QBI researcher Professor Frederic Meunier is passionate about using highly innovative technology to discover how our brain cells communicate. His lab uses advanced nanoscale imaging (super-resolution microscopy) to observe single molecules in living neurons as they perform their function. In collaboration with mathematicians, the Meunier lab is analysing how small mutations can affect the nanoscale dynamics of single proteins and their function to help us understand the origins of brain disorders and diseases.     

  In this conversation, Fred traverses far-ranging topics, including:   

  • Our brain’s chaotic inner cellular environment  
  • How imaging technology is evolving to accelerate discoveries  
  • Why video games led to a new spatiotemporal data analysis approach  
  • What Botox can teach us about the function of the synapse between two brain cells  
  • Why pharmaceutical companies are starting to invest in single molecule imaging  

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Related papers and resources  

The Dynamic Synapse  

Single-molecule localization microscopy 

Super-resolved trajectory-derived nanoclustering analysis using spatiotemporal indexing  

Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry 

Eikon Therapeutics  


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