Madhusoothanan Bhagavathi Perumal (PhD Exit Seminar)

Queensland Brain Institute, University of Queensland

Title:  Organization of a reverberating cell assembly in the basolateral amygdala


One of the most remarkable features of the brain is its intrinsic disposition to generate oscillatory network activity even in the absence of sensory inputs. Synchronized activity in neurons is readily observed extracellularly as electrical field potential oscillations. These network oscillations are hypothesised to perform many functions, one of which is to facilitate memory consolidation processes. Hebb’s cell assembly hypothesis is one important conceptual framework to correlate network activity and memory. Hebb postulated that neurons with recurrent connections among themselves generate a reverberating activity within a specific temporal window to encode memory traces. This form of temporally organized neural circuit can form a functional unit called a cell assembly. However, what types of neurons are present in a cell assembly and how they are organized to generate reverberating activity are not known.

We investigated how the organization of neurons in the basolateral amygdala (BLA), a key structure for emotional memory consolidation, generates network oscillations. In our preparation, BLA networks spontaneously generated widespread synchronized activity as Sharp Wave oscillations (SWs), a distinct network activity associated with memory consolidation processes. During SWs, stereotypical multi-synaptic events occurred simultaneously in widespread BLA neurons. These SWs could be initiated by a rare and special subset of GABAergic interneuron, the Chandelier neuron (Chn). Simultaneous recordings from pairs of neurons showed the presence of strong glutamatergic and GABAergic feedforward and feedback circuits in the BLA to facilitate reverberating activity. These results provide a novel circuit model for the organization of neurons in Hebb’s reverberating cell assembly for generation of SW oscillations in the BLA.



About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

The scheduled QBI Neuroscience Seminar series are held on Wednesdays from 11am-12pm in the Level 7 Auditorium of the Queensland Brain Institute, Building 79, St Lucia Campus, The University of Queensland. Additional seminars may be held at other times as listed below.


Neuroscience Seminars archive 2005-2016