The Physiologic Role of Alpha Synuclein at the Synapse
Professor Subhojit Roy
University of California, San Diego
USA
Title: The Physiologic Role of Alpha Synuclein at the Synapse
Abstract: Alpha synuclein is a cytosolic presynaptic protein that is strongly implicated in the pathogenesis of Parkinson's disease and related disorders. Despite substantial research, the normal function of alpha synuclein has been controversial, largely because germline single alpha-synuclein knockout mice have mild phenotypes, and deletion of the entire family of synucleins (alpha, beta, gamma) lead to extraneous effects and unwanted compensatory changes at synapses. I will talk about our scientific journey exploring the role of this enigmatic protein, starting from identifying functional interacting partners at the synapse and post-translational regulators, to more recent experiments using somatic gene-editing that achieves acute knockdown without unwanted effects.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details.
