Dr Ramon Martinez-Marmol

Small, Christopher, Martínez-Mármol, Ramon, Amor, Rumelo, Meunier, Frederic A. and Joensuu, Merja (2021). Combining single molecule super-resolution imaging techniques to unravel the nanoscale organization of the presynapse. Exocytosis and endocytosis: methods and protocols. (pp. 265-286) edited by Florence Niedergang, Nicolas Vitale and Stéphane Gasman. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1044-2_18

Joensuu, Merja, Martínez-Mármol, Ramon, Mollazade, Mahdie, Padmanabhan, Pranesh and Meunier, Frédéric A. (2020). Single-molecule imaging of recycling synaptic vesicles in live neurons. Single molecule microscopy in neurobiology. (pp. 81-114) edited by Nobuhiko Yamamoto and Yasushi Okada. New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-0532-5_5

Donato, Alessandra, Ritchie, Fiona K., Lu, Lachlan, Wadia, Mehershad, Martinez-Marmol, Ramon, Kaulich, Eva, Sankorrakul, Kornraviya, Lu, Hang, Coakley, Sean, Coulson, Elizabeth J. and Hilliard, Massimo A. (2025). OSP-1 protects neurons from autophagic cell death induced by acute oxidative stress. Nature Communications, 16 (1) 300, 300. doi: 10.1038/s41467-024-55105-0

Small, Christopher, Harper, Callista, Jiang, Anmin, Kontaxi, Christiana, Pronot, Marie, Yak, Nyakuoy, Malapaka, Anusha, Davenport, Elizabeth C., Wallis, Tristan P., Gormal, Rachel S., Joensuu, Merja, Martínez‐Mármol, Ramón, Cousin, Michael A. and Meunier, Frédéric A. (2024). SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling. Journal of Neurochemistry, 168 (9), 3188-3208. doi: 10.1111/jnc.16186

Longfield, Shanley F., Gormal, Rachel S., Feller, Matis, Parutto, Pierre, Reingruber, Jürgen, Wallis, Tristan P., Joensuu, Merja, Augustine, George J., Martínez-Mármol, Ramón, Holcman, David and Meunier, Frédéric A. (2024). Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles. Nature Communications, 15 (1) 2217, 1-18. doi: 10.1038/s41467-024-46256-1

Gormal, Rachel S., Martinez-Marmol, Ramon, Brooks, Andrew J. and Meunier, Frédéric A. (2024). Location, location, location: Protein kinase nanoclustering for optimised signalling output. eLife, 13 e93902, 1-21. doi: 10.7554/elife.93902

Fath, Thomas, Sytnyk, Vladimir and Martínez‐Mármol, Ramón (2023). ‘10th cell architecture in development and disease (CADD)’: Meeting report. Cytoskeleton, 81 (6-7), 264-265. doi: 10.1002/cm.21815

Longfield, Shanley F., Mollazade, Mahdie, Wallis, Tristan P., Gormal, Rachel S., Joensuu, Merja, Wark, Jesse R., van Waardenberg, Ashley J., Small, Christopher, Graham, Mark E., Meunier, Frédéric A. and Martínez-Mármol, Ramón (2023). Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles. Nature Communications, 14 (1) 7277, 1-20. doi: 10.1038/s41467-023-43130-4

Martínez-Mármol, Ramón, Muhaisen, Ashraf, Cotrufo, Tiziana, Roselló-Busquets, Cristina, Ros, Oriol, Hernaiz-Llorens, Marc, Pérez-Branguli, Francesc, Andrés, Rosa Maria, Parcerisas, Antoni, Pascual, Marta, Ulloa, Fausto and Soriano, Eduardo (2023). Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion. Frontiers in Molecular Neuroscience, 16 1253954, 1-19. doi: 10.3389/fnmol.2023.1253954

Martínez-Mármol, Ramón, Giordano-Santini, Rosina, Kaulich, Eva, Cho, Ann-Na, Przybyla, Magdalena, Riyadh, Md Asrafuzzaman, Robinson, Emilija, Chew, Keng Yih, Amor, Rumelo, Meunier, Frédéric A., Balistreri, Giuseppe, Short, Kirsty R., Ke, Yazi D., Ittner, Lars M. and Hilliard, Massimo A. (2023). SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity. Science Advances, 9 (23) eadg2248, 1-15. doi: 10.1126/sciadv.adg2248

Martínez‐Mármol, Ramón, Chai, YeJin, Conroy, Jacinta N., Khan, Zahra, Hong, Seong‐Min, Kim, Seon Beom, Gormal, Rachel S., Lee, Dae Hee, Lee, Jae Kang, Coulson, Elizabeth J., Lee, Mi Kyeong, Kim, Sun Yeou and Meunier, Frédéric A. (2023). Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to ERK1 /2 signaling enhancing spatial memory. Journal of Neurochemistry, 165 (6), 791-808. doi: 10.1111/jnc.15767

Martínez-Mármol, Ramón, Small, Christopher, Jiang, Anmin, Palliyaguru, Tishila, Wallis, Tristan P., Gormal, Rachel S., Sibarita, Jean-Baptiste, Götz, Jürgen and Meunier, Frédéric A. (2022). Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates. Molecular Psychiatry, 28 (2), 946-862. doi: 10.1038/s41380-022-01825-y

Hernaiz-Llorens, Marc, Martínez-Mármol, Ramón, Roselló-Busquets, Cristina and Soriano, Eduardo (2021). One raft to guide them all, and in axon regeneration inhibit them. International Journal of Molecular Sciences, 22 (9) 5009, 5009. doi: 10.3390/ijms22095009

Hernaiz-Llorens, Marc, Roselló-Busquets, Cristina, Durisic, Nela, Filip, Adam, Ulloa, Fausto, Martínez-Mármol, Ramón and Soriano, Eduardo (2020). Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors. Cellular and Molecular Life Sciences, 78 (6), 2797-2820. doi: 10.1007/s00018-020-03663-z

Harper, Callista B., Small, Christopher, Davenport, Elizabeth C., Low, Darryl W., Smillie, Karen J., Martínez-Mármol, Ramón, Meunier, Frédéric A. and Cousin, Michael A. (2020). An epilepsy-associated SV2A mutation disrupts Synaptotagmin-1 expression and activity-dependent trafficking. The Journal of Neuroscience, 40 (23), 4586-4595. doi: 10.1523/jneurosci.0210-20.2020

Roselló-Busquets, Cristina, Hernaiz-Llorens, Marc, Soriano, Eduardo and Martínez-Mármol, Ramon (2020). Nystatin regulates axonal extension and regeneration by modifying the levels of nitric oxide. Frontiers in Molecular Neuroscience, 13 56, 56. doi: 10.3389/fnmol.2020.00056

Martínez-Mármol, Ramón, Mohannak, Nika, Qian, Lei, Wang, Tong, Gormal, Rachel S, Ruitenberg, Marc J, Vanhaesebroeck, Bart, Coulson, Elizabeth J and Meunier, Frédéric A (2019). p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model. Journal of Neuroscience, 39 (40), 7976-7991. doi: 10.1523/JNEUROSCI.0674-19.2019

Padmanabhan, Pranesh, Martínez-Mármol, Ramón, Xia, Di, Götz, Jürgen and Meunier, Frédéric A. (2019). Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife, 8 e45040. doi: 10.7554/elife.45040

Rosello-Busquets, Cristina, de la Oliva, Natalia, Martinez-Marmol, Ramon, Hernaiz-Llorens, Marc, Pascual, Marta, Muhaisen, Ashraf, Navarro, Xavier, del Valle, Jaume and Soriano, Eduardo (2019). Cholesterol depletion regulates axonal growth and enhances central and peripheral nerve regeneration. Frontiers in Cellular Neuroscience, 13 40, 40. doi: 10.3389/fncel.2019.00040

Kasula, Ravikiran, Blum, Ailisa, Salla-Martret, Merce, Chai, Ye Jin, Jiang, Anmin, Wallis, Tristan P., Gormal, Rachel S., Brouillet, Julie Z., Padmanabhan, Pranesh, Weeratunga, Saroja K., Livingstone, Emma K., Mollazade, Mahdie, Joensuu, Merja, Martínez-Mármol, Ramón, Collins, Brett M. and Meunier, Frederic (2019). VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming. SSRN Electronic Journal. doi: 10.2139/ssrn.3362260

Ros, Oriol, Jose Barrecheguren, Pablo, Cotrufo, Tiziana, Schaettin, Martina, Rosello-Busquets, Cristina, Vilchez-Acosta, Alba, Hernaiz-Llorens, Marc, Martinez-Marmol, Ramon, Ulloa, Fausto, Stoeckli, Esther T., Araujo, Sofia J. and Soriano, Eduardo (2018). A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse. PLoS Genetics, 14 (6) e1007432, e1007432. doi: 10.1371/journal.pgen.1007432

Polanco, Juan Carlos, Li, Chuanzhou, Bodea, Liviu-Gabriel, Martinez-Marmol, Ramon, Meunier, Frederic A and Götz, Jürgen (2017). Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies. Nature reviews. Neurology, 14 (1), 22-40. doi: 10.1038/nrneurol.2017.162

Joensuu, Merja, Martinez-Marmol, Ramon, Padmanabhan, Pranesh, Glass, Nick R., Durisic, Nela, Pelekanos, Matthew, Mollazade, Mahdie, Balistreri, Giuseppe, Amor, Rumelo, Cooper-White, Justin J., Goodhill, Geoffrey J. and Meunier, Frederic A. (2017). Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules. Nature Protocols, 12 (12), 2590-2622. doi: 10.1038/nprot.2017.116

Martinez-Marmol, Ramón, Styrczewska, Katarzyna, Perez-Verdaguer, Mireia, Vallejo-Gracia, Albert, Comes, Núria, Sorkin, Alexander and Felipe, Antonio (2017). Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation. Scientific Reports, 7 (1) 42395, 42395. doi: 10.1038/srep42395

Sole, Laura, Roig, Sara R., Vallejo-Gracia, Albert, Serrano-Albarras, Antonio, Martinez-Marmol, Ramon, Tamkun, Michael M. and Felipe, Antonio (2016). The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit. Journal of Cell Science, 129 (22), 4265-4277. doi: 10.1242/jcs.191650

Martinez-Marmol, Ramón, Barneda-Zahonero, Bruna, Soto, David, Andres, Rosa Maria, Coccia, Elena, Gasull, Xavier, Planells-Ferrer, Laura, Moubarak, Rana S., Soriano, Eduardo and Comella, Joan X. (2016). FAIM-L regulation of XIAP degradation modulates synaptic long-term depression and axon degeneration. Scientific Reports, 6 (1) 35775. doi: 10.1038/srep35775

Wang, Tong, Martin, Sally, Nguyen, Tam H., Harper, Callista B., Gormal, Rachel S., Martinez-Marmol, Ramon, Karunanithi, Shanker, Coulson, Elizabeth J., Glass, Nick R., Cooper-White, Justin J., Van Swinderen, Bruno and Meunier, Frederic A. (2016). Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB. Nature Communications, 7 (1) 12976, 12976. doi: 10.1038/ncomms12976

Martínez-Mármol, Ramón, Salla-Martret, Mercè, Sastre, Daniel, Estadella, Irene and Felipe, Antonio (2016). EGF and the potassium channel Kv1.3 are promising pharmacological targets against neuro-degenerative diseases. Journal of Neurology and Neuromedicine, 1 (5).

Martinez-Marmol, Ramon, Comes, Nuria, Styrczewska, Katarzyna, Perez-Verdaguer, Mireia, Vicente, Ruben, Pujadas, Lluis, Soriano, Eduardo, Sorkin, Alexander and Felipe, Antonio (2016). Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis. Cellular and Molecular Life Sciences, 73 (7), 1515-1528. doi: 10.1007/s00018-015-2082-0

Perez-Verdaguer, Mireia, Capera, Jesusa, Martinez-Marmol, Ramon, Camps, Marta, Comes, Nuria, Tamkun, Michael M. and Felipe, Antonio (2016). Caveolin interaction governs Kv1.3 lipid raft targeting. Scientific Reports, 6 (1) 22453, 22453. doi: 10.1038/srep22453

Ros, Oriol, Cotrufo, Tiziana, Martinez-Marmol, Ramon and Soriano, Eduardo (2015). Regulation of patterned dynamics of local exocytosis in growth cones by Netrin-1. Journal of Neuroscience, 35 (13), 5156-5170. doi: 10.1523/JNEUROSCI.0124-14.2015

Ulloa, Fausto, Gonzalez-Junca, Alba, Meffre, Delphine, Barrecheguren, Pablo Jose, Martinez-Marmol, Ramon, Pazos, Irene, Olive, Nuria, Cotrufo, Tiziana, Seoane, Joan and Soriano, Eduardo (2015). Blockade of the SNARE protein syntaxin 1 inhibits glioblastoma tumor growth. PLoS One, 10 (3) e0119707, e0119707. doi: 10.1371/journal.pone.0119707

Martinez-Marmol, Ramon, Perez-Verdaguer, Mireia, Roig, Sara R., Vallejo-Gracia, Albert, Gotsi, Pelagia, Serrano-Albarras, Antonio, Isabel Bahamonde, Maria, Ferrer-Montiel, Antonio, Fernandez-Ballester, Gregorio, Comes, Nuria and Felipe, Antonio (2013). A non-canonical di-acidic signal at the C-terminus of Kv1.3 determines anterograde trafficking and surface expression. Journal of Cell Science, 126 (24), 5681-5691. doi: 10.1242/jcs.134825

Cotrufo, Tiziana, Maria Andres, Rosa, Ros, Oriol, Perez-Branguli, Francesc, Muhaisen, Ashraf, Fuschini, Giulia, Martinez, Ramon, Pascual, Marta, Comella, Joan X. and Soriano, Eduardo (2012). Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip. European Journal of Neuroscience, 36 (9), 3152-3164. doi: 10.1111/j.1460-9568.2012.08259.x

David, Miren, Macias, Alvaro, Moreno, Cristina, Prieto, Angela, Martinez-Marmol, Ramon, Vicente, Ruben, Gonzalez, Teresa, Felipe, Antonio, Tamkun, Michael M. and Valenzuela, Carmen (2012). Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome. Journal of Biological Chemistry, 287 (25), 21416-21428. doi: 10.1074/jbc.M111.328278

Martinez-Marmol, Ramon, Villalonga, Nuria, Sole, Laura, Vicente, Ruben, Tamkun, Michael M., Soler, Concepcio and Felipe, Antonio (2008). Multiple Kv1.5 targeting to membrane surface microdomains. Journal of Cellular Physiology, 217 (3), 667-673. doi: 10.1002/jcp.21538

Martínez-Mármol, Ramón, Roura-Ferrer, Meritxell and Felipe, Antonio (2008). Targeting potassium channels: New advances in cardiovascular therapy. Recent Patents on Cardiovascular Drug Discovery, 3 (2), 105-118. doi: 10.2174/157489008784705386

Roura-Ferrer, Meritxell, Sole, Laura, Martinez-Marmol, Ramon, Villalonga, Nuria and Felipe, Antonio (2008). Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation. Biochemical and Biophysical Research Communications, 369 (4), 1094-1097. doi: 10.1016/j.bbrc.2008.02.152

Villalonga, Nuria, Martinez-Marmol, Ramon, Roura-Ferrer, Meritxell, David, Miren, Valenzuela, Carmen, Soler, Concepcio and Felipe, Antonio (2008). Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation. Biochimica Et Biophysica Acta-Molecular Cell Research, 1783 (5), 728-736. doi: 10.1016/j.bbamcr.2008.01.001

David, Miren, Martinez-Marmol, Ramon, Gonzalez, Teresa, Felipe, Antonio and Valenzuela, Carmen (2008). Differential regulation of Navβ subunits during myogenesis. Biochemical and Biophysical Research Communications, 368 (3), 761-766. doi: 10.1016/j.bbrc.2008.01.138

Martinez-Marmol, Ramon, David, Miren, Sanches, Rosario, Roura-Ferrer, Meritxell, Villalonga, Nuria, Sorianello, Eleonora, Webb, Susan M., Zorzano, Antonio, Guma, Anna, Valenzuela, Cannen and Felipe, Antonio (2007). Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair. Cardiovascular Research, 76 (3), 430-441. doi: 10.1016/j.cardiores.2007.08.009

Felipe, Antonio, Vicente, Ruben, Villalonga, Nuria, Roura-Ferrer, Meritxell, Martinez-Marmol, Ramon, Sole, Laura, Ferreres, Joan C. and Condom, Enric (2006). Potassium channels: new targets in cancer therapy. Cancer Detection and Prevention, 30 (4), 375-385. doi: 10.1016/j.cdp.2006.06.002

Sanders, Shanley F., Mollazade, Mahdie, Wallis, Tristan P., Gormal, Rachel S., Joensuu, Merja, Wark, Jesse R., Waardenberg, Ashley J., Small, Christopher, Graham, Mark E., Martinez-Marmol, Ramon and Meunier, Frederic A. (2023). Tau - A master regulator of recycling synaptic vesicle clustering at the presynapse. ISN-ESN 2023 Meeting, Porto, Portugal, 8 - 11 August 2023. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.15897

Martinez-Marmon, Ramon, Styrczewska, Katarzyna, Perez-Verdaguer, Mireia, Vallejo-Gracia, Albert, Comes, Nuria, Sorkin, Alexander and Felipe, Antonio (2018). PKC Activation Induces Ubiquitination-Dependent KV1.3 Endocytosis Mediated by Nedd4-2 Ubiquitin Ligase. 62nd Annual Meeting of the Biophysical-Society, San Francisco, CA United States, 17-21 February 2018. Cambridge, United Kingdom: Cell Press. doi: 10.1016/j.bpj.2017.11.1713

Perez-Verdaguer, Mireia, Capera, Jesusa, Martinez-Marmol, Ramon, Camps, Marta, Comes, Nuria, Tamkun, Michael M. and Felipe, Antonio (2017). Deciphering the Kv1.3/Caveolin Interaction. 58th Annual Meeting of the Biophysical-Society, San Francisco Ca, Feb 15-19, 2014. CELL PRESS. doi: 10.1016/j.bpj.2016.11.1375

Roig, Sara R., Sole, Laura, Vallejo-Gracia, Albert, Sastre, Daniel, Serrano-Albarras, Antonio, Serrano-Novillo, Clara, Martinez-Marmol, Ramon, Tamkun, Michael M. and Felipe, Antonio (2017). The C-Terminal Domain of Kv1.3 Interacts with KCNE4 to form Oligo-meric Channels. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, 15-19 February 2014. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2016.11.2944

Styrczewska, Katarzyna, Martinez-Marmol, Ramon, Comes, Nuria, Estadella, Irene, Perez-Verdaguer, Mireia, Pujadas, Lluis, Soriano, Eduardo, Sorkin, Alexander and Felipe, Antonio (2017). ERK1/2 Mediates EGF-Dependent Kv1.3 Endocytosis. 58th Annual Meeting of the Biophysical-Society, San Francisco Ca, Feb 15-19, 2014. CELL PRESS. doi: 10.1016/j.bpj.2016.11.1374

Martinez-Marmol, R., Perez-Verdaguer, M., Roig, S. R., Vallejo-Gracia, A., Capera, J., Serrano-Albarras, A., Serrano-Novillo, C., Ferrer-Montiel, A., Fernandez-Ballester, G., Comes, N. and Felipe, A. (2014). A DI-ACIDIC MOTIF IS RESPONSIBLE FOR Kv1.3 MEMBRANE SURFACE EXPRESSION VIA COPII-DEPENDENT MECHANISMS. WILEY-BLACKWELL.

Martinez-Marmol, Ramon, Perez-Verdaguer, Mireia, Roig, Sara R., Vallejo-Gracia, Albert, Gotsi, Pelagia, Serrano-Albarras, Antonio, Isabel Bahamonde, Ma, Ferrer-Montiel, Antonio, Fernandez-Ballester, Gregorio, Comes, Nuria and Felipe, Antonio (2014). A Non-Canonical Di-Acidic Signal at the C-Terminal of KV1.3 Determines Anterograde Trafficking and Surface Expression. 58th Annual Meeting of the Biophysical Society, San Francisco, CA United States, 15-19 February 2014. St. Louis, MO United States: Cell Press. doi: 10.1016/j.bpj.2013.11.4072

Villalonga, Nuria, Martinez-Marmol, Ramon, Sole, Laura, Vicente, Ruben, Soler, Concepcio, Tamkun, Michael M. and Felipe, Antonio (2009). Partnership interactions target Kv1.5 to distinct membrane surface microdomains. CAMBRIDGE: CELL PRESS. doi: 10.1016/j.bpj.2008.12.820

Gormal, Rachel, Meunier, Frederic, Martinez-Marmol, Ramon, Mollazade, Mahdie, Wallis, Tristan, Joensuu, Merja, Sanders, Shanley and Small, Christopher (2023). Longield et al_2023_NatComm_Raw. The University of Queensland. (Dataset) doi: 10.48610/a9c9def

Dr Ramon Martinez-Marmol

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