A/Professor Zhiyi Wei, Department of Biology, Southern University of Science and Technology (SUSTech), Guangdong Sheng, China. "Structural Insights into Presynaptic Active Zone Assembly"
Speaker
A/Professor Zhiyi Wei
Department of Biology, Southern University of Science and Technology (SUSTech), Guangdong Sheng, China
Abstract
Neurotransmitter release relies on an highly specialized presynaptic terminal region, called the active zone. The active zone contains a large number of proteins, including adhesion molecules, receptors, adaptors and scaffolds, which are assembled to form the electron-dense material. How the active zone is assembled properly to fulfill its function and how the assembly is regulated remain elusive. Liprin-alpha, a synaptic scaffold, was found to play a critical role in active zone assembly, by recruiting numerous synaptic proteins. To understand the assembly mechanism of the active zone, we characterized liprin-alpha by combining structural biology, biochemistry and cell biology. Here, I will present our findings.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
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