Neurobiology

• Developmental vitamin D-deficiency produces autism-relevant behaviours and gut-health associated alterations in a rat model

Tamang, Man Kumar, Ali, Asad, Pertile, Renata Nedel, Cui, Xiaoying, Alexander, Suzy, Nitert, Marloes Dekker, Palmieri, Chiara and Eyles, Darryl (2023). Developmental vitamin D-deficiency produces autism-relevant behaviours and gut-health associated alterations in a rat model. Translational Psychiatry, 13 (1) 204. doi: 10.1038/s41398-023-02513-3

• Vitamin D: A potent regulator of dopaminergic neuron differentiation and function

  Pertile, Renata Aparecida Nedel, Brigden, Rachel, Raman, Vanshika, Cui, Xiaoying, Du, Zilong and Eyles, Darryl (2023). Vitamin D: A potent regulator of dopaminergic neuron differentiation and function. Journal of Neurochemistry, 166 (5), 779-789. doi: 10.1111/jnc.15829

• Animal models of relevance to the schizophrenia prodrome

  Petty, Alice, Howes, Oliver and Eyles, Darryl (2023). Animal models of relevance to the schizophrenia prodrome. Biological Psychiatry Global Open Science, 3 (1), 22-32. doi: 10.1016/j.bpsgos.2021.12.001

• Vitamin D and the central nervous system: causative and preventative mechanisms in brain disorders

  Cui, Xiaoying and Eyles, Darryl W. (2022). Vitamin D and the central nervous system: causative and preventative mechanisms in brain disorders. Nutrients, 14 (20) 4353, 1-20. doi: 10.3390/nu14204353

• Mixture analysis of air pollution and endocrine disrupting chemicals in relation to Vitamin D concentrations in pregnancy

  Berger, Kimberly, Poon, Victor, Kharrazi, Marty, Eyles, Darryl, Lyall, Kristen, Volk, Heather E., Croen, Lisa A., Windham, Gayle and Pearl, Michelle (2022). Mixture analysis of air pollution and endocrine disrupting chemicals in relation to Vitamin D concentrations in pregnancy. ISEE Conference Abstracts, 2022 (1). doi: 10.1289/isee.2022.o-op-271

• Developmental vitamin D-deficiency increases the expression of microRNAs involved in dopamine neuron development

  Aparecida Nedel Pertile, Renata, Kiltschewskij, Dylan, Geaghan, Michael, Barnett, Michelle, Cui, Xiaoying, Cairns, Murray J. and Eyles, Darryl (2022). Developmental vitamin D-deficiency increases the expression of microRNAs involved in dopamine neuron development. Brain Research, 1789 147953, 147953. doi: 10.1016/j.brainres.2022.147953

• Prenatal hypoxia alters the early ontogeny of dopamine neurons

  Brandon, Anastasia, Cui, Xiaoying, Luan, Wei, Ali, Asad Amanat, Pertile, Renata Aparecida Nedel, Alexander, Suzanne Adele and Eyles, Darryl Walter (2022). Prenatal hypoxia alters the early ontogeny of dopamine neurons. Translational Psychiatry, 12 (1) 238, 238. doi: 10.1038/s41398-022-02005-w

• Does the gut microbiome mediate antipsychotic-induced metabolic side effects in schizophrenia?

  Vasileva, Svetlina S., Tucker, Jack, Siskind, Dan and Eyles, Darryl (2022). Does the gut microbiome mediate antipsychotic-induced metabolic side effects in schizophrenia?. Expert Opinion on Drug Safety, 21 (5), 1-15. doi: 10.1080/14740338.2022.2042251

• Animal models of relevance to the schizophrenia prodrome

  Petty, Alice, Howes, Oliver and Eyles, Darryl (2021). Animal models of relevance to the schizophrenia prodrome. Biological Psychiatry Global Open Science. doi: 10.1016/j.bpsgos.2021.12.001

• Association between circulating 25-hydroxyvitamin D concentrations and hip replacement for osteoarthritis: a prospective cohort study

  Hussain, Sultana Monira, Wang, Yuanyuan, Heath, Alicia K., Giles, Graham G., English, Dallas R., Eyles, Darryl W., Williamson, Elizabeth J., Graves, Stephen E., Wluka, Anita E. and Cicuttini, Flavia M. (2021). Association between circulating 25-hydroxyvitamin D concentrations and hip replacement for osteoarthritis: a prospective cohort study. BMC Musculoskeletal Disorders, 22 (1) 887, 887. doi: 10.1186/s12891-021-04779-4

• Developmental vitamin D deficiency in pregnant rats does not induce preeclampsia

  Ali, Asad, Alexander, Suzanne, Ko, Pauline, Cuffe, James S. M., Whitehouse, Andrew J. O., McGrath, John J. and Eyles, Darryl (2021). Developmental vitamin D deficiency in pregnant rats does not induce preeclampsia. Nutrients, 13 (12) 4254. doi: 10.3390/nu13124254

• Developmental inhibition of long intergenic non-coding RNA, HOTAIRM1, impairs dopamine neuron differentiation and maturation

  Cui, Xiaoying, Pertile, Renata Ap. Nedel, Du, Zilong, Wei, Wei, Sun, Zichun, Eyles, Darryl W. and Kesby, James P. (2021). Developmental inhibition of long intergenic non-coding RNA, HOTAIRM1, impairs dopamine neuron differentiation and maturation. International Journal of Molecular Sciences, 22 (14) 7268, 7268. doi: 10.3390/ijms22147268

• How do established developmental risk-factors for schizophrenia change the way the brain develops?

  Eyles, Darryl W. (2021). How do established developmental risk-factors for schizophrenia change the way the brain develops?. Translational Psychiatry, 11 (1) 158, 158. doi: 10.1038/s41398-021-01273-2

• Vitamin D deficiency worsens maternal diabetes induced neurodevelopmental disorder by potentiating hyperglycemia-mediated epigenetic changes

  Liang, Yujie, Yu, Hong, Ke, Xiaoyin, Eyles, Darryl, Sun, Ruoyu, Wang, Zichen, Huang, Saijun, Lin, Ling, McGrath, John J., Lu, Jianping, Guo, Xiaoling and Yao, Paul (2021). Vitamin D deficiency worsens maternal diabetes induced neurodevelopmental disorder by potentiating hyperglycemia-mediated epigenetic changes. Annals of the New York Academy of Sciences, 1491 (1), 74-88. doi: 10.1111/nyas.14535

• Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome

  Petty, Alice, Cui, Xiaoying, Ali, Asad, Du, Zilong, Srivastav, Sunil, Kesby, James P., Kirik, Deniz, Howes, Oliver and Eyles, Darryl (2021). Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome. Scientific Reports, 11 (1) 4294, 4294. doi: 10.1038/s41598-021-83681-4

• Vitamin D and schizophrenia: 20 years on

  Cui, Xiaoying, McGrath, John J., Burne, Thomas H. J. and Eyles, Darryl W. (2021). Vitamin D and schizophrenia: 20 years on. Molecular Psychiatry, 26 (7), 2708-2720. doi: 10.1038/s41380-021-01025-0

• Developmental vitamin D deficiency increases foetal exposure to testosterone

  Ali, Asad Amanat, Cui, Xiaoying, Pertile, Renata Aparecida Nedel, Li, Xiang, Medley, Gregory, Alexander, Suzanne Adele, Whitehouse, Andrew J. O., McGrath, John J. and Eyles, Darryl Walter (2020). Developmental vitamin D deficiency increases foetal exposure to testosterone. Molecular Autisum, 11 (1) 96, 96. doi: 10.1186/s13229-020-00399-2

• Maternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders (ASD) or Intellectual Disability (ID) in Offspring; Exploring Non-linear Patterns and Demographic Sub-groups

  Windham, Gayle C., Pearl, Michelle, Poon, Victor, Berger, Kimberly, Soriano, Jasmine W., Eyles, Darryl, Lyall, Kristen, Kharrazi, Martin and Croen, Lisa A. (2020). Maternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders (ASD) or Intellectual Disability (ID) in Offspring; Exploring Non-linear Patterns and Demographic Sub-groups. Autism Research, 13 (12), 2216-2229. doi: 10.1002/aur.2424

• Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

  Revez, Joana A., Lin, Tian, Qiao, Zhen, Xue, Angli, Holtz, Yan, Zhu, Zhihong, Zeng, Jian, Wang, Huanwei, Sidorenko, Julia, Kemper, Kathryn E., Vinkhuyzen, Anna A. E., Frater, Julanne, Eyles, Darryl, Burne, Thomas H. J., Mitchell, Brittany, Martin, Nicholas G., Zhu, Gu, Visscher, Peter M., Yang, Jian, Wray, Naomi R. and McGrath, John J. (2020). Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration. Nature Communications, 11 (1) 1647, 1-12. doi: 10.1038/s41467-020-15421-7

• Circulating 25-hydroxyvitamin D concentration and cause-specific mortality in the Melbourne Collaborative Cohort Study

  Heath, Alicia K., Hodge, Allison M., Ebeling, Peter R., Kvaskoff, David, Eyles, Darryl W., Giles, Graham G., English, Dallas R. and Williamson, Elizabeth J. (2020). Circulating 25-hydroxyvitamin D concentration and cause-specific mortality in the Melbourne Collaborative Cohort Study. Journal of Steroid Biochemistry and Molecular Biology, 198 105612, 105612. doi: 10.1016/j.jsbmb.2020.105612

• Genetic contributions to maternal and neonatal vitamin D levels

  Traglia, Michela, Windham, Gayle C., Pearl, Michelle, Poon, Victor, Eyles, Darryl, Jones, Karen L., Lyall, Kristen, Kharrazi, Martin, Croen, Lisa A. and Weiss, Lauren A. (2020). Genetic contributions to maternal and neonatal vitamin D levels. Genetics, 214 (4), 1091-1102. doi: 10.1534/genetics.119.302792

• Enhanced dopamine in prodromal schizophrenia (EDiPS): a new animal model of relevance to schizophrenia

  Petty, Alice, Cui, Xiaoying, Tesiram, Yasvir, Kirik, Deniz, Howes, Oliver and Eyles, Darryl (2019). Enhanced dopamine in prodromal schizophrenia (EDiPS): a new animal model of relevance to schizophrenia. NPJ Schizophrenia, 5 (1) 6, 6. doi: 10.1038/s41537-019-0074-z

• 1,25-Dihydroxyvitamin D modulates L-type voltage-gated calcium channels in a subset of neurons in the developing mouse prefrontal cortex

  Gooch, Helen, Cui, Xiaoying, Anggono, Victor, Trzaskowski, Maciej, Tan, Men Chee, Eyles, Darryl W., Burne, Thomas H. J., Jang, Se Eun, Mattheisen, Manuel, Hougaard, David M., Pedersen, Bent Nørgaard, Cohen, Arieh, Mortensen, Preben B., Sah, Pankaj and McGrath, John J. (2019). 1,25-Dihydroxyvitamin D modulates L-type voltage-gated calcium channels in a subset of neurons in the developing mouse prefrontal cortex. Translational Psychiatry, 9 (1) 281, 281. doi: 10.1038/s41398-019-0626-z

• Developmental vitamin D deficiency in the rat impairs recognition memory, but has no effect on social approach or hedonia

  Overeem, Kathie, Alexander, Suzy, Burne, Thomas H J, Ko, Pauline and Eyles, Darryl W (2019). Developmental vitamin D deficiency in the rat impairs recognition memory, but has no effect on social approach or hedonia. Nutrients, 11 (11) 2713, 2713. doi: 10.3390/nu11112713

• Developmental vitamin D and autism spectrum disorders: findings from the Stockholm Youth Cohort

  Lee, Brian K., Eyles, Darryl W., Magnusson, Cecilia, Newschaffer, Craig J., McGrath, John J., Kvaskoff, David, Ko, Pauline, Dalman, Christina, Karlsson, Håkan and Gardner, Renee M. (2019). Developmental vitamin D and autism spectrum disorders: findings from the Stockholm Youth Cohort. Molecular Psychiatry, 26 (5), 1578-1588. doi: 10.1038/s41380-019-0578-y

• Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case–control study

  Schmidt, Rebecca J., Niu, Qiaojuan, Eyles, Darryl W., Hansen, Robin L. and Iosif, Ana-Maria (2019). Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case–control study. Autism Research, 12 (6), 976-988. doi: 10.1002/aur.2118

• Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: a case–control study in California

  Windham, Gayle C., Pearl, Michelle, Anderson, Meredith C., Poon, Victor, Eyles, Darryl, Jones, Karen L., Lyall, Kristen, Kharrazi, Martin and Croen, Lisa A. (2019). Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: a case–control study in California. Autism Research, 12 (6), 989-998. doi: 10.1002/aur.2092

• Developmental vitamin D deficiency produces behavioral phenotypes of relevance to Autism in an animal model

  Ali, Asad, Vasileva, Svetlina, Langguth, Mia, Alexander, Suzanne, Cui, Xiaoying, Whitehouse, Andrew, McGrath, John J. and Eyles, Darryl (2019). Developmental vitamin D deficiency produces behavioral phenotypes of relevance to Autism in an animal model. Nutrients, 11 (5) 1187, 1187. doi: 10.3390/nu11051187

• Circulating 25-hydroxyvitamin D concentration and risk of breast, prostate, and colorectal cancers: the Melbourne Collaborative Cohort Study

  Heath, Alicia K., Hodge, Allison M., Ebeling, Peter R., Eyles, Darryl W., Kvaskoff, David, Buchanan, Daniel D., Giles, Graham G., Williamson, Elizabeth J. and English, Dallas R. (2019). Circulating 25-hydroxyvitamin D concentration and risk of breast, prostate, and colorectal cancers: the Melbourne Collaborative Cohort Study. Cancer Epidemiology, Biomarkers and Prevention, 28 (5), 900-908. doi: 10.1158/1055-9965.EPI-18-1155

• A collaborative analysis of individual participant data from 19 prospective studies assesses circulating Vitamin D and prostate cancer risk

  Travis, Ruth C., Perez-Cornago, Aurora, Appleby, Paul N., Albanes, Demetrius, Joshu, Corinne E., Lutsey, Pamela L., Mondul, Alison M., Platz, Elizabeth A., Weinstein, Stephanie J., Layne, Tracy M., Helzlsouer, Kathy J., Visvanathan, Kala, Palli, Domenico, Peeters, Petra H., Bueno-de-Mesquita, Bas, Trichopoulou, Antonia, Gunter, Marc J., Tsilidis, Konstantinos K., Sanchez, Maria-Jose, Olsen, Anja, Brenner, Hermann, Schottker, Ben, Perna, Laura, Holleczek, Bernd, Knekt, Paul, Rissanen, Harri, Yeap, Bu B., Flicker, Leon, Almeida, Osvaldo P. ... Allen, Naomi E. (2019). A collaborative analysis of individual participant data from 19 prospective studies assesses circulating Vitamin D and prostate cancer risk. Cancer Research, 79 (1), 274-285. doi: 10.1158/0008-5472.CAN-18-2318

• Half the genetic variance in vitamin D concentration is shared with skin colour and sun exposure genes

  Mitchell, Brittany L., Zhu, Gu, Medland, Sarah E., Renteria, Miguel. E., Eyles, Darryl W., Grasby, Katrina L., McGrath, John J. and Martin, Nicholas G. (2019). Half the genetic variance in vitamin D concentration is shared with skin colour and sun exposure genes. Behavior Genetics, 49 (4), 386-398. doi: 10.1007/s10519-019-09954-x

• The association between neonatal vitamin D status and risk of schizophrenia

  Eyles, Darryl W., Trzaskowski, Maciej, Vinkhuyzen, Anna A. E., Mattheisen, Manuel, Meier, Sandra, Gooch, Helen, Anggono, Victor, Cui, Xiaoying, Tan, Men Chee, Burne, Thomas H. J., Jang, Se Eun, Kvaskoff, David, Hougaard, David M., Nørgaard-Pedersen, Bent, Cohen, Arieh, Agerbo, Esben, Pedersen, Carsten B., Børglum, Anders D., Mors, Ole, Sah, Pankaj, Wray, Naomi R., Mortensen, Preben B. and McGrath, John J. (2018). The association between neonatal vitamin D status and risk of schizophrenia. Scientific Reports, 8 (1) 17692, 17692. doi: 10.1038/s41598-018-35418-z

• Functional and molecular changes in the nucleus accumbens of MK-801-sensitized rats

  Lefevre, Emilia, Gooch, Helen, Josh, Peter, Alexander, Suzy, Eyles, Darryl W. and Burne, Thomas H. J. (2018). Functional and molecular changes in the nucleus accumbens of MK-801-sensitized rats. Behavioural Pharmacology, 30 (5), 1-395. doi: 10.1097/FBP.0000000000000447

• Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons

  Pertile, Renata A. N., Cui, Xiaoying, Hammond, Luke and Eyles, Darryl W. (2018). Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons. The FASEB Journal, 32 (2), fj201700713R-828. doi: 10.1096/fj.201700713R

• Increasing paternal age alters anxiety-related behaviour in adult mice

  Foldi, Claire J., Eyles, Darryl W., McGrath, John J. and Burne, Thomas H. J. (2018). Increasing paternal age alters anxiety-related behaviour in adult mice. Genes, Brain and Behavior, 18 (2) e12522, e12522. doi: 10.1111/gbb.12522

• Associations of maternal and fetal vitamin D status with childhood body composition and cardiovascular risk factors

  Miliku, Kozeta, Felix, Janine F., Voortman, Trudy, Tiemeier, Henning, Eyles, Darryl W., Burne, Thomas H., McGrath, John J. and Jaddoe, Vincent W. V. (2018). Associations of maternal and fetal vitamin D status with childhood body composition and cardiovascular risk factors. Maternal and Child Nutrition, 15 (2) e12672, e12672. doi: 10.1111/mcn.12672

• Maternal vitamin D prevents abnormal dopaminergic development and function in a mouse model of prenatal immune activation

  Luan, Wei, Hammond, Luke Alexander, Vuillermot, Stephanie, Meyer, Urs and Eyles, Darryl Walter (2018). Maternal vitamin D prevents abnormal dopaminergic development and function in a mouse model of prenatal immune activation. Scientific Reports, 8 (1) 9741, 9741. doi: 10.1038/s41598-018-28090-w

• Vitamin D status and the risk of type 2 diabetes: the Melbourne Collaborative Cohort Study

  Heath, Alicia K., Williamson, Elizabeth J., Hodge, Allison M., Ebeling, Peter R., Eyles, Darryl W., Kvaskoff, David, O'Dea, Kerin, Giles, Graham G. and English, Dallas R. (2018). Vitamin D status and the risk of type 2 diabetes: the Melbourne Collaborative Cohort Study. Diabetes Research and Clinical Practice, 149, 179-187. doi: 10.1016/j.diabres.2018.05.007

• The placental immune response is dysregulated developmentally vitamin D deficient rats: Relevance to autism

  Ali, Asad, Cui, Xiaoying, Alexander, Suzanne and Eyles, Darryl (2018). The placental immune response is dysregulated developmentally vitamin D deficient rats: Relevance to autism. The Journal of Steroid Biochemistry and Molecular Biology, 180, 73-80. doi: 10.1016/j.jsbmb.2018.01.015

• Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience

  Kesby, J. P., Eyles, D. W., McGrath, J. J. and Scott, J. G. (2018). Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience. Translational Psychiatry, 8 (1) 30, 1-12. doi: 10.1038/s41398-017-0071-9

• Early life Vitamin D depletion alters the postnatal response to skeletal loading in growing and mature bone

  Borg, Stephanie A., Buckley, Harriet, Owen, Robert, Marin, Ana Campos, Lu, Yongtau, Eyles, Darryl, Lacroix, Damien, Reilly, Gwendolen C., Skerry, Tim M. and Bishop, Nick J. (2018). Early life Vitamin D depletion alters the postnatal response to skeletal loading in growing and mature bone. PLoS One, 13 (1) e0190675, e0190675. doi: 10.1371/journal.pone.0190675

• The vitamin D receptor (VDR) binds to the nuclear matrix via its hinge domain: a potential mechanism for the reduction in VDR mediated transcription in mitotic cells

  Cui, Xiaoying, Pertile, Renata and Eyles, Darryl W. (2017). The vitamin D receptor (VDR) binds to the nuclear matrix via its hinge domain: a potential mechanism for the reduction in VDR mediated transcription in mitotic cells. Molecular and Cellular Endocrinology, 472, 18-25. doi: 10.1016/j.mce.2017.11.015

• Prevalence and correlates of suboptimal vitamin D status in people living with psychotic disorders: data from the Australian Survey of High Impact Psychosis

  Suetani, Shuichi, Saha, Sukanta, Eyles, Darryl W., Scott, James G. and McGrath, John J. (2017). Prevalence and correlates of suboptimal vitamin D status in people living with psychotic disorders: data from the Australian Survey of High Impact Psychosis. Australian and New Zealand Journal of Psychiatry, 51 (9), 921-929. doi: 10.1177/0004867416681853

• Developmental vitamin D deficiency alters multiple neurotransmitter systems in the neonatal rat brain

  Kesby, James P., Turner, Karly M., Alexander, Suzanne, Eyles, Darryl W., McGrath, John J. and Burne, Thomas H.J. (2017). Developmental vitamin D deficiency alters multiple neurotransmitter systems in the neonatal rat brain. International Journal of Developmental Neuroscience, 62 (C), 1-7. doi: 10.1016/j.ijdevneu.2017.07.002

• Short- and long-term effects of risperidone on catalepsy sensitisation and acquisition of conditioned avoidance response: adolescent vs adult rats

  Moe, Aung Aung Kywe, Medely, Gregory A., Reeks, Timothy, Burne, Thomas H. J. and Eyles, Darryl W. (2017). Short- and long-term effects of risperidone on catalepsy sensitisation and acquisition of conditioned avoidance response: adolescent vs adult rats. Pharmacological Research, 121, 1-13. doi: 10.1016/j.phrs.2017.04.013

• Vitamin D and the brain: genomic and non-genomic actions

  Cui, Xiaoying, Gooch, Helen, Petty, Alice, McGrath, John J. and Eyles, Darryl (2017). Vitamin D and the brain: genomic and non-genomic actions. Molecular and Cellular Endocrinology, 453 (C), 131-143. doi: 10.1016/j.mce.2017.05.035

• Effect of the glucocorticoid receptor antagonist RU486 on MK-801 induced behavioural sensitization

  Lefevre, Emilia M., Medley, Gregory A., Reeks, Timothy, Alexander, Suzy, Burne, Thomas H. J. and Eyles, Darryl W. (2017). Effect of the glucocorticoid receptor antagonist RU486 on MK-801 induced behavioural sensitization. PLoS One, 12 (4) e0176156, e0176156. doi: 10.1371/journal.pone.0176156

• Developmental vitamin D (DVD) deficiency reduces Nurr1 and TH expression in post-mitotic dopamine neurons in rat mesencephalon

  Luan, Wei, Hammond, Luke Alexander, Cotter, Edmund, Osborne, Geoffrey William, Alexander, Suzanne Adele, Nink, Virginia, Cui, Xiaoying and Eyles, Darryl Walter (2017). Developmental vitamin D (DVD) deficiency reduces Nurr1 and TH expression in post-mitotic dopamine neurons in rat mesencephalon. Molecular Neurobiology, 55 (3), 2443-2453. doi: 10.1007/s12035-017-0497-3

• Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation

  Vuillermot, Stephanie, Luan, Wei, Meyer, Urs and Eyles, Darryl (2017). Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation. Molecular Autism, 8 (9) 9, 9. doi: 10.1186/s13229-017-0125-0

• Gestational vitamin D deficiency and autism spectrum disorder

  Vinkhuyzen, Anna A. E., Eyles, Darryl W., Burne, Thomas H. J., Blanken, Laura M. E., Kruithof, Claudia J., Verhulst, Frank, White, Tonya, Jaddoe, Vincent W., Tiemeier, Henning and McGrath, John J. (2017). Gestational vitamin D deficiency and autism spectrum disorder. BJPsych Open, 3 (2), 85-90. doi: 10.1192/bjpo.bp.116.004077

• Transient dysregulation of dopamine signaling in a developing drosophila arousal circuit permanently impairs behavioral responsiveness in adults

  Ferguson, Lachlan, Petty, Alice, Rohrscheib, Chelsie, Troup, Michael, Kirszenblat, Leonie, Eyles, Darryl W. and van Swinderen, Bruno (2017). Transient dysregulation of dopamine signaling in a developing drosophila arousal circuit permanently impairs behavioral responsiveness in adults. Frontiers in Psychiatry, 8 (FEB) 22, 22. doi: 10.3389/fpsyt.2017.00022

• Determinants of neonatal vitamin D levels as measured on neonatal dried blood spot samples

  Smith, Chloe A., Sun, Cong, Pezic, Angela , Rodda, Christine, Cameron, Fergus, Allen, Katie, Craig, Maria E. , Carlin, John, Dwyer, Terry, Lucas, Robyn M., Eyles, Darryl W. , Kemp, Andrew S., Ellis, Justine A. and Ponsonby, Anne-Louise (2017). Determinants of neonatal vitamin D levels as measured on neonatal dried blood spot samples. Neonatology, 111 (2), 153-161. doi: 10.1159/000448680

• Developmental vitamin D deficiency and autism: putative pathogenic mechanisms

  Ali, Asad, Cui, Xiaoying and Eyles, Darryl (2016). Developmental vitamin D deficiency and autism: putative pathogenic mechanisms. Journal of Steroid Biochemistry and Molecular Biology, 175, 108-118. doi: 10.1016/j.jsbmb.2016.12.018

• Gestational vitamin D deficiency and autism-related traits: the Generation R Study

  Vinkhuyzen, A. A. E., Eyles, D. W., Burne, T. H. J., Blanken, L. M. E., Kruithof, C. J., Verhulst, F., Jaddoe, V. W., Tiemeier, H. and McGrath, J. J. (2016). Gestational vitamin D deficiency and autism-related traits: the Generation R Study. Molecular Psychiatry, 23 (2), 240-246. doi: 10.1038/mp.2016.213

• Vitamin D signaling and the differentiation of developing dopamine systems

  Pertile, Renata A. N., Cui, Xiaoying and Eyles, Darryl W. (2016). Vitamin D signaling and the differentiation of developing dopamine systems. Neuroscience, 333, 193-203. doi: 10.1016/j.neuroscience.2016.07.020

• Risperidone induces long-lasting changes in the conditioned avoidance response and accumbal gene expression selectively in animals treated as adolescents

  Moe, Aung Aung Kywe, Kurniawan, Nyoman D., Alexander, Suzanne, Cui, Xiaoying, Burne, Thomas H. J. and Eyles, Darryl W. (2016). Risperidone induces long-lasting changes in the conditioned avoidance response and accumbal gene expression selectively in animals treated as adolescents. Neuropharmacology, 108, 264-274. doi: 10.1016/j.neuropharm.2016.04.035

• Neural changes induced by antipsychotic administration in adolescence: a review of studies in laboratory rodents

  Moe, Aung Aung Kywe, Scott, James G., Burne, Thomas H. J. and Eyles, Darryl W. (2016). Neural changes induced by antipsychotic administration in adolescence: a review of studies in laboratory rodents. Journal of Psychopharmacology, 30 (8), 771-794. doi: 10.1177/0269881116654776

• Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes

  Miliku, Kozeta, Vinkhuyzen, Anna, Blanken, Laura M. E., McGrath, John J., Eyles, Darryl W., Burne, Thomas H., Hofman, Albert, Tiemeier, Henning, Steegers, Eric A. P., Gaillard, Romy and Jaddoe, Vincent W. V. (2016). Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes. American Journal of Clinical Nutrition, 103 (6), 1514-1522. doi: 10.3945/ajcn.115.123752

• The relationship between vitamin D status and allergic diseases in New Zealand preschool children

  Cairncross, Carolyn, Grant, Cameron, Stonehouse, Welma, Conlon, Cath, McDonald, Barry, Houghton, Lisa, Eyles, Darryl, Camargo, Carlos A., Coad, Jane and von Hurst, Pamela (2016). The relationship between vitamin D status and allergic diseases in New Zealand preschool children. Nutrients, 8 (6) 326, 326. doi: 10.3390/nu8060326

• Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood eczema: The Generation R Study

  Gazibara, Tatjana, Elbert, Niels J., den Dekker, Herman T., de Jongste, Johan C., Reiss, Irwin, McGrath, John J., Eyles, Darryl W., Burne, Thomas H., Tiemeier, Henning, Jaddoe, Vincent W. V., Pasmans, Suzanne G. M. A. and Duijts, Liesbeth (2016). Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood eczema: The Generation R Study. Pediatric Allergy and Immunology, 27 (3), 283-289. doi: 10.1111/pai.12530

• Minimizing matrix effects for the accurate quantification of 25-hydroxyvitamin D metabolites in dried blood spots by LC-MS/MS

  Kvaskoff, David, Heath, Alicia K., Simila, Henry A., Ko, Pauline, English, Dallas R. and Eyles, Darryl W. (2016). Minimizing matrix effects for the accurate quantification of 25-hydroxyvitamin D metabolites in dried blood spots by LC-MS/MS. Clinical Chemistry, 62 (4), 639-646. doi: 10.1373/clinchem.2015.251538

• 25-hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study

  Heath, Alicia K., Williamson, Elizabeth J., Kvaskoff, David, Hodge, Allison M., Ebeling, Peter R., Baglietto, Laura, Neale, Rachel E., Giles, Graham G., Eyles, Darryl W. and English, Dallas R. (2016). 25-hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study. Public Health Nutrition, 20 (10), 1775-1784. doi: 10.1017/S1368980016000501

• Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood lung function and asthma: the Generation R Study

  Gazibara, Tatjana, den Dekker, Herman T., de Jongste, Johan C., McGrath, John J., Eyles, Darryl W., Burne, Thomas H., Reiss, Irwin, Franco, Oscar H., Tiemeier, Henning, Jaddoe, Vincent W. V. and Duijts, Liesbeth (2016). Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood lung function and asthma: the Generation R Study. Clinical and Experimental Allergy, 46 (2), 337-346. doi: 10.1111/cea.12645

• Behavioural sensitisation to MK-801 is dose-dependent and independent of environmental context

  Lefevre, Emilia M., Eyles, Darryl W. and Burne, Thomas H. J. (2016). Behavioural sensitisation to MK-801 is dose-dependent and independent of environmental context. Behavioural Brain Research, 298 (Part B), 241-245. doi: 10.1016/j.bbr.2015.11.014

• The impact of vitamin D deficiency on behaviour and brain function in rodents

  Overeem, Kathie, Eyles, Darryl W., McGrath, John J. and Burne, Thomas H. J. (2016). The impact of vitamin D deficiency on behaviour and brain function in rodents. Current Opinion in Behavioral Sciences, 7, 47-52. doi: 10.1016/j.cobeha.2015.11.012

• Predictors of vitamin D status in New Zealand preschool children

  Cairncross, C.T., Stonehouse, W., Conlon, C. A., Grant, C. C., McDonald, B., Houghton, L. A., Eyles, Darryl, Camargo Jr, C. A., Coad, J. and von Hurst, P. R. (2016). Predictors of vitamin D status in New Zealand preschool children. Maternal and Child Nutrition, 13 (3) e12340, e12340. doi: 10.1111/mcn.12340

• Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator

  Cui, X., Pertile, R., Liu, P. and Eyles, D. W. (2015). Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator. Neuroscience, 304, 90-100. doi: 10.1016/j.neuroscience.2015.07.048

The University of Queensland

• Professor John McGrath, QBI
• Associate Professor Tom Burne, QBI
• Associate Professor Bruno Van Swinderen, QBI
• Dr Ethan Scott

National

• Prof Andrew Whitehouse Telethon Kids Institute Perth, WA
• Dr. Jake Gratten TRI, Brisbane

International

• E Fernell Karolinska, Sweden
• B. Lee Drexel University, USA
• U. Meyer, ETH Zurich, Switzerland
• O. Howes Kings college London
• R. Schmidt, University of California Davis, USA
• G Windham, Division of Environmental and Occupational Disease Control, USA
• P Hurst Massey University Auckland NZ.
• D Kirik Lund University Sweden

We have developed a new animal model of schizophrenia. We elevate dopamine selectively in the dorsal striatum by stereotaxically delivering genetic constructs to the substantia. We call this model Elevated Dopamine in Prodromal Schizophrenia (EDiPs). Our aim is to follow the course and examine the alterations in brain connectivity induced by EDiPS. Our ultimate aim is to intervene to block the disease process.

Project 1:  How does EDiPS affect cortical and subcortical connectivity and can we intervene to block EDiPS induced abnormalities in connectivity and behavioural phenotypes?

Project 2:  This project will firstly establish a new and more dopaminergically-selective EDiPS model using a TH-Cre rat and DREADD technology. Secondly, the student will establish whether early post-natal or late (Puberty) stages of brain development represent the critical window for EDiPS-induced phenotypes.

In a second series of studies we have selectively blocked both early features of autism and late characteristic behaviours associated with schizophrenia in the well-described Maternal Immune Activation animal model using the hormonal form of vitamin D.

Project 3:  We now want to understand what neuroprotective mechanisms we have triggered in this model and if we could also replicate these findings using the dietary form of vitamin D.

How to apply