Meunier Publications
Selected journal publications
Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic.
Bademosi, Adekunle T. , Steeves, James, Karunanithi, Shanker, Zalucki, Oressia H, Gormal, Rachel S, Liu, Shu, Lauwers, Elsa, Verstreken, Patrik, Anggono, Victor, Meunier, Frederic A and van Swinderen, Bruno (2018). Cell reports, 22 2: 427-440. doi:10.1016/j.celrep.2017.12.054
Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies. Polanco, Juan Carlos, Li, Chuanzhou, Bodea, Liviu-Gabriel, Martinez-Marmol, Ramon, Meunier, Frederic A and Götz, Jürgen (2017). Nature reviews. Neurology, 14 1: 22-40. doi:10.1038/nrneurol.2017.162
Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules.
Joensuu, Merja, Martinez-Marmol, Ramon, Padmanabhan, Pranesh, Glass, Nick R., Durisic, Nela, Pelekanos, Matthew, Mollazade, Mahdie, Balistreri, Giuseppe, Amor, Rumelo, Cooper-White, Justin J., Goodhill, Geoffrey J. and Meunier, Frederic A. (2017) Nature Protocols, 12 12:2590-2622. doi:10.1038/nprot.2017.116
The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals.
Vanhauwaert, Roeland, Kuenen, Sabine, Masius, Roy, Bademosi, Adekunle, Manetsberger, Julia, Schoovaerts, Nils, Bounti, Laura, Gontcharenko, Serguei, Swerts, Jef, Vilain, Sven, Picillo, Marina, Barone, Paolo, Munshi, Shashini T., de Vrij, Femke M. S., Kushner, Steven A., Gounko, Natalia V., Mandemakers, Wim, Bonifati, Vincenzo, Meunier, Frederic A., Soukup, Sandra‐Fausia and Verstreken, Patrik (2017)EMBO Journal, 36 10: 1392-1411. doi:10.15252/embj.201695773
In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters
Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, Van Swinderen, Bruno and Meunier, Frederic A. (2017) Nature Communications, 8 . doi:10.1038/ncomms13660
Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles
Joensuu, Merja, Padmanabhan, Pranesh, Durisic, Nela, Bademosi, Adekunle T. D., Cooper-Williams, Elizabeth, Morrow, Isabel C., Harper, Callista B., Jung, WooRam, Parton, Robert G., Goodhill, Geoffrey J., Papadopulos, Andreas and Meunier, Frederic A. (2016) Journal of Cell Biology, 215 2: 277-292. doi:10.1083/jcb.201604001
Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB
Wang, Tong, Martin, Sally, Nguyen, Tam H., Harper, Callista B., Gormal, Rachel S., Martinez-Marmol, Ramon, Karunanithi, Shanker, Coulson, Elizabeth J., Glass, Nick R., Cooper-White, Justin J., Van Swinderen, Bruno and Meunier, Frederic A. (2016) Nature Communications, 7 . doi:10.1038/ncomms12976
The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming
Kasula, Ravikiran, Chai, Ye Jin, Bademosi, Adekunle T., Harper, Callista B., Gormal, Rachel S., Morrow, Isabel C., Hosy, Eric, Collins, Brett M., Choquet, Daniel, Papadopulos, Andreas and Meunier, Frederic A. (2016) The Journal of Cell Biology, 214 7: 847-858. doi:10.1083/jcb.201508118
Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation
Chai, Ye Jin, Sierecki, Emma, Tomatis, Vanesa M., Gormal, Rachel S., Giles, Nichole, Morrow, Isabel C., Xia, Di, Götz, Jürgen, Parton, Robert G., Collins, Brett M., Gambin, Yann and Meunier, Frédéric A. (2016) The Journal of Cell Biology, 214 6: 705-718. doi:10.1083/jcb.201512016
Profiling of free fatty acids using stable isotope tagging uncovers a role for saturated fatty acids in neuroexocytosis
Narayana, Vinod K., Tomatis, Vanesa M., Wang, Tong, Kvaskoff, David and Meunier, Frederic A. (2015) Chemistry and Biology, 22 11: 1552-1561. doi:10.1016/j.chembiol.2015.09.010
Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release
Jackson, J., Papadopulos, A., Meunier, F. A., McCluskey, A., Robinson, P. J. and Keating, D. J. (2015) Molecular Psychiatry, 20 7: 810-819. doi:10.1038/mp.2015.56
Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type A
Wang, Tong, Martin, Sally, Papadopulos, Andreas, Harper, Callista B., Mavlyutov, Timur A., Niranjan, Dhevahi, Glass, Nick R., Cooper-White, Justin J., Sibarita, Jean-Baptiste, Choquet, Daniel, Davletov, Bazbek and Meunier, Frederic A. (2015) Journal of Neuroscience, 35 15: 6179-6194. doi:10.1523/JNEUROSCI.3757-14.2015
Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking
Papadopulos, Andreas, Gomez, Guillermo A., Martin, Sally, Jackson, Jade, Gormal, Rachel S., Keating, Damien J., Yap, Alpha S. and Meunier, Frederic A. (2015) Nature Communications, 6 6297: 1-11. doi:10.1038/ncomms7297
An acto-myosin II constricting ring initiates the fission of activity-dependent bulk endosomes in neurosecretory cells
Gormal, Rachel S, Nguyen, Tam H, Martin, Sally, Papadopulos, Andreas and Meunier, Frederic A (2015) Journal of Neuroscience, 35 4: 1380-1389. doi:10.1523/JNEUROSCI.3228-14.2015
Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis
Martin, Sally, Papadopulos, Andreas, Tomatis, Vanesa M., Sierecki, Emma, Malintan, Nancy T., Gormal, Rachel S., Giles, Nichole, Johnston, Wayne A., Alexandrov, Kirill, Gambin, Yann, Collins, Brett M. and Meunier, Frederic A. (2014) Cell Reports, 9 1: 206-218. doi:10.1016/j.celrep.2014.08.059
PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model
Low, Pei Ching, Manzanero, Silvia, Mohannak, Nika, Narayana, Vinod K., Nguyen, Tam H., Kvaskoff, David, Brennan, Faith H., Ruitenberg, Marc J., Gelderblom, Mathias, Magnus, Tim, Kim, Hyun Ah, Broughton, Brad R. S., Sobey, Christopher G., Vanhaesebroeck, Bart, Stow, Jennifer L., Arumugam, Thiruma V. and Meunier, Frédéric A. (2014) Nature Communications, 5 3450: 1-12. doi:10.1038/ncomms4450
Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin
Tomatis, Vanesa M., Papadopulos, Andreas, Malintan, Nancy T., Martin, Sally, Wallis, Tristan, Gormal, Rachel S., Kendrick-Jones, John, Buss, Folma and Meunier, Frederic A. (2013) Journal of Cell Biology, 200 3: 301-320. doi:10.1083/jcb.201204092
Secretagogue stimulation of neurosecretory cells elicits filopodial extensions uncovering new functional release sites
Papadopulos, Andreas, Martin, Sally, Tomatis, Vanesa M., Gormal, Rachel S. and Meunier, Frederic A. (2013) Secretagogue stimulation of neurosecretory cells elicits filopodial extensions uncovering new functional release sites.Journal of Neuroscience, 33 49: 19143-19153. doi:10.1523/JNEUROSCI.2634-13.2013
Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors
Harper, Callista B., Popoff, Michel R., McCluskey, Adam, Robinson, Phillip J. and Meunier, Frederic A. (2013) Trends in Cell Biology, 23 2: 90-101. doi:10.1016/j.tcb.2012.10.007
Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells
Wen, Peter J., Osborne, Shona L., Zanin, Mark, Low, Pei Ching, Wang, Hai-Tao A., Schoenwaelder, Simone M., Jackson, Shaun P., Wedlich-Soldner, Roland, Vanhaesebroeck, Bart, Keating, Damien J. and Meunier, Frederic A. (2011) Nature Communications, 2 1: 491.1-491.11. doi:10.1038/ncomms1500
Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion
Low, Pei Ching, Misaki, Ryo, Schroder, Kate, Stanley, Amanda C., Sweet, Matthew J., Teasdale, Rohan D., Vanhaesebroeck, Bart, Meunier, Frédéric A., Taguchi, Tomohiko and Stow, Jennifer L. (2010) Journal of Cell Biology, 190 6: 1053-1065. doi:10.1083/jcb.201001028
Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella
Kerr, Markus C., Wang, Jack T. H., Castro, Natalie A., Hamilton, Nicholas A., Town, Liam, Brown, Darren L., Meunier, Frederic A., Brown, Nat F., Stow, Jennifer L. and Teasdale, Rohan D. (2010) EMBO Journal, 29 8: 1331-1347. doi:10.1038/emboj.2010.28
Abrogating Munc18-1 SNARE complex interaction has limited impact on exocytosis in PC12 cells
Malintan, Nancy, Nguyen, Tam H, Han, Liping, Latham, Catherine F., Osborne, Shona L., Wen, Peter, Lim, Siew, Joo, Tiffany, Sugita, Shuzo, Collins, Brett M. and Meunier, Frederic A. (2009) The Journal of Biological Chemistry, 284 32: 21637-21646. doi:10.1074/jbc.M109.013508
p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate
Coulson, E. J., May, L. M., Osborne, S. L., Reid, K., Underwood, C. K., Meunier, F. A., Bartlett, P. F. and Sah, P. (2008) Journal of Neuroscience, 28 1: 315-324. doi:10.1523/JNEUROSCI.2699-07.2008
Identification of secretory granule phosphatidylinositol 4,5-bisphosphateinteracting proteins using an affinity pulldown strategy
Osborne, SL, Wallis, TP, Jimenez, JL, Gorman, JJ and Meunier, FA (2007) Molecular & Cellular Proteomics, 6 7: 1158-1169. doi:10.1074/mcp.M600430-MCP200
Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the alpha-conotoxin MII
Clark, R. J., Fischer, H., Dempster, L., Daly, N. L., Rosengren, K. J., Nevin, S. T., Meunier, F. A., Adams, D. J. and Craik, D. J. (2005) Proceedings of The National Academy of Sciences of The United States of America, 102 39: 13767-13772. doi:10.1073/pnas.0504613102
Getting muscles moving again after botulinum toxin: novel therapeutic challenges
Foran, PG, Davletov, B and Meunier, FA (2003) Trends In Molecular Medicine, 9 7: 291-299. doi:10.1016/S1471-4914(03)00113-8
Glycerotoxin from Glycera convoluta stimulates neurosecretion by up-regulating N-type Ca2+ channel activity
Meunier, Frédéric A., Feng, Zhong-Ping, Molgó, Jordi, Zamponi, Gerald W. and Schiavo, Giampietro (2002) The EMBO Journal, 21 24: 6733-6743. doi:10.1093/emboj/cdf677