Dr Esteban Cruz Gonzalez
Postdoctoral Research Fellow
Clem Jones Centre for Ageing Dementia Research
Book Chapter
Lai, Felcia, Hawkins, Bryson A., Cruz, Esteban, Hanrahan, Jane R., Groundwater, Paul W. and Hibbs, David E. (2021). Drug targets for biologics. Biologics, biosimilars, and biobetters: an introduction for pharmacists, physicians, and other health practitioners. (pp. 195-212) edited by Iqbal Ramzan. Hoboken, NJ United States: Wiley. doi: 10.1002/9781119564690.ch5
Journal Articles
Cruz, Esteban, Nisbet, Rebecca M, Padmanabhan, Pranesh, van Waardenberg, Ashley J, Graham, Mark E, Nkajja, Godfrey, Tapaswi, Swara, Connor, Bradley J, Robinson, Phil and Götz, Jürgen (2024). Proteostasis as a fundamental principle of Tau immunotherapy. Brain. doi: 10.1093/brain/awae254
Padmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Briner, Adam and Götz, Jürgen (2024). Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular Brain, 17 (1) 7. doi: 10.1186/s13041-024-01078-6
Cruz, Esteban, Nisbet, Rebecca M. and Götz, Jürgen (2023). Break and accelerator—The mechanics of Tau (and amyloid) toxicity. Cytoskeleton, 81 (1), 24-29. doi: 10.1002/cm.21781
Chen, Liyu, Cruz, Esteban, Oikari, Lotta E., Padmanabhan, Pranesh, Song, Jae and Götz, Jürgen (2022). Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound. Advanced Drug Delivery Reviews, 189 114517, 1-18. doi: 10.1016/j.addr.2022.114517
Bajracharya, Rinie, Cruz, Esteban, Götz, Jürgen and Nisbet, Rebecca M. (2022). Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy. Journal of Controlled Release, 349, 634-648. doi: 10.1016/j.jconrel.2022.07.026
Padmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Amor, Rumelo, Sibarita, Jean‐Baptiste and Götz, Jürgen (2022). Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion. The EMBO Journal, 41 (19) e111265, 1-16. doi: 10.15252/embj.2022111265
Chen, Liyu, Sutharsan, Ratneswary, Lee, Jonathan LF, Cruz, Esteban, Asnicar, Blaise, Palliyaguru, Tishila, Wasielewska, Joanna M, Gaudin, Arnaud, Song, Jae, Leinenga, Gerhard and Götz, Jürgen (2022). Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics, 12 (5), 1952-1970. doi: 10.7150/thno.65539
Cruz, Esteban, Sifniotis, Vicki, Sumer-Bayraktar, Zeynep, Reslan, Mouhamad, Wilkinson-White, Lorna, Cordwell, Stuart and Kayser, Veysel (2021). Glycan profile analysis of engineered trastuzumab with rationally added glycosylation sequons presents significantly increased glycan complexity. Pharmaceutics, 13 (11) 1747, 1747. doi: 10.3390/pharmaceutics13111747
Götz, Jürgen, Richter-Stretton, Gina and Cruz, Esteban (2021). Therapeutic ultrasound as a treatment modality for physiological and pathological ageing including Alzheimer’s disease. Pharmaceutics, 13 (7) 1002, 1002. doi: 10.3390/pharmaceutics13071002
Reslan, Mouhamad, Sifniotis, Vicki, Cruz, Esteban, Sumer-Bayraktar, Zeynep, Cordwell, Stuart and Kayser, Veysel (2020). Enhancing the stability of adalimumab by engineering additional glycosylation motifs. International Journal of Biological Macromolecules, 158, 189-196. doi: 10.1016/j.ijbiomac.2020.04.147
Suades, Albert, Alcaraz, Antonio, Cruz, Esteban, Álvarez-Marimon, Elena, Whitelegge, Julian P., Manyosa, Joan, Cladera, Josep and Perálvarez-Marín, Alex (2019). Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris. Scientific Reports, 9 (1) 1203. doi: 10.1038/s41598-018-37445-2
Sifniotis, Vicki, Cruz, Esteban, Eroglu, Barbaros and Kayser, Veysel (2019). Current advancements in addressing key challenges of therapeutic antibody design, manufacture, and formulation. Antibodies, 8 (2) 36, 36. doi: 10.3390/antib8020036
Cruz, Esteban and Kayser, Veysel (2019). Synthesis and enhanced cellular uptake in vitro of anti-HER2 multifunctional gold nanoparticles. Cancers, 11 (6) 870, 870. doi: 10.3390/cancers11060870
Cruz, Esteban and Kayser, Veysel (2019). Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy. Biologics: Targets and Therapy, 13, 33-51. doi: 10.2147/BTT.S166310
Moussa, Yvonne E., Ong, Yu Qing Elysia, Perry, John D., Cheng, Zhengqi, Kayser, Veysel, Cruz, Esteban, Kim, Ryung Rae, Sciortino, Natasha and Wheate, Nial J. (2018). Demonstration of in vitro host-guest complex formation and safety of para-sulfonatocalix[8]arene as a delivery vehicle for two antibiotic drugs. Journal of Pharmaceutical Sciences, 107 (12), 3105-3111. doi: 10.1016/j.xphs.2018.08.016
Cruz, Esteban, Cain, Joel, Crossett, Ben and Kayser, Veysel (2018). Site-specific glycosylation profile of influenza A (H1N1) hemagglutinin through tandem mass spectrometry. Human Vaccines and Immunotherapeutics, 14 (3), 508-517. doi: 10.1080/21645515.2017.1377871
Elgundi, Zehra, Reslan, Mouhamad, Cruz, Esteban, Sifniotis, Vicki and Kayser, Veysel (2017). The state-of-play and future of antibody therapeutics. Advanced Drug Delivery Reviews, 122, 2-19. doi: 10.1016/j.addr.2016.11.004
Elgundi, Zehra, Sifniotis, Vicki, Reslan, Mouhamad, Cruz, Esteban and Kayser, Veysel (2017). Laboratory scale production and purification of a therapeutic antibody. Journal of Visualized Experiments, 2017 (119) e55153. doi: 10.3791/55153