Marmoset Brain Mapping Project: Bridging Connectome and Transcriptome
Speaker: Dr Cirong Liu
Lab of Translational Brain Imaging
Institute of Neuroscience
Chinese Academy of Sciences
Shanghai, P.R.China
Title: Marmoset Brain Mapping Project: Bridging Connectome and Transcriptome
Abstract: In this presentation, I will provide an overview of the Marmoset Brain Mapping Project, which aims to create detailed maps of the marmoset brain to advance our understanding of brain anatomy and function. A key highlight will be the latest cerebellum atlas, Version 5, which leverages multimodal MRI and spatial transcriptomics to offer a comprehensive view of the cerebellum. We employed ultra-high-resolution MRI for precise neuroanatomical mapping and conducted awake resting-state fMRI studies to reveal distinct functional gradient patterns that differentiate the marmoset cerebellum from that of humans. Using Stereo-seq, a cutting-edge spatial transcriptomics technique, we identified region-specific gene expressions and explored the relationship between the transcriptome and the functional connectome. These new atlases integrate structural, connectivity, and molecular data, providing an unprecedented understanding of the cerebellum. Finally, I will discuss our ongoing efforts to collect ultra-high-resolution MRI data from various species to enhance our knowledge of brain evolution and biodiversity.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details.
