Speaker:  Dr Matilde Balbi

University of British Columbia, Vancouver, Canada

Title: "Activity dependent neuroprotection in the acute phase after stroke"

Abstract: Stroke is a leading cause of death and disability worldwide. Recovery is widely variable across survivors and can have severe implications on behavioral autonomy and lifestyle. This variability is highly dependent on the level of blood flow restored to affected areas. Blood flow supply can be controlled by directly altering brain activity in the critical first hours after stroke. However, acute activity-dependent neuroprotection has been unsuccessful in restoring behavioral function or reducing lesion size in mice. To address this, I investigated the effects of specific types of neuronal activation to discern which types of stimulation, if any, are capable of rescuing affected brain tissue and behavioral function. Changes in gamma oscillations (20–50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies is unclear. I investigated the effect of the gamma-range modulation in the acute phase after stroke using a new model for stroke induction in awake, head-fixed mice. I employed optogenetics stimulation in conjunction with laser speckle imaging, electrophysiology and behavioral tasks to describe the beneficial effects of acute, 40 Hz brain stimulation: reduced lesion volume and improved motor function after stroke. Finally, I lay out a plan for future studies to investigate the subtypes of interneurons underlying the observed therapeutic effects and characterize intrinsic mechanisms of the brain that may be harnessed to enhance recovery after stroke.

 

About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

The scheduled QBI Neuroscience Seminar series are held on Wednesdays from 11am-12pm in the Level 7 Auditorium of the Queensland Brain Institute, Building 79, St Lucia Campus, The University of Queensland. Additional seminars may be held at other times as listed below.

 

Neuroscience Seminars archive 2005-2018