Speaker : 

A/Professor Zachary Knight
Howard Hughes Medical Institute, University of California, San Francisco

Title: "The Neurobiology of Homeostasis"

Abstract: Our research investigates the neural mechanisms that govern hunger and thirst. Nearly a century ago, lesioning studies suggested that these fundamental drives originate from subcortical structures such as hypothalamus that are specialized for monitoring internal state. However the structure and dynamics of the underlying neural circuits has been poorly defined. I will discuss our work using calcium imaging to record the natural activity of some of the key cell types that control eating and drinking in vivo. We have discovered that these homeostatic neurons receive sensory information from the outside world, which they use predict impending physiologic changes and adjust behavior preemptively. I will discuss our work investigating how these homeostatic circuits integrate external sensory cues with internal signals arising from the  body in order to generate and shape goal-directed behaviors.



About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018