Speaker : 

Dr Victor Anggono,
Queensland Brain Institute, University of Queensland

Title: "Molecular Mechanisms of Glutamate Receptor Trafficking"

Abstract: Neuronal communication at excitatory synapses relies on the release of glutamate from the presynaptic terminals and their subsequent binding to postsynaptic glutamate receptors. The number of glutamate receptors at the synapse is one of the major determinants of synaptic efficacy. Dynamic changes in synaptic strength, known as synaptic plasticity, are thought to underlie information coding and storage during learning and memory. Aberrant trafficking of glutamate receptors into and out of synapses usually leads to impairment in synaptic plasticity and deficits in learning and memory. More importantly, there are growing evidence that demonstrate a strong link between defective glutamatergic neurotransmission and cognitive decline associated with various neurodegenerative diseases and neuropsychiatric disorders. Here, I will present data and discuss our efforts in elucidating the molecular mechanisms that control the trafficking of two major glutamate receptors, namely AMPA- and NMDA-receptors, by intracellular glutamate receptor interacting proteins and post-translational modifications that occur on their carboxyl termini.
 

 

About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

The scheduled QBI Neuroscience Seminar series are held on Wednesdays from 11am-12pm in the Level 7 Auditorium of the Queensland Brain Institute, Building 79, St Lucia Campus, The University of Queensland. Additional seminars may be held at other times as listed below.

 

Neuroscience Seminars archive 2005-2018