Dr Susannah Tye

Queensland Brain Institute, University of Queensland

Title: "Insulin Signalling Moderates the Rapid Antidepressant Actions of Ketamine in Treatment Resistant Depression"

Abstract: Low-dose ketamine is effective in a subset of patients with treatment-resistant depression. The mechanisms of action through which ketamine elicits its rapid antidepressant response are, however, not well understood. Using an animal model of antidepressant-resistance we have identified an association between brain insulin signalling and antidepressant-like behavioural responses to ketamine in the forced swim test. Our work has explored the association between insulin signalling in brain and blood tissue, and ketamine’s therapeutic actions in antidepressant-resistant rats. We have validated the association between insulin signalling in peripheral blood mononuclear cells (PBMCs) and clinical response to ketamine in patients with treatment resistant depression. We have further shown in rats that targeting this mechanism can improve response rates. Our data suggests the direct effects of ketamine on insulin signalling serves as critical co-regulator of antidepressant response in individuals with treatment resistant depression.


About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018