Speaker:

Professor Bryan Mowry

Queensland Brain Institute, University of Queensland

Title: Genetic analyses of schizophrenia in Tamil Nadu, India

Abstract:
Schizophrenia is highly polygenic. Genome-wide association studies (GWAS), primarily in European datasets have begun to dissect the underlying genetic complexity, so far identifying over 100 schizophrenia-associated loci. Other major world populations also warrant intensive study. Our schizophrenia GWAS has been conducted in a sample of Tamil ancestry individuals from Chennai, Tamil Nadu. This sample consists of schizophrenia families and unrelated cases and controls, and demonstrates characteristics that may be beneficial for genetic analysis. We observed a genome-wide significant association between schizophrenia and a chromosome 8q locus. European polygenic risk scores predicted schizophrenia in our Indian sample. We further investigated the regulatory effects of our top association signal, with bioinformatic analyses highlighting one gene for functional testing in Indian cell lines and in zebrafish. We are also conducting a whole exome study of Indian families, aiming to identify mutations; an update on progress in this study will be presented. Studying the genetics of schizophrenia in such populations should enrich our understanding of the global impact of this disorder. We further provide evidence for genome-wide sharing of common genetic variation for schizophrenia between Europe and India.

About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

The scheduled QBI Neuroscience Seminar series are held on Wednesdays from 11am-12pm in the Level 7 Auditorium of the Queensland Brain Institute, Building 79, St Lucia Campus, The University of Queensland. Additional seminars may be held at other times as listed below.

 

Neuroscience Seminars archive 2005-2016