Professor Loren Frank

Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco

Title: "Neural substrates of memories and decisions"


The ability to use experience to guide behavior is one of the most remarkable abilities of the brain. Our goal is to understand how activity and plasticity in neural circuits underlie both learning and the ability to use learned information to make decisions. These processes engage widely distributed brain circuits, and in this talk I will describe studies that shed light on the links between specific patterns of brain activity and both memory retrieval and memory consolidation.  I will focus on work we have done that identifies hippocampal sharp-wave ripple (SWR) events as a candidate substrate for these memory processes. I will first describe results linking these events to awake memory processes.  I will then present an examination of patterns of cortical – hippocampal information flow around the time of sleep SWRs and discuss the implications for our understanding of memory consolidation.



About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

The scheduled QBI Neuroscience Seminar series are held on Wednesdays from 11am-12pm in the Level 7 Auditorium of the Queensland Brain Institute, Building 79, St Lucia Campus, The University of Queensland. Additional seminars may be held at other times as listed below.


Neuroscience Seminars archive 2005-2016