Professor Loren Frank

Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco

Title: "Neural substrates of memories and decisions"


The ability to use experience to guide behavior is one of the most remarkable abilities of the brain. Our goal is to understand how activity and plasticity in neural circuits underlie both learning and the ability to use learned information to make decisions. These processes engage widely distributed brain circuits, and in this talk I will describe studies that shed light on the links between specific patterns of brain activity and both memory retrieval and memory consolidation.  I will focus on work we have done that identifies hippocampal sharp-wave ripple (SWR) events as a candidate substrate for these memory processes. I will first describe results linking these events to awake memory processes.  I will then present an examination of patterns of cortical – hippocampal information flow around the time of sleep SWRs and discuss the implications for our understanding of memory consolidation.



About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018