Determining disease mechanism to optimise therapeutic strategies in ALS
Associate Professor Cathy Blizzard
Brain Health Theme Leader
Menzies Institute for Medical Research
University of Tasmania
Title: Determining disease mechanism to optimise therapeutic strategies in ALS
Abstract: Cathy leads a dedicated team of researchers at Menzies focused on uncovering the biological mechanisms that drive the neurodegenerative disease, amyotrophic lateral sclerosis (ALS). With no cure and limited treatment options currently available, there is an urgent need for effective therapies.
Research has shown that increased levels of circulating glutamate and heightened excitability in the motor cortex are key features in ALS, suggesting that disruptions in motor neuron excitability play a critical role in both disease onset and progression. While many clinical trials have aimed to reduce excitotoxicity by dampening neuronal activity, the outcomes have been mixed.
Cathy will present her team’s body of research, which explores the role of altered neuronal excitability in ALS and investigates novel strategies for targeting this pathological process. Their work aims to pave the way for more effective interventions and ultimately improve the lives of those affected by ALS.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details.
