PhD project in neurogenetics

The primary aim of this research is to unravel the neurodevelopmental and neuronal function of a number of genes recently discovered to be strongly associated with schizophrenia, including miR-137, a short non-coding RNA molecule that regulates the expression levels of other genes. To decipher the role of these risk-genes, the candidate will first use an innovative gene-silencing approach to generate transgenic zebrafish lines presenting gene loss- or gain-of-function. The PhD student will subsequently take advantage of the fast-developing zebrafish brain, high-end microscopy and automatic systems to characterize in vivo the effect of each risk-gene on early brain development and nervous system functions. This research has strong potential to facilitate understanding of the basic neuronal functions and underlying mechanisms implicated in the development and progression of psychiatric disorders such as schizophrenia.

The candidate will join the established lab group of Professor Bryan Mowry at QBI. To know more about Professor Mowry and the lab group, please peruse information on the Mowry lab group page.

Expressions of Interest are invited from outstanding and enthusiastic international and Australian science graduates ideally with a background in neuroscience, molecular biology, microscopy, biomedical engineering or other relevant scientific discipline. Candidates will have a First Class Honours degree or equivalent and should be eligible for UQ scholarship consideration. Expertise in molecular biology, microscopy and zebrafish genetics is desirable.

How to apply