Hilliard publications
Giordano-Santini, Rosina, Kaulich, Eva, Galbraith, Kate M., Ritchie, Fiona K., Wang, Wei, Li, Zhaoyu and Hilliard, Massimo A. (2020). Fusogen-mediated neuron−neuron fusion disrupts neural circuit connectivity and alters animal behavior. Proceedings of the National Academy of Sciences, 117 (37), 201919063-23065. doi: 10.1073/pnas.1919063117
Coakley, Sean, Ritchie, Fiona K., Galbraith, Kate M. and Hilliard, Massimo A. (2020) Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration. Nature Communications, 11 1: 1-12. doi:10.1038/s41467-019-13795-x
Axonal repair by fusion: pitfalls, consequences and solutions
Neumann, Brent and Hilliard, Massimo A. (2019) Axonal repair by fusion: pitfalls, consequences and solutions. FASEB Journal, 33 12: 13071-13074. doi:10.1096/fj.201901407R
Linton, Casey, Riyadh, M. Asrafuzzaman, Ho, Xue Yan, Neumann, Brent, Giordano-Santini, Rosina and Hilliard, Massimo A. (2019) Disruption of RAB-5 increases EFF-1 fusogen availability at the cell surface and promotes the regenerative axonal fusion capacity of the neuron. Journal of Neuroscience, 39 15: 2823-2836. doi:10.1523/jneurosci.1952-18.2019
Axonal fusion: an alternative and efficient mechanism of nerve repair
Neumann, Brent, Linton, Casey, Giordano-Santini, Rosina and Hilliard, Massimo A. (2019) Axonal fusion: an alternative and efficient mechanism of nerve repair. Progress in Neurobiology, 173 88-101. doi:10.1016/j.pneurobio.2018.11.004
Neuronal sub-compartmentalization: a strategy to optimize neuronal function
Donato, Alessandra, Kagias, Konstantinos, Zhang, Yun and Hilliard, Massimo A. (2019) Neuronal sub-compartmentalization: a strategy to optimize neuronal function. Biological Reviews, . doi:10.1111/brv.12487
Offenburger, Sarah-Lena, Ho, Xue Yan, Tachie-Menson, Theresa, Coakley, Sean, Hilliard, Massimo A. and Gartner, Anton (2018) 6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33. PLoS Genetics, 14 1: 1-27. doi:10.1371/journal.pgen.1007125
Chand, Kirat K., Lee, Kah Meng, Lee, John D., Qiu, Hao, Willis, Emily F., Lavidis, Nickolas A., Hilliard, Massimo A. and Noakes, Peter G. (2018) Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 32 5: fj201700835R-2689. doi:10.1096/fj.201700835R
The heterochronic gene lin-14 controls axonal degeneration in C. elegans neurons
Ritchie, Fiona K., Knable, Rhianna, Chaplin, Justin, Gursanscky, Rhiannon, Gallegos, Maria, Neumann, Brent and Hilliard, Massimo A. (2017) The heterochronic gene lin-14 controls axonal degeneration in C. elegans neurons. Cell Reports, 20 12: 2955-2965. doi:10.1016/j.celrep.2017.08.083
Gokce, Sertan Kutal, Hegarty, Evan Marley, Mondal, Sudip, Zhao, Peisen, Ghorashian, Navid, Hilliard, Massimo A. and Ben-Yakar, Adela (2017) A multi-trap microfluidic chip enabling longitudinal studies of nerve regeneration in Caenorhabditis elegans. Scientific Reports, 7 9837: 9837. doi:10.1038/s41598-017-10302-4
Abay, Zehra C, Wong, Michelle Yu-Ying, Teoh, Jean-Sébastien, Vijayaraghavan, Tarika, Hilliard, Massimo A and Neumann, Brent (2017) Phosphatidylserine save-me signals drive functional recovery of severed axons in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America, 114 47: 1-10. doi:10.1073/pnas.1703807114
Fogarty, Matthew J., Klenowski, Paul M., Lee, John D., Drieberg-Thompson, Joy R., Bartlett, Selena E., Ngo, Shyuan T., Hilliard, Massimo A., Bellingham, Mark C. and Noakes, Peter G. (2016) Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis. Scientific Reports, 6 . doi:10.1038/srep37968
Cell-cell fusion in the nervous system: alternative mechanisms of development, injury and repair
Giordano-Santini, Rosina, Linton, Casey and Hilliard, Massimo A. (2016) Cell-cell fusion in the nervous system: alternative mechanisms of development, injury and repair. Seminars in Cell and Developmental Biology, 60 146-154. doi:10.1016/j.semcdb.2016.06.019
Gallotta, Ivan, Mazzarella, Nadia, Donato, Alessandra, Esposito, Alessandro, Chaplin, Justin C., Castro, Silvana, Zampi, Giuseppina, Battaglia, Giorgio S., Hilliard, Massimo A., Bazzicalupo, Paolo and Di Schiavi, Elia (2016) Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism. Human Molecular Genetics, . doi:10.1093/hmg/ddw119
The apoptotic engulfment machinery regulates axonal degeneration in C. elegans neurons
Nichols, Annika L.A., Meelkop, Ellen, Linton, Casey, Giordano-Santini, Rosina, Sullivan, Robert K., Donato, Alessandra, Nolan, Cara, Hall, David H., Xue, Ding, Neumann, Brent and Hilliard, Massimo A. (2016) The apoptotic engulfment machinery regulates axonal degeneration in C. elegans neurons. Cell Reports, 14 7: 1673-1683. doi:10.1016/j.celrep.2016.01.050
EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway
Neumann, Brent, Coakley, Sean, Giordano-Santini, Rosina, Linton, Casey, Lee, Eui Seung, Nakagawa, Akihisa, Xue, Ding and Hilliard, Massimo A. (2015) EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway. Nature, 517 7533: 219-222. doi:10.1038/nature14102
Lee, Hyewon, Kim, Shin Ae, Coakley, Sean, Mugno, Paula, Hammarlund, Marc, Hilliard, Massimo A. and Lu, Hang (2014) A multi-channel device for high-density target-selective stimulation and long-term monitoring of cells and subcellular features in C. elegans. Lab on a Chip - Miniaturisation for Chemistry and Biology, 14 23: 4513-4522. doi:10.1039/c4lc00789a
Loss of MEC-17 leads to microtubule instability and axonal degeneration
Neumann, Brent and Hilliard, Massimo A. (2014) Loss of MEC-17 leads to microtubule instability and axonal degeneration. Cell Reports, 6 1: 93-103. doi:10.1016/j.celrep.2013.12.004
Williams, Daniel C., El Bejjani, Rachid, Mugno Ramirez, Paula, Coakley, Sean, Kim, Shin Ae, Lee, Hyewon, Wen, Quan, Samuel, Aravi, Lu, Hang, Hilliard, Massimo A. and Hammarlund, Marc (2013) Rapid and permanent neuronal inactivation in vivo via subcellular generation of reactive oxygen with the use of KillerRed. Cell Reports, 5 2: 553-563. doi:10.1016/j.celrep.2013.09.023
Kirszenblat, Leonie, Neumann, Brent, Coakley, Sean and Massimo Hilliard (2013) A dominant mutation in mec-7/β-tubulin affects axon development and regeneration in Caenorhabditis elegans neurons. Molecular Biology of the Cell,24 3: 285-296. doi:10.1091/mbc.E12-06-0441
A core metabolic enzyme mediates resistance to phosphine gas
Schlipalius, David I., Valmas, Nicholas, Tuck, Andrew G., Jagadeesan, Rajeswaran, Ma, Li, Kaur, Ramandeep, Goldinger, Anita, Anderson, Cameron, Kuang, Jujiao, Zuryn, Steven, Mau, Yosep S., Cheng, Qiang, Collins, Patrick J., Nayak, Manoj K., Schirra, Horst Joachim, Hilliard, Massimo A. and Ebert, Paul R. (2012) A core metabolic enzyme mediates resistance to phosphine gas. Science, 338 6108: 807-810. doi:10.1126/science.1224951
Cáceres, Ivan de Carlos, Valmas, Nicholas, Hilliard, Massimo A. and Lu, Hang (2012) Laterally orienting C. elegans using geometry at microscale for high-throughput visual screens in neurodegeneration and neuronal development studies. PLoS One, 7 4: e35037.1-e35037.8. doi:10.1371/journal.pone.0035037
LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C. elegans neurons
Kirszenblat, Leonie, Pattabiraman, Divya and Hilliard, Massimo A. (2011) LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C. elegans neurons. PLoS Biology, 9 9: 0nline. doi:10.1371/journal.pbio.1001157
Axonal regeneration proceeds through specific axonal fusion in transected C. elegans neurons
Neumann, Brent, Nguyen, Ken C. Q., Hall, David H., Ben-Yakar, Adela and Hilliard, Massimo A. (2011) Axonal regeneration proceeds through specific axonal fusion in transected C. elegans neurons. Developmental Dynamics,240 6: 1365-1372. doi:10.1002/dvdy.22606
Big ideas for small brains: What can psychiatry learn from worms, flies, bees and fish?
Burne, T. H. J., Scott, E., van Swinderen, B., Hilliard, M., Reinhard, J., Claudianos, C., Eyles, D. W. and McGrath, J. J. (2011) Big ideas for small brains: What can psychiatry learn from worms, flies, bees and fish?. Molecular Psychiatry,16 1: 7-16. doi:10.1038/mp.2010.35
Axonal degeneration and regeneration: a mechanistic tug-of-war
Hilliard, Massimo (2009) Axonal degeneration and regeneration: a mechanistic tug-of-war. Journal Of Neurochemistry, 108 1: 23-32. doi:10.1111/j.1471-4159.2008.05754.x
Femtosecond laser nanoaxotomy lab-on-a-chip for in vivo nerve regeneration studies
Guo, Samuel X., Bourgeois, Frederic, Chokshi, Trushal, Durr, Nicholas J., Hilliard, Massimo A., Chronis, Nikos and Ben-Yakar, Adela (2008) Femtosecond laser nanoaxotomy lab-on-a-chip for in vivo nerve regeneration studies.Nature Methods, 5 6: 531-533. doi:10.1038/nmeth.1203
Chalasani, Sreekanth H., Feinberg, Evan H. and Hilliard, Massimo A. (2007) Global 'worming'. Genome Biology, 8 9: 314-1-314-3. doi:10.1186/gb-2007-8-9-314
Pan, Chun-Liang, Howell, James Endres, Clark, Scott G., Hilliard, Massimo, Cordes, Shaun, Bargmann, Cornelia I. and Garriga, Gian (2006) Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans. Developmental cell, 10 3: 367-377. doi:10.1016/j.devcel.2006.02.010
Wnt signals and Frizzled activity orient anterior-posterior axon outgrowth in C. elegans
Hilliard, Massimo A. and Bargmann, Cornelia I. (2006) Wnt signals and Frizzled activity orient anterior-posterior axon outgrowth in C. elegans. Developmental Cell, 10 3: 379-390. doi:10.1016/j.devcel.2006.01.013
Sapio, Maria Rosaria, Hilliard, Massimo A., Cermola, Michele, Favre, Reneé and Bazzicalupo, Paolo (2005) The Zona Pellucida domain containing proteins, CUT-1, CUT-3 and CUT-5, play essential roles in the development of the larval alae in Caenorhabditis elegans. Developmental Biology, 282 1: 231-245. doi:10.1016/j.ydbio.2005.03.011
In vivo imaging of C. elegans ASH neurons: Cellular response and adaptation to chemical repellents
Hilliard, Massimo A., Apicella, Alfonso J., Kerr, Rex, Suzuki, Hiroshi, Bazzicalupo, Paolo and Schafer, William R. (2005) In vivo imaging of C. elegans ASH neurons: Cellular response and adaptation to chemical repellents. The EMBO Journal 24, 1489-1489, 24 63-72. doi:10.1038/sj.emboj.7600493
Hilliard, Massimo A., Bergamasco, Carmela, Arbucci, Salvatore, Plasterk, Ronald H. A. and Bazzicalupo, Paolo (2004) Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans.The EMBO Journal, 23 5: 1101-1111. doi:10.1038/sj.emboj.7600107
C. elegans responds to chemical repellents by integrating sensory inputs from the head and the tail
Hilliard, Massimo A., Bargmann, Cornelia I. and Bazzicalupo, Paolo (2002) C. elegans responds to chemical repellents by integrating sensory inputs from the head and the tail. Current Biology, 12 9: 730-734. doi:10.1016/S0960-9822(02)00813-8