Professor Michael Hausser FRS

Wolfson Institute for Biomedical Research, University College London, UK

Title: "All-optical closed-loop manipulation of neural circuits in vivo"

Abstract:  Understanding the causal relationship between activity patterns in neural circuits and behavior will require the ability to perform rapid and targeted interventions in ongoing neuronal activity. I will describe a novel closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. This involves rapid tailoring and delivery of two-photon optogenetic stimulation based on readout of activity using simultaneous two-photon imaging of the same neural population. This closed-loop feedback control can be used to clamp spike rates at pre-defined levels, boost weak sensory-evoked responses, and activate network ensembles based on detected activity. By optically 'yoking together' neighboring neurons, it can also be used to induce long-term changes in network dynamics. This approach thus allows the rate and timing of activity patterns in neural circuits to be flexibly manipulated ‘on the fly’ during behavior.



About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018