Experience-Driven Molecular Architects of Neuronal Adaptation in Brain Development
Speaker: Dr Nathalie Dehorter
Queensland Brain Institute
University of Queensland
Title: Experience-Driven Molecular Architects of Neuronal Adaptation in Brain Development
Abstract: During the early postnatal period, experience plays a crucial role in shaping the activity of developing neural circuits, influencing brain maturation. Disruptions in this experience-dependent regulation can lead to maladaptive neural circuit formation, contributing to neurodevelopmental disorders such as autism spectrum disorder (ASD). My research explores the role of these activity-dependent mechanisms in brain plasticity and cognitive function during development. I will present recent findings on the tuning of neuronal function and maturation, using a multidisciplinary approach that includes in vivo calcium imaging, fiber photometry, electrophysiological techniques, and genetic analyses. I will demonstrate that early activation of neural circuits during the first postnatal weeks in mice can prevent core behavioural manifestations of ASD and restore the brain's developmental trajectory.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details.
