Speaker: 

Professor Elly Nedivi
Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge MA 02139, USA

Title: "Visualizing molecular events in synapse formation in vivo"

Abstract: The introduction of two-photon microscopy for in vivo imaging has opened the door to chronic monitoring of individual neurons in the adult brain, and the study of structural plasticity mechanisms at a very fine scale. Perhaps the biggest contribution of this modern anatomical method has been the discovery that even across the stable excitatory dendritic scaffold there is significant capacity for synaptic remodeling, and that adjusting synapse strength and number are key mechanisms mediating neural circuit adaptation and behavioral plasticity in the adult. The activity-regulated gene cpg15/neuritin has been previously implicated in stabilization and maturation of excitatory synapses. We combined multicolor two-photon microscopy with genetic and sensory manipulations to delineate, in vivo, steps in synapse formation and maturation, and examine sufficiency and requirement for activity and CPG15 at these defined steps.

 

 

About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

The scheduled QBI Neuroscience Seminar series are held on Wednesdays from 11am-12pm in the Level 7 Auditorium of the Queensland Brain Institute, Building 79, St Lucia Campus, The University of Queensland. Additional seminars may be held at other times as listed below.

 

Neuroscience Seminars archive 2005-2018