Boots, beanies and all, QBI researcher Dr Adam Walker is in the fight to find a cure for motor neurone disease (MND). His team uses genetic editing techniques and rapidly advancing technology to study what’s happening at the early onset of disease. By understanding the biological processes that cause MND, they hope to design new therapies that prevent or halt its progression.  

In this inspiring conversation, Adam explores:  

  • How the brain initiates movement  
  • Why expensive muesli can help explain MND 
  • The protein TDP-43 and its role in the death of motor neurons 
  • The exciting potential for targeted MND therapeutics  
  • Philanthropy’s vital role in blue sky MND research   


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Related papers and resources  

Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD 

Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43 

TDP-43 pathology: From noxious assembly to therapeutic removal 

Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation 

MND Research Australia 


 MND and Me