. Frontiers in Molecular Neuroscience, 13 56, 56. doi: 10.3389/fnmol.2020.00056
Martínez-Mármol, Ramón, Mohannak, Nika, Qian, Lei, Wang, Tong, Gormal, Rachel S, Ruitenberg, Marc J, Vanhaesebroeck, Bart, Coulson, Elizabeth J and Meunier, Frédéric A (2019). p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model. Journal of Neuroscience, 39 (40), 7976-7991. doi: 10.1523/JNEUROSCI.0674-19.2019
Padmanabhan, Pranesh, Martínez-Mármol, Ramón, Xia, Di, Götz, Jürgen and Meunier, Frédéric A. (2019). Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife, 8 e45040. doi: 10.7554/elife.45040
Rosello-Busquets, Cristina, de la Oliva, Natalia, Martinez-Marmol, Ramon, Hernaiz-Llorens, Marc, Pascual, Marta, Muhaisen, Ashraf, Navarro, Xavier, del Valle, Jaume and Soriano, Eduardo (2019). Cholesterol depletion regulates axonal growth and enhances central and peripheral nerve regeneration. Frontiers in Cellular Neuroscience, 13 40, 40. doi: 10.3389/fncel.2019.00040
Kasula, Ravikiran, Blum, Ailisa, Salla-Martret, Merce, Chai, Ye Jin, Jiang, Anmin, Wallis, Tristan P., Gormal, Rachel S., Brouillet, Julie Z., Padmanabhan, Pranesh, Weeratunga, Saroja K., Livingstone, Emma K., Mollazade, Mahdie, Joensuu, Merja, Martínez-Mármol, Ramón, Collins, Brett M. and Meunier, Frederic (2019). VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming. SSRN Electronic Journal. doi: 10.2139/ssrn.3362260
Ros, Oriol, Jose Barrecheguren, Pablo, Cotrufo, Tiziana, Schaettin, Martina, Rosello-Busquets, Cristina, Vilchez-Acosta, Alba, Hernaiz-Llorens, Marc, Martinez-Marmol, Ramon, Ulloa, Fausto, Stoeckli, Esther T., Araujo, Sofia J. and Soriano, Eduardo (2018). A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse. PLoS Genetics, 14 (6) e1007432, e1007432. doi: 10.1371/journal.pgen.1007432
Polanco, Juan Carlos, Li, Chuanzhou, Bodea, Liviu-Gabriel, Martinez-Marmol, Ramon, Meunier, Frederic A and Götz, Jürgen (2017). Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies. Nature reviews. Neurology, 14 (1), 22-40. doi: 10.1038/nrneurol.2017.162
Joensuu, Merja, Martinez-Marmol, Ramon, Padmanabhan, Pranesh, Glass, Nick R., Durisic, Nela, Pelekanos, Matthew, Mollazade, Mahdie, Balistreri, Giuseppe, Amor, Rumelo, Cooper-White, Justin J., Goodhill, Geoffrey J. and Meunier, Frederic A. (2017). Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules. Nature Protocols, 12 (12), 2590-2622. doi: 10.1038/nprot.2017.116
Martinez-Marmol, Ramón, Styrczewska, Katarzyna, Perez-Verdaguer, Mireia, Vallejo-Gracia, Albert, Comes, Núria, Sorkin, Alexander and Felipe, Antonio (2017). Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation. Scientific Reports, 7 (1) 42395, 42395. doi: 10.1038/srep42395
Sole, Laura, Roig, Sara R., Vallejo-Gracia, Albert, Serrano-Albarras, Antonio, Martinez-Marmol, Ramon, Tamkun, Michael M. and Felipe, Antonio (2016). The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit. Journal of Cell Science, 129 (22), 4265-4277. doi: 10.1242/jcs.191650
Martinez-Marmol, Ramón, Barneda-Zahonero, Bruna, Soto, David, Andres, Rosa Maria, Coccia, Elena, Gasull, Xavier, Planells-Ferrer, Laura, Moubarak, Rana S., Soriano, Eduardo and Comella, Joan X. (2016). FAIM-L regulation of XIAP degradation modulates synaptic long-term depression and axon degeneration. Scientific Reports, 6 (1) 35775. doi: 10.1038/srep35775
Wang, Tong, Martin, Sally, Nguyen, Tam H., Harper, Callista B., Gormal, Rachel S., Martinez-Marmol, Ramon, Karunanithi, Shanker, Coulson, Elizabeth J., Glass, Nick R., Cooper-White, Justin J., Van Swinderen, Bruno and Meunier, Frederic A. (2016). Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB. Nature Communications, 7 (1) 12976, 12976. doi: 10.1038/ncomms12976
Martínez-Mármol, Ramón, Salla-Martret, Mercè, Sastre, Daniel, Estadella, Irene and Felipe, Antonio (2016). EGF and the potassium channel Kv1.3 are promising pharmacological targets against neuro-degenerative diseases. Journal of Neurology and Neuromedicine, 1 (5).
Martinez-Marmol, Ramon, Comes, Nuria, Styrczewska, Katarzyna, Perez-Verdaguer, Mireia, Vicente, Ruben, Pujadas, Lluis, Soriano, Eduardo, Sorkin, Alexander and Felipe, Antonio (2016). Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis. Cellular and Molecular Life Sciences, 73 (7), 1515-1528. doi: 10.1007/s00018-015-2082-0
Perez-Verdaguer, Mireia, Capera, Jesusa, Martinez-Marmol, Ramon, Camps, Marta, Comes, Nuria, Tamkun, Michael M. and Felipe, Antonio (2016). Caveolin interaction governs Kv1.3 lipid raft targeting. Scientific Reports, 6 (1) 22453, 22453. doi: 10.1038/srep22453
Ros, Oriol, Cotrufo, Tiziana, Martinez-Marmol, Ramon and Soriano, Eduardo (2015). Regulation of patterned dynamics of local exocytosis in growth cones by Netrin-1. Journal of Neuroscience, 35 (13), 5156-5170. doi: 10.1523/JNEUROSCI.0124-14.2015
Ulloa, Fausto, Gonzalez-Junca, Alba, Meffre, Delphine, Barrecheguren, Pablo Jose, Martinez-Marmol, Ramon, Pazos, Irene, Olive, Nuria, Cotrufo, Tiziana, Seoane, Joan and Soriano, Eduardo (2015). Blockade of the SNARE protein syntaxin 1 inhibits glioblastoma tumor growth. PLoS One, 10 (3) e0119707, e0119707. doi: 10.1371/journal.pone.0119707
Martinez-Marmol, Ramon, Perez-Verdaguer, Mireia, Roig, Sara R., Vallejo-Gracia, Albert, Gotsi, Pelagia, Serrano-Albarras, Antonio, Isabel Bahamonde, Maria, Ferrer-Montiel, Antonio, Fernandez-Ballester, Gregorio, Comes, Nuria and Felipe, Antonio (2013). A non-canonical di-acidic signal at the C-terminus of Kv1.3 determines anterograde trafficking and surface expression. Journal of Cell Science, 126 (24), 5681-5691. doi: 10.1242/jcs.134825
Cotrufo, Tiziana, Maria Andres, Rosa, Ros, Oriol, Perez-Branguli, Francesc, Muhaisen, Ashraf, Fuschini, Giulia, Martinez, Ramon, Pascual, Marta, Comella, Joan X. and Soriano, Eduardo (2012). Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip. European Journal of Neuroscience, 36 (9), 3152-3164. doi: 10.1111/j.1460-9568.2012.08259.x
David, Miren, Macias, Alvaro, Moreno, Cristina, Prieto, Angela, Martinez-Marmol, Ramon, Vicente, Ruben, Gonzalez, Teresa, Felipe, Antonio, Tamkun, Michael M. and Valenzuela, Carmen (2012). Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome. Journal of Biological Chemistry, 287 (25), 21416-21428. doi: 10.1074/jbc.M111.328278
Martinez-Marmol, Ramon, Villalonga, Nuria, Sole, Laura, Vicente, Ruben, Tamkun, Michael M., Soler, Concepcio and Felipe, Antonio (2008). Multiple Kv1.5 targeting to membrane surface microdomains. Journal of Cellular Physiology, 217 (3), 667-673. doi: 10.1002/jcp.21538
Martínez-Mármol, Ramón, Roura-Ferrer, Meritxell and Felipe, Antonio (2008). Targeting potassium channels: New advances in cardiovascular therapy. Recent Patents on Cardiovascular Drug Discovery, 3 (2), 105-118. doi: 10.2174/157489008784705386
Roura-Ferrer, Meritxell, Sole, Laura, Martinez-Marmol, Ramon, Villalonga, Nuria and Felipe, Antonio (2008). Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation. Biochemical and Biophysical Research Communications, 369 (4), 1094-1097. doi: 10.1016/j.bbrc.2008.02.152
Villalonga, Nuria, Martinez-Marmol, Ramon, Roura-Ferrer, Meritxell, David, Miren, Valenzuela, Carmen, Soler, Concepcio and Felipe, Antonio (2008). Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation. Biochimica Et Biophysica Acta-Molecular Cell Research, 1783 (5), 728-736. doi: 10.1016/j.bbamcr.2008.01.001
David, Miren, Martinez-Marmol, Ramon, Gonzalez, Teresa, Felipe, Antonio and Valenzuela, Carmen (2008). Differential regulation of Navβ subunits during myogenesis. Biochemical and Biophysical Research Communications, 368 (3), 761-766. doi: 10.1016/j.bbrc.2008.01.138
Martinez-Marmol, Ramon, David, Miren, Sanches, Rosario, Roura-Ferrer, Meritxell, Villalonga, Nuria, Sorianello, Eleonora, Webb, Susan M., Zorzano, Antonio, Guma, Anna, Valenzuela, Cannen and Felipe, Antonio (2007). Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair. Cardiovascular Research, 76 (3), 430-441. doi: 10.1016/j.cardiores.2007.08.009
Felipe, Antonio, Vicente, Ruben, Villalonga, Nuria, Roura-Ferrer, Meritxell, Martinez-Marmol, Ramon, Sole, Laura, Ferreres, Joan C. and Condom, Enric (2006). Potassium channels: new targets in cancer therapy. Cancer Detection and Prevention, 30 (4), 375-385. doi: 10.1016/j.cdp.2006.06.002
Conference Papers
Martinez-Marmon, Ramon, Styrczewska, Katarzyna, Perez-Verdaguer, Mireia, Vallejo-Gracia, Albert, Comes, Nuria, Sorkin, Alexander and Felipe, Antonio (2018). PKC Activation Induces Ubiquitination-Dependent KV1.3 Endocytosis Mediated by Nedd4-2 Ubiquitin Ligase. 62nd Annual Meeting of the Biophysical-Society, San Francisco, CA United States, 17-21 February 2018. Cambridge, United Kingdom: Cell Press. doi: 10.1016/j.bpj.2017.11.1713
Styrczewska, Katarzyna, Martinez-Marmol, Ramon, Comes, Nuria, Estadella, Irene, Perez-Verdaguer, Mireia, Pujadas, Lluis, Soriano, Eduardo, Sorkin, Alexander and Felipe, Antonio (2017). ERK1/2 Mediates EGF-Dependent Kv1.3 Endocytosis. 58th Annual Meeting of the Biophysical-Society, San Francisco Ca, Feb 15-19, 2014. CELL PRESS. doi: 10.1016/j.bpj.2016.11.1374
Perez-Verdaguer, Mireia, Capera, Jesusa, Martinez-Marmol, Ramon, Camps, Marta, Comes, Nuria, Tamkun, Michael M. and Felipe, Antonio (2017). Deciphering the Kv1.3/Caveolin Interaction. 58th Annual Meeting of the Biophysical-Society, San Francisco Ca, Feb 15-19, 2014. CELL PRESS. doi: 10.1016/j.bpj.2016.11.1375
Roig, Sara R., Sole, Laura, Vallejo-Gracia, Albert, Sastre, Daniel, Serrano-Albarras, Antonio, Serrano-Novillo, Clara, Martinez-Marmol, Ramon, Tamkun, Michael M. and Felipe, Antonio (2017). The C-Terminal Domain of Kv1.3 Interacts with KCNE4 to form Oligo-meric Channels. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, 15-19 February 2014. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2016.11.2944
Martinez-Marmol, Ramon, Perez-Verdaguer, Mireia, Roig, Sara R., Vallejo-Gracia, Albert, Gotsi, Pelagia, Serrano-Albarras, Antonio, Isabel Bahamonde, Ma, Ferrer-Montiel, Antonio, Fernandez-Ballester, Gregorio, Comes, Nuria and Felipe, Antonio (2014). A Non-Canonical Di-Acidic Signal at the C-Terminal of KV1.3 Determines Anterograde Trafficking and Surface Expression. 58th Annual Meeting of the Biophysical Society, San Francisco, CA United States, 15-19 February 2014. St. Louis, MO United States: Cell Press. doi: 10.1016/j.bpj.2013.11.4072
Martinez-Marmol, R., Perez-Verdaguer, M., Roig, S. R., Vallejo-Gracia, A., Capera, J., Serrano-Albarras, A., Serrano-Novillo, C., Ferrer-Montiel, A., Fernandez-Ballester, G., Comes, N. and Felipe, A. (2014). A DI-ACIDIC MOTIF IS RESPONSIBLE FOR Kv1.3 MEMBRANE SURFACE EXPRESSION VIA COPII-DEPENDENT MECHANISMS. WILEY-BLACKWELL.