QBI researcher Dr Nela Durisic is fascinated with how the brain coordinates electrical activity and how faulty electrical communication can lead to brain disorders like epilepsy. By observing the architecture and function of single molecules and their intricate connections, the Durisic lab aims to discover what leads to genetic epilepsy and uncover new ways to treat it. This knowledge may also advance our understanding of other brain disorders, including depression, addiction and autism.

In this conversation, Nela dives into intriguing topics, including:

  • The triggers and genetic causes of epilepsy
  • The different roles of excitatory and inhibitory neurons
  • What happens in the brain before and during a seizure
  • How microscopy and organoids are advancing her lab’s research
  • Potential new directions for the treatment of genetic epilepsy

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Related papers and resources

Effects of GABA(A) Receptor alpha 3 Subunit Epilepsy Mutations on Inhibitory Synaptic Signaling

Growth Cone Repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors 

SAHA (Vorinostat) corrects inhibitory synaptic deficits caused by missense epilepsy mutations to the GABA(A) receptor gamma 2 subunit 

Epilepsy Queensland 

Epilepsy Foundation of Australia  



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