International Leaders in Neuroscience Seminar


Professor Dame Linda Partridge 

Max Planck Institute for Biology of Ageing, Cologne, Germany and Institute for Healthy Ageing, and GEE, University College London, UK

Title: "The ageing fly nervous system"

Abstract: Ageing is a complex process of loss of function in multiple cell types and tissues, but has nonetheless proved to be malleable to genetic and environmental intervention. Reduced activity of the insulin/insulin-like growth factor (Igf)/target of rapamycin signalling network has proved capable of ameliorating age-related decline in the nematode worm Caenorhabditis elegans, Drosophila and mice, and increasing genetic and phenotypic evidence points to its importance in human ageing. Drosophila is an excellent model for both natural ageing of the nervous system and neurodegenerative disease. Lowered insulin/Igf/TOR signalling can ameliorate natural age-related decline in neural function, and metabolic intervention with enhanced glucose transport can rescue the pathology associated with a fly model of Alzheimer’s Disease. The nervous system is therefore an important target for the health benefits of this intervention into the ageing process.

About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018