Speaker: 

Dr Justin Wong

Head, Gene Regulation in Cancer Lab, Gene and Stem Cell Therapy Program, Centenary Institute of Cancer Medicine & Cell Biology, University of Sydney, NSW

Title: "Intronic nonsense: Why we should stop ignoring them?"

Abstract:

Eukaryotic messenger RNAs (mRNAs) consist of coding regions called exons, separated by non-coding regions called introns. Under normal circumstances, introns are removed by a process called mRNA splicing, which allows joining together of exons to form mature mRNA transcripts, ready for protein translation. Retention of intron is traditionally viewed as a consequence of mis-splicing with little biological relevance. However, we and others have recently shown that intron retention is a widespread and conserved mechanism of gene expression control in normal cells. Aberrant intron retention is also implicated in diverse human disease. In this talk, I will highlight the functions of intron retention in normal biology and disease including those occurring in neuronal cells. I will also discuss my recent work concerning the control of intron retention via MeCP2-mediated splicing factor recruitment consequent to reduced DNA methylation.

 

About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

The scheduled QBI Neuroscience Seminar series are held on Wednesdays from 11am-12pm in the Level 7 Auditorium of the Queensland Brain Institute, Building 79, St Lucia Campus, The University of Queensland. Additional seminars may be held at other times as listed below.

 

Neuroscience Seminars archive 2005-2016