Speaker:

Dr Alessandra Martini

Institute for Memory Impairments and Neurological Disorders, University of California - Irvine (UCI)

Title: "Amyloid-beta impairs interleukin-1β signaling: impact on Alzheimer’s Disease"

Abstract: Inflammation is a fundamental protective response, but if it becomes dysregulated it can be a major cofactor in the pathogenesis of many chronic human diseases, including Alzheimer disease (AD). Interleukin-1β (IL-1β)-mediated chronic inflammation represents a key mechanism by which Aβ drives the development of synaptic impairment and cognitive decline in AD. The pro-inflammatory activities of IL-1β are regulated at three levels: synthesis and release; activation/degradation of the membrane receptor; and intracellular signal transduction, all of which are tightly controlled to ensure proper activation and resolution of immune responses. The disruption of these processes may cause excessive inflammatory responses, however, the underlying mechanisms by which Aβ modulates IL-1β signaling remain unknown. We aim to evaluate if changes in intracellular protein clearance and trafficking are early Aβ-triggered events leading to exacerbated IL-1β-mediated inflammation, which in turn elicits tau pathology, synaptic dysfunction and cognitive decline. 

 

 

About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

The scheduled QBI Neuroscience Seminar series are held on Wednesdays from 11am-12pm in the Level 7 Auditorium of the Queensland Brain Institute, Building 79, St Lucia Campus, The University of Queensland. Additional seminars may be held at other times as listed below.

 

Neuroscience Seminars archive 2005-2018